79 results about "Tiopronin" patented technology

The invention provides a combination medicament of ilaprazole sodium. The medicament is characterized by comprising the following raw materials in percentage by weight: 5-10 percent of ilaprazole sodium, 25-35 percent of reduction composition containing glutathione and tiopronin with a weight ratio of 1:10 and 45-55 percent of diammonium glycyrrhizinate. The invention also provides a preparation process of the medicament. According to a pharmaceutically acceptable dosage of the ilaprazole sodium, the combination medicament can be respectively prepared into medical preparations of the dosage forms of injections of the combination medicament of the ilaprazole sodium, freeze-drying injections of combination medicament of the ilaprazole sodium, coated tablets of the combination medicament of the ilaprazole sodium, enteric capsules, sprays, and the like and is used for treating gastric ulcer.

A freeze-dried powder injection of tiopronin is prepared from tiopronin and the excipient chosen from amino acid, the salt of amino acid, and phosphate through proportionally and respectively dissolving them in the water for injecting, mixing, stirring, sterilizing, pouring in containers and freeze drying.

The invention provides a method for preparing tiopronin. The method comprises the following steps of: (1) making alpha-chloropropionic acid react with thionyl chloride to obtain alpha-chloropropionylchloride; (2) making alpha-chloropropionylchloride react with glycine to obtain alpha-chloroglycine; and (3) making alpha-chloroglycine react further to obtain the tiopronin. The method has the advantages of small quantity of steps, low pollution and high yield.

The invention discloses a pantoprazole sodium combined drug and a preparation method thereof. The pantoprazole sodium combined drug contains the following active ingredients in parts by weight: 35-100 parts of pantoprazole sodium, 15-35 parts of tiopronin, 90-200 parts of calcium glutamate and 15-25 parts of edetate disodium. The pantoprazole sodium combined drug has the functions of preventing damages caused by pantoprazole sodium to liver and other adverse reactions. The invention has the advantages of high drug quality, stable curative effect and advanced preparation method.

The invention relates to the application of a method for refining tiopronin through component solvent. Tiopronin is resolved in mixed solvent of ester solvent and oxazolidinone solvent or mixed solvent of ester solvent, oxazolidinone solvent and aliphatic alkane solvent, and the effect of removing impurities of tiopronin can be achieved through a crystallization procedure; and through the method, the effect of removing the impurity of a-chloro propionyl glycine in tiopronin is remarkable. The method has the advantages that the process procedures are simple, the operation is easy and the product yield is high.

A slow-releasing enteric tiopronin without stimulation and by-effect is prepared from tiopronin (3-65 Wt%), slow-releasing material (5-90) and enteric coating material (3-30).

A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from Erythromycin, Roxithromycin, Clarithromycin, Azithromycin, Dirithromycin; and pharmaceutically acceptable salts or esters thereof. The mucolytic is a mucolytically active thiol, especially N-acetylcysteine, mercaptoethanesulfonic acid, tiopronin or methylcysteine. The adducts can be isolated via a simple and efficient process.

A freeze-dried powder injection of tiopronin is prepared from tiopronin and the human body receptable non-active carrier chosen from dextran, glucose, mannitol, xylitol, lactose, amino acid, etc through preparing liquid medicine, regulating pH value, removing heat source and bacteria, filling in bottles and freeze drying.

The invention relates to a freeze dry tiopronin preparation without adjuvant for intravenous injection and its preparation process, wherein the preparation contains only medicinal Tiopronin but no addition agent of any kinds, one dosage unit of the freeze-dried preparation contains 10-1000mg of Tiopronin. The ratio of the medicament and water in the freeze-dried preparation can be 1:100 to 1:1, the purity of the Tiopronin medicament can be 85-100%.

The invention relates to a medicine-potassium tiopronin used for curing acute and chronic hepatopathy, a method for manufacturing the same and the application in medication. The tiopronin is prepared into potassium salt so as to increase the potassium salt supplement for hepatopaths, and thus the electrolyte balance disorder of hepatopaths is adjusted. The manufacturing method comprises the following steps of: adding tiopronin and potassic inorganic base in organic solvent to undergo the acids-bases salifying reaction with sulfhydryl protecting group assisted in the reaction process; adding precipitator in the system to precipitate at the end of reaction; filtering and drying; finally obtaining potassium tiopronin.

The invention relates to a liposome drug combination and a preparation method of the drug combination. The weights of the effective drug components are listed as follows: the weight of the admixture for hydrogenated soybean phosphatide and sheep brain lecithin with a weight ratio of 2:1 is 300 to 550; the weight of the admixture for cholesterol, stearamide and beta-sitosterol with a weight ratio of 1:1:0.1 is 200 to 400; the weight of the admixture for tiopronin and vitamin E with a weight ratio of 4:1 is 100 to 200; the weight of the admixture for polyethylene glycol-4000 and polyethylene glycol-6000 with a discretional weight ratio is 150 to 200; the weight of vitamin C is 150 to 180; the weight of the admixture for tert-butyl alcohol and anhydrous alcohol with a weight ratio of 1.5 to 2.2:0.01 to 0.05 is 4000 to 7000; the weight of the admixture for paclitaxel and polyene paclitaxel with a discretional weight ratio is 20 and 40; the weight of the admixture for diphenhydramine and cimetidine with a weight ratio of 1:6 is 350 to 500. The invention has the advantages of reducing the drug dosage by nearly one time, increasing the curative effect by over 15 percent, and greatly reducing the side effect of the drugs.

The present invention relates to one kind of Tiopronin amidate for treating acute and chronic hepatosis and its preparation process. The general expression of Tiopronin amidate is shown. The present invention changes Tiopronin with easy oxidation, degradation, volatilation and decomposition into stable Tiopronin amidate with raised smelting point and raised medicinal effect. The Tiopronin amidate may be further used to prepare other medicine preparation.

The invention discloses a nitrogen and sulfur co-doped carbon dot as well as a preparation method and application thereof. The preparation method comprises the steps: heating a carbon source and a nitrogen source in a solvent containing mercaptoglycerol to prepare the carbon dot. Sulfur-containing mercaptoglycerol is used as a sulfur source to participate in the reaction, and mercaptoglycerol canalso be used as a solvent of a reaction system, so that dispersion compatibility among various substances participating in the reaction is good, hydrophilic mercaptan is combined to carbon dot surfaceatoms, and dispersion of carbon dots in a polar solvent is stabilized at the same time. The nitrogen and sulfur co-doped carbon dots are prepared by adopting mercaptoglycerol as the sulfur source, sothat not only can copper ions be detected in a trace amount, but also tiopronin can be further detected, and therefore, the nitrogen and sulfur co-doped carbon dots can be used for constructing a dual-detection sensor capable of simultaneously detecting the contents of the copper ions and tiopronin. The carbon dots are also proved to have low toxicity and good biocompatibility, have differentialantibacterial ability to gram-positive bacteria (including drug-resistant bacteria) and gram-negative bacteria, and have the potential of treating biological bacterial infection.

The invention provides a method for preparing Tiopronin enteric-coated tablet. The method comprises the steps of preparing Tiopronin tablet, tablet wrapping isolation clothes, wrapping enteric coating and the like. The Tiopronin enteric-coated tablet produced according to the method of the invention features simple technique and low cost, and can effectively cover the odor of Tiopronin.

The invention relates to a method for producing and purifying tiopronin disulphide. The method comprises the following steps of: using hydrogen peroxide to oxidize tiopronin to prepare tiopronin disulphide; and using a chromatographic column with C18 as the filling material, and using 0.1% of formic acid aqueous solution which adopts 5-10% of acetonitrile by volume concentration ratio as mobile phase to purify. The tiopronin which is easy to purchase is used as material, and the hydrogen peroxide which is easy to remove is used as the oxidant in the method; the aqueous solution is only adopted in the preparation process, and 0.1% of formic acid aqueous solution which contains only 5-10% of acetonitrile, is primarily adopted in the purification process, so that the dosage of the organic solvent is a little, the environment pollution is reduced and the cost is reduced; simultaneously, residue organic solvent in the tiopronin disulphide reference substance is reduced; moreover, the whole process has simple process steps, is easy to operate with good reproduction quality.

The invention discloses a pharmaceutical composition of tiopronin and its preparing process, wherein the composition is prepared from the following raw materials: tiopronin 100-300, anti-oxidizing agent 2-10. liposome 100-400, vitamin C 100-300, sodium glutamate 400-1000. The invention also provides the process for preparing the pharmaceutical composition.

The present invention relates to a kind of new preparation of hepatitis B treating medicine, and is especially hepatitis B treating soft Tiopronin capsule preparation suitable for being taken orally. The soft capsule contains physiologically effective Tiopronin and medicine carrier suitable for soft capsule, and the pharmaceutically acceptable carrier includes dispersing medium, antioxidant, metal chelate and/or medicine release regulating material.

The invention discloses a special ultrafine tiopronin powder lyophilized preparation and a preparation method thereof. The preparation method comprises the following steps: reacting 2-chloropropionic acid with phosphorus trichloride to generate 2-chloropropionyl chloride, reacting 2-chloropropionyl chloride with glycine to generate 2-chloropropionyl glycine, reacting 2-chloropropionyl glycine with sodium disulfide, reducing by zinc powder to obtain crude tiopronin, purifying, carrying out air jet ultrafine crushing, and lyophilizing to prepare the special ultrafine tiopronin powder lyophilized preparation. The special ultrafine tiopronin powder lyophilized preparation has the advantages of good clarity, high stability, high purity, few impurities, small particle size, large specific surface area, good solubility, small toxic side effects, difficult allergy and the like.

The invention relates to a stable solution containing tiopronin for injection which comprises tiopronin and anti-oxidant as anti-oxidant, wherein the chelating agent is calcium disodium edeate, the acidity regulator is natrium hydroxydatum, osmoregulation agent is sodium chloride, and the bacteria inhibitor is benzoic alcohol. The invention can effectively guarantee the constancy of t he injections during storage and application. The product employs a dosage form of transfusion, thus is especially suitable for in-hospital treatment and patients with difficulty in deglutition.

This invention relates tiopronin amino acid salt used to cure chronic hepatitis and its preparation method. Its constitutional formula is shown as follow; R is 1-20 carbon atoms straight chain or branched chain alkyl radical. This invention solves the problem of tiopronin oxidation degradation in water, and volatilization decomposition in heat. The tiopronin in this invention is prepared into amino acid salt, it prevent the tiopronin combining with oxygen, and its oxidation. Medical using substance melting point is improved, so its thermal stability is greatly improved, so its medical effect as effective constituent is greatly improved.

The invention relates to a tiopronin injection and preparation method, which overcomes the tiopronin's shortcoming of poor stability in water, and provides a tiopronin injection. The invention also provides the process for preparing the tiopronin injection.