30 results about "Glycal" patented technology

The application belongs to the field of organic synthesis chemistry and relates to a method for preparing alkyl-substituted glycine derivatives by using a visible light-driven decarboxylation alkylation reaction. The method comprises the following steps: mixing glycine derivatives, N-hydroxyphthalimide (NHPI) ester, 2D-COF-4 and an organic solvent, reacting under a blue LED lamp for 24 hours in an argon environment, and obtaining alkyl-substituted glycine derivatives. The method avoids the use of noble metal photocatalysts, the heterogeneous photosensitizer in the reaction is easy to recycle and reuse, the scope of the substrate is wide, and the functional group compatibility is good; the method can be successfully applied to a kilogram-scale amplification experiment, has a good industrial application prospect, and uses a green solvent, ethanol, which is conducive to reducing production cost and production risk and meets the requirements of developing green and environment-friendly chemistry.

This invention provides an oil-purifying cleansing mud and its preparation method. The cleansing mud, by weight, comprises 1-5 parts of a viscosity modifier, 0.01-0.1 parts of a chelating agent, 10-20 parts of a moisturizer, 15-25 parts of a surfactant, 0.1-1 parts of a thickener, 0.1-5 parts of a cleanser, 0.1-2 parts of an antioxidant, 0.1-1 parts of a fragrance, and 50-75 parts of water. The surfactant is a combination of sodium cocoyl glycinate, lauryl hydroxysulfonate betaine, cocoyl glutamic acid, decyl glucoside, potassium cocoyl glycinate, and cetearyl alcohol polyether-25. This oil-purifying cleansing mud, through the use of surfactants, cleansers, and moisturizers, gently cleanses pores, absorbs oil and dirt, and simultaneously soothes the skin, preventing dryness and tightness. The synergistic combination of these components achieves a balance between cleansing, oil removal, and gentleness, precisely regulating the skin's balance and thus enhancing the consumer experience.

The invention provides a synthesis method of [1, 3, 5]-triazinane-1, 3, 5-trimethyl triacetate, which comprises the following steps: reacting glycine methyl ester hydrochloride with alkali in a solvent, and separating the generated product to obtain glycine methyl ester and salt; the preparation method comprises the following steps: carrying out efficient cyclization on glycine methyl ester and a formaldehyde solution under the catalysis of a catalyst to generate [1, 3, 5]-triazinane-1, 3, 5-trimethyl triacetate; and gradient separation of the solvent, the by-product and the product is realized through a gradient separation process, so that the high-content trimethyl [1, 3, 5]-triazinane-1, 3, 5-triacetate is obtained.

This invention relates to a chiral preparation method for florfenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and synthesizes the key chiral intermediate I through an asymmetric aldol reaction process under the action of a pyridinium salt carbonyl catalyst. Subsequently, through reduction, cyclization, fluorination, and hydrolysis ring-opening reactions, the chiral product florfenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction process, highly selectively constructing the two chiral centers on the florfenicol structure, obtaining the desired chiral configuration, and finally synthesizing florfenicol. The preparation method of this invention is simple, rapid, and efficient.

Providing a cosmetic that is not sticky, has excellent skin affinity, and has a smooth feeling. 【Solution means】The cosmetic according to the present disclosure contains (A) 0.1% by mass to 5% by mass of a glycine derivative represented by formula (1) or a salt thereof, (B) niacin or a derivative thereof, (C) a higher alcohol having 14 to 22 carbon atoms, (D) a hydrophilic polyoxyethylene alkyl ether, and (E) a glycerin monoalkyl ether. TIFF2026105749000006.tif43169 (In the formula, R 1 and R 2 each independently represents H, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, etc., and R 3 represents H, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R 1 , R 2 , R 3 do not simultaneously become H.)

This invention belongs to the field of organic synthesis technology, specifically relating to a creatine glycinate and its preparation method, comprising the following steps: pretreatment, drying creatine monohydrate, passing glycine through a 100-mesh sieve and storing it in a desiccator for later use, and selecting a reaction solvent; raw material dissolution, adding the reaction solvent to a reaction vessel, starting stirring and heating, adding creatine monohydrate, and stirring at a constant temperature until completely dissolved, finally obtaining a creatine solution; complexation reaction, adding glycine, increasing the stirring rate and heating after the addition is complete, maintaining the temperature for the complexation reaction, using staged stirring until the complexation reaction is complete; after the reaction is complete, using a gradient cooling method; crystallization and ripening, followed by constant temperature and low-speed stirring for 2 hours, then allowing the crystals to settle completely; after filtration, vacuum drying is performed to finally obtain creatine glycinate. This application solves the problems of uneven reaction, poor crystal quality, and low purity and yield in existing processes, achieving efficient and high-quality preparation of creatine glycinate.

This invention relates to a method for preparing chiral drosildopa. Specifically, the method uses compound 1 and glycine ester as starting materials, and an asymmetric aldol reaction occurs under the action of a pyridinium salt carbonyl catalyst, followed by hydrolysis to obtain drosildopa. Compared with the prior art, this invention utilizes the strong catalytic ability of small molecule pyridinium salt carbonyl catalysts, starts with inexpensive and readily available raw materials, reduces the steps of introducing and removing protecting groups, shortens the synthetic route, and efficiently synthesizes optically pure drosildopa. Furthermore, the preparation method of this invention is simple to operate and environmentally friendly.

This invention relates to the field of phase change energy storage materials technology, specifically to a high-energy-storage composite phase change material for low-temperature applications and its preparation method. Addressing the problems of high supercooling, slow crystallization rate, and poor heat transfer performance in existing low-temperature phase change materials, this invention uses a glycylglycine aqueous system as the high-energy-storage matrix, introduces organic sugar alcohols as phase change temperature regulators, and constructs heterogeneous nucleation sites by adding inorganic nanoparticles. These nanoparticles significantly reduce the nucleation energy barrier of the system, effectively suppressing supercooling and improving the internal heat transfer efficiency of the material. The material obtained by this invention crystallizes rapidly and releases heat efficiently, making it widely applicable in cold chain logistics and food preservation.

This invention provides an absorbent for capturing carbon dioxide and a method for capturing carbon dioxide. By volume percentage, the absorbent comprises 20-60% glycine salt aqueous solution, 10-50% triethylene glycol monomethyl ether, 5-10% ethylene glycol, and the balance being water. This absorbent combines the advantages of glycine salt systems, such as low volatility, non-toxicity, safety, and better antioxidant degradation resistance, while avoiding the risk of solid precipitates forming after absorption by the glycine salt system, which could cause pipeline blockage.

The invention discloses a royal jelly oil control composition. The preparation method of the royal jelly oil-control composition comprises the following steps: freeze-drying collected fresh royal jelly, then putting the material into a supercritical extraction kettle, and introducing CO2 containing an ethanol additive for extraction to obtain a royal jelly fat-soluble component; adding the royal jelly fat-soluble component, capryloyl glycine and ethanol into a reaction kettle, vacuumizing, then adding a carbon dioxide / nitrogen mixture, pressurizing and stirring; removing the pressure, and carrying out rotary evaporation to remove ethanol to obtain a crude product; adding a solvent into the crude product, and stirring and dissolving under ultrasound; centrifuging, and taking supernate, so as to obtain the royal jelly oil control composition. According to the royal jelly oil control composition, a water-soluble supramolecular layered micelle structure is formed through the intermolecular non-covalent bond effect, so that the problem that the composition is insoluble in water is solved, continuous release of active ingredients is realized through a non-covalent bond network, and the bioavailability is improved.

The present invention addresses the problem of utilizing, as resources before being discarded or being used as fertilizer, feed, or biofuel, coffee beans and coffee grounds that are scheduled to be discarded from the viewpoint of effective cyclical use of unused or underutilized resources.　Provided are: an enzymatic reaction composition of coffee beans or coffee grounds containing glutamyl-valyl-glycine; a fermentation composition of coffee beans or coffee grounds containing glutamyl-valyl-glycine; methods for producing the same; and a seasoning composition containing any one of the same.

The invention belongs to the technical field of feed enzymes, and particularly relates to a granulation method of glucose oxidase. The enzyme in the enzyme granules is glucose oxidase, is suitable for feed additives, and is beneficial to animal nutrition and health care. The enzyme powder prepared by mixing the raw materials containing glucoamylase, peach gum, calcium chloride and the like and then spray-drying the mixture has the advantages of partial immobilized enzyme, and the stability is improved. Meanwhile, the surfaces of the enzyme particles are coated with a solution containing xanthan gum and calcium glycinate, the positive reaction is promoted through the calcium glycinate, the effect of catalase in the intestinal tract is inhibited, and the acting effect of the glucose oxidase particles is further improved.

To provide an oil-in-water emulsion cosmetic that blends easily into the skin during application, provides excellent moisturizing properties after application, and is less sticky. [Solution] (A) Glycine derivative or a salt thereof, (B) Hydrophilic nonionic surfactant selected from the group consisting of POE castor oil derivatives and hydrogenated castor oil derivatives, (C) Water-soluble solvent, (D) an oil-in-water emulsion cosmetic comprising oil and (E) water. The content of component (A) is 0.3 to 5% by mass based on the total mass of the cosmetic. This cosmetic comprises emulsion particles containing component (B) dispersed in the aqueous phase.

The objective of this invention is to provide an oil-in-water emulsion cosmetic that maintains or improves the skin's dryness and tightness even when containing glycine derivatives and / or their salts. The solution is an oil-in-water emulsion cosmetic comprising (A) a glycine derivative and / or its salt as shown in formula (a), (B) a polyoxyalkylene-modified silicone, (C) an oil, and (D) water, wherein the content of component (A) is 0.1% by mass or more and 7% by mass or less, based on the total mass of the cosmetic. 3 -O-C(=O)-CH2-NR 1 R 2 (a)

To provide a cosmetic product that blends well with the skin and provides excellent firming and tightening effects. [Solution] The cosmetic composition contains (A) a glycine derivative represented by formula (1) or a salt thereof, (B) a liquid oil that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and (C) a solid or semi-solid oil that is solid at 25°C and contains at least one selected from the group consisting of glyceryl monoalkyl ether, higher alcohols having 18 or more carbon atoms, and candelilla wax. TIFF2026111285000010.tif43169 (R 1 and R 2 R independently represents a hydrogen atom, alkyl group, alkenyl group, aryl group, aralkyl group, aminomethylcarbonyl group, amidino group, alkylcarbonyl group, etc. 3 (This represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group.)

The invention discloses a glycine-derived nitrogen-doped carbon-coated platinum catalyst as well as a preparation method and application thereof. The preparation method of the catalyst comprises the following steps: (1) adding a supported platinum catalyst into a uniform glycine aqueous solution, and uniformly dispersing the supported platinum catalyst; (2) transferring the mixture into a reaction kettle for hydrothermal reaction; (3) cooling the mixture to room temperature, collecting a product through suction filtration, fully washing with ethanol, and then carrying out vacuum drying; and (4) grinding the dried product into uniform powder, and roasting for 2-10 hours at a high temperature of 300-800 DEG C in an inert protective atmosphere to prepare the glycine-derived nitrogen-doped carbon-coated platinum catalyst. The invention provides the application of the glycine-derived nitrogen-doped carbon-coated platinum catalyst in preparation of p-aminophenol through nitrobenzene hydrogenation rearrangement, and the glycine-derived nitrogen-doped carbon-coated platinum catalyst shows high catalytic activity, high selectivity and high stability.

The application relates to the technical field of roxadustat, and particularly discloses a preparation method of roxadustat, which comprises the following steps: S1, taking 4-bromobenzyl bromide as a starting raw material, refluxing 4-bromobenzyl bromide and sodium methoxide in methanol to prepare an intermediate 2; S2, subjecting the intermediate 2 to a Friedel-Crafts acylation reaction with acetic anhydride to prepare an intermediate 3; S3, subjecting the intermediate 3 to an Ullmann coupling reaction with phenol in toluene by using glycine copper as a catalyst to prepare an intermediate 4; the starting raw material is 4-bromobenzyl bromide, the raw material is easy to obtain and low in price, a low-cost conventional reagent is used as a catalytic system, and cheap catalytic systems are used in key reactions, and low-cost alkali-solvent combinations are selected for steps such as aminolysis, so that the preparation cost is greatly compressed from the aspects of raw materials and reagents.

The invention discloses a multi-type gangue synchronous green composite inhibitor for rare earth ore flotation and a flotation method. The inhibitor is formed by compounding water glass, methylglycine trisodium diacetate and starch in proportion. The compound inhibitor is applied to a one-roughing, three-refining and one-sweeping closed-circuit flotation process and is added in the roughing stage. The sodium silicate is used as a dispersing agent and a silicate inhibitor, the trisodium methylglycine diacetate is used as a biodegradable strong chelating agent, carbonate and iron-containing gangue minerals are selectively complexed and inhibited, and the starch is used as a macromolecular covering effect inhibitor. The three components synergistically construct a dispersion-chelating-covering three-stage synergistic inhibition system, silicate, carbonate and iron minerals with different properties in rare earth ore can be synchronously and efficiently inhibited, and the concentrate grade is remarkably improved while the high rare earth recovery rate is guaranteed. The method is high in selectivity, excellent in index, environmentally friendly and suitable for industrial separation of complex rare earth ore represented by bayan obo ore.

The invention discloses a novel 6, 6, 5-tricyclic compound structure, and in particular relates to a 3a-cyano-4-carbonyl-3-aryl-2, 3, 3a, 4-tetrahydrochroman [3, 4-c] pyrrolidine-9bH-1-carboxylic ester derivative, which is called benzopyran [3, 4-c] pyrrolidine derivative for short. In addition, the invention also discloses a preparation method of the benzopyran [3, 4-c] pyrrolidine derivative, which comprises the following steps: by using a transition metal catalyst, dissolving 3-cyano coumarin and a glycine imine ester derivative as raw materials in an organic solvent according to a certain proportion, and carrying out [3 + 2] 1, 3-dipolar cycloaddition reaction to obtain the benzopyran [3, 4-c] pyrrolidine derivative. The catalytic synthesis method is simple and convenient to operate, the used raw materials are all commercial reagents, the reaction condition is mild, the raw material application range is wide, the product yield is high, and certain stereoselectivity is achieved. The novel 6, 6, 5-tricyclic compound comprises coumarin and pyrrolidine structures with potential biological activity, and the synthetic method provides a synthetic scheme for the compound with potential biological activity and has important application value in the field of drug research and development.

This invention provides a method for controlling 3-MCPDE in oils and fats, belonging to the field of oil and fat technology. The reaction steps are as follows: glycine and xylose are added to soybean enzymatic hydrolysate, stirred, and then zinc gluconate is added for ultrasonic treatment. The mixture is dried to a moisture content of 18-22% and the pH is adjusted to 6.8-7.0 to obtain the reaction system. The reaction system is then transferred to a sealed container and reacted at 168-172°C for 27-30 minutes to obtain the Maillard reaction product. The control method of this invention is simple and effective, and can effectively control the 3-MCPDE content.

The present application relates to a cosmetic. [Problem] To provide a cosmetic which is excellent in use feeling. [Solution] A cosmetic comprising (A) a glycine derivative having a specific structure or a salt thereof, (B) a polyglycerin fatty acid ester, and (C) water.

The invention discloses a method for synthesizing L-p-hydroxyphenylglycine methyl ester through solid alkaline catalysis, and belongs to the field of organic synthesis. The preparation method comprises the following steps: firstly, taking ethylene glycol as a raw material, preparing glyoxal through catalytic oxidation, and then preparing glyoxylic acid through ozone oxidation; the preparation method comprises the following steps: reacting glyoxylic acid, urea and phenol under the action of an acidic catalyst to obtain p-hydroxyphenyl hydantoin, reacting p-hydroxyphenyl hydantoin, water and NaCl in the presence of a solid base catalyst to generate p-hydroxyphenylglycine, and splitting the p-hydroxyphenylglycine through D-3-bromocamphorsulfonic acid to obtain the L-p-hydroxyphenylglycine. And finally, reacting under an acidic condition to obtain the L-p-hydroxyphenylglycine methyl ester. The solid base catalyst shows high catalytic activity and recyclability in hydrolysis of p-hydroxyphenyl hydantoin, and is low in reaction temperature, high in reaction efficiency and suitable for industrial production.

The utility model belongs to chemical equipment technical field provides a kind of reaction kettle for cocoyl glycinate synthesis, including the kettle main body being provided with inner kettle body and outer kettle body, inner kettle body is provided with reaction cavity, outer kettle body is sleeved in inner kettle body outside and forms isolation cavity between both, inner kettle body is provided with cooling jacket, cooling jacket is located in isolation cavity;Kettle main body top is provided with main feeding port, lye filling port and cocoyl chloride dropping port, lye filling port position is provided with lye filling pump, and cocoyl chloride dropping port position is provided with precooling component.The utility model provides the reaction kettle for cocoyl glycinate synthesis, by lye filling port and lye filling pump injection lye, to carry out regulation and control to pH in synthesis reaction process, simultaneously by cooling jacket and precooling component synergic temperature control, ensure that in low temperature environment state in synthesis reaction process, to improve synthesis reaction efficiency and product purity and product yield.

The present invention provides a cosmetic composition containing a high concentration of a glycine derivative or a salt thereof, exhibiting excellent usability and stability. [Solution] (A) A glycine derivative having a specific structure or a salt thereof, (B) Monohydric lower alcohols, (C) Spherical powder, and (D)Water A cosmetic composition comprising, The content of component (A) is 0.3 to 5% by mass relative to the total amount of the cosmetic. A cosmetic product in which the content of component (B) is 3% by mass or more relative to the total amount of the cosmetic product.

The invention relates to the technical field of glyphosate production, and particularly discloses a synthesis method and application of a glyphosate intermediate, and during synthesis of the intermediate, the synthesis method comprises the following steps: S1, taking paraformaldehyde as a raw material, adding triethylamine and methanol, mixing, adding glycine, and heating until a solid is dissolved; s2, mixing the feed liquid obtained in the step S1 with dimethyl phosphite, then adding triethylamine to adjust the pH value, and carrying out heating reaction; s3, cooling the reaction liquid obtained in S2, adding a regulator which is weak acid or strong alkali weak acid salt, uniformly mixing, heating, and removing the solvent under negative pressure; and S4, cooling the feed liquid obtained in S3, adding hydrochloric acid, uniformly mixing, standing, crystallizing, filtering, washing, and drying to obtain the glyphosate intermediate. By synthesizing the intermediate, dynamic monitoring, real-time production guidance, yield improvement and cost reduction in the production process are facilitated.

This invention relates to a chiral method for preparing thiamphenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and carries out an asymmetric aldol reaction in the presence of a pyridinium salt carbonyl catalyst, followed by a reduction and amidation reaction to obtain thiamphenicol. This invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starts with inexpensive and readily available raw materials, reduces the steps of introducing and removing protecting groups, shortens the synthetic route, and efficiently synthesizes optically pure thiamphenicol. Furthermore, the preparation method of this invention is simple to operate and environmentally friendly.

This invention relates to a chiral preparation method for chloramphenicol. Specifically, the method uses p-nitrobenzaldehyde and glycine ester as starting materials, and an asymmetric aldol reaction occurs under the action of a pyridinium salt carbonyl catalyst. Following reduction and amidation reactions, chloramphenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction, and to obtain the desired stereoconfiguration product, chloramphenicol, in a single dose. The preparation method of this invention reduces the protection of active groups, shortens the chiral synthetic route of chloramphenicol, is simple to operate, and is environmentally friendly.

The invention discloses a liquid SNCR (selective non-catalytic reduction) denitration synergist and a preparation method, and relates to the technical field of flue gas purification and denitration. The synergist is a clarified homogeneous aqueous solution, and is composed of 55-65% of glucose, 25-35% of maltodextrin, 5-10% of glycine (core active component), 0.5-1.5% of plant source stabilizer and deionized water with conductivity less than or equal to 10 [mu] S / cm, the mass concentration is 10%, and the synergist needs to be matched with urea or ammonia gas for use and adapts to 700-1050 DEG C working conditions (power station boilers, circulating fluidized bed boilers and the like). The preparation method comprises the steps of segmented dissolution, stabilizer addition and constant volume filtration. And storing at 5-30 DEG C, shading, sealing and filling nitrogen, and ensuring that the shelf life is more than or equal to 12 months. The low-temperature denitration efficiency (700-750 DEG C > = 80%) is improved, the ammonia escape (< = 5ppm) is reduced, the storage is stable, the adaptability is strong, and both environmental protection and economy are considered.

An amphiphilic block copolymer, comprising a hydrophobic block and a hydrophilic block, wherein the hydrophobic block is a polydopamine amino acid, and the hydrophilic block is selected from at least one of polysarcosine, polyethylene glycol, polyvinylpyrrolidone, polyacrylic acid, polyacrylamide, poly-N-ethylglycine, polyglutamic acid, polymethyloxazoline, polyethyloxazoline, monomethyl ether polyethylene glycol, polyethylene oxide or polyvinyl alcohol. A polymer nanomicelle, which is a chelate obtained by chelating a phenolic hydroxyl on a side chain of the amphiphilic block copolymer with trivalent bismuth ions. A hyaluronic acid-modified iron-based polymer nanomicelle probe, comprising an iron-based nanomicelle and hyaluronic acid modified on the outer layer thereof, wherein the iron-based nanomicelle is obtained by chelating the amphiphilic block copolymer with a ferric ion compound.

This invention provides a cosmetic that imparts a moisturizing sensation immediately after application and suppresses stickiness. The cosmetic of this invention comprises: (A) a glycine derivative; (B) at least one hydrophilic surfactant selected from the group consisting of polyoxyethylene hydrogenated castor oil and polyoxyethylene phytosterols; (C) at least one lipophilic surfactant selected from the group consisting of polyglycerol diisostearate, sorbitan sesquiisostearate, and sorbitan sesquioleate; (D) an oil component; and (E) water.