497results about How to "Shorten healing time" patented technology

The invention is a medical implantable device which is coated by the method according to the invention. The surface of the substrate used for the implantable device, in the raw condition, following a cleaning regime and physiochemical pretreatments, is coated using a biomimetic process in a supersaturated calcium phosphate solution (SCPS) to obtain the desired coating coverage and morphology maintaining a ratio of calcium to phosphorus pH, as well as solution temperature plays a major role in yielding precipitation of the proper phase of CaP so that composition, morphologies, crystal structures, and solubility characteristics are optimal for the deposition process. The biomimetic coating adds the attribute of osteoconductivity to the implant device. To maximize bone growth, the implant must also induce bone growth, or possess the attribute of osteoinductivity. This attribute is acquired by the use of therapeutic agents, i.e. bone morphogenic proteins (BMP), growth factors, stem cells, etc. The preparation of the SCPS solution is slightly altered so that during the immersion of the implant in the SCPS, the therapeutic agents are co-precipitated and bonded with the CaP directly on the underlying surface of the implant device. A final dipping process into a BMP solution provides an initial burst of cellular activity. For delivering stem and / or progenitor cell, after drying the dipped solution of BMP, the cells are cultured on the surface of the implant.

An intraocular lens has an optic made of a foldable material and at least two haptics integrally formed with the optic. The optic comprises an optical element with optical power, a transition region disposed around the entire perimeter of the optical element, and a support disposed about at least a portion of the transition region, the thickness of the support being greater than the thickness of the transition region. The transition region advantageously has a thickness of between at least about 0.07 mm and about 0.40 mm.

A percutaneously implantable orthopedic device is a shape-changing joint prosthesis with a generally arcuate or generally rectilinear configuration which is delivered through a delivery device in a substantially straightened or slightly curved configuration into a joint in a patient. The generally arcuate configuration may include an open ring or spiral shape. The generally rectilinear configuration may include a polygon or zig-zag shape. The delivery and retrieval device can be a syringe, hypodermic needle or cannula. The orthopedic device is moveable into its generally arcuate or generally rectilinear configuration in the joint by manipulation or a shape memory set. The orthopedic device acts as a soft compliant bearing surface or cushion that minimizes the bone-on-bone wear from articulation and loading.

A vibration device for providing a vibration sensation to a user, the device including: a base; a vibrating element; a power source; and, an actuation mechanism configured to facilitate an electrical connection between the power source and vibrating element, thereby causing the vibrating element to vibrate. A system for providing a vibrating sensation to a user for pain management and a method of manufacturing a vibration device for providing a vibrating sensation to a user are also disclosed.

Non-invasive apparatus and methods are disclosed for treatment of soft-tissues of a human or animal body, and, more particularly, non-invasive treatment apparatus and methods for destruction of adipose tissues of a patient using focused delivery of ultrasonic energy in a group focal zone.

The invention discloses a porous complex gel-nanofiber oxygen permeation dressing and a preparation method thereof. The method comprises the following steps: obtaining a collagen nanofiber membrane by adopting a collagen solution by virtue of an electrostatic spinning method; performing chemical crosslinking on two natural and non-toxic macromolecule polysaccharides such as chitosan and alginic acid, and preparing complex gel; and preparing the porous sponge-nanofiber double-layer composite material in a freeze-drying mode, wherein the upper gel layer of the dressing is in a sponge state during drying and is in a gel state after moisture absorption. The biological wound dressing is prepared under the condition that any toxic chemical crosslinking agent is not added, the process is simple, and the safety is high. The prepared biological wound dressing disclosed by the invention has the characteristics of excellent oxygen permeation performance, water-absorbing quality, water permeability, moisture penetrability and high biocompatibility, a physiological wet environment of the wound surface can be maintained, wound healing and effective haemostasis are promoted, wound infection can be avoided, the recovery is accelerated, the wound surface can be effectively recovered, and the dressing is applied to multiple wound surfaces such as trauma, burns and ulceration.

The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

The present invention is preparation process of collagen-based surface wound repairing membrane possessing tissue induction function, and features that the collagen-based surface wound repairing membrane modified physically and chemically has introduced gelatin-base slow releasing microsphere containing cell growth factor, pores of 20-200 micron size, pore rate not smaller than 80 %, tensile strength not smaller than 1 MPa, pH 5.0-6.0, and excellent degradation and biocompatibility. It has the functions of absorbing wound diffusate, induce the adhesion, proliferation and differentiation of autocell, induce the growth of blood vessel, release cell growth factor to the wound for long time, speed wound healing and avoid scar. The present invention is used for injury, burns, scalds, skin ulcer, etc.

The invention relates to a new method for preparing an antibiotic bioactive coating material on the surface of titanium alloy and magnesium alloy by ultrasonic-microarc oxidation composite technology, which can be used for obtaining a biological coating material which is compact at the bottom layer and is porous at the surface layer, wherein Ca, P and Ag contained in the coating can improve the bioactivity and the corrosion resistance of magnesium and titanium, and reduce bacterial infection caused by implantation. The invention can meet the requirements of bearing bones of human beings for mechanical properties of implanted materials, and can overcome disadvantages of the traditional surface modification method for biologic materials. In the coating composite material, the coating thickness of titanium alloy is 50-85 mu m, the surface hole diameter is 4-25 mu m, the porosity is 20-30%, and the bonding strength between the coating and the matrix is 23-40 MPa. The coating thickness of magnesium alloy is 16-22 mu m, the surface hole diameter is 5-28 mu m, the porosity is 21-30%, and the bonding strength between the coating and the matrix is 8-20 MPa.

The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.

A non-user controllable electro-therapy device has a housing for a microprocessor, power source, status indicator, activation switch, and one or more channels for electrode contact. Only the activation switch is user-accessible. The microprocessor generates a non-user controllable frequency dependent mixed electrical signal through the electrodes, wherein the mixed electrical signal is a combination of at least two different frequencies, a first frequency having a first minimum and maximum microamp range and a second frequency having a different second minimum and maximum microamp range. The higher of the two frequencies is superimposed on the lower frequency, creating a current intensity window as an envelope along a profile of the lower frequency. The mixed electrical signal is automatically applied for a pre-determined period of time, and amplitude and / or duration and / or frequencies is varied according to a pre-set schedule programmed into a controller coupled to the one or more electrodes.

The present invention provides methods and compositions for increasing bone production and / or decreasing bone fracture healing time in a subject, by administering an effective amount of periostin and / or active peptides and / or fragments thereof.

A elf-tapping dental implant has a unitary body with an open end and a bottom tip end, The implant is tapered downward from the open top to the tip end and has an internal cavity extending for substantially the length of the implant. Smooth inner sidewalls are located at the upper end of the cavity and internal threads extend from the sidewalls down into the cavity. The method of utilizing the dental implant includes tapping the implant into the patient's mandible bone and utilizing a healing screw to heal. the patient's gum and an abatement member permanently locked into the implant to which the permanent crown is secured.

The invention discloses a hyaluronic acid dressing and a preparation method thereof. The dressing comprises the following components in percentage by mass: 0.01-0.3% of medium-molecular-weight hyaluronic acid, 0.01-0.5% of small-molecular-weight hyaluronic acid, 0.03-1% of allantoin, 0.1-1% of Carbomer, 2-5% of sorbitol, 0.2-1% of trehalose, 0.7-2.5% of witch hazel distillate, 0.1-0.5% of D-panthenol, 0.05-0.15% of alpha-bisabolol, 0.2-1.0% of oat glucan, 2-10% of glycerinum, 0.06-1% of water-soluble silicon wax, 0.05-0.9% of an antalkali, 0.004-0.2% of 2-methyl-4-isothiazoline-3-one, 0.05-0.4% of phenoxyethanol, 0.005-0.05% of pentanediol, 0.01-0.06% of octylene glycol, 0.025-0.5% of methylparaben and the balance of water. The dressing disclosed by the invention is capable of permeating into the deep layers of the skin to remove excessive free radicals, promoting the generations of blood vessels, and accelerating the union of wounds, in particular, acnes, eczematous dermatitis, photorejuvenation postoperation repair and the like.

A biodegradable polyurethane scaffold, comprising at least one polyisocyante, polyisocyanate prepolymer, or both, at least one polyester polyol, at least one catalyst, wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore, and wherein the scaffold incorporates at least one biologically active component in powder form.

A tissue harvesting device (1), comprising a rotary cutting tool (10) adapted to cut soft tissue and a collection container (20) including a central bore (21) extending in a longitudinal direction and with a distal opening (22), wherein the cutting tool is arranged in the central bore of the collection container and adapted to pass through the distal opening and draw harvested soft tissue fragments into the collection container, and a housing (30) accommodating the cutting tool and the collection container, wherein the collection container is axially movable with respect to the housing.

The present invention relates to a composition for reducing sport injury and promoting sport injury repair. The composition comprises the following raw materials and auxiliary materials, by weight, 500-2000 parts of hydrolyzed collagen protein, 100-400 parts of soybean protein peptide, 50-400 parts of chondroitin sulphate, 50-400 parts of glucosamine or a salt thereof, 100-1000 parts of a traditional Chinese medicine, 10-400 parts of haematococcus pluvialis, 1-100 parts of vitamin, and 1-100 parts of a mineral. The composition provides good effects for sport injury reduction and sport injury repair promotion.

An improved surgical instrument for the removal of previously fragmented tissues and fluids from a patient through a small incision including a multi-lumen cannula, one lumen of which is used to supply an irrigating fluid to suspend and dilute the fragmented tissue and the other lumen for the application of suction to remove the tissue and fluids. The second lumen has a resistive ratio that is between 0.5 and 1.5 times the resistive ratio of the first lumen.

The invention discloses a preparation method of a titanium and titanium alloy surface black protective film for surgical implantation, comprising the following steps: step 1: carrying out micro-arc oxidation coloring processing on titanium and titanium alloy surface to be processed, in the process, firstly, preparing a micro-arc oxidation electrolysing solution, and then carrying out the micro-arcoxidation coloring processing; and step 2: carrying out subsequent processing on the micro-arc oxidation film, wherein the subsequent processing comprises the following steps: firstly, preparing a mixed solution for hydro-thermal processing, completely dipping the titanium and titanium alloy after micro-arc oxidation shading processing in the mixed solution, carrying out the hydro-thermal processing on the surface by adopting a hydro-thermal method, drying the titanium and titanium alloy under the condition of low temperature when the hydro-thermal processing is completed, and generating a layer of pure black micro-arc oxidation film with uniform and plump surface on the titanium and titanium alloy surface. The invention has simple and convenient operation, economy, high production efficiency, and high bonding strength between a generated ceramic film, i.e. the micro-arc oxidation film and a substrate, and the invention can effectively overcome various defects and deficiencies which exist in the prior coating processing techniques.

The present invention provides a nutritional composition effective in faciliating bone healing in human, comprising lysine, proline, ascorbic acid, copper, vitamin B6. The nutritional composition contains 27-34% wt lysine, 14-16% wt proline, and 42-47% wt ascorbic acid. The nutritional composition further comprises vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, niacin, folic acid, vitamin B12, biotin, pantothenic acid, calcium, phosphorus, magnesium, zinc, selenium, manganese, chromium, molybdenum, potassium, citrus fruit peel bioflavanoids, arginine, cysteine, inositol, carnitine, coenzyme Q10, and pycnogenol. The present invention also provides a method of administering the nutritional composition in human effective in facilitating bone healing.

The invention discloses a nano-hydroxyapatite / polyether-ether-ketone composite material and a bone repair body as well as a preparation method and application thereof. The preparation method of the composite material comprises the following steps: uniformly mixing 30-35wt% of 200nm-1mu m hydroxyapatite powder and 65-70wt% of 5-15mu m polyether-ether-ketone powder to obtain mixed powder; and processing the mixed powder and moulding to obtain the composite material. The composite material has good biocompatibility and bioactivity as well as mechanical properties matching the bone tissue, effectively prevents the stress shielding effect, and can stimulate bone growth, accelerate bone healing, shorten the healing time of the injury after material implantation of bone and reduce the probability of second operation. The preparation technology of the composite material can be adjusted to prepare bone repair bodies different in shape, specification and mechanical properties to meet the clinical needs. Inflammatory reaction is avoided after the implantation of the bone repair bodies, the mechanical properties are matched with human bone, negative effects such as bone repair material loosening and bone resorption are prevented, and the clinical needs for bone repair can be met.

The invention discloses a tissue wound repairing material and a related product preparation method thereof, relating to the field of tissue wound repairing. The tissue wound repairing material is prepared from a component A and a component B in a weight ratio of 1:1, wherein the component A comprises 10-25 parts of bioactive glass, 3-15 parts of medical glycerol, 1-5 parts of medical liquid paraffin, 1-3 parts of polyethylene glycol 400 and 30-65 parts of medical vaseline; and the component B comprises 1-30 parts of plant essential oil, 0.5-5 parts of medical chitosan, 0.1-2 parts of sodium hyaluronate, 0.001-0.005 part of triethanolamine, 0.001-0.005 part of medical preservative and 0.01-0.05 part of carbomer. The preparation method comprises the following steps: mixing the component A and the component B in parts by weight at 80-130 DEG C, carrying out homogeneous stirring and vacuum defoaming to obtain gel, and then, filling and sterilizing the gel to obtain pasty tissue wound repairing gel; and coating and baking the gel, and then, cutting, sub-packaging and sterilizing the gel to obtain a dressing type tissue wound repairing material. The prepared tissue wound repairing material is high in healing promoting speed, capable of inhibiting scars, wide in range of application and convenient to operate.

The invention provides a stepless adjustable skin stapler, and belongs to the apparatus for operation. The stepless adjustable skin stapler comprises a block shaped double sticky tape. The stepless adjustable skin stapler is characterized by further comprising a flexible wire, a main pull buckle, a secondary pull buckle, a hook and loop fastener connected to the end of the flexible wire, a fabric piece used for fixing or releasing the hook and loop fastener, and release paper, wherein the main pull buckle and the secondary pull buckle are respectively composed of a main adhering piece, a secondary adhering piece, a main pull buckle column and a secondary pull buckle column; the other end of the flexible wire, connected with the hook and loop fastener, is fixed on the neck of the secondary pull buckle. The test result shows that the stepless adjustable skin stapler meets the demand on opening a stapled wound and also realizes continuous fine adjustment of wound stapling force, thus the potential risk that the wound healing is seriously influenced by excessive tightening, staggering of skins in both sides of the wound, and non-uniform stressing on different parts of a nonlinear wound during stapling can be avoided; the blood microcirculation of the wound skin is prompted, the wound is sped up to heal, and the wound healing period is reduced from 11 to 12 days in the prior art to 8 to 9 days, which is close to the healing period of the wound stapled with the traditional medicinal needle and line.

Disclosed is a prosthetic implant comprising an implantable magnetic base structure that supports or couples with a prosthetic suprastructure for implantation in a mammal to fulfill a prosthetic need. The implantable base more quickly fuses with surrounding tissue or bone with the aid of a magnetic field. The suprastructure abuts and is supported by the implantable base, and each comprises a biocompatible magnetic material to establish a magnetic field in the region of the tissue surrounding the implantable base. An anchoring arrangement may be employed to fasten the suprastructure to the base. Together, the magnetic base, suprastructure, and / or anchoring arrangement are positioned relative to each other to concentrate a magnetic field in the region of the implant in order to facilitate fusion of the base structure with surrounding bone or tissue. Advantageously, the magnetic field shortens the healing time and retards bacterial growth whereby to quickly fuse the base structure with the surrounding bone or tissue.

The invention provides an artificial dental abutment, an artificial dental multi-part implanting system and an implanting method. A crown connection section and an implant connection section are respectively arranged at two ends of the artificial dent abutment, wherein the included angle of the axis of the crown connection section and the axis of the implant connection section is 10-30 degrees. The artificial dental abutment can adapt to various oral implanting conditions and angles. An artificially implanted tooth has a harmonious and beautiful repairing effect with surrounding tissues and remained dentition by adopting the abutment. The invention discloses an artificial dental multi-part implanting system comprising the artificial dental abutment, wherein the implant is a multi-part and nonsubmerged technology combined implant, is high in stability and strength, and can adapt to various oral implanting conditions and angles, can be used for effectively reducing the local stress, shortening the healing time and reducing the hurt of patients.

Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with the surface. As shown in the examples below, clinical observations, digital radiography, and a battery of well-accepted ex vivo analytical methods show that the presence of a hydrophobic polycationic polymer coating, such as N,N-dodecyl,methyl-PEI coating on the surface of a metal implant, was effective in eliminating the clinical signs of infection in vivo in a large animal infection model. Moreover, the coated plates supported bone healing, and in fact decreased healing times, even in the presence of significant bacterial contamination compared to a control.

The invention provides a preparation method of a magnesium surface ultrasonic micro-arc oxidation-HF-silane coupling agent multistage compound bioactive coating, relates to a method for preparing a pure magnesium bioactive coating composite material, and aims to solve the problems of low bonding strength and poor biocompatibility of a coating and a base in a bioactive coating composite material. The method comprises the following steps: 1, roughly grinding and cleaning a pure magnesium sample; 2, preparing an Na2SiO3 electrolyte A and a KOH electrolyte B, mixing the two electrolytes, and adding KF to obtain a micro-arc oxidation electrolyte; 3, regulating parameters of micro-arc oxidation equipment, and performing micro-arc oxidation on the sample to prepare a coating composite material; and 4, sequentially soaking the rinsed coating composite material in an HF solution and a silane coupling agent, thus completing preparation of the bioactive coating. According to the invention, the bonding strength of the coating and the base in the obtained bioactive coating is high; and meanwhile, magnesium fluoride and magnesium silicate in the oxidation layer ensure favorable biocompatibility.

The invention relates to a hydrogel woundplast containing traditional Chinese medicine extracts and a preparation method thereof. The hydrogel woundplast comprises a back lining layer, a medicated hydrogel layer and a stripping layer. The preparation method comprises the following steps: uniformly mixing the following components in percentage by weight: 0.5-4.0% of chitosan, 1.0-3.0% of polyvinyl alcohol, 0.2-1.0% of gelatin, 1.0-3.0% of glycerol, 0.5-2.5% of menthol, 0.2-1.0% of coptis extract, 1.0-2.5% of honeysuckle flower extract, 15-25% of anhydrous ethanol and 50-80% of distilled water; performing cyclic refrigerating-melting treatment to obtain the medicated hydrogel layer; bonding the back lining layer on one side of the hydrogel layer; and bonding the stripping layer on the other side of the hydrogel layer. The hydrogel woundplast containing traditional Chinese medicine extracts is simple in structure and convenient to use, and can absorb wound surface exudates and keep wound wetness; and meanwhile, the hydrogel woundplast has the effects of resisting bacteria, diminishing inflammation and stopping bleeding, and can effectively accelerate wound healing.

The invention discloses a composite, a raw material composition, a bone repair body, a preparation method and an application. The raw material composition of the composite comprises the following components of tantalum material powder and polyaryletherketone powder, wherein the volume ratio of the tantalum material powder to the polyaryletherketone powder is(1:4) to (1:1), and the particle diameter of the tantalum material powder is 100nm-5 [mu]m. The composite prepared by the composition has favorable bioactivity and compatibility, is good in mechanical properties, can promote cell adhering,proliferation and polarization, can stimulate bone growth, can accelerate bone healing, and can reduce healing time after a bone implant material is implanted. The bone repair body prepared by the composition cannot cause inflammatory reaction after being implanted, the mechanical properties of the bone repair body including modulus of elasticity, toughness, rupture strength and the like, can cooperate with human bones, and the bone repair body cannot cause negative effect of loosening of the bone repair material caused by stress shielding, bone absorption and the like, and can meet requirements of clinical application for bone repair.