755results about How to "Meet clinical needs" patented technology

The invention relates to a controlled degradation magnesium alloy coating stent and a preparation method. The stent body is made of medical high purity magnesium or magnesium alloy by mechanical processing or laser carving; the stent body is provided with a drug-loading coating which bears curative drug; the surface of the stent body is provided with an anti-corrosive coating; the surface of the anti-corrosive coating is provided with a degradable polymer film drug-loading coating; the preparation method includes surface cleaning, preparation of the degradable polymer film drug-loading coating, and application of curative drug; through (1)surface cleaning, (2)preparation of the degradable polymer film drug-loading coating, and (3)application of curative drug, an oxide film is formed on the surface; different drugs and dosage can be fixed by regulating the molecular weight and the thickness of the polymer layer, the drug-loading quantity is more than 30 percent, which improves the fixed stability of the drug, greatly reduces the degradation speed of the magnesium alloy and controls release of the drug, delays corrosion of the magnesium alloy, extends the service life of the stent, is safe in use, and meets the clinical requirement.

The invention discloses a physiological information-based depressive disorder evaluation system, which comprises an information acquisition module, a signal processing module, a parameter calculating module, a characteristic selecting module, a machine learning module and a result output module. The invention further discloses a depressive disorder evaluation method based on multiple pieces of physiological information, which comprises the following steps: 1, processing one or more than one signal of an electrocardiosignal, a pulse wave signal, an electroencephalographic signal, a galvanic skin response signal, an electrogastrogram signal, an electromyographic signal, an electrooculogram signal, a polysomnogram signal and a temperature signal, and calculating signal parameters; 2, carrying out normalization on the obtained signal parameters, and carrying out characteristic selection on a parameter set consisting of the signal parameters subjected to the normalization, so as to obtain a characteristic parameter set; 3, carrying out machine learning on the characteristic parameter set, and establishing a depressive disorder evaluation mathematic model according to the relationship between the characteristic parameter set and the levels of the depressive disorder, and evaluating the levels of the depressive disorder. The physiological information-based depressive disorder evaluation system and method have the advantages that subjectivity of scale evaluation and the like can be avoided.

A composite medicine for preventing and treating primary liver cancer, lung cancer, rectum cancer, lymph cancer, gynecologic cancers, etc is proportionally prepared from gynostemma pentaphyllum or its extract, American ginseng or its extract, and astragalus root or its extract. Its preparing process is also disclosed.

The invention discloses an automatic optimization method for an on-line self-adaption radiotherapy plan and a device. The method comprises the following steps: by reading an original radiotherapy plan and the information, such as acquired present gradation guide image and sketching target section, calculating a beam direction view of each frame angle, thereby acquiring the optimized newly generated sub-view and corresponding dose distribution, machine hop count and the like; finishing the on-line self-adaption automatic optimization of the radiotherapy plan; and meanwhile, performing secondary check on the dose distribution of the automatic radiotherapy plan through the calculation and assessment for a three-dimensional gamma index value; if failing to pass, performing normalization operation and updating the machine hop count of the new sub-view, thereby finishing the quality ensuring work. Furthermore, through the radiotherapy plan parameter transmission process check, the possibly present problem in a parameter transmitting and writing executing system is effectively avoided, and the safety monitoring is performed through real-time dosage detection during a plan executing process. The on-line self-adaption optimization of the radiotherapy plan, the quality ensuring and the full automation of parameter transmission check and real-time dosage detection are realized.

The invention relates to an acellular biological patch, a preparation method and an apparatus thereof. In the invention, small intestines of pigs are taken as raw materials, which are subjected to a series of decellularization treatment by means of an acid, hydrogen peroxide, a mixed solution of high salt and alkali so as to obtain the acellular biological patch. According to the preparation method, after treatment by the hydrogen peroxide, the mixed solution of high salt and alkali can be employed to conduct twice recycling treatment, thus reaching the effects of thorough decellularization and antigen removal. The employment of a transverse and longitudinal alternating laying way maintains uniformity of the patch's mechanical properties, the tensile strength, suture tear force, tear strength and other mechanical indexes can well meet clinical demands, thus facilitating surgical suture operation. The employed drying mode has no need of any adhesive and suture line for fixation, so that a natural three-dimensional support structure of the product is maintained, and after implantation into the human body, no strong inflammatory response and immunological rejection response can occur. The patch has no toxicity on cells, so that infection and adhesion cannot occur in a repair process. The acellular biological patch provided in the invention is suitable for repair of body tissue defects and soft tissue injuries, and also can be used in the bioengineering field to serve as the tissue for reinforcing repair of membranous defects and infected wounds and serve as a biological scaffold material, etc.

The invention provides an automatic division method for pulmonary parenchyma of a CT image. According to the automatic division method, the CT is divided through carrying out a random migration algorithm for two times to obtain the accurate pulmonary parenchyma; in the first time, the random migration algorithm is used for dividing to obtain a similar pulmonary parenchyma mask; and in the second time, the random migration algorithm is used for repairing defects of the periphery of a lung and dividing to obtain an accurate pulmonary parenchyma result. Seed points, which are set by adopting the random migration algorithm to divide, are rapidly and automatically obtained through methods including an Otsu threshold value, mathematical morphology and the like; and manual calibration is not needed so that the working amount and operation time of doctors are greatly reduced. According to the automatic division method provided by the invention, a process of 'selecting the seed points for two times and dividing for two times' is provided and is an automatic dividing process from a coarse size to a fine size; and finally, the dependence on the selection of the initial seed points by a dividing result is reduced, so that the accuracy, integrity, instantaneity and robustness of the dividing result are ensured. The automatic division method provided by the invention is funded by Natural Science Foundation of China (NO: 61375075).

The invention relates to a hemodynamic fast planning method for personalized coronary artery bypass graft surgery. According to the method, a personalized coronary artery lumped parameter model is built according to information of a patient, the coronary artery fractional flow reserve for reflecting coronary artery functional diseases is calculated, the surgery indication is evaluated, and in combination with SYNTAX grading of anatomic disease extension, the evaluation is used as the comprehensive evaluation basis for selecting a coronary artery bypass graft surgery strategy. A bypass graft scheme is selected on the premise of adaptation and involves the bypass graft blood vessel number, the bypass graft position, the transfer catheter type and the like. The personalized lumped parameter model is calculated, and postoperative coronary artery flow and pressure changes and postoperative bypass graft blood vessel parameters are obtained. According to the average wall shear stress, the wall shear stress oscillation index and the competitive flow degree, the long-term permeability of the transfer catheter of the scheme is analyzed. The long-term permeability of transfer catheters in different bypass graft schemes is compared, and the best bypass graft scheme is obtained. The hemodynamic fast planning method solves the problems that an existing method is invasive, indirect, long in consumed time and the like.

The invention discloses a polylactic acid-based composite material surgical medical film and a preparation method thereof. By adopting electrostatic spinning equipment and exploring proper technological parameters, different types of polylactic acid-based composite material macromolecular fiber thin films are finally formed and are applied to the field of biomedicine. In addition, by regulating and controlling composition of a macromolecular composite material system and thickness of an electro-spinning thin film, the surgical medical film which has good flexibility, high tensile strength, controllable degradation rate as well as excellent waterproof, antibacterial and air permeable performances is obtained finally. The surgical medical film is applicable to the field of various biomedicines such as healing film, wound surface dressing and anti-adhesion medicine; the medical film not only can be better adhered to tissues and avoid biotoxicity, but also can effectively promote transmission functions of blood, nutrients and growth factors in a human body due to the nature of semipermeable membrane. The process of the invention is simple and environment-friendly; the preparation method is easy to operate, low in cost, applicable to large-scale production and good in controllability, and is expected to be widely applied to various medical fields.

The invention discloses a method for implementing an automatic and composite radiation therapy plan. The method includes the following steps: acquiring specific image features of a patient and saving the image features to a database; at thebeginning of preparing a patient radiation therapy plan, with the image features as searching criteria, searching for a most identical image group from the database of image features and extracting the image group and taking the image group as a sample group, selecting an appropriate a registration algorithm on the demands of clinic application and performing corresponding operation, introducing a target area sketch information to a patent image, and automatically sketching the target area and an endangered organ; after a doctor confirming the result of the sketching, inputting relevant therapy dose parameters, automatically conducting dose distribution simulation operation on the radiation therapy plan, a physician or physicist confirming the result of the simulation, thus completing the radiation therapy plan. According to the invention, the method can improve the sketching of the target area and information of relevant organs in a precise manner, and can be applied to the field of tumor radiation therapy; the method can quickly generate a new treatment plan for the patient and provide evidence for the physician to make profession determination as long as an anatomical structure image of the patient is acquired.

The invention provides a detection method for genomic copy number variation and a device comprising the method. The method comprises the following steps: inputting original data, cleaning quality control, aligning sequences to a reference genome, calculating a unique alignment sequence number by using windows of different sizes, performing GC correction and reference correction, shielding undetectable areas, segmenting CBS, integrating karyotype reports and generating reports, a complete set of the detection methods and devices is established through experimental exploration and optimization,through successive application of the specific sequential steps, the step of the reference correction is creatively adopted, and the windows with different sizes are used for performing alignment andintegration, the steps cooperate mutually, and finally the sensitivity and specificity are improved, so that the detection accuracy and result forms can conform to clinical demands, and the detectionmethod for the genomic copy number variation and the device comprising the method are high in automation degree, easy to expand, high in detection accuracy, capable of lowering the cost of data analysis, and extremely high in application value.

The invention discloses a novel endoscope object taking bag and a delivery system. The novel endoscope object taking bag comprises a flexible bag, an elastic silk, a connector and a sliding block. The elastic silk movably penetrates through a through hole at an open end of the flexible bag. The elastic silk can movably penetrate through a through hole of the sliding block, and the sliding block can move along the elastic silk. When a relative distance between the sliding block and the connector is increased, the elastic silk is furled step by step by using the sliding block as an obligatory point, so as to furl a bag mouth of the flexible bag. When the relative distance between the sliding block and the connector is reduced, the elastic silk is unfolded step by step by using the sliding block as the obligatory point, so as to unfold the bag mouth of the flexible bag. The delivery system has a sleeve structure consisting of an outer sheath and an inner sheath. According to the novel endoscope object taking bag and the delivery system, the bag mouth of the novel endoscope object taking bag not only can be opened conveniently in a human body, but also can be closed conveniently, and particularly can be released in the body through a tiny endoscope pipeline, so that an excised sample is taken out, and the defects that the endoscope object taking bag in the prior art cannot be opened after the bag mouth is sealed and is difficult to be delivered through a tiny pipeline are overcome.

The invention discloses an electric film printing system based on DICOM, comprising an image device and an electric film printer, the image device is used for sending a shot electric film image to the electric film printer to print through a DICOM PRINT protocol, the electric film printer comprises an electric film printing server and at least a DICOM web camera, the electric film printing server is respectively connected the image device and the DICOM web camera. The invention also discloses an electric film management method based on DICOM, comprising the following steps: send a film image to the electric film printing server through the DICOMPRINT protocol by the image device; identify patient information from the film image by the server; store the file head and the image data body of the film image after the patient information is identified in the file system of the electric film printing server; when the patient needs to print the electric film, send the electric film to the DICOM web camera to print. Print on demand of the electric film is realized by the invention, thereby reducing the usage cost of the film and increasing the printing efficiency.

The invention relates to a hyaluronic acid modified polycaprolactone/polylactic acid three-dimensional porous composite scaffold and a preparation method thereof. The composite scaffold comprises the components of polycaprolactone PCL, polylactic acid PLA and hyaluronic acid HA. The preparation method comprises: (1) dissolving PCL and PLA into a cosolvent to derive transparent blend solution; (2) adjusting electrostatic spinning process, spinning the blend solution to a nanometer/submicron graded fibrofelt, and vacuumizing in a vacuum oven to remove residual solvents; (3) overlapping and filling the fibrofelt to a die of specific shape and placing in the vacuum oven, cooling, demoulding, modifying a plasma, and immersing in hyaluronic acid HA solution; (4) placing the HA modified composite scaffold in the vacuum oven to be dried, sterilizing with epoxy ethane and deriving the three-dimensional porous composite scaffold. The three-dimensional porous tissue engineering composite scaffold material of the invention has the advantages of uniform internal pore structure, stable architecture and simple preparation method, and can be used as the scaffold of bone and cartilage tissue engineering cell.

A preparing method of a porous calcium phosphate filling material sequentially comprises the following technical steps: 1, uniformly mixing 5-15 parts by mass of calcium phosphate powder or 10-50 parts by volume of calcium phosphate slurry, 10-50 parts by volume of a sodium alginate water solution, 1-10 parts by volume of an adhesive and 1-20 parts by volume of deionized water, then adding 1-5 parts by volume of hydrogen peroxide or 1-50 parts by mass of a solid pore forming agent, and carrying out uniform mixing to obtain mixed slurry; 2, dripping the mixed slurry obtained in step 1 to a soluble calcium salt solution with 1-10% mass concentration to form a complex gel microsphere, and then curing, washing and drying the complex gel microsphere; 3, presintering the complex gel microsphere obtained in step 2 at 500-800 DEG C for 1-5 hours, then sintering at 900-1200 DEG C, and cooling to a room temperature after finishing sintering. The calcium phosphate filling material prepared according to the method is adjustable in grain size and controllable in crystalline grain size, and accordingly, is convenient to implant in clinic.

The invention discloses Zn-Cu series zinc alloy as well as a preparation method and applications of the Zn-Cu series zinc alloy. The Zn-Cu series zinc alloy comprises Zn and Cu, specifically, the weight percentage of Cu in the Zn-Cu series zinc alloy is 0-30 %, but is not 0. The preparation method comprises the following steps: (1) mixing Zn and Cu, thus obtaining a mixture; (2) carrying out treatment on the mixture according to the following step (a) or (b), and carrying out cooling, thus obtaining the Zn-Cu series zinc alloy: (a) carrying out smelting or sintering on the mixture under the protection of the atmosphere of CO2 and SF6; and (b) under the protection of vacuum atmosphere, dissolving hydrogen in the mixture, and carrying out smelting. The prepared Zn-Cu series zinc alloy has the suitable mechanical property, adjustable corrosion rate, good cell compatibility, good blood compatibility and excellent antibacterial property, and can be used for preparing biomedical implantation materials.

A thickness balancing method and device for a breast image. The thickness balancing method for the breast image includes the steps of: obtaining a breast image; filtering the breast image to obtain a low frequency breast image and a high frequency breast image; performing gray scale transformation on a preset area in the low frequency breast image to obtain a first image, a gray value of a preset area in the first image tending to be consistent with a gray value of a neighborhood, and the preset area referring to an area at a predetermined distance from an edge of the low frequency breast image; and reconstructing the first image and the high frequency breast image to generate a thickness-balanced breast image. The breast image after balancing which is obtained through the technical scheme of the invention has uniform gray scale while details of the breast image are not lost, satisfies actual clinical needs, the breast image after balancing is adopted to be diagnosed on a window level of a certain window width, and loss of edge information of the breast image does not occur, thereby lowering the rate of missed diagnosis, and improving the accuracy rate of diagnosis.

The invention relates to a preparation method of a bioactive protein or polypeptide coat biological bracket. The method of anode polarization is adopted, a bracket body is taken as the anode, and is inserted into bioactive protein or polypeptide solution together with the cathode; under the action of the electric field of a power supply, the bioactive protein or polypeptide is ionized to have negative electrification to move towards the anode of the bracket and evenly coats on the surface of the bracket. The preparation method provided by the invention dose not need to additionally prepare a medicine loading coat, has no obvious interface, can envelop a bioactive protein or polypeptide coat on the whole bracket body or part surface of the bracket through the function of anode polarization; the bioactive protein or polypeptide has stable enveloping amount and is not easily eluted, has safe use, simple operation and low cost, and is suitable for large-scale production in industry.

The invention relates to the biomedical field of high molecular materials, in particular to a nerve grafting object containing an orientation nanofiber nerve tract and a preparing method of the nerve grafting object. A core (A) composed of the nanofiber tract is placed in the middle of the nerve grafting object, a sheath (B) composed of an irregular fiber layer (B2) and an orientation layer (B1) is arranged on the outer face of the nerve grafting object, the diameter of the core (A) composed of the nanofiber tract is 2-5mm, the length of the core (A) composed of the nanofiber tract is 3-15mm, the fiber diameter of the nanofiber tract is 40-300nm, the length of the sheath (B) is 9-25mm, the orientation layer (B1) comprises parallel-arrayed fibers of 100-500nm, and the irregular fiber layer (B2) comprises disorder-arrayed fibers of 100-500nm. The technology is stable, grafting object size is adjustable, the clinic requirement is met, production efficiency is improved, industrialization is convenient, guiding performance is high, using is convenient, and practicability is improved.

The invention relates to a disposable high speed turbine dental drill handpiece with a light producing device which is characterized in that a place of a front operating handle close to a handpiece isconnected with a lamp socket for installing a light-emitting diode, the head of the light-emitting diode is exposed from a hole of the lamp socket and opposites to a cutting position of a dill point,two electrodes at the tail part of the light-emitting diode are respectively connected with two light-emitting diode lead wires; a rear operation handle is provided with a battery bin which is provided with a battery bin cover, a space containing a illuminating gas switch is arranged below the battery bin, the bottom of the space is communicated with an air passage of the illuminating gas switchin the rear operating handle, the air passage of the illuminating gas switch is parallel to the air passage of a driving drill point and the two air passages are both communicated with a gas pipelineat the tail part of the rear operating handle, a button battery is put in the battery bin, the positive pole of the button battery is communicated with a lead wire of the light-emitting diode, and thenegative pole of the button battery is connected with the other lead wire of the light-emitting diode by the illuminating gas switch. The dental drill handpiece is characterized by low cost, safe andconvenient use, and good illuminating effect, and is applicable to be arranged in various dental units.

A gingko leaf extract used for preparing liquid injection or freeze-dried powder injection is prepared from gingko leaves through breaking, thermal reflux extracting with the aqueous solution of alcohol, vacuum volatilizing of solvent, depositing in ammonia water to remove polyphenol, extracting with n-hexane to remove ginkgolic acid, adsorbing by macroreticular resin, separating, refining, ultrafiltration and spray drying.

A liquid preparation of meloxican is prepared from the meloxicam or its medical salt and water-soluble cyclodextrin derivative HP-beta-CD used as solubilizer and stabilizer, proportionally mixing, adding cosolvent, pH regulator and water for injection, heating and membrane filtering. It has long storage time at low temp.

The invention discloses a medical image retrieval method based on feature extraction and similarity matching. In the process of a radiotherapy plan, image registration is a very important key step. The purpose of the image registration in the radiotherapy plan is to find out a template image the most appropriate for a target image and to obtain a best registration result by matching operation for clinical target delineation, organ dose simulation or treatment. Therefore, it is quite important how to search out the most appropriate template image. In the method, 10 morphological features related to the form is combined with medical history information, the features are endowed with different discrimination weights, and finally 10 groups of the most similar images and related information are selected and provided for the doctor to choose, and the most appropriate template image is selected by comprehensive consideration. The operation of the method can guarantee the similarity between the template image and a target image so that it is possible to improve the applicability and the accuracy of the image registration operation in the radiotherapy plan.