117results about How to "Shorten wound healing time" patented technology

A method and morphologically adaptable apparatus for altering the charge distribution upon living membranes with functional stabilization of the membrane physical electrical integrity further comprising a method for using quadripolar, circular, center charged, energy balanced magnetic device in a four (4) magnet array of alternating polarity in which the magnetic poles are in multiple planes and are separated by a predetermined distance which provide an effective magnetic sphere of influence on all adjacent poles to suppress the firing of action potentials of mammalian sensory neurons. The method and apparatus further provides a static magnetic device for production of a magnetic field for treatment of various disorders that can be focused at the site of pain or edema to deliver a gradient in the magnetic field to prevent or reduce charge flow. Further there is provided a static magnetic device for production of a magnetic field for treatment of disorders wherein the device provides a static magnetic field such that the focused magnetic field gradient is oriented To be perpendicular to the neuron or membrane charge flow providing maximum deflection of the ion or charge flow.

The present invention is preparation process of collagen-based surface wound repairing membrane possessing tissue induction function, and features that the collagen-based surface wound repairing membrane modified physically and chemically has introduced gelatin-base slow releasing microsphere containing cell growth factor, pores of 20-200 micron size, pore rate not smaller than 80 %, tensile strength not smaller than 1 MPa, pH 5.0-6.0, and excellent degradation and biocompatibility. It has the functions of absorbing wound diffusate, induce the adhesion, proliferation and differentiation of autocell, induce the growth of blood vessel, release cell growth factor to the wound for long time, speed wound healing and avoid scar. The present invention is used for injury, burns, scalds, skin ulcer, etc.

A method and morphologically adaptable apparatus for altering the charge distribution upon living membranes with functional stabilization of the membrane physical electrical integrity further comprising a method for using quadripolar, circular, center charged, energy balanced magnetic device in a four (4) magnet array of alternating polarity in which the magnetic poles are in multiple planes and are separated by a predetermined distance which provide an effective magnetic sphere of influence on all adjacent poles to suppress the firing of action potentials of mammalian sensory neurons. The method and apparatus further provides a static magnetic device for production of a magnetic field for treatment of various disorders that can be focused at the site of pain or edema to deliver a gradient in the magnetic field to prevent or reduce charge flow. Further there is provided a static magnetic device for production of a magnetic field for treatment of disorders wherein the device provides a static magnetic field such that the focused magnetic field gradient is oriented To be perpendicular to the neuron or membrane charge flow providing maximum deflection of the ion or charge flow.

The invention discloses a stem cells preparation for repairing a wound surface and preparation method thereof, wherein the stem cells preparation uses umbilical cords, placentae or mesenchymal stem cells between amniotic membranes as living cells, and is added with high polymer material sodium alginate with excellent biocompatibility, sodium hyaluronate, chitosan and hydroxyethyl starch as cell stabilizer. The stem cells preparation for repairing the wound surface has higher cell viability and is durable in action, and breaks through technical limitations of effectiveness of the mesenchymal stem cells for treating.

The invention discloses a sternum gathering up holder. The sternum gathering up holder comprises a locking wheel, a male fixing component and a female fixing component, wherein the male fixing component and the female fixing component can be connected together in an inserting mode. The section of the locking wheel is of an olive shape or an oval shape. The male fixing component is provided with an elastic plug and a first paw-shaped hook plate, wherein first saw teeth are arranged at two sides of the elastic plug, a tightening groove is formed in the middle of the elastic plug, and a locking hole which is in transition fit with the outer wall face of the locking wheel is formed in the tightening groove, and the long axis direction of the locking hole is the insert-connect direction of the male fixing component and the female fixing component. The female fixing component is provided with a second paw-shaped hook plate and a plug seat, wherein the plug seat is provided with an inserting groove which is matched with the elastic plug, second saw teeth which are matched with the first saw teeth are arranged on two sides of the inserting groove, the rotatable locking wheel is installed inside the locking hole so as to rotate the locking wheel. When the tightening groove is enlarged, the second saw teeth are meshed with the second saw teeth. When the tightening groove is decreased, the first saw teeth are separated from the second saw teeth. The sternum gathering up holder is not only capable of conveniently adjusting the opened chest gathering up width, but also easy and convenient to fix and stable, and capable of not producing cutting phenomenon to sternum.

The invention provides a collagen gel and a preparation method thereof. The collagen gel comprises collagen and an antibacterial agent, wherein the antibacterial agent is at least one of chitosan and nano silver. The collagen gel also comprises a preservative, a substrate, a dispersing agent, a film-forming agent and water; and 1g of gel comprises 0.5 to 8.0mg of collagen, 0.001 to 15mg of antibacterial agent, 1 to 50mg of preservative, 10 to 50mg of matrix, 50 to 100mg of dispersing agent, 1 to 10mg of film-forming agent, and the balance of water. The method for preparing the collagen gel comprises the following steps of: performing dispersion and dissolution on the substrate by adopting the dispersing agent under ten-thousand grade clean environment; adding the dispersing agent, the substrate, the preservative, the antibacterial agent, and collagen solution into a vacuum emulsified homogenizer one by one; after fully mixing, standing and defoaming, filling the product. The collagen gel is applied to various open wounds and infected wounds, lightens hyperpigmentation, has good effect of accelerating wound healing, and can maintain long-term anti-bacteria function.

The invention discloses an anti-aging and wrinkle-removing composition. The anti-aging and wrinkle-removing composition is prepared from the following components in percentage by mass: 3-10% of hydrolyzed collagen, 3-15% of polypeptide, 0.4-10% of humectant, 1-3% of compound amino acid, 0.5-1% of ceramide-3, 3-10% of polyhydric alcohol, 1-10% of antioxidant, 0.1-1% of preservative, 0.02-1% of chelating agent, 0.1-5% of anti-allergic agent and the balance deionized water. According to the anti-aging and wrinkle-removing composition, the hydrolyzed collagen, the polypeptide, the humectant, the compound amino acid, the ceramide 3, the polyhydric alcohol and the antioxidant are scientifically proportioned according to the structural characteristics of skin and the physiological function requirements of the skin, so that the anti-aging and wrinkle-removing composition can be used for removing wrinkles instantly and removing wrinkles for a long time; and after the anti-aging and wrinkle-removing composition is used for a long time, the effects of reconstructing a skin cell collagen network, deeply removing wrinkles and resisting aging, plumping the skin, improving the water content of epidermal cells, enhancing the skin barrier function, brightening the skin, increasing the skin elasticity and brightening the skin color are achieved.

The invention relates to cosmetics, in particular to skin repairing liquid and application thereof. The skin repairing liquid is prepared from, by weight, 1-10 parts of glycerinum, 0.1-1 part of 1,2-pentanediol, 0.05-0.15 part of dipotassium glycyrrhizinate, 0.01-0.05 part of oligopeptide-1, 0.05-0.5 part of sodium hyaluronate, 0.3-0.9 part of aloe barbadensis leaf juice and 87.4-98.49 parts of water. The skin repairing liquid is applied to cosmetics and especially facial masks. The preparation method of the skin repairing liquid includes the following steps of firstly, completely dispersing and dissolving glycerinum, 1,2-pentanediol and water in a heating pot at a high speed in a homogeneous mode and keeping the temperature at 75 DEG C or higher; secondly, adding dipotassium glycyrrhizinate, oligopeptide-1, sodium hyaluronate and aloe barbadensis leaf juice when the temperature in the heating pot is lowered to be 45 DEG C or lower, completely stirring and dissolving the materials, and conducting filtering and discharging; thirdly, conducting standing, subpackaging and packaging after discharging. The skin repairing liquid effectively improves the skin repairing effect.

The invention discloses freeze-dried powder for repairing acne marks and scars. The freeze-dried powder is prepared by the steps of: A, preparing raw materials; B, dissolving mannitol, oligopeptide-3, disodium hydrogen phosphate and oligopeptide-2 in water at normal temperature, placing the solution in a 121 DEG C autoclave, and performing sterilization at a constant temperature for 20 minutes to form a solution A; C, sequentially adding sodium dihydrogen phosphate and serum albumin into the solution A, shaking the mixture uniformly, and performing filtration by using a filter membrane to obtain a solution B; D, standing the solution B for 18-36h, and then performing filling; E, performing freeze drying on the solution B after filling; and F, packaging the product after drying. The freeze-dried powder prepared by the invention can achieve multiple repair and protection of a skin damaged by acnes, and can promote skin microcirculation and improve the acne marks to ensure that the skin can recovered to a healthy state.

The invention relates to a preparation method of tissue engineering xenoskin, which adopts a baby pig with rich source as a skin source to obtain the finished product through the steps of taking the skin, fixing the skin, cutting, removing hypodermal cells, modifying three-dimensional collagenic structure, changing physical characteristics and sterilizing and packaging, and the finished product can be stored for more than 2 years under the environment of 2-10 DEG C. The tissue engineering xenoskin is applied to deep burn and defect of skin, has the functional characteristics of low immunogenicity, compact adhesion on wound surface, and moisture maintenance, can be used as a protection wound surface of a provisional wound surface cover of a human body, and can also be used as a growth repair wound surface of permanently remaining corium bracket. The invention solves the defects of high cost, limit source, long fabrication time, short storage time and organism hurt by secondary skin-grafting in the prior artificial skin product. The prepared product material has wide material source, short product period, short storage time and low cost, and is widely applied to the clinic.

The invention discloses a fusion protein with antibacterial and repairing function and a production method and application thereof. A fusion gene is prepared by splicing an anthropogenic antibacterial peptide gene and a cell growth factor gene through a segment of hydrophobic polypeptide joint; and the fusion protein is prepared by adopting the expression of a prokaryocyte or yeast expression system, and is encoded by the anthropogenic antibacterial peptide, the polypeptide joint and the cell growth factor gene from an N end to a C end of the fusion protein. The invention simultaneously provides application of the fusion protein to the preparation of medicaments for treating wounds, burns / scalds, cold injury, chronic ulcer or bedsore. The invention creatively fuses the two kinds of polypeptide genes together to successfully construct a fusion protein with dual function of preventing infection and accelerating the repair of the damaged tissue, improves the safety of clinical medicament simultaneously, and prolongs the half-life period of the fusion protein.

The invention belongs to the field of medicinal dressings and in particular relates to a medicinal dressing with bioactivity and a preparation method of the medicinal dressing. The medicinal dressing with the bioactivity comprises the following components in parts by weight: 1-2 parts of hyaluronic acid, 2-4 parts of carbomer, 5-10 parts of bioactivity components, 0.5-1 part of propyl p-hydroxybenzoate, 8-12 parts of glycerin, 0.2-0.4 part of sodium hydrogen sulfite, 3-8 parts of chitosan oligosaccharide, 0.5-1.5 parts of triethanolamine and 65-80 parts of deionized water. The medicinal dressing with the bioactivity, which is provided by the invention, is high in comfort degree, is capable of promoting wound heal, remarkably shortening the wound heal time and preventing adhesion, is painless in dressing change and free of irritation, is capable of preventing bacteria and scar and has multiple effects of excellent bioactivity, efficient bacterial resistance, good pain relieving functions, wound heal promotion and the like, a slightly wet heal environment is created and maintained, wound infection is prevented, and wound adhesion is avoided.

An artificial skin for repairing the skin defect caused by inflammation, ulcer, burn, etc is composed of surface epidermal cells and fibroblasts. It is prepared through preparing culture liquid, preparing the solution of artificial skin matrix, and culturing artificial skin.

The invention relates to an anti-acne composition, which comprises following components in parts by weight: 1.0 to 5.0 parts of salicylic acid liposome, 1.0 to 5.0 parts of ceramide liposome, 1.0 to 5.0 parts of sulfur liposome, 1.0 to 5.0 parts of camellia seed oil, 1.0 to 10 parts of beta-glucan, 1.0 to 5.0 parts of vitamin E, and 0.2 to 1.0 part of mint. Components cooperate with each other toexert the effects; the moisture retaining performance of the skin is enhanced, the grease balance of the skin is adjusted, the excess sebum secretion is inhibited, the reproduction of propionibacterium acnes and inflammation are prevented, the generation of acne marks is inhibited, the composition can reach the focus of infection quickly, the pore will not be obstructed by grease, the skin inflammation will not deteriorate; the pore size is reduced, the grease secretion is balanced; the mite, bacteria, and inflammation are prominently inhibited; the barrier function of the skin is repaired andimproved; the wound healing time is shortened, the scars are reduced, and the skin becomes smooth and soft.

The invention provides a wound dressing based on hydrogel-core-shell microspheres and a preparation method thereof, and belongs to the technical field of wound dressings. The preparation method includes the steps that a coaxial electrostatic spraying method with an RCSPs solution serving as the inner axis and a sodium alginate solution serving as the outer axis is adopted, and formed microdropletsare collected into a calcium chloride solution for crosslinking to obtain sodium alginate / RCSPs core-shell microspheres; gelatin and a polyvinyl alcohol solution are mixed to obtain a homogeneous gelprecursor, the sodium alginate / RCSPs core-shell microspheres are added into the homogeneous gel precursor, the mixture is stirred to be uniform, and then freeze-drying is performed to obtain the wound dressing based on the hydrogel-core-shell microspheres. The invention further provides the wound dressing based on the hydrogel-core-shell microspheres obtained by the preparation method. The core-shell microspheres can achieve a high encapsulation rate on drugs, the combined application of the core-shell microspheres and hydrogel effectively achieves slow release of the drugs, and the wound dressing can act on wounds with a long-lasting effect and significantly promote wound healing.

The present invention discloses a deep vein thrombosis (“DVT”) device that is portable, tubeless, and battery-operated, which ensures that the patient will have maximum mobility during recovery. The DVT device provides a pneumatically controlled bladder portion, which is actuated by an electronically controlled air pump, where the pump / bladder combination is enclosed in a “pocket” of a wrap or cuff during use. All pump, battery, and control components are protectively housed in a plastic case that is permanently attached to the bladder portion. Once the pump / bladder combination is placed in the “pocket” the wrap or cuff will be sealed. The wraps or cuffs are single use, disposable garments designed to provide an absorbent barrier during use, where the bladder portion and air pump remain clean during use and can be reused by the patient or hospital staff. Tabs or extensions may be used to secure the pump / bladder combination after insertion into the “pocket” of the wrap or cuff.

The invention provides a medical vacuum sealing drainage device, which comprises a porous foam soft pad and a drainage tube which is arranged in the porous foam soft pad and of which the tail end extends out of the outer side of the porous foam soft pad, wherein an elastic sealing adhesive film extending out of a tube system is arranged on the outer side of the porous foam soft pad; a sealing opening out of which the tube system extends is formed on the elastic sealing adhesive film, and the diameter D of the opening part of the sealing opening is less than the outer diameter of a corresponding extending tube; a plurality of small holes are formed on the side wall of the drainage tube; when multiple drainage tubes are arranged, tail ends of the drainage tubes are connected with a multi-ported joint; a flushing tube is arranged in the drainage tube, one end of the flushing tube extends into the drainage tube, and the other end of the flushing tube is led out from the side wall of the tail end of the drainage tube; a sealing cover is arranged at the tail end of the flushing tube; and the sealing opening out of which the tube system extends on the elastic sealing adhesive film is a circular hole or a tubular hole, and preferably the tubular hole is in an inversed horn shape. The medical vacuum sealing drainage device solves the problems of air leakage of extending parts in the tube system of the vacuum sealing drainage device and sealing serving as the key technology in the vacuum drainage technology completely, and is convenient to operate.

The invention relates to the technical field of plant grafting cultivation, in particular to a walnut seedling grafting propagation method. According to the walnut seedling grafting propagation method, a culture solution is prepared from, by weight, 3-5 parts of ethyl alcohol, 2-3 parts of sodium hypochlorite, 3-5 parts of streptomycin, 3-5 parts of gibberellic acid, 4-6 parts of brassinolide, 3-5 parts of 2,3-dichlorphenoxyacetic acid, 3-5 parts of N-(3-chloro-4-pyridyl)-N'-phenylurea, 2-3 parts of rosin, 4-6 parts of jasmonic acid, 4-6 parts of salicylic acid, 3-5 parts of rooting powder and 2-3 parts of water-retaining agent, and then the propagation steps of stock and scion preparation, disinfection, grafting, soaking and the like are carried out. The walnut seedling grafting propagation method is scientific and reasonable in formula, the walnut seedling wound healing time can be shortened, growth can be promoted, and the grafting survival rate can be increased.

The invention belongs to the technical field of new indications of drugs, and particularly discloses an application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer. The externally used skin generation oil can effectively improve low temperature at soles due to peripheral circulation disturbance in early stage of diabetic foot ulcer, recover the sole pain threshold to a normal level, accelerate diabetic foot ulcer wound repair and shorten the wound repair time. The area of a foot ulcer wound surface of a diabetic rat is reduced to (4.0 plus or minus 0.1 mm<2>) from (51.3 plus or minus 3.5 mm<2>) after treated with the skin generation oil for 35 days, the wound surface heals basically, the skin is red and dry, and the skin surface is smooth; HE (hematoxylin-eosin) dyeing results show that the skin tissue structures of the foot wound surfaces of rats in an externally used skin generation oil group and an externally used skin generation oil and metformin group is relatively complete, collagen fibers at the wound edge are arranged in order, and inflammatory cell infiltration of wound surface tissue is reduced obviously.

The invention relates to fast restoration liquid for burn and scald injury and a preparation method thereof. Stem cells obtained through conventional separation are used; human fibronectin (FN) is subjected to overexpression by a molecular clone technology; the stem cells richly containing various autocrine cell factors and overexpression FN are used for culturing supernatant; the obtained restoration liquid is applied to the restoration treatment on burn and scald injury patients and severe and lingering ulceration wounds. The method is simple and convenient; the implementation is easy; the fast restoration liquid is applicable to the large-scale production of stem cell culture supernatants with different sources. In addition, the kinds of products are applied to the restoration treatmentof burn and scald injury patients and severe and lingering ulceration wounds. A novel path is provided for the application of the stem cells in medical conversion career.

The invention provides a skin care composition capable of dispelling wrinkles and resisting ageing, and a purpose of the skin care composition capable of dispelling wrinkles and resisting ageing, andbelongs to the technical field of cosmetics. The composition comprises growth factors comprising recombinant human crust growth factors, hydrating agents comprising low molecular weight hyaluronic acid which exists in protective colloid and exists in the form of dispersoid, an active peptide composition comprising acetyl hexapeptide-3 and acetyl hexapeptide-8, and an antioxidant which exists in the form of lipid nanocapsules and comprises astaxanthin and lycopene. The composition provided by the invention can arouse cell activity, delay running off of protein, promote increase of protein content, repair skin injury, retain water, replenish water, reduce the dissipating quantity of skin moisture, controlling water-oil balance, increase skin elasticity and alleviate skin photoaging, is highin transdermal absorption efficiency and absorption rate, high in retention volume and effective utilization rate and good in storage stability, and can restrain the activity of matrix metalloproteinase-1; and the composition can be used for cosmetics, wound surface rehabilitation materials or / and scar reduction materials.

The present invention generally relates to compositions and methods for topical or transdermal delivery, for promoting wound healing, reducing scarring, and / or promoting hair growth. Specifically, the present disclosure is directed to a topical arginine silicate formulation that demonstrates surprising improvement in wound healing time leading to more advantageous recovery and reducing hospital costs. Such formulations may also lessen scarring. The formulations may, for example, be applied to skin or to mucous membranes to facilitate wound healing.

The invention belongs to the field of Chinese medicine, in particular relates to a Chinese medicinal composition for treating burn and scald and the application thereof, and solves the problems that the cure rate of the burn and the scald is improved, the healing time of the wound surface is shortened and scars on the wound surface of burn and scald are reduced. The invention provides the Chinese medicinal composition for treating the burn and the scald, which is prepared from phellodendron amurense, milkvetch root and elm bark, and has the efficacies of clearing away heat and toxic material, reducing swelling and alleviating pain, inhibiting and eliminating bacteria, reducing seepage of body liquid, removing necrosis and promoting granulation, improving the local blood supply and promoting the wound healing. The Chinese medicinal composition has high cure rate and short healing time, almost has no scar in treating the burn and scald, and can be used for treating decubitus.

The invention belongs to the technical field of planting, and particularly relates to a peach tree seedling raising and grafting method. Grafting of a peach pit is completed through the eight steps of picking, peach pit processing, sand storing, seedling raising, scion processing, stock processing, grafting and water and fertilizer management; the survival rate and the seedling rate of hte peach pit can be effectively increased, and meanwhile the yield of peaches can be increased; the peaches are crispy and sweet in taste and bright in color and luster.

The invention discloses an external-use drug and preparation with analgesic and antibacterial effect and a preparation method thereof. The external-use drug comprises a component A like silver sulfadiazine, a component B like zinc sulfadiazine and an analgesic component like lidocaine. Excipients of the preparation include Carbomer, glycerin, triethanolamine and water. The preparation method includes: adding water into Carbomer for swelling, and adding triethanolamine to adjust pH to obtain transparent colloid; adding glycerin dispersed with the components A and B into the transparent colloid to obtain milky colloid; using water to disperse and dissolve the analgesic component, adding into the milky colloid, using water to adjust water content, and stirring well. The external-used drug and preparation has the analgesic and antibacterial effect, wound healing time can be shortened remarkably, and the preparation method is simple, convenient, economical and wide in application prospect.

The invention discloses a wrinkle removing composition as well as a preparation method and application thereof. The wrinkle removing composition is prepared from the following components in percentageby weight: 2-14 percent of an active matter, 5-9 percent of a humectant, 10-35 percent of polyol, 0.1-2 percent of a thickening agent, 0.3-1 percent of a preservative, 0.5-5 percent of an anti-allergic agent, 0.1-2 percent of a pH regulator and the balance of deionized water, wherein the active matter is at least two of beta-glucan, oligopeptide-1, oligopeptide-3, oligopeptide-5 and yeast polypeptides. By containing active ingredients, such as the oligopeptide-1, the oligopeptide-3, the oligopeptide-5 and the yeast polypeptides, the wrinkle removing composition is capable of enabling skin tobe smooth and elastic, helping and promoting formation of collagen in a corium layer, promoting cell growth, improving cell activity and the skin relaxation phenomenon, repairing damaged cells, shortening wound healing time and reducing scar formation.

The invention discloses an anus lotion, which is prepared from the following raw materials by weight: 25-35g of radix sophorae flavescentis, 15-25g of cortex phellodendri, 10-20g of radix aconiti preparata, 10-20g of prepared kusnezoff monkshood root, 15-25g of radix angelicae, 25-35g of stephania terandra, 25-35g of dittany bark, 8-12g of dried alum, 12-18g of rheum officinale and 15-25g of gallnut in a manner of decocting after adding water. The anus lotion has the beneficial effects that the anus lotion has the main characteristics of convenience for use and wide pharmacological action, and simultaneously can treat anus diseases with a plurality of concurrent symptoms such as bleeding, pain, pruritus, secretion increase and the like. Clinical application finds that most of haemorrhoids can retract and dissipate as to internal hemorrhoids, inflammatory external hemorrhoids, external hemorrhoids and mixed hemorrhoids at each stage after a patient takes the anus lotion for 5-7 days. Anal eczema can scab and heal after the anus lotion is used for 1-2 weeks while the symptoms are obviously relieved after the patients with anus itching, condyloma acuminata and anal fissure take the anus lotion. Especially for the patient with an anus operation, the anus lotion can relieve swelling and pain, also can purify the wound, reduces the frequency of dressing change, and obviously shortens the wound healing time.

The invention discloses a composition capable of promoting wound healing and reducing scarring. The composition comprises the following components in percentage by weight: 5-9 percent of carbomer, 1-5 percent of tea tree oil, 0.0001-0.0009 percent of recombinant human epidermal growth factors, and 10-20 percent of glycerinum. The composition can effectively regulate the moisture content of dynamic cells in different environments, does not have irritation or sensitization response, can inhibit wound bacterial reproduction, is advantageous to growth of wound capillary vessels, can promote subcutaneous collagen growth and fibrous tissue recombination, can promote creeping of epithelial cells, can shorten the time of wound healing, has the effects of diminishing inflammation and stopping bleeding, relieving pains and protecting wound, repairing wounds and skin ulcer. The composition has repairing and healing effects on face mild-moderate acnes and injuries caused by laser treatment, can reduce the scarring, prevents hyperpigmentation, and improves healing quality.

A hygienical comestic, especially a whitening cosmetic and its preparation method. It contains five materials of AíóBíóCíóD and E. A material comprises SS methyl gluoside, stearate, SSE-20 methyl gluoside, and addition compound of stearic acid and ethylene oxide, silicon oil DC-200 and son on. B material comprises CAD940,water, glycerol and so on. C material comprises TEA, water. D material comprises EGF, ATB-26000, STAY-C50. E material comprises essences.