External-use drug and preparation with analgesic and antibacterial effect and preparation method thereof

A technology for external preparations and external drugs, applied in the field of medicine, can solve the problems of severe pain in wounds, inconvenient daily activities of patients, and monotony, and achieve the effects of simple and economical preparation methods, shortened wound healing time, and broad application prospects

Active Publication Date: 2016-08-17
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In superficial skin injuries, because the nerve endings are exposed to stimulation, the wound will cause severe pain. In addition, if the wound bleeding is not treated in time, it will also bring inconvenience to the patient's daily activities
Current to

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  • External-use drug and preparation with analgesic and antibacterial effect and preparation method thereof
  • External-use drug and preparation with analgesic and antibacterial effect and preparation method thereof
  • External-use drug and preparation with analgesic and antibacterial effect and preparation method thereof

Examples

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[0025] The present invention will be described in detail below with reference to the drawings and embodiments.

[0026] (1) Pharmacology part of dual-effect gel

[0027] 1. Double-effect gel prescription

[0028] Prescription 1: Silver sulfadiazine 10.0g (1%), zinc sulfadiazine 20.0g (2%), lidocaine 5.0g (0.5%), carbomer-940 10g (1%), glycerin 200g (20%) , Triethanolamine 18.87g (1.887%), distilled water (73.613%), a total of 1000g.

[0029] Prescription 2: Silver sulfadiazine 10.0g, zinc sulfadiazine 20.0g, lidocaine 5.0g, carbomer-940 10g, glycerin 200g, triethanolamine 18.87g, polyethylene glycol 400 20g (2%), distilled water (71.613) %), a total of 1000g.

[0030] Description: Determine the dose-effect relationship of the effective components silver sulfadiazine, zinc sulfadiazine and lidocaine according to the study in the burn rat model; the preparation type of the drug of the present invention is a gel, which is used as a drug carrier and an adjuvant carbomer The dosage of gly...

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Abstract

The invention discloses an external-use drug and preparation with analgesic and antibacterial effect and a preparation method thereof. The external-use drug comprises a component A like silver sulfadiazine, a component B like zinc sulfadiazine and an analgesic component like lidocaine. Excipients of the preparation include Carbomer, glycerin, triethanolamine and water. The preparation method includes: adding water into Carbomer for swelling, and adding triethanolamine to adjust pH to obtain transparent colloid; adding glycerin dispersed with the components A and B into the transparent colloid to obtain milky colloid; using water to disperse and dissolve the analgesic component, adding into the milky colloid, using water to adjust water content, and stirring well. The external-used drug and preparation has the analgesic and antibacterial effect, wound healing time can be shortened remarkably, and the preparation method is simple, convenient, economical and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a compound medicine with dual effects of analgesia and antibacterial and a preparation method of a gel thereof. Background technique [0002] Trauma problems such as lacerations, abrasions, burns and scalds caused by various reasons have a high frequency of occurrence. Skin damage can easily lead to infection of the injured part, and exposure of wound facial nerves can easily cause severe pain. The dual threat of injury and infection will seriously affect the patient's health. In good health, if the treatment is not timely, it will often induce insomnia, autonomic dysfunction, limited exercise capacity, chronic pain and depression, etc., which will seriously affect the quality of life of the patient. [0003] At present, most of the topical medicines for treating wounds and burns are single-function (anti-infection or pain-relieving) preparations, which are difficul...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K33/38A61K33/30A61K31/167A61K9/06A61P17/02A61P29/00A61P31/04
CPCA61K9/0014A61K9/06A61K31/167A61K33/30A61K33/38A61K45/06A61K2300/00
Inventor 贾艳艳文爱东尚刚伟赵瑾怡高凯宋颖白娟崔冬晓
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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