This invention discloses a strain of *
Lactobacillus plantarum* CCFM1487 and its prepared metagener for lowering lipids and alleviating
fatty liver, as well as its application in converting cassiaside. It belongs to the fields of microbial technology and food and health product technology. This strain can efficiently convert cassiaside into cassiaside
aglycone. The core of this invention lies in providing a metagener prepared from this strain through
fermentation and inactivation treatment. Experiments in a high-
fat diet mouse model have demonstrated that it significantly reduces serum
total cholesterol and
triglyceride levels, and can alleviate
hepatic lipid deposition and improve hepatic
steatosis. Based on this metagener, foods, medicines, or health products can be developed for the prevention and / or
adjuvant treatment of metabolic disorders such as
hyperlipidemia and non-
alcoholic fatty liver disease, possessing significant application value.