Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof

A hydrogel and band-aid technology, applied in the field of medical supplies, can solve problems such as health hazards, and achieve the effects of good comfort, excellent mechanical properties, and good biocompatibility

Inactive Publication Date: 2017-01-11
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding antibacterial ingredients to hydrogel can endow the hydrogel with antibacterial

Method used

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  • Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof
  • Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof
  • Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0035] Preparation of Coptis extract: pulverize Coptis chinensis, add it to 12 times the volume fraction of 60% ethanol solution to soak overnight, then perform ultrasound at 45°C for 1 hour with ultrasound power of 250W, filter while hot, concentrate the filtrate and freeze-dry , To obtain the Coptis extract, wherein the content of berberine hydrochloride is 25.0%, the content of palmatine is 6.0%, the content of berberine is 5.4%, and the content of epiberberine is 3.8%;

[0036] The preparation of honeysuckle extract: crush the honeysuckle and add it to 10 times the volume fraction of 60% ethanol solution overnight, sonicate it at 40°C for 45min, the ultrasonic power is 250W, filter while hot, concentrate the filtrate and freeze-dry it. The honeysuckle extract is obtained, wherein the content of chlorogenic acid is 5.4%.

Example Embodiment

[0037] Example 1

[0038] (1) Weigh 0.8 g of chitosan and add it to 36 mL of an acetic acid solution with a mass concentration of 1.2%, and stir evenly to form solution A;

[0039] (2) Weigh 1.0 g of polyvinyl alcohol, add it to 15 mL of distilled water for heating to dissolve, stir evenly, and cool down to form solution B;

[0040] (3) Weigh 0.2g of gelatin, add it to 14mL of distilled water, and swell at 60°C to form solution C;

[0041] (4) Weigh 0.8 g of menthol, add it to 5 mL of absolute ethanol solution, stir evenly to form solution D;

[0042] (5) Weigh 0.2 g of Coptis extract and add it to 10 mL of ethanol solution with a volume fraction of 60%, stir evenly to form solution E;

[0043] (6) Weigh 1.0 g of honeysuckle extract, add it to 20 mL of ethanol solution with a volume fraction of 60%, stir evenly to form solution F;

[0044] (7) Add solutions B, C, D, E, F and 0.8 mL of glycerin to solution A in sequence, and stir evenly to form solution G;

[0045] (8) The solution G is sub...

Example Embodiment

[0048] Example 2

[0049] (1) Weigh 1.6 g of chitosan and add it to 30 mL of an acetic acid solution with a mass concentration of 1.2%, and stir evenly to form solution A;

[0050] (2) Weigh 2.0 g of polyvinyl alcohol, add it to 12 mL of distilled water for heating to dissolve, stir evenly, and cool down to form solution B;

[0051] (3) Weigh 0.6 g of gelatin, add it to 12 mL of distilled water, and swell at 60°C to form solution C;

[0052] (4) Weigh 1.6g of menthol, add it to 3mL of absolute ethanol solution, stir evenly to form solution D;

[0053] (5) Weigh 0.5 g of Coptis extract, add it to 20 mL of ethanol solution with a volume fraction of 60%, stir evenly to form solution E;

[0054] (6) Weigh 1.0 g of honeysuckle extract, add it to 20 mL of ethanol solution with a volume fraction of 60%, stir evenly to form solution F;

[0055] (7) Add solutions B, C, D, E, F and 1.2 mL of glycerin to solution A in sequence, and stir evenly to form solution G;

[0056] (8) The solution G is subjec...

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Abstract

The invention relates to a hydrogel woundplast containing traditional Chinese medicine extracts and a preparation method thereof. The hydrogel woundplast comprises a back lining layer, a medicated hydrogel layer and a stripping layer. The preparation method comprises the following steps: uniformly mixing the following components in percentage by weight: 0.5-4.0% of chitosan, 1.0-3.0% of polyvinyl alcohol, 0.2-1.0% of gelatin, 1.0-3.0% of glycerol, 0.5-2.5% of menthol, 0.2-1.0% of coptis extract, 1.0-2.5% of honeysuckle flower extract, 15-25% of anhydrous ethanol and 50-80% of distilled water; performing cyclic refrigerating-melting treatment to obtain the medicated hydrogel layer; bonding the back lining layer on one side of the hydrogel layer; and bonding the stripping layer on the other side of the hydrogel layer. The hydrogel woundplast containing traditional Chinese medicine extracts is simple in structure and convenient to use, and can absorb wound surface exudates and keep wound wetness; and meanwhile, the hydrogel woundplast has the effects of resisting bacteria, diminishing inflammation and stopping bleeding, and can effectively accelerate wound healing.

Description

technical field [0001] The invention relates to a band-aid and a preparation method thereof, in particular to a hydrogel band-aid containing Chinese medicine extract and a preparation method thereof, belonging to the technical field of medical supplies. Background technique [0002] Band-aid is a medical product that protects wounds, prevents wound contamination, and promotes wound healing. Traditional band-aids have the advantages of small size, simple use, and convenient portability. However, the adhesive tape used has poor air permeability, and the sweat normally secreted by the human body cannot pass through the adhesive tape, so it is easy to cause skin wrinkles. At the same time, the wound pad layer of the traditional band-aid cannot keep the wound moist, and it is easy to adhere to the wound, causing secondary damage. [0003] Hydrogel is a network polymer swelling body containing a large amount of water, which is widely used in wound dressings, artificial skin, bon...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/24A61L15/40A61L15/42A61L15/44A61L15/46
CPCA61L15/32A61L15/24A61L15/26A61L15/28A61L15/40A61L15/42A61L15/44A61L15/46A61L2300/30A61L2300/404A61L2300/41A61L2300/418A61L2400/04C08L89/06C08L5/08C08L29/04C08L75/04
Inventor 钟文英吴灿陈乔何苏云王俊玲
Owner CHINA PHARM UNIV
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