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Compound preparation for treating cholestatic jaundice and preparing method thereof

A compound preparation and cholestasis technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as ineffective therapeutic effects, restore normal physiological functions, improve liver function, and reduce levels of Effect

Inactive Publication Date: 2016-10-12
徐海燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of cholestatic jaundice mainly focuses on clearing away heat and removing dampness, and aiding in relieving the surface. Although some results have been achieved, the therapeutic effect is not obvious. Therefore, it is extremely important to develop a drug that has a significant effect and has little side effects on the human body.

Method used

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  • Compound preparation for treating cholestatic jaundice and preparing method thereof
  • Compound preparation for treating cholestatic jaundice and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Example 1: This example prepares a compound capsule for the treatment of cholestatic jaundice, which is composed of the following components by weight: 57 parts of adenosylmethionine butanedisulfonate, 49 parts of diammonium glycyrrhizinate, 42 parts of dihydroxy dibutyl ether, 38 parts of baicalin, 27 parts of methionine, 22 parts of anetthio, 17 parts of potassium magnesium aspartate, 14 parts of dimethyl crocetin, 12 parts of glucuronolactone, 9 parts of cholestyramine, 3 parts of nicotinamide, 1 part of trimethoprim lactate, 1 part of bumetanide, 0.6 part of piperazine citrate, and 0.1 part of azathioprine.

[0017] Among them, the dihydroxy dibutyl ether is a colorless and transparent compound synthesized by using 1,3-butanediol as a raw material, using sulfonamide resin as a catalyst, and reacting for 2 hours at 140°C with the amount of the catalyst being 5% of the amount of the raw material. of oily liquid. Dihydroxydibutyl ether can promote the rapid, strong an...

Embodiment 2

[0025] Example 2: This example prepares a compound capsule for the treatment of cholestatic jaundice, which is composed of the following components by weight: 65.5 parts of adenosylmethionine butanedisulfonate, 56 parts of diammonium glycyrrhizinate, 46.5 parts of dihydroxydibutyl ether, 41.5 parts of baicalin, 31.5 parts of methionine, 26.5 parts of anetis trisulfide, 21 parts of potassium magnesium aspartate, 16.5 parts of dimethyl crocetin, 14.5 parts of glucuronolactone, Cholestyramine 11 parts, hydroxymethyl nicotinamide 5 parts, trimethoprim lactate 3 parts, bumetanide 2 parts, piperazine citrate 0.8 parts, azathioprine 0.3 parts.

[0026] Among them, the dihydroxy dibutyl ether is a colorless product synthesized by using 1,3-butanediol as raw material and sulfonamide resin as a catalyst at 140°C with the catalyst amount being 5% of the raw material amount and reacting for 2.5 hours. Transparent oily liquid. Dihydroxydibutyl ether can promote the rapid, strong and persi...

Embodiment 3

[0034] Example 3: This example prepares a compound capsule for the treatment of cholestatic jaundice, which is composed of the following components by weight: 74 parts of adenosylmethionine butanedisulfonate, 63 parts of diammonium glycyrrhizinate, 51 parts of dihydroxy dibutyl ether, 45 parts of baicalin, 36 parts of methionine, 33 parts of anetis trisulfide, 25 parts of potassium magnesium aspartate, 19 parts of dimethyl crocetin, 17 parts of glucuronolactone, Cholestyramine 13 parts, hydroxymethyl nicotinamide 7 parts, trimethoprim lactate 5 parts, bumetanide 3 parts, piperazine citrate 1 part, azathioprine 0.5 parts.

[0035] Among them, the dihydroxy dibutyl ether is a colorless and transparent compound synthesized by using 1,3-butanediol as raw material and sulfonamide resin as a catalyst at 140°C with a catalyst amount of 5% of the raw material amount and reacting for 3 hours. of oily liquid. Dihydroxydibutyl ether can promote the rapid, strong and persistent secretion...

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Abstract

The invention discloses a compound preparation for treating cholestatic jaundice and a preparing method thereof. The compound preparation is prepared from ademetionine 1,4-butanedisulfonate, diammonium glycyrrhizinate, dihydroxydibutylether, baicalin, methionine, anethol trithione, potassium magnesium aspartate, crocetin dimethyl ester, glucurolactone, cholestyramlne, hydroxymethylnicotinamide, trimethoprim lactate, bumetanide, piperazine citrate and azathioprine. The compound preparation has the effects of resisting bacteria and diminishing inflammations, clearing dampness and heat, soothing the liver and benefiting the gallbladder, removing the toxicity and eliminating jaundice and strengthening the spleen and the stomach, can reduce stasis of bile in liver cells, promote bile excretion, improve the liver functions and the tissue cell respiration function, reduce accumulation of fat in the liver and promote jaundice elimination and liver function recovery and is significant in treatment effect, safe and few in side effect when the compound preparation is used for treating the cholestatic jaundice and complications thereof.

Description

technical field [0001] The invention relates to the technical field of gastroenterology medicine, in particular to a compound preparation for treating cholestatic jaundice and a preparation method thereof. Background technique [0002] Cholestatic jaundice refers to the obstruction of bile secretion and excretion due to various harmful factors, forming cholestasis. Those with lesions in the liver are called intrahepatic cholestasis, and those outside the liver are called extrahepatic cholestasis. Cholestatic jaundice is dominated by elevated conjugated direct bilirubin. Cholestatic jaundice is characterized by obstructive jaundice without visible intrahepatic or extrahepatic biliary obstruction. Clinically, it may show jaundice, hepatomegaly, skin rash, loss of appetite, fatigue and other phenomena. Complications are common in intrahepatic stones, tumor thrombi, parasitic diseases, primary biliary cirrhosis, common bile duct stones, tumors, roundworms, and inflammatory ede...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K31/7076A61K31/704A61K31/08A61K31/7048A61K31/198A61K31/385A61K31/232A61K31/505A61K31/63A61K31/495A61K31/52A61K9/48A61P1/16
CPCA61K9/4866A61K31/08A61K31/198A61K31/232A61K31/385A61K31/495A61K31/505A61K31/52A61K31/63A61K31/704A61K31/7048A61K31/7076A61K31/785A61K2300/00
Inventor 徐海燕
Owner 徐海燕
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