The invention relates to an effervescent mixture, specifically relates to a solid effervescent mixture for the oral absorption and preparation method thereof. The invention comprises the alkalic component of a mixture consisting one or more than one of alkali metal carbonate, alkali metal bicarbonate, alkaline earth metal carbonate or pearl powder; the acid component of a mixture consisting one or more than one of tartaric acid, citric acid, adipic acid, fumaric acid, maleic acid, malic acid, folic acid andacid phosphate; The medical component of a mixture consisting of one or more than one of vitamin C, glucurolactone, natural caffeine, haw extract, green tea extract, hovenia acerba extract, semen myristicae extract, Poria cocos extract, Amomum tsao-ko extract, root of kudzu vine extract, spina date seed extract, cassia twig extract, Lesser Galangal Rhizome extract, and chrysanthemum extract; the wrapper and auxiliary material of a mixture consisting one or more than one of polyethylene glycol (PEG), panthenol and glycerin monostearate. The invention comprises, by weight, 5-50% of alkalic component; 5-50% of acid component; 1-40% of medical component; 0.5-35% of wrapper; 1-10% of auxiliary material. The invention has advantages of being fast in effect, and convenient in medicine taking and carrying.