94results about How to "Meet clinical needs" patented technology

The invention discloses an acute kidney injury risk early warning system, and relates to the technical field of clinical decision support systems. In order to solve the problems that in the prior art, due to the fact that a large amount of data preprocessing and model training need long-time data processing and model operation, the early warning opportunity is not accurate, the real-time performance is low, personalized early warning prompting cannot be carried out for patient groups, and early warning fatigue and early warning desensitization are likely to be caused. Through data preprocessing, model construction and risk analysis, real-time monitoring and accurate prediction of the AKI risk of a patient are realized, the early recognition rate is improved, the early warning decision unit generates specific early warning information according to risk scores and kidney function change rules and provides targeted treatment suggestions, and meanwhile, through an early warning threshold adjustment and approach matching module, the early warning decision unit can perform early warning on the AKI risk of the patient. The early warning strategy is optimized, the response speed of medical staff and the compliance of patients are improved, and the user interaction unit continuously optimizes the early warning system through a feedback mechanism.

The invention discloses a hollow skeleton type drug-loading rod core as well as a preparation method and application thereof. The raw material composition comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; 0.45 to 20 parts of hydrogen-containing silicone oil; more than or equal to 0.000002 parts of a catalyst; the content of vinyl in the R-vinyl silicone rubber is 0.1-0.5 mol%; the content of Si-H groups in the hydrogen-containing silicone oil is 0.18 to 1.6 mol%; the molar ratio of the Si-H group to the vinyl group is (0.5-20): 1. According to the invention, methyl vinyl silicone rubber, hydrogen-containing silicone oil, a platinum catalyst and other components are taken as a basic prescription of silicone rubber, and a model drug and the silicone rubber are mixed by using an extrusion technology to prepare the hollow skeleton type drug-loaded rod core. Advantages of traditional storage type implants and skeleton type implants are integrated, the production process is simple, the medicine application range is wide, the release amount is stable, and the release amount is large.

The invention provides a method for converting a multi-stage non-iodine contrast CT image into a coronary artery CTA image, and the method comprises the steps: obtaining an NCCT volume and a CTA volume which are matched, carrying out the data preprocessing, and constructing a training data set; respectively constructing an NCCT encoder-decoder network and a CTA encoder-decoder network, and carrying out pre-training based on the training data set; a mark reconstruction network is constructed and trained, a masked low-resolution CTA mark is reconstructed under the condition of an NCCT token obtained by a trained encoder, and then a low-resolution CTA volume is reconstructed by a trained decoder; a super-resolution network is constructed and trained, and a high-resolution CTA image is generated from the low-resolution CTA image; a high resolution CTA volume is generated from the low resolution NCCT volume using the trained multi-stage model. The method has the beneficial effects that the problem of posterior crash is avoided, the decoding speed during reasoning is higher, and the training process is more stable; in the low-resolution stage, the model can learn multi-scale context information, and in the high-resolution stage, the model focuses on recovering details, more fine structures are reserved in final output, and clinical requirements can be met.

The invention relates to the technical field of computer vision and image processing, in particular to a high-precision target recognition and positioning method. The method comprises the following steps: carrying out image acquisition and preprocessing on a target area to obtain original image data; calibrating and correcting the original image data to obtain accurate image information; calculating depth information of the target by adopting a depth estimation method based on an SGM algorithm; parallax optimization is carried out on the depth information, and the accuracy and stability of the image are improved; and through a post-processing and output control module, depth information output in various formats is generated. The depth estimation method based on the SGM algorithm and the single-channel separation processing of the YUV image data are introduced, so that the target recognition and positioning precision and the processing speed are remarkably improved, and especially in potential application in the medical field, powerful technical support is provided for an intelligent microcirculation skin therapeutic instrument.

The invention relates to the technical field of medicines, and provides a cyclic peptide compound, a pharmaceutical composition and application. The cyclopeptide compound provided by the invention has a structure as shown in a formula I. The cyclopeptide compound has remarkable EphA2 targeting affinity, has remarkable drug development potential on an EphA2 target spot, and has a wide application prospect in diagnosis, prevention and treatment of related diseases with high expression of EphA2. The result of the embodiment shows that the affinity constant KD of the cyclopeptide compound provided by the invention and an EphA2 target is between 1 * 10 <-9 > M and 1 * 10 <-7 > M, the cyclopeptide compound is difficult to dissociate after being combined with the target, and meanwhile, the cyclopeptide compound has very strong competitive capacity for a ligand Ephrin-A1 of the EphA2 target. # imgabs0 #

The invention discloses a leukocyte-rich PRP extraction method based on a leukocyte-rich PRP extraction device. The extraction device comprises a centrifugal tube body and a tube cap which are buckled with each other, the centrifugal tube body sequentially comprises a first cavity, a second cavity and a third cavity from top to bottom, the first cavity, the second cavity and the third cavity are communicated in sequence, and the tube inner diameter of the second cavity is smaller than that of the third cavity; one end of the piston is fixedly connected to the base; one end of the second cavity is embedded in the first cavity, the other end of the second cavity is embedded in the third cavity, the base covers an opening of the third cavity through threaded connection, the volume of a collected blood sample is defined as Lml, the minimum volume of the third cavity reaching the top limit position is 0.30-0.35 * L, and the volume of the second cavity is 0.2-0.3 * L; the separating device comprises a screw rod which sequentially penetrates through the base and the piston and extends to the third cavity, and a plug and a knob cap which are connected to the two ends of the screw rod; and the plug is used for blocking the second cavity.

The invention relates to the technical field of oral cavity treatment instruments, and provides an oral cavity multi-professional endoscope and an image artificial intelligence processing auxiliary diagnosis method. The multi-specialty endoscope for the oral cavity comprises an insertion part, an operation part, a signal line and light-guide fibers, the front end of the operation part is connected with the insertion part, the front end of the insertion part is provided with an image acquisition element, the image acquisition element is connected with the signal line, and the signal line is connected with the host; a light source is arranged in the operation part or the main machine, and when the light source is located in the main machine, light is transmitted to the insertion part through the optical fiber; the lens tube of the insertion part is in a hook shape, a bent shape, a straight rod shape or other shapes capable of being observed. According to the embodiment of the invention, fine structures of oral tissues such as tooth pulp cavity root canal, periodontium, implant cavity and salivary gland catheter can be directly examined.

The invention is applicable to the technical field of drug-loaded polymer medical preparations, and provides a flurbiprofen-based analgesic spray and a preparation method thereof, the flurbiprofen-based analgesic spray comprises the following components by weight: 0.5%-10% of flurbiprofen, 5%-15% of a cosolvent, 0.5%-15% of a humectant, 0.01%-1.5% of a preservative, 0.1%-5% of a penetration enhancer, and the balance of purified water; preferably, the analgesic spray comprises the following components in percentage by weight: 1.0%-8.0% of flurbiprofen, 8%-12% of a cosolvent, 5%-10% of a humectant, 0.01%-1.0% of a preservative, 0.5%-3% of a penetration enhancer and the balance of purified water. According to the scheme, the high-dose flurbiprofen spray can release more quickly than a sustained-release patch within the same time, the analgesic spray is more stable in efficacy and more quick in effect, and the analgesic spray is simple in preparation process, moderate in dosage of raw materials and auxiliary materials, stable in efficacy and capable of meeting clinical requirements.

The invention relates to the technical field of solution electrolyte detection, in particular to an on-line real-time quantitative detection method for iCa in laser-induced breakdown spectroscopy dialyzate, which comprises the following steps: obtaining an original spectrum according to a training sample set, preprocessing the original spectrum to obtain a preprocessed spectrum, converting the preprocessed spectrum into a two-dimensional spectrum matrix, and calculating the iCa in the two-dimensional spectrum matrix; carrying out feature extraction to obtain a feature spectrum; the initial model is trained according to the characteristic spectrum and the first training sample set to obtain an optimization model; and establishing a regression curve by the optimization model according to the test sample set, and evaluating the optimization model to obtain a concentration prediction model. According to the invention, the original spectrum is pretreated to obtain the pretreated spectrum, so that the problems of non-uniform distribution of substances in the dialysate and non-uniform excitation degrees of the same sample in an experiment are solved; a concentration prediction model is obtained according to the regression curve, accurate detection of the content of the two elements of ionized calcium or potassium in the real flowing dialysate is achieved according to the concentration prediction model, and clinical requirements are completely met.

The invention discloses a composition containing a recombinant human nerve growth factor, application of the composition and an ophthalmic preparation. The composition is prepared from the following components in parts by weight: 0.005 to 1 part of recombinant human nerve growth factor, 20 to 70 parts of trehalose, 5 to 30 parts of mannitol and 1 to 13 parts of polyvinyl alcohol. The trehalose, the mannitol and the polyvinyl alcohol are compounded with the recombinant human nerve growth factor, so that the stability of the recombinant human nerve growth factor can be remarkably improved, and the loss of pharmacological active ingredients of the ophthalmic preparation in the preparation, transportation and long-term storage periods is reduced, so that the medication safety and the treatment effect are ensured; and the recombinant human nerve growth factor in the ophthalmic preparation is good in stability, so that the clinical requirements of patients with eye diseases can be better met.

The invention discloses an iron-based metal nano diagnosis and treatment agent as well as a preparation method and application thereof. The iron-based metal nano diagnosis and treatment agent comprises an iron-based metal nano material and a diagnosis and treatment agent loaded with therapeutic nuclide 177Lu and / or a micromolecular chemotherapeutic drug F16. The iron-based metal nano diagnosis and treatment agent contains an iron element, can be used for MRI imaging and can induce tumor ferroptosis at the same time, radionuclide 177Lu can emit gamma rays for SPECT imaging and can emit beta rays for tumor internal radiotherapy, tumor mitochondria targeting small molecule medicine F16 has the fluorescence characteristic and can be used for tumor real-time fluorescence imaging, and the application range is wide. Meanwhile, a mitochondrial targeting tumor killing effect is achieved. Therefore, the iron-based metal nano diagnosis and treatment agent disclosed by the invention can realize comprehensive collaborative treatment of intratumor radiotherapy, targeted chemotherapy and ferroptosis under the guidance of MRI (Magnetic Resonance Imaging), SPECT (Single Photon Emission Computed Tomography) and multi-mode imaging of fluorescence imaging, and improves the precise diagnosis and treatment of tumors.

The invention discloses an objective optical system for a paranasal sinus endoscope, which comprises a first lens group with negative focal power, a second lens group with positive focal power, a diaphragm, a third lens group with negative focal power and a fourth lens group with positive focal power in sequence from an object side, and meets the following conditional expressions: (1) 14.0 lt; vd (RN) lt; 19.6, 19.6; (2) 18.0 lt; vd (RN) lt; 23.3, 23.3; (3) 380 lt; vd (RN) / (ng-nF) lt; 1080, 1080; (4) vd (RP) + vd (RN) lt; 79); (5) f1 / flt; -1.1,...,-1.1; (6) f2 / flt; -2.2,-2.2; (7) 1.92 lt; f < 2 > is 6 / f < lt >; 3; the effect of inhibiting magnification chromatic aberration is achieved, the requirement for a large clear range can be met, and confocal of white light and fluorescent light is achieved; meanwhile, optical shooting guarantee is provided for the paranasal sinus endoscopic medical imaging technology, the completeness and authenticity of optical data are guaranteed, and the effectiveness of the optical data is improved for imaging medical treatment and remote medical treatment.

The present application relates to the technical field of biomedicine, and specifically discloses a sodium alginate embolic particle and its preparation method and application. The preparation method of the sodium alginate embolic particle disclosed in the present application comprises the following steps: dissolution, primary freeze drying, infiltration, cross-linking, secondary freeze drying, crushing and screening, and sterilization; dissolution is: preparing a 1.7-2.3wt% sodium alginate aqueous solution, adding a freeze-drying protective agent, stirring at 55-65°C, and cooling to 0-5°C; infiltration is: infiltrating the sodium alginate sponge obtained by primary freeze drying in a sodium alginate aqueous solution with a mass concentration of 0.1-0.8wt% to reach saturation, and obtaining a sodium alginate infiltrate; cross-linking is: immersing the sodium alginate infiltrate in a cross-linking liquid for cross-linking reaction. Using the technical solution provided by the present application, sodium alginate embolic particles with high porosity, uniform particle size, small average pore size, suitable water absorption, excellent suspension performance, and excellent catheter passing performance can be obtained.

The utility model discloses a detachable gas pipeline detection alarm device, including first gas pipeline and second gas pipeline, first gas pipeline and second gas pipeline both ends are connected through two three -way pipes each other, set up oxygen detection subassembly respectively on first gas pipeline and second gas pipeline, set up pressure sensor and audible -visual alarm respectively on the side of oxygen detection subassembly, set up respectively on first gas pipeline and second gas pipeline, set up solenoid valve on three -way pipe two output respectively, the utility model discloses a two gas pipelines cooperation setting will be convenient according to the demand adjustment replacement and use, when one of them gas pipeline produces use abnormality can close use another gas pipeline, improve its work efficiency, need not to stop machine replacement, utilize oxygen detection subassembly, pressure sensor, audible -visual alarm simultaneously to real -time monitoring to gas pipeline, if appearing abnormality will through audible -visual alarm and remind medical staff in time handle.

The utility model discloses a kind of obstetric flushers, including liquid storage tank, connecting pipe, extension piece, direction-changing arm and spray head, liquid storage tank includes the tank body for storing cleaning fluid and is set to the pressing portion of tank body tail end, pressing portion is corrugated structure, with good elasticity and resilience, tank body opening end is connected connecting pipe and extension piece in turn by thread, extension piece one end is equipped with rotatable direction-changing arm, direction-changing arm one end is equipped with locating head and input hole, the other end is connected with spray head, liquid can be in palm pressing pressing portion after via passage and input hole into direction-changing arm and from spray head to spray to realize flushing function, the extension piece outside is provided with accommodating groove for folding storage direction-changing arm, connecting pipe outside is equipped with antiskid structure to facilitate operation, structure design is reasonable, connection is stable, spray direction is adjustable and convenient to store.

The invention belongs to the technical field of macromolecular biological materials, and particularly provides a preparation method of a polyether-ether-ketone material, which comprises the following steps: 1) pretreating polyether-ether-ketone, cleaning the surface and removing surface burrs; 2) performing surface high-temperature carbonization treatment on the pretreated polyether-ether-ketone to carbonize the surface of the polyether-ether-ketone to form a carbonized layer with a porous structure; (3) carrying out surface deposition treatment on the modified polyether-ether-ketone obtained in the step (2), and directly depositing a carbide coating on the surface of the carbonization layer with the porous structure or depositing and constructing a metal coating, a biological ceramic coating and a polymer coating on the surface of the carbonization layer; 4, the modified polyether-ether-ketone obtained in the step 3 is subjected to aftertreatment to eliminate surface residual stress, and the polyether-ether-ketone material with the high biological activity is obtained.The polyether-ether-ketone material has good biocompatibility and biological activity and can meet the clinical requirements of the medical field.

The utility model relates to the technical field of medical instruments, and provides a plugging support and a plugging balloon catheter, and the plugging support comprises a supporting part and an intercepting part; the supporting part can be contracted and unfolded for supporting, one end of the intercepting part is connected with the supporting part, the other end of the intercepting part is gradually contracted and extends to form a cone shape, the supporting part and the intercepting part are both provided with hollowed-out parts, and a woven mesh is arranged in the hollowed-out part of at least one of the supporting part and the intercepting part. According to the utility model, the woven mesh is arranged in the hollow part of at least one of the supporting part and the intercepting part, so that the gap of the occlusion stent is further reduced, and the woven mesh can better leave substances in blood vessels, so that the occlusion time is shortened, and the clinical requirements of acute vascular embolism occlusion are met.

The utility model discloses a long-arm vertical molar buccal tube which comprises a bracket and a buccal tube body, the two sides of the buccal tube body are connected with the bracket and an L-shaped first traction arm respectively, and the tail end of the first traction arm is connected with a second traction arm parallel to the buccal tube body. And the tail ends of the first traction arm and the second traction arm are respectively provided with a first traction hook and a second traction hook. According to the utility model, the adjustable force application point design is adopted, forces in different directions are applied to the molar through the control supporting point, the vertical movement of the root can be controlled, the overall parallel movement can also be carried out, and the three-dimensional accurate control of the molar can be realized through the combined use, so that the treatment requirements of different patients can be met; and the possibility of personalized design and adjustment is provided for the patient.

The invention provides an implantable dialysis device with a temperature control function, and belongs to the technical field of dialysis, the implantable dialysis device comprises an implantable dialysis body and an external temperature control base, the implantable dialysis body comprises a blood temporary storage port and a blood vessel communicating pipe, the blood temporary storage port is composed of a port seat and a puncture part, the port seat comprises a nickel-titanium alloy middle layer and an outer coating layer, and the outer coating layer comprises a nickel-titanium alloy outer coating layer. The puncture part comprises a stent membrane which can be punctured by the puncture needle, and the blood vessel communicating pipe is located at at least one end of the blood temporary storage port, communicates with the blood temporary storage port and is used for being connected with an artery or vein blood vessel; the external temperature control base comprises an electrified coil, and an electromagnetic field can be formed between the electrified coil and the nickel-titanium alloy middle layer to heat the nickel-titanium alloy middle layer; the device not only can replace internal fistula in a traditional dialysis mode, but also can heat subcutaneously to a proper temperature based on an electromagnetic heating principle, so that the dialysis quality is improved, and the risk of related complications caused by dialysis is reduced or avoided.

The application relates to the technical field of nanobiosensors, and discloses a bimodal nanoprobe for uric acid detection and a preparation method and application thereof. The bimodal nanoprobe is a fluorescence-photothermal bimodal nanoprobe, and is a core-shell structure nanoparticle, which comprises, from the inner layer to the outer layer, a) a fluorescent inner core composed of carbon dots and a silica layer coated outside the carbon dots; b) a manganese dioxide layer coated outside the fluorescent inner core; and c) a molecularly imprinted polymer layer coated outside the manganese dioxide layer. The bimodal nanoprobe in the application integrates a fluorescence signal source (carbon dots), a signal modulation and photothermal unit and a specific recognition layer (a uric acid molecularly imprinted polymer) through ingenious structure design, realizes bimodal sensing of "specific recognition -> MnO2 etching -> fluorescence recovery / photothermal weakening" on UA, and effectively solves the problems of poor selectivity, complicated operation and high cost of traditional methods.

This invention discloses a novel L-shaped SPECT probe design method, relating to the field of SPECT probe design. It includes the following steps: S1: Determine the position of the L-shaped gantry based on the patient's clinical requirements, and design an L-shaped slide rail according to the L-shaped gantry; S2: The SPECT probes are evenly arranged on the L-shaped slide rail, and the SPECT probes are driven by a motor; S3: The SPECT probes compensate for the acquisition dead zones between them by changing their position left and right on the L-shaped slide rail. Furthermore, the SPECT probes can enter different position modes by changing the forward and backward displacement of the L-shaped slide rail. This invention provides a novel L-shaped SPECT probe design method that can meet the clinical needs of patients with dextrocardia, obesity, and claustrophobia; the acquisition method conforms to the patient's body structure, improves the acquisition count and the amount of acquired information, enhances spatial resolution, and improves the accuracy of image quality.

The present invention discloses a pharmaceutical composition, a preparation, a preparation method and a use of an antibody-drug conjugate. The present invention provides a pharmaceutical composition comprising the following components: 5 to 25 mg / mL of F0124-ADC; 7 to 90 mg / mL of a protein protective agent; 0.05 to 1.0 mg / mL of a surfactant; 5 to 20 mM of a buffer salt; water; the pH value of the pharmaceutical composition is 5.0 to 5.5; wherein F0124-ADC is an antibody conjugate. The pharmaceutical composition greatly improves the production, storage and use stability of the drug, avoids the premature release of small molecule active substances; the long-term stability experiment verifies that the formula can meet the clinical needs of F0124-ADC; and improves the safety of clinical use.

The utility model belongs to orthopedics instrument technical field, specifically disclose a kirschner wire angle positioning sleeve, including sleeve body, sleeve body is circular table shape, and the centre positioning hole is passed through and is established in the middle part, and the centre positioning hole is surrounded and is set up a plurality of inclined guide hole outside ring, still surround and set up a plurality of fixed adjusting holes outside the centre positioning hole, fixed adjusting hole is located between the centre positioning hole and inclined guide hole, and the aperture of fixed adjusting hole is less than the aperture of inclined guide hole and centre positioning hole. When carrying out the predetermined introduction of kirschner wire, first, kirschner wire is vertically entered into bone cortex through the centre positioning hole, and then according to the need, the angle of kirschner wire is adjusted and introduced through the inclined guide hole, then the kirschner wire is introduced through the fixed adjusting hole to fix the position or adjust the parallel position, realize the angle and parallel position adjustment of kirschner wire in the same needle point, satisfy the clinical demand.

A spine internal fixing device with a fusion function comprises a pedicle screw, the pedicle screw comprises a screw body, a screw tail is arranged at the upper end of the screw body, a nut is connected to the screw tail through internal threads, the screw body and the screw tail are of a honeycomb structure simulating cancellous bone, and solid external threads are arranged on the outer surface of the screw body. According to the spinal internal fixation device with the fusion function, a full-assembly simulation cancellous bone honeycomb structure of a pedicle screw rod nut and a matched connecting piece is prepared by adopting a 3D printing technology, and meanwhile, solid structures of key stress parts such as an external thread tip threaded connection surface are reserved so as to guarantee early mechanical fixation strength; after the components are assembled, a continuous bone ingrowth channel is formed, so that the transformation of internal fixation of the spine from temporary mechanical support to permanent osseous fusion is realized, and various intervertebral, intervertebral, posterior lateral and transverse process bone grafting fusion steps in a traditional spine fusion operation can be omitted.

An autograft press-fitting shaping device with an anti-overpressure function, comprising a base, a fixed block is fixedly connected to the top of the base, a lower mold is installed on the outer side of the fixed block, a support rod is fixedly connected to the top of the base, a top plate is fixedly connected to the top end of the support rod, a pressure rod is threadedly inserted into the middle of the top plate, and a mounting block is rotatably connected to the bottom end of the pressure rod; the application realizes quick replacement of the mold, moves the limiting block away from the positioning block by driving the unlocking block to move the linkage sliding plate through the pressure rod, realizes quick disassembly and replacement of the upper mold and the lower mold, and significantly improves the adaptation ability of the device to autografts of different shapes; the detachable mold structure design makes the upper mold and the lower mold flexible to replace according to different surgical needs, meets the clinical needs of diversified graft press-fitting shaping, simplifies maintenance and cleaning, the mold can be independently disassembled, is convenient for thorough cleaning and inspection, avoids wear or pollution caused by long-term use, and ensures shaping precision and graft product quality.

The invention discloses a DR characteristic index calibration method and a DR imaging system, and the method comprises the steps: obtaining a current DR characteristic index baseline value, the DR characteristic index baseline value is used for representing the reference level of a DR characteristic index, and the DR characteristic index baseline value is used for representing the reference level of the DR characteristic index; the DR feature index is determined according to at least one image feature of a gray scale entropy feature, a texture feature, a noise feature, a gradient feature and a divergence feature extracted from the DR image; carrying out calibration operation on the current DR characteristic index baseline value; calibrating the current DR characteristic index baseline value in response to the calibration operation, and obtaining a calibrated DR characteristic index baseline value; and displaying the calibrated DR characteristic index baseline value. The reference level of the DR feature index is represented through the DR feature index baseline value, the imaging effect of the DR image can be reflected more accurately, and the DR feature index baseline value can better meet clinical requirements by calibrating the DR feature index baseline value.

The utility model discloses a slit lamp with a positioning cursor, which relates to the field of medical instruments and equipment and comprises a base, a lens body mounted at the upper end of the base, a lens seat and a lens barrel arranged on the lens body, an observation eyepiece arranged on the lens seat, and an optical convex lens mounted at one end of the lens barrel. The end, close to the optical convex lens, of the lens cone is in threaded connection with a threaded locking ring, the upper end of the lens base is fixedly connected with a mounting base, one end of the mounting base is provided with a fixing plate, the fixing plate is internally provided with a connecting mechanism, the upper end of the mounting base is provided with a mounting plate, the upper end of the mounting plate is movably connected with a positioning cursor body, and the mounting plate is internally and symmetrically provided with fixing mechanisms. By the adoption of the structure, a doctor or a technician can quickly complete mounting or dismounting work, complex operation steps or professional tools are not needed, work efficiency is improved, operation difficulty is lowered, and the checking accuracy and efficiency are improved by quickly replacing a proper positioning cursor.

The present application discloses a registration method, device and equipment for multi-view medical images, which relates to the field of medical image technology, and provides a method for registering multi-view medical images using densely sampled image features in the effective area of ​​the projection, reducing the loss of 3D spatial information during the perspective projection process, and improving the registration efficiency. The method includes: obtaining a feature image of a reference image and a feature image of a floating image, determining the effective area of ​​the perspective projection according to the feature image of the reference image, and using the effective area of ​​the perspective projection to project the feature image of the floating image to obtain at least one two-dimensional projection image; registering by moving the floating image, and using at least one two-dimensional projection image during the registration process to calculate the similarity measure of the registration for the current spatial position of the floating image; if the similarity measure of the registration meets the preset conditions, the rigid transformation result of the registration is output according to the current spatial position of the floating image.

The utility model relates to a porous plate sperm screening device based on upstream method, including porous plate base and sperm screening spare, the body middle part recessed and recessed bottom interval of porous plate base is provided with two or more than two culture holes, and each culture hole is provided with a sperm screening spare in a matched mode, the main part of sperm screening spare is embedded in the culture hole, and the culture hole wall top is sleeved in through the sleeve setting of sperm screening spare top, the main part bottom of sperm screening spare sets up the annular buffer ring groove that forms relative to the main part of sperm screening spare and extends inwards, and multiple channels are arranged on the inner side groove wall of buffer ring groove, and the main part bottom of sperm screening spare forms the communicating port in the inner side of buffer ring groove, and the filter membrane that seals the communicating port and is used for sperm upstream is arranged at the communicating port, at least one concave sampling groove is arranged at the bottom of buffer ring groove.

The utility model provides a tenon-and-mortise joint bridge body structure based on a fixed bridge, which comprises a first bridge body arranged on a first abutment tooth, a second bridge body arranged on a second abutment tooth, and a connecting assembly arranged between the first bridge body and the second bridge body, and the connecting assembly comprises a first connecting groove formed in the first bridge body, and a second connecting groove formed in the second bridge body; the connecting lug is arranged at the position, corresponding to the first connecting groove, of the second bridge body, and the limiting part is arranged between the first connecting groove and the connecting lug. By adopting a tenon-and-mortise design mode, the problem that conventional bridge repairing is difficult to implement when a plurality of abutment teeth have large undercuts or have no common path of insertion is effectively solved, an adhesive is prevented from being directly exposed to an oral environment, the service life of a bridge body is prolonged, and the stability and reliability of a repairing effect are improved; the structure has the advantages of being firm in combination, attractive, natural and controllable in precision, the repair experience and the oral health level of a patient can be improved, innovativeness and practicability are achieved, and popularization and implementation are convenient.