61 results about "Glycal" patented technology

The invention discloses a ferrous glycinate and EDTA ferric sodium compound product and a preparation method thereof. The compound product comprises a core material and a double-layer wall material, the core material is prepared from ferrous glycinate and EDTA (Ethylene Diamine Tetraacetic Acid) ferric sodium; the inner-layer wall material is cyclodextrin and Arabic gum; the outer-layer wall material is pectin and hydroxypropyl methyl cellulose; in the compound product, the mass percentage content of the ferrous glycinate is 20%-25%; the mass percentage content of the EDTA ferric sodium is 8%-10%; the mass percentage content of the inner-layer wall material is 60%-70%; and the mass percentage of the outer layer wall material is 2-5%. The EDTA ferric sodium and the ferrous glycinate are compounded to serve as the core material, and the double-layer embedding wall material is adopted, so that the iron fishy smell of the ferrous glycinate can be effectively covered on the basis of relatively high iron absorption and utilization rate, and relatively good stability can be achieved when the iron-iron composite material is applied to a liquid preparation product.

The invention discloses a carbon-coated high-entropy oxide composite material and a preparation method and application thereof.The preparation method comprises the steps that 1, soluble salt of Al, soluble salt of Mn, soluble salt of Co, soluble salt of Ni and soluble salt of Zn are mixed and dissolved in water, and a metal salt mixed solution is prepared; 2) adding glycine into the metal salt mixed solution, and carrying out a water bath reaction; (3) drying the reaction liquid to obtain a gel-like product, continuously putting the gel-like product into the muffle furnace for combustion reaction, and cooling to obtain high-entropy oxide powder; 4) mixing glucose with the high-entropy oxide powder, grinding, and adding a grinding aid during grinding to obtain composite powder; 5, the composite powder is subjected to vacuum drying, sintered in a tubular furnace under the inert atmosphere and naturally cooled to the room temperature. Glucose is adopted as a single carbon source to replace an existing multi-carbon-source complex regulation and control system, the raw material purchasing cost is remarkably reduced, the process control difficulty of multi-carbon-source matching optimization is reduced, and the production stability is improved.

The invention provides a safe and environment-friendly coal-based waste modified hole sealing material, the modified hole sealing material comprises a dry material mixture and water, the dry material mixture comprises the following components by weight: 68-88 parts of coal-based waste; 3 to 5 parts of hydrogel; 2 parts of a bionic binder; 1-5 parts of a modifier; the coal-based wastes comprise coal gangue powder, pulverized coal and fly ash in a weight part ratio of (5-6): 1: 4; the hydrogel is prepared from cellulose ether, high-molecular water-absorbent resin, glyoxal and sodium polyhydroxycarboxylate; the bionic adhesive is prepared from at least one of 3, 4-dihydroxy phenylalanine, N-(N-L-gamma-glutamyl-L-cysteinyl) glycine, acrylic acid and ammonium persulfate. The modified hole sealing material has the advantages of environmental protection, low cost, efficient hole sealing and the like. The invention also discloses a preparation method of the material. The preparation method is simple and feasible.

The purpose of the present invention is to provide a novel beer-flavor fermented alcoholic beverage which has a reduced sugar concentration and a good balance between taste strength and aftertaste. The present invention provides a beer-taste fermented alcoholic beverage having a saccharide concentration of 2.5 g / 100 mL or less, the beer-taste fermented alcoholic beverage having a glycine concentration of 5.5 mg / L or more, an alanine concentration of 4.4 mg / L or more, and a total concentration of glycine and alanine of 10 mg / L or more and 180 mg / L or less.

The application belongs to the field of organic synthesis chemistry and relates to a method for preparing alkyl-substituted glycine derivatives by using a visible light-driven decarboxylation alkylation reaction. The method comprises the following steps: mixing glycine derivatives, N-hydroxyphthalimide (NHPI) ester, 2D-COF-4 and an organic solvent, reacting under a blue LED lamp for 24 hours in an argon environment, and obtaining alkyl-substituted glycine derivatives. The method avoids the use of noble metal photocatalysts, the heterogeneous photosensitizer in the reaction is easy to recycle and reuse, the scope of the substrate is wide, and the functional group compatibility is good; the method can be successfully applied to a kilogram-scale amplification experiment, has a good industrial application prospect, and uses a green solvent, ethanol, which is conducive to reducing production cost and production risk and meets the requirements of developing green and environment-friendly chemistry.

This invention provides an oil-purifying cleansing mud and its preparation method. The cleansing mud, by weight, comprises 1-5 parts of a viscosity modifier, 0.01-0.1 parts of a chelating agent, 10-20 parts of a moisturizer, 15-25 parts of a surfactant, 0.1-1 parts of a thickener, 0.1-5 parts of a cleanser, 0.1-2 parts of an antioxidant, 0.1-1 parts of a fragrance, and 50-75 parts of water. The surfactant is a combination of sodium cocoyl glycinate, lauryl hydroxysulfonate betaine, cocoyl glutamic acid, decyl glucoside, potassium cocoyl glycinate, and cetearyl alcohol polyether-25. This oil-purifying cleansing mud, through the use of surfactants, cleansers, and moisturizers, gently cleanses pores, absorbs oil and dirt, and simultaneously soothes the skin, preventing dryness and tightness. The synergistic combination of these components achieves a balance between cleansing, oil removal, and gentleness, precisely regulating the skin's balance and thus enhancing the consumer experience.

The invention provides a synthesis method of [1, 3, 5]-triazinane-1, 3, 5-trimethyl triacetate, which comprises the following steps: reacting glycine methyl ester hydrochloride with alkali in a solvent, and separating the generated product to obtain glycine methyl ester and salt; the preparation method comprises the following steps: carrying out efficient cyclization on glycine methyl ester and a formaldehyde solution under the catalysis of a catalyst to generate [1, 3, 5]-triazinane-1, 3, 5-trimethyl triacetate; and gradient separation of the solvent, the by-product and the product is realized through a gradient separation process, so that the high-content trimethyl [1, 3, 5]-triazinane-1, 3, 5-triacetate is obtained.

This invention relates to a chiral preparation method for florfenicol. Specifically, the method uses p-methylsulfonylbenzaldehyde and glycine ester as starting materials, and synthesizes the key chiral intermediate I through an asymmetric aldol reaction process under the action of a pyridinium salt carbonyl catalyst. Subsequently, through reduction, cyclization, fluorination, and hydrolysis ring-opening reactions, the chiral product florfenicol is obtained. Compared with existing technologies, this invention utilizes the strong catalytic ability of small-molecule pyridinium salt carbonyl catalysts, starting from inexpensive and readily available raw materials, to efficiently control the stereoselectivity of the aldol reaction process, highly selectively constructing the two chiral centers on the florfenicol structure, obtaining the desired chiral configuration, and finally synthesizing florfenicol. The preparation method of this invention is simple, rapid, and efficient.

Providing a cosmetic that is not sticky, has excellent skin affinity, and has a smooth feeling. 【Solution means】The cosmetic according to the present disclosure contains (A) 0.1% by mass to 5% by mass of a glycine derivative represented by formula (1) or a salt thereof, (B) niacin or a derivative thereof, (C) a higher alcohol having 14 to 22 carbon atoms, (D) a hydrophilic polyoxyethylene alkyl ether, and (E) a glycerin monoalkyl ether. TIFF2026105749000006.tif43169 (In the formula, R 1 and R 2 each independently represents H, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, etc., and R 3 represents H, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R 1 , R 2 , R 3 do not simultaneously become H.)

The invention belongs to the technical field of preparation of green materials, and particularly relates to polymethoxylated flavone co-hybridized hydromagnesite composite powder, a preparation method thereof and application of the polymethoxylated flavone co-hybridized hydromagnesite composite powder in natural rubber master batches. The polymethoxylated flavone co-hybridized hydromagnesite composite powder provided by the invention comprises hydromagnesite, a glycine derivative coated on the surface of the hydromagnesite, and polymethoxylated flavone coated on the surface of the glycine derivative, the hydromagnesite and the glycine derivative are connected through an ester bond, and the polymethoxylated flavone and the glycine derivative are connected through electrostatic adsorption. The polymethoxylated flavone co-hybridized hydromagnesite composite powder provided by the invention not only has better particle size distribution, structural stability, low oil absorption value, low surface polarity and difficulty in agglomeration, but also has high dispersity in rubber, and a composite material prepared from the polymethoxylated flavone co-hybridized hydromagnesite composite powder and the rubber has high mechanical properties and can achieve internal and external synergistic flame retardance and smoke suppression.

This invention belongs to the field of organic synthesis technology, specifically relating to a creatine glycinate and its preparation method, comprising the following steps: pretreatment, drying creatine monohydrate, passing glycine through a 100-mesh sieve and storing it in a desiccator for later use, and selecting a reaction solvent; raw material dissolution, adding the reaction solvent to a reaction vessel, starting stirring and heating, adding creatine monohydrate, and stirring at a constant temperature until completely dissolved, finally obtaining a creatine solution; complexation reaction, adding glycine, increasing the stirring rate and heating after the addition is complete, maintaining the temperature for the complexation reaction, using staged stirring until the complexation reaction is complete; after the reaction is complete, using a gradient cooling method; crystallization and ripening, followed by constant temperature and low-speed stirring for 2 hours, then allowing the crystals to settle completely; after filtration, vacuum drying is performed to finally obtain creatine glycinate. This application solves the problems of uneven reaction, poor crystal quality, and low purity and yield in existing processes, achieving efficient and high-quality preparation of creatine glycinate.

This invention relates to a method for preparing chiral drosildopa. Specifically, the method uses compound 1 and glycine ester as starting materials, and an asymmetric aldol reaction occurs under the action of a pyridinium salt carbonyl catalyst, followed by hydrolysis to obtain drosildopa. Compared with the prior art, this invention utilizes the strong catalytic ability of small molecule pyridinium salt carbonyl catalysts, starts with inexpensive and readily available raw materials, reduces the steps of introducing and removing protecting groups, shortens the synthetic route, and efficiently synthesizes optically pure drosildopa. Furthermore, the preparation method of this invention is simple to operate and environmentally friendly.

The invention provides a preparation method of 5-bromo-4-chloro-1H-indole-3-alcohol, which comprises the following steps: S1.2, carrying out bromination reaction on chloro-6-fluorobenzoic acid and a brominating agent under the action of a catalyst to obtain an intermediate 1; s2, the intermediate 1 and glycine are subjected to an ammonification reaction under the action of organic alkali, and an intermediate 2 is obtained; s3, under the inert gas atmosphere, the intermediate 2 and acetic anhydride are subjected to a cyclization reaction under the action of organic alkali, and an intermediate 3 is obtained; and S4, in an inert gas atmosphere, the intermediate 3 is subjected to a hydrolysis reaction under an alkaline condition, such that 5-bromo-4-chloro-1H-indole-3-ol is obtained. The invention relates to a novel method for synthesizing 5-bromo-4-chloro-1H-indole-3-alcohol by using 2-chloro-6-fluorobenzoic acid as a raw material through four-step reaction of bromination, ammonification, cyclization and hydrolysis. Compared with the prior art, the reaction process is optimized, the number of reaction steps is reduced, and cost control and industrial production are facilitated.

This invention relates to the field of phase change energy storage materials technology, specifically to a high-energy-storage composite phase change material for low-temperature applications and its preparation method. Addressing the problems of high supercooling, slow crystallization rate, and poor heat transfer performance in existing low-temperature phase change materials, this invention uses a glycylglycine aqueous system as the high-energy-storage matrix, introduces organic sugar alcohols as phase change temperature regulators, and constructs heterogeneous nucleation sites by adding inorganic nanoparticles. These nanoparticles significantly reduce the nucleation energy barrier of the system, effectively suppressing supercooling and improving the internal heat transfer efficiency of the material. The material obtained by this invention crystallizes rapidly and releases heat efficiently, making it widely applicable in cold chain logistics and food preservation.

This invention provides an absorbent for capturing carbon dioxide and a method for capturing carbon dioxide. By volume percentage, the absorbent comprises 20-60% glycine salt aqueous solution, 10-50% triethylene glycol monomethyl ether, 5-10% ethylene glycol, and the balance being water. This absorbent combines the advantages of glycine salt systems, such as low volatility, non-toxicity, safety, and better antioxidant degradation resistance, while avoiding the risk of solid precipitates forming after absorption by the glycine salt system, which could cause pipeline blockage.

The invention discloses a royal jelly oil control composition. The preparation method of the royal jelly oil-control composition comprises the following steps: freeze-drying collected fresh royal jelly, then putting the material into a supercritical extraction kettle, and introducing CO2 containing an ethanol additive for extraction to obtain a royal jelly fat-soluble component; adding the royal jelly fat-soluble component, capryloyl glycine and ethanol into a reaction kettle, vacuumizing, then adding a carbon dioxide / nitrogen mixture, pressurizing and stirring; removing the pressure, and carrying out rotary evaporation to remove ethanol to obtain a crude product; adding a solvent into the crude product, and stirring and dissolving under ultrasound; centrifuging, and taking supernate, so as to obtain the royal jelly oil control composition. According to the royal jelly oil control composition, a water-soluble supramolecular layered micelle structure is formed through the intermolecular non-covalent bond effect, so that the problem that the composition is insoluble in water is solved, continuous release of active ingredients is realized through a non-covalent bond network, and the bioavailability is improved.

The present invention addresses the problem of utilizing, as resources before being discarded or being used as fertilizer, feed, or biofuel, coffee beans and coffee grounds that are scheduled to be discarded from the viewpoint of effective cyclical use of unused or underutilized resources.　Provided are: an enzymatic reaction composition of coffee beans or coffee grounds containing glutamyl-valyl-glycine; a fermentation composition of coffee beans or coffee grounds containing glutamyl-valyl-glycine; methods for producing the same; and a seasoning composition containing any one of the same.

The invention belongs to the technical field of feed enzymes, and particularly relates to a granulation method of glucose oxidase. The enzyme in the enzyme granules is glucose oxidase, is suitable for feed additives, and is beneficial to animal nutrition and health care. The enzyme powder prepared by mixing the raw materials containing glucoamylase, peach gum, calcium chloride and the like and then spray-drying the mixture has the advantages of partial immobilized enzyme, and the stability is improved. Meanwhile, the surfaces of the enzyme particles are coated with a solution containing xanthan gum and calcium glycinate, the positive reaction is promoted through the calcium glycinate, the effect of catalase in the intestinal tract is inhibited, and the acting effect of the glucose oxidase particles is further improved.

The present invention relates to the technical field of p-chlorophenylglycine preparation, and proposes a method for preparing p-chlorophenylglycine, comprising the following steps: S1, mixing ammonia water and sodium hydroxide solution, and introducing ammonia gas until saturated to obtain a mixed solution I; S2, adding p-chlorobenzaldehyde and a phase transfer catalyst to chloroform to obtain a mixed solution II; S3, adding the mixed solution II to the mixed solution I, adding ammonium bicarbonate, and stirring for reaction to obtain p-chlorophenylglycine; the phase transfer catalyst comprises tetrabutylammonium bromide and polyethylene glycol 400; the molar ratio of tetrabutylammonium bromide to polyethylene glycol 400 is 7:1-7. The above technical solution solves the problem of low p-chlorophenylglycine yield in the related art.

To provide an oil-in-water emulsion cosmetic that blends easily into the skin during application, provides excellent moisturizing properties after application, and is less sticky. [Solution] (A) Glycine derivative or a salt thereof, (B) Hydrophilic nonionic surfactant selected from the group consisting of POE castor oil derivatives and hydrogenated castor oil derivatives, (C) Water-soluble solvent, (D) an oil-in-water emulsion cosmetic comprising oil and (E) water. The content of component (A) is 0.3 to 5% by mass based on the total mass of the cosmetic. This cosmetic comprises emulsion particles containing component (B) dispersed in the aqueous phase.

The objective of this invention is to provide an oil-in-water emulsion cosmetic that maintains or improves the skin's dryness and tightness even when containing glycine derivatives and / or their salts. The solution is an oil-in-water emulsion cosmetic comprising (A) a glycine derivative and / or its salt as shown in formula (a), (B) a polyoxyalkylene-modified silicone, (C) an oil, and (D) water, wherein the content of component (A) is 0.1% by mass or more and 7% by mass or less, based on the total mass of the cosmetic. 3 -O-C(=O)-CH2-NR 1 R 2 (a)

The invention discloses a synthesis method of (3-chlorophenethyl) glycine benzyl ester, relates to the technical field of synthesis of (3-chlorophenethyl) glycine benzyl ester, and aims at solving the problems that the yield of (3-chlorophenethyl) glycine benzyl ester is low and production is not easy to amplify. And reacting with benzyl bromoacetate in a reaction solvent to generate (3-chlorophenethyl) glycine benzyl ester. According to the method, sodium carbonate is introduced as a basic catalyst, so that the reaction path is optimized. By accurately regulating and controlling the molar ratio (1: 1.2: 1.2) of 3-chlorophenylethylamine, sodium carbonate and benzyl bromoacetate and adopting the low-temperature (0-10 DEG C) reaction condition, side reaction is effectively inhibited, and the yield of a target product is increased to 85% and is increased by 40% or above compared with that in the prior art; dichloromethane is used as a reaction solvent and has the characteristics of high solubility and low boiling point, and an organic phase can be directly extracted and separated, so that the production period is greatly shortened.

The invention discloses a royal jelly oil control composition. The preparation method of the royal jelly oil-control composition comprises the following steps: freeze-drying collected fresh royal jelly, then putting the material into a supercritical extraction kettle, and introducing CO2 containing an ethanol additive for extraction to obtain a royal jelly fat-soluble component; adding the royal jelly fat-soluble component, capryloyl glycine and ethanol into a reaction kettle, vacuumizing, then adding a carbon dioxide / nitrogen mixture, pressurizing and stirring; removing the pressure, and carrying out rotary evaporation to remove ethanol to obtain a crude product; adding a solvent into the crude product, and stirring and dissolving under ultrasound; centrifuging, and taking supernate, so as to obtain the royal jelly oil control composition. According to the royal jelly oil control composition, a water-soluble supramolecular layered micelle structure is formed through the intermolecular non-covalent bond effect, so that the problem that the composition is insoluble in water is solved, continuous release of active ingredients is realized through a non-covalent bond network, and the bioavailability is improved.

The invention discloses a method for synthesizing an amatoxin intermediate through Rh / Cu concerted catalysis, and belongs to the technical field of allylic alkylation reaction, an Rh / Cu concerted catalysis system is used for carrying out chiral selectivity and stereoselectivity allylic alkylation reaction on p-diphenyl imine glycine tert-butyl ester and racemic carboxylic acid allyl ester, and the amatoxin intermediate is synthesized. The rhodium catalyst controls the configuration of electrophilic carbon atoms in allyl ester, the copper catalyst controls the configuration of nucleophilic carbon atoms in unstable enol salt, and finally the amatoxin intermediate is obtained. According to the method for synthesizing the amatoxin intermediate through Rh / Cu concerted catalysis, an Rh / Cu concerted catalysis system can achieve ortho-position three-level three-dimensional center construction, multiple aryl and aliphatic substituted branched chain allyl products are obtained through the Rh / Cu concerted catalysis system, the yield is good or higher, cis-trans isomerization selectivity is high, and the method is suitable for industrial production. The enantiomeric selectivity is good to excellent.

The invention relates to tobacco essence and a heated cigarette, the tobacco essence comprises a flavor substance and a glycine glucose Amadori compound, and the mass ratio of the flavor substance to the glycine glucose Amadori compound is (0.05-20): 1; the fragrant substance comprises an alcohol compound, an alcohol glucoside compound or a combination of the alcohol compound and the alcohol glucoside compound. According to the tobacco essence, the irritation of smoke generated by heating a cigarette can be reduced, offensive odor in the front section, the middle section and the rear section of smoking can be covered, the aftertaste can be improved, the comfort degree in the smoking process can be improved, the stable release rate of the flavor substances can be increased through the mutual synergistic effect of the flavor substances and the glycine glucose Amadori compound, and the flavor substances can be effectively released. And the consistency of the aroma characteristics and the aroma quality of the cigarette can be kept in the smoking process of the heated cigarette.

This application relates to the field of environmentally friendly PCB processing, disclosing an environmentally friendly film removal solution and its preparation method. The environmentally friendly film removal solution is prepared from the following raw materials in weight percentages: 2-4% alkaline hydroxide, 3-5% diethylene glycol butyl ether, 3.5-5.5% tetrahydrofurfuryl alcohol, 2-4% ethylene glycol hexyl ether, 3-5% accelerator, 4-6% stabilizer, and water as the balance; the stabilizer is prepared from hydroxypropyl chitosan, N-tris(hydroxymethyl)methylglycine, quaternary ammonium salt, and water. The environmentally friendly film removal solution of this application is suitable for high-precision PCB board processing, exhibiting good environmental friendliness and dry film removal efficiency, while reducing corrosion of the PCB board's circuit patterns.

The invention discloses a preparation method of tiopronin, and belongs to the technical field of organic synthesis. The process comprises the following three steps of: 1, carrying out amine ester exchange reaction on glycine tert-butyl ester and methyl lactate in an organic solvent under the action of alkali to generate 2-hydroxy propionyl glycine tert-butyl ester; 2, enabling 2-hydroxy propionyl glycine tert-butyl ester and thioacetic acid to generate an intermediate 2 under the action of dialkyl azo dicarboxylate and triaryl phosphine / trialkyl phosphine; and 3, hydrolyzing the intermediate 2 in an organic solvent under the action of acid and alkali in sequence, and carrying out deprotection to generate tiopronin. According to the technical scheme, operation is easy, convenient and stable, products in all steps are easy to separate, the yield is high, environment friendliness is achieved, and a new synthesis way is provided for the compound.

The application discloses a dispersion emulsification composition, a preparation method and a cleansing composition, and relates to 25-35% of non-ionic water-soluble polymer, 15-35% of non-ionic surfactant, 20-30% of emulsifier and 10-20% of polyhydric alcohol; the non-ionic water-soluble polymer is polyethylene glycol; the non-ionic surfactant is a copolymer of ethylene oxide and propylene oxide, the average molecular weight of the copolymer is 1000-5000, the addition mole number of ethylene oxide is 5-35, and the addition mole number of propylene oxide is 25-30; the emulsifier is propylene glycol glycerol ether; and the polyhydric alcohol is one or more of maltitol, dipropylene glycol, propylene glycol and diglycerol. The application further discloses a preparation method of the dispersion emulsification composition and a cleansing composition. In the production process of daily cleansing cosmetics with fatty acid salt and N-acyl glycine salt as common anionic surfactants, the application improves the reaction rate of each raw material, promotes the reaction, increases the solubility and uniformity of crystallization at room temperature, and makes the product more stable.

To provide a cosmetic product that blends well with the skin and provides excellent firming and tightening effects. [Solution] The cosmetic composition contains (A) a glycine derivative represented by formula (1) or a salt thereof, (B) a liquid oil that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and (C) a solid or semi-solid oil that is solid at 25°C and contains at least one selected from the group consisting of glyceryl monoalkyl ether, higher alcohols having 18 or more carbon atoms, and candelilla wax. TIFF2026111285000010.tif43169 (R 1 and R 2 R independently represents a hydrogen atom, alkyl group, alkenyl group, aryl group, aralkyl group, aminomethylcarbonyl group, amidino group, alkylcarbonyl group, etc. 3 (This represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group.)

The invention discloses a glycine-derived nitrogen-doped carbon-coated platinum catalyst as well as a preparation method and application thereof. The preparation method of the catalyst comprises the following steps: (1) adding a supported platinum catalyst into a uniform glycine aqueous solution, and uniformly dispersing the supported platinum catalyst; (2) transferring the mixture into a reaction kettle for hydrothermal reaction; (3) cooling the mixture to room temperature, collecting a product through suction filtration, fully washing with ethanol, and then carrying out vacuum drying; and (4) grinding the dried product into uniform powder, and roasting for 2-10 hours at a high temperature of 300-800 DEG C in an inert protective atmosphere to prepare the glycine-derived nitrogen-doped carbon-coated platinum catalyst. The invention provides the application of the glycine-derived nitrogen-doped carbon-coated platinum catalyst in preparation of p-aminophenol through nitrobenzene hydrogenation rearrangement, and the glycine-derived nitrogen-doped carbon-coated platinum catalyst shows high catalytic activity, high selectivity and high stability.