25results about How to "Meet clinical needs" patented technology

The utility model discloses a detachable gas pipeline detection alarm device, including first gas pipeline and second gas pipeline, first gas pipeline and second gas pipeline both ends are connected through two three -way pipes each other, set up oxygen detection subassembly respectively on first gas pipeline and second gas pipeline, set up pressure sensor and audible -visual alarm respectively on the side of oxygen detection subassembly, set up respectively on first gas pipeline and second gas pipeline, set up solenoid valve on three -way pipe two output respectively, the utility model discloses a two gas pipelines cooperation setting will be convenient according to the demand adjustment replacement and use, when one of them gas pipeline produces use abnormality can close use another gas pipeline, improve its work efficiency, need not to stop machine replacement, utilize oxygen detection subassembly, pressure sensor, audible -visual alarm simultaneously to real -time monitoring to gas pipeline, if appearing abnormality will through audible -visual alarm and remind medical staff in time handle.

The utility model discloses a kind of obstetric flushers, including liquid storage tank, connecting pipe, extension piece, direction-changing arm and spray head, liquid storage tank includes the tank body for storing cleaning fluid and is set to the pressing portion of tank body tail end, pressing portion is corrugated structure, with good elasticity and resilience, tank body opening end is connected connecting pipe and extension piece in turn by thread, extension piece one end is equipped with rotatable direction-changing arm, direction-changing arm one end is equipped with locating head and input hole, the other end is connected with spray head, liquid can be in palm pressing pressing portion after via passage and input hole into direction-changing arm and from spray head to spray to realize flushing function, the extension piece outside is provided with accommodating groove for folding storage direction-changing arm, connecting pipe outside is equipped with antiskid structure to facilitate operation, structure design is reasonable, connection is stable, spray direction is adjustable and convenient to store.

The utility model relates to the technical field of medical instruments, and provides a plugging support and a plugging balloon catheter, and the plugging support comprises a supporting part and an intercepting part; the supporting part can be contracted and unfolded for supporting, one end of the intercepting part is connected with the supporting part, the other end of the intercepting part is gradually contracted and extends to form a cone shape, the supporting part and the intercepting part are both provided with hollowed-out parts, and a woven mesh is arranged in the hollowed-out part of at least one of the supporting part and the intercepting part. According to the utility model, the woven mesh is arranged in the hollow part of at least one of the supporting part and the intercepting part, so that the gap of the occlusion stent is further reduced, and the woven mesh can better leave substances in blood vessels, so that the occlusion time is shortened, and the clinical requirements of acute vascular embolism occlusion are met.

The application relates to the technical field of nanobiosensors, and discloses a bimodal nanoprobe for uric acid detection and a preparation method and application thereof. The bimodal nanoprobe is a fluorescence-photothermal bimodal nanoprobe, and is a core-shell structure nanoparticle, which comprises, from the inner layer to the outer layer, a) a fluorescent inner core composed of carbon dots and a silica layer coated outside the carbon dots; b) a manganese dioxide layer coated outside the fluorescent inner core; and c) a molecularly imprinted polymer layer coated outside the manganese dioxide layer. The bimodal nanoprobe in the application integrates a fluorescence signal source (carbon dots), a signal modulation and photothermal unit and a specific recognition layer (a uric acid molecularly imprinted polymer) through ingenious structure design, realizes bimodal sensing of "specific recognition -> MnO2 etching -> fluorescence recovery / photothermal weakening" on UA, and effectively solves the problems of poor selectivity, complicated operation and high cost of traditional methods.

This invention discloses a novel L-shaped SPECT probe design method, relating to the field of SPECT probe design. It includes the following steps: S1: Determine the position of the L-shaped gantry based on the patient's clinical requirements, and design an L-shaped slide rail according to the L-shaped gantry; S2: The SPECT probes are evenly arranged on the L-shaped slide rail, and the SPECT probes are driven by a motor; S3: The SPECT probes compensate for the acquisition dead zones between them by changing their position left and right on the L-shaped slide rail. Furthermore, the SPECT probes can enter different position modes by changing the forward and backward displacement of the L-shaped slide rail. This invention provides a novel L-shaped SPECT probe design method that can meet the clinical needs of patients with dextrocardia, obesity, and claustrophobia; the acquisition method conforms to the patient's body structure, improves the acquisition count and the amount of acquired information, enhances spatial resolution, and improves the accuracy of image quality.

The utility model belongs to orthopedics instrument technical field, specifically disclose a kirschner wire angle positioning sleeve, including sleeve body, sleeve body is circular table shape, and the centre positioning hole is passed through and is established in the middle part, and the centre positioning hole is surrounded and is set up a plurality of inclined guide hole outside ring, still surround and set up a plurality of fixed adjusting holes outside the centre positioning hole, fixed adjusting hole is located between the centre positioning hole and inclined guide hole, and the aperture of fixed adjusting hole is less than the aperture of inclined guide hole and centre positioning hole. When carrying out the predetermined introduction of kirschner wire, first, kirschner wire is vertically entered into bone cortex through the centre positioning hole, and then according to the need, the angle of kirschner wire is adjusted and introduced through the inclined guide hole, then the kirschner wire is introduced through the fixed adjusting hole to fix the position or adjust the parallel position, realize the angle and parallel position adjustment of kirschner wire in the same needle point, satisfy the clinical demand.

A spine internal fixing device with a fusion function comprises a pedicle screw, the pedicle screw comprises a screw body, a screw tail is arranged at the upper end of the screw body, a nut is connected to the screw tail through internal threads, the screw body and the screw tail are of a honeycomb structure simulating cancellous bone, and solid external threads are arranged on the outer surface of the screw body. According to the spinal internal fixation device with the fusion function, a full-assembly simulation cancellous bone honeycomb structure of a pedicle screw rod nut and a matched connecting piece is prepared by adopting a 3D printing technology, and meanwhile, solid structures of key stress parts such as an external thread tip threaded connection surface are reserved so as to guarantee early mechanical fixation strength; after the components are assembled, a continuous bone ingrowth channel is formed, so that the transformation of internal fixation of the spine from temporary mechanical support to permanent osseous fusion is realized, and various intervertebral, intervertebral, posterior lateral and transverse process bone grafting fusion steps in a traditional spine fusion operation can be omitted.

An autograft press-fitting shaping device with an anti-overpressure function, comprising a base, a fixed block is fixedly connected to the top of the base, a lower mold is installed on the outer side of the fixed block, a support rod is fixedly connected to the top of the base, a top plate is fixedly connected to the top end of the support rod, a pressure rod is threadedly inserted into the middle of the top plate, and a mounting block is rotatably connected to the bottom end of the pressure rod; the application realizes quick replacement of the mold, moves the limiting block away from the positioning block by driving the unlocking block to move the linkage sliding plate through the pressure rod, realizes quick disassembly and replacement of the upper mold and the lower mold, and significantly improves the adaptation ability of the device to autografts of different shapes; the detachable mold structure design makes the upper mold and the lower mold flexible to replace according to different surgical needs, meets the clinical needs of diversified graft press-fitting shaping, simplifies maintenance and cleaning, the mold can be independently disassembled, is convenient for thorough cleaning and inspection, avoids wear or pollution caused by long-term use, and ensures shaping precision and graft product quality.

The utility model relates to a porous plate sperm screening device based on upstream method, including porous plate base and sperm screening spare, the body middle part recessed and recessed bottom interval of porous plate base is provided with two or more than two culture holes, and each culture hole is provided with a sperm screening spare in a matched mode, the main part of sperm screening spare is embedded in the culture hole, and the culture hole wall top is sleeved in through the sleeve setting of sperm screening spare top, the main part bottom of sperm screening spare sets up the annular buffer ring groove that forms relative to the main part of sperm screening spare and extends inwards, and multiple channels are arranged on the inner side groove wall of buffer ring groove, and the main part bottom of sperm screening spare forms the communicating port in the inner side of buffer ring groove, and the filter membrane that seals the communicating port and is used for sperm upstream is arranged at the communicating port, at least one concave sampling groove is arranged at the bottom of buffer ring groove.

The utility model provides a tenon-and-mortise joint bridge body structure based on a fixed bridge, which comprises a first bridge body arranged on a first abutment tooth, a second bridge body arranged on a second abutment tooth, and a connecting assembly arranged between the first bridge body and the second bridge body, and the connecting assembly comprises a first connecting groove formed in the first bridge body, and a second connecting groove formed in the second bridge body; the connecting lug is arranged at the position, corresponding to the first connecting groove, of the second bridge body, and the limiting part is arranged between the first connecting groove and the connecting lug. By adopting a tenon-and-mortise design mode, the problem that conventional bridge repairing is difficult to implement when a plurality of abutment teeth have large undercuts or have no common path of insertion is effectively solved, an adhesive is prevented from being directly exposed to an oral environment, the service life of a bridge body is prolonged, and the stability and reliability of a repairing effect are improved; the structure has the advantages of being firm in combination, attractive, natural and controllable in precision, the repair experience and the oral health level of a patient can be improved, innovativeness and practicability are achieved, and popularization and implementation are convenient.

The invention provides a vincristine sulfate injection and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The preparation method of the vincristine sulfate injection comprises the following steps: (1) adding vincristine sulfate and rosmarinic acid into an acetate buffer solution, uniformly stirring and mixing, filtering, collecting powder, drying, grinding and sieving to obtain a vincristine sulfate-rosmarinic acid eutectic; (2) adding mannitol into the water for injection for later use; and (3) adding the vincristine sulfate-rosmarinic acid eutectic into the system in the step (2), stirring, adjusting the pH value to 4.5-5.5, filtering with a microporous membrane, sterilizing, and filling to obtain the vincristine sulfate injection. The vincristine sulfate injection disclosed by the invention is simple in preparation process, good in reproducibility and easy for industrial production. The vincristine sulfate injection has the advantages of simple raw materials, no need of any synthetic carrier material, definite components and high safety, and the prepared vincristine sulfate injection has high stability and good application prospects.

The utility model relates to a disposable surgical filter, which belongs to the technical field of surgical filters and comprises a catheter, a flow controller and a filter. The air inlet connector and the air outlet connector are connected to the two ends of the outer filtering bin, an inner filtering bin is further arranged in the filter, and an efficient filtering medium is arranged in the inner filtering bin; a plurality of outer bin filtering layers are distributed between the inner wall of the outer filtering bin and the outer wall of the inner filtering bin at equal intervals, and a guide pipe is further arranged at the top end of the inner filtering bin in a penetrating mode; according to the design, a double-layer filtering bin structure is adopted, an efficient filtering medium is adopted for inner-layer filtering, the inner-layer filtering is composed of a plurality of glass fiber layers and activated carbon, smells in operation smoke can be adsorbed, fine smoke particles with the particle size larger than 0.3 micrometer can be effectively adsorbed, then adsorption and filtering of smoke gas can be further improved through outer-layer filtering, and the filtering quality is improved; and a multi-interface design is adopted, so that clinical requirements of different equipment can be met.

The present application provides a kind of palmatine derivative, the structural general formula is as follows: the present application selects palmatine as raw material, through multi-step synthesis, corresponding compound with high yield can be obtained, the palmatine derivative can effectively resist antibiotic resistant helicobacter pylori strain, especially spherical mutant strain, has good bacteriostatic activity, solves the antibiotic resistance and retention recurrence problem of helicobacter pylori in clinical treatment, is suitable for industrial production and clinical application.

According to the heart rate interference self-adaptive suppression method and system, the brain blood oxygen signals and the heart rate signals are collected, the heart rate signals in the brain blood oxygen signals are deducted through the self-adaptive regression deduction method, the dynamic change of the heart rate is effectively tracked, accurate deduction of heart rate interference is achieved, and the accuracy of heart rate interference suppression is improved. Then the processed signals are subjected to power spectrum analysis so as to judge whether deduction processing is thorough or not, center jump interference of the brain blood oxygen signals can be effectively filtered out, meanwhile, other signal frequencies except heartbeat interference signals are reserved, the collected brain blood oxygen signals are more accurate, and through a dual judgment mechanism of power spectrum analysis and physiological feature verification, the accuracy of the brain blood oxygen signals is improved. It is ensured that heart rate interference is fully suppressed, the accuracy and reliability of output signals are higher, and scientific research and clinical application requirements are met.

The invention belongs to the technical field of molecular detection of biological medicines, and particularly relates to a nucleic acid extraction-free SFTSV detection kit, primer probes and a method. The primer probe composition comprises an upstream primer SEQ ID NO: 1 for specifically recognizing the SFTSV, a downstream primer SEQ ID NO: 2 of which the 5'end is labeled with biotin, and a probe SEQ ID NO: 3 of which the 5 'end is labeled with a reporter group and contains THF modification. The kit comprises the composition, a nucleic acid releasing agent and a lateral flow chromatography test strip. The method comprises the following steps: treating a serum / plasma sample by using a nucleic acid releasing agent, carrying out RPA isothermal amplification by directly taking a lysate as a template, and detecting a result through a test strip. The RPA-LFD rapid detection of the SFTSV is realized, the sensitivity (200copies / mL) and the specificity are high, the operation is simple, convenient and rapid (about 40 minutes), a complex instrument and a nucleic acid extraction step are not needed, and the method is suitable for base-level field screening.

The application provides a model continuous learning optimization method, an electronic device and a storage medium. By inputting an initial sample data set into a diagnosis model, a core gradient space of the initial sample data set when training the diagnosis model is obtained. When subsequently optimizing the model by using a new sample data set, the diagnosis effect on historical data can be maintained, the diagnosis capability on new data can be improved, the catastrophic forgetting problem of the diagnosis model can be avoided, and the training cost and workload of the model are not increased. Therefore, the compatibility of the model on different data can be improved while meeting clinical requirements. A new sample data set is obtained according to the initial sample data set and the new sample data set. A gradient transfer value is obtained according to the new sample data set, the core gradient space and the new sample data set. The target gradient of the diagnosis model is determined according to the gradient transfer value, the direction of the optimization of the diagnosis model can be distinguished, and the overall effect of the optimization of the diagnosis model can be improved.

The invention discloses an exosome freeze-drying protective agent and application of the exosome freeze-drying protective agent in an oral soluble film. The protective agent is prepared from the following solid matters in parts by weight: 1 to 20 parts of zwitterionic polymer containing choline phosphate side groups, 10 to 80 parts of polyoxazoline polymer and 1 to 20 parts of volatile ammonium salt. The zwitterionic polymer containing the choline phosphate side group forms zwitterionic pair interaction through charge arrangement complementation between a choline phosphate group and a phosphatidylcholine head group on the surface of an exosome membrane, so that directional protection is provided for the exosome membrane structure; after the polyoxazoline polymer is freeze-dried, a glassy state curing matrix is formed to embed and support the exosome; the volatile ammonium salt is decomposed and volatilized in the freeze-drying secondary drying stage, and a communicated pore channel is formed in the membrane body. The invention also provides an application of the protective agent in preparation of an exosome freeze-drying preparation or an exosome oral soluble film, and the obtained oral soluble film can be rapidly disintegrated, can maintain the structural stability of the exosome, and is suitable for normal-temperature storage and rapid administration.

The invention relates to a monitor setting method and device, electronic equipment, a storage medium and a program product. The method comprises the following steps: detecting the connection state of the monitor and the extension equipment; in response to detecting that the monitor is connected to the extension equipment, automatically reading equipment information of the extension equipment from a memory of the extension equipment; determining that the expansion equipment is replaced based on the equipment information of the expansion equipment, and automatically generating a position information determination interface; obtaining current position information of the monitor from the position information determination interface; target setting information, matched with the current position information, of the monitor is obtained, and the monitor is set according to the target setting information.

The present application relates to a kind of dry suspension preparations of montelukast sodium, belong to the field of pharmaceutical pharmacy.The dry suspension preparation component is composed of montelukast sodium, carbomer, fumed silica, corn starch, sucrose, cherry powder essence, banana powder essence.By montelukast sodium and carbomer primary coating, again with fumed silica coating, enhanced protective layer, avoid the continued destruction of external light, oxygen, good stability effect is obtained.Through accelerated test, long-term test investigation, appearance, dissolution, content, related substances are superior to prior art.Preparation process uses large particle size solid drug substance, avoids the loss of raw material in preparation process, product preparation process is simple, easy to operate, quality meets the requirements, facilitate commercial production.

The application discloses an ultrahigh dose rate radiotherapy plan optimization system based on compensator modulation, relates to the technical field of radiotherapy, and comprises a data acquisition module, a FLASH biological effect evaluation module and a plan optimization module.The data acquisition module is used for acquiring medical image data of a patient and receiving clinical targets, wherein the clinical targets include a target area prescription dose, a critical organ limit and a minimum dose rate threshold required for triggering and maintaining a FLASH effect.The FLASH biological effect evaluation module is used for calculating a FLASH biological effective dose distribution corresponding to a physical dose distribution through an embedded biological effect model based on the input physical dose distribution and dose rate distribution.The improved linear quadratic model of the application is embedded with a FLASH correction factor, the physical dose is converted into accurate FLASH biological effective dose, the tumor killing effect of the target area is guaranteed, normal tissue protection is enhanced with the aid of tissue differentiation correction factors, the industry pain point that the physical dose meets the standard but the biological effect does not meet the expectation is effectively solved, and the treatment plan is more suitable for the core needs of clinical efficacy and safety.

This invention relates to the field of deep learning, disclosing a deep learning-based cell imaging method and apparatus. The method includes: reconstructing a fundus image using a trained pre-processor neural network model to obtain a reconstructed fundus image; registering the reconstructed image and the cell imaging image to obtain a registered reconstructed image and a registered cell imaging image; fusing the registered reconstructed image and the registered cell imaging image to obtain a fused image; using the reconstructed image as input data for a pre-trained post-processor neural network model, and using the cell imaging image and the fused image as target data for the pre-trained post-processor neural network model, thereby training the pre-trained post-processor neural network model using the input data and target data; and performing cell imaging on a current patient's fundus image using the trained pre-processor neural network model and the trained post-processor neural network model to obtain cell imaging results. This invention can meet clinical needs through cell imaging.

This invention discloses a medical puncture point protective dressing, its preparation method, and its uses, relating to the field of medical dressings. The protective dressing is configured as a multi-layer composite base type protective dressing for puncture point compression hemostasis and has a temperature-sensitive color-changing indication function. The multi-layer composite base type protective dressing includes a second protective layer, a compression function layer, a pre-colored flexible substrate layer, and a peelable protective layer stacked sequentially. The medical puncture point protective dressing, its preparation method, and its uses achieve a visual and objective indication of compression time by setting a visual contrast between the temperature-sensitive color-changing material and the pre-colored background layer, while preventing dressing displacement through an elastic positioning layer.

The utility model discloses a radiotherapy system which comprises a rack and at least two treatment head groups located on the rack, and each treatment head group comprises at least two treatment heads. The rack can drive the treatment heads of the at least two treatment head sets to rotate around the rotation center of the rack, and beams emitted by the treatment heads of the at least two treatment head sets intersect at the isocenter. Wherein the beam centers of at least two treatment heads in each treatment head group and the rotation center of the rack are in the same plane; and the beam centers of the treatment heads in different treatment head groups are in different planes. Therefore, high-dose-rate non-coplanar irradiation treatment can be realized through rotation of the rack.

The invention discloses a seminal fluid liquefaction analyzer, and relates to the technical field of seminal fluid detection equipment. The device comprises a workbench, wherein a constant-temperature bearing module, a wire drawing execution module, a detection sensing module, a control processing module and a result output module are arranged on the workbench; the constant-temperature bearing module is used for bearing a semen sample and providing a constant-temperature environment of 36.5-37.5 DEG C for the semen sample; the wire drawing execution module is matched with the constant-temperature bearing module and is used for sequentially taking the semen samples from a plurality of wire drawing devices in sequence, and standard sample insertion, vertical wire drawing lifting and resetting actions of the semen samples are completed through the wire drawing devices; the detection sensing module is linked with the wire drawing execution module and is used for collecting wire drawing length data in a semen wire drawing process and tension data when the wire drawing is broken in real time. The device has the advantages that the device is designed based on a physical wire drawing judgment method, automation and standardization of the detection process are achieved, and the device is simple in structure, portable, practical and wide in adaptability.

The invention discloses pentoxyverine citrate tablets and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The pentoxyverine citrate tablet is composed of pentoxyverine citrate, a filling agent, a disintegrating agent, an adhesive, a lubricant, a stabilizer, an opacifying agent and a wetting agent, a composite stabilizer system composed of sodium pyrosulfite, pinoresinol diglucoside and glycine is adopted, all the components have a synergistic effect, and influences of environmental factors such as light, heat and humidity can be resisted in a targeted mode. The tablet prepared by the invention has the advantages of obviously improved stability, less degradation of effective components, excellent and balanced physical properties, mechanical stability and bioavailability, scientific and controllable preparation process and strong repeatability, is suitable for industrial production, and has important clinical application value and market prospect.