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Application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer

A technology for diabetic foot ulcers and peripheral circulation, which is applied in the directions of skin diseases, drug combinations, and medical preparations containing active ingredients, etc., to achieve the effects of shortening healing time, convenient use, and improving diabetic peripheral circulation disorders.

Active Publication Date: 2015-11-04
唐和斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our research results show that topical Shengfu oil has the effects of nourishing qi, activating blood circulation, removing blood stasis and promoting muscle regeneration, and can promote the rapid healing of third-degree burn wounds (the effect of Sanhuang topical Shengfu oil on third-degree burn wounds in rabbits. Chinese Journal of Burns, 2013 ,29:50–54), but did not involve whether it can improve diabetic peripheral circulatory disorders, or even treat diabetic foot ulcers and its pharmacological mechanism

Method used

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  • Application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer
  • Application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer
  • Application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The establishment of embodiment 1 diabetes rat model

[0039] The tested animals were 50 male Wistar rats of SPF grade (provided by the Hubei Provincial Center for Disease Control and Prevention), weighing 150-180 g, free to drink water and diet, the room temperature in the feeding room was kept at 25±1°C, and the light and dark cycle was 12 hours.

[0040] 1. Preparation of diabetic rat model

[0041] After the rats adapted to the environment for 1 week, 40 rats were randomly selected as the diabetes group and 10 rats as the control group. Rats in the diabetic group were intraperitoneally injected with 30 mg / kg streptozotocin (STZ, Sigma Company of the United States; a solution of 10 mg / ml was configured with citric acid-sodium citrate buffer, pH 4.2), and the control group was intraperitoneally injected with the same amount of citric acid - Sodium citrate buffer. After 3 weeks, blood was collected from the tail vein to measure the oral glucose tolerance. The standar...

Embodiment 2

[0046] Example 2 External use of Shengpi oil to restore the foot temperature of rats with diabetic peripheral circulatory disorder

[0047] Skin tonic oil for external use (the skin tonic oil 1 prepared in Example 1 or the skin tonic oil 2 prepared from Example 2 in the Chinese patent whose patent number is ZL201210426168.X, and the authorized announcement number to CN 102895526 B are as follows: Referred to as Shengfuyou 1 or Shengfuyou 2) to improve diabetic peripheral circulatory disorders and restore the foot temperature of diabetic rats.

[0048] Animals: 50 male Wistar rats of SPF grade (provided by the Hubei Provincial Center for Disease Control and Prevention), weighing 150-180 g, free to drink water and diet, kept room temperature at 25±1°C, and the light and dark cycle was 12 hours.

[0049] 1. Preparation and administration of diabetic peripheral circulatory disorder model

[0050] Carry out grouping and establish diabetes model the same as the method described in ...

Embodiment 3

[0055] Example 3 External application of Shengpi oil reduces the thermal pain threshold of diabetic rats with peripheral circulatory disorder

[0056] Skin oil for external use (the skin oil 3 prepared in Example 3 or the skin oil 4 prepared in Example 4 in the Chinese patent whose patent number is ZL201210426168.X, and the authorized announcement number of CN 102895526 B are as follows: It is called Shengfuyou 3 or Shengfuyou 4) to improve diabetic peripheral circulatory disturbance and restore the thermal pain threshold of the plantar of diabetic rats.

[0057] Animals: 50 male Wistar rats of SPF grade (provided by the Hubei Provincial Center for Disease Control and Prevention), weighing 150-180 g, free to drink water and diet, kept room temperature at 25±1°C, and the light and dark cycle was 12 hours.

[0058] 1. Preparation and administration of diabetic peripheral circulatory disorder model

[0059] According to the method described in Example 1, the groups were grouped ...

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Abstract

The invention belongs to the technical field of new indications of drugs, and particularly discloses an application of externally used skin generation oil in preparation of drugs for preventing or treating diabetic peripheral circulation disturbance and foot ulcer. The externally used skin generation oil can effectively improve low temperature at soles due to peripheral circulation disturbance in early stage of diabetic foot ulcer, recover the sole pain threshold to a normal level, accelerate diabetic foot ulcer wound repair and shorten the wound repair time. The area of a foot ulcer wound surface of a diabetic rat is reduced to (4.0 plus or minus 0.1 mm<2>) from (51.3 plus or minus 3.5 mm<2>) after treated with the skin generation oil for 35 days, the wound surface heals basically, the skin is red and dry, and the skin surface is smooth; HE (hematoxylin-eosin) dyeing results show that the skin tissue structures of the foot wound surfaces of rats in an externally used skin generation oil group and an externally used skin generation oil and metformin group is relatively complete, collagen fibers at the wound edge are arranged in order, and inflammatory cell infiltration of wound surface tissue is reduced obviously.

Description

technical field [0001] The invention relates to the technical field of new indications of medicines, in particular to the application of external skin-skin oil in the preparation of medicines for preventing or treating diabetic peripheral circulatory disorders and foot ulcers. Background technique [0002] Diabetic foot ulcers are one of the serious complications of diabetes. The clinical signs caused by early peripheral circulatory disturbance in diabetic foot ulcers are decreased skin temperature of the lower limbs, and insensitivity or loss of pain and pressure sensations. Improper external pressure can easily lead to foot trauma, tissue ulceration, and eventually ulcers (risk factors and treatment progress of diabetic foot ulcers. Chinese General Medicine, 2013, 16: 3159–3163). The refractory wound of diabetic foot ulcer has always been the focus of clinical research (Vincent Falanga. Wound healing and its injury in the diabetic foot. Lancet. 2005, 366:1736–1743). [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P3/10A61P9/14A61P17/02A61P31/04A61K31/155
Inventor 唐和斌万妍杨燕京李玉桑李小军
Owner 唐和斌
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