Hyaluronic acid dressing and preparation method thereof

A technology of hyaluronic acid and mass percentage, applied in the field of medicine, can solve the problems such as inability to take into account the wound healing of high molecular weight hyaluronic acid, inability to exert the effect of hyaluronic acid, inability to take into account the quick effect and long-term effect, etc., to reduce the anti-inflammatory effect, The effect of promoting healing ability and improving intermediate metabolism

Active Publication Date: 2015-05-06
NANJING TZONE BIOLOGICAL SCI & TECH
View PDF4 Cites 27 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most products on the market are prepared from hyaluronic acid with a single molecular weight, so it cannot take into account the multiple effects of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid on wound healing, nor can it take into account both quick-acting and long-acting effects; medical dressings generally use medium Molecular weight of hyaluronic acid to achieve a better moisturizing effect, but only a single molecular weight of hyaluronic acid has a limited effect and cannot exert the best effect of hyaluronic acid

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hyaluronic acid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A hyaluronic acid dressing, comprising the following components in mass percentage: 0.1% medium molecular weight hyaluronic acid, 0.05% small molecular weight hyaluronic acid, 0.08% allantoin, 0.2% carbomer, 3.0% sorbitol, 0.5% % trehalose, 1.5% witch hazel distillate, 0.3% D-panthenol, 0.05% α-bisabolol, 0.6% oat dextran, 6% glycerin, 0.5% water-soluble silicone wax, 0.24% alkaline Neutralizer, 0.02% 2-methyl-4-isothiazolin-3-one, 0.1% phenoxyethanol, 0.006% pentanediol, 0.02% octanediol, 0.2% methylparaben, the balance is water.

[0042] Medium molecular weight hyaluronic acid has a molecular weight of 1.0×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 3000.

[0043] The carbomer is carbomer 980.

[0044] The alkaline neutralizer is triethanolamine.

[0045] The water-soluble silicone wax is Silok® 268W-30 from Guangzhou Silok Chemical Co., Ltd.

[0046] The water is purified water.

[0047] The preparation method of above-mentioned h...

Embodiment 2

[0053] A hyaluronic acid dressing, comprising the following components by mass percentage: 0.05% medium molecular weight hyaluronic acid, 0.1% small molecular weight hyaluronic acid, 1.0% allantoin, 0.15% carbomer, 3% sorbitol, 0.7 % trehalose, 1% witch hazel distillate, 0.1% D-panthenol, 0.05% α-bisabolol, 0.6% oat dextran, 5% glycerin, 0.1% water-soluble silicone wax, 0.1% alkaline Neutralizing agent, 0.008% 2-methyl-4-isothiazolin-3-one, 0.05% phenoxyethanol, 0.01% pentanediol, 0.01% octanediol, 0.3% methylparaben, remaining The amount is water.

[0054] The molecular weight of medium molecular weight hyaluronic acid is 1.8×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 10000.

[0055] The carbomer is carbomer 980.

[0056] The alkaline neutralizer is an aqueous sodium hydroxide solution (mass concentration: 1.0 mol / L).

[0057] The water-soluble silicone wax is Silok® 268W-30 from Guangzhou Silok Chemical Co., Ltd.

[0058] The water is wat...

Embodiment 3

[0065] A hyaluronic acid dressing, comprising the following components by mass percentage: 0.05% medium molecular weight hyaluronic acid, 0.05% small molecular weight hyaluronic acid, 0.2% allantoin, 0.15% carbomer, 3% sorbitol, 0.4 % trehalose, 1.5% witch hazel distillate, 0.3% D-panthenol, 0.06% α-bisabolol, 0.6% oat dextran, 6% glycerin, 0.3% water-soluble silicone wax, 0.075% alkaline Neutralizer, 0.01% 2-methyl-4-isothiazolin-3-one, 0.06% phenoxyethanol, 0.006% pentanediol, 0.02% octanediol, 0.2% methylparaben, the balance is water.

[0066] The molecular weight of medium molecular weight hyaluronic acid is 1.4×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 5800.

[0067] The carbomer is carbomer 980.

[0068] The alkaline neutralizer is triethanolamine.

[0069] The water-soluble silicone wax is Silok® 268W-30 from Guangzhou Silok Chemical Co., Ltd.

[0070] The water is purified water.

[0071] The preparation method of above-mentioned ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to view more

Abstract

The invention discloses a hyaluronic acid dressing and a preparation method thereof. The dressing comprises the following components in percentage by mass: 0.01-0.3% of medium-molecular-weight hyaluronic acid, 0.01-0.5% of small-molecular-weight hyaluronic acid, 0.03-1% of allantoin, 0.1-1% of Carbomer, 2-5% of sorbitol, 0.2-1% of trehalose, 0.7-2.5% of witch hazel distillate, 0.1-0.5% of D-panthenol, 0.05-0.15% of alpha-bisabolol, 0.2-1.0% of oat glucan, 2-10% of glycerinum, 0.06-1% of water-soluble silicon wax, 0.05-0.9% of an antalkali, 0.004-0.2% of 2-methyl-4-isothiazoline-3-one, 0.05-0.4% of phenoxyethanol, 0.005-0.05% of pentanediol, 0.01-0.06% of octylene glycol, 0.025-0.5% of methylparaben and the balance of water. The dressing disclosed by the invention is capable of permeating into the deep layers of the skin to remove excessive free radicals, promoting the generations of blood vessels, and accelerating the union of wounds, in particular, acnes, eczematous dermatitis, photorejuvenation postoperation repair and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hyaluronic acid dressing and a preparation method thereof. Background technique [0002] Hyaluronic acid (HA), sodium hyaluronate, is a linear polysaccharide composed of repeating disaccharide units of alternately bonded β-D-N-acetylglucosamine and β-D-glucuronic acid. The molecules of hyaluronic acid can carry more than 500 times of water, can maintain the water in the extracellular matrix, promote cell migration and differentiation, have very excellent biocompatibility, and are recognized as the best moisturizing ingredients today, and are widely used In skin care products and cosmetics. [0003] Wound healing of human skin and mucous membranes is a process involving the reconstruction and regeneration of extracellular matrix by various cells and their secreted products. Maintaining the humidity of the wound surface has a very obvious promoting effect on wound healing, which is not ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44
Inventor 金玉
Owner NANJING TZONE BIOLOGICAL SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap