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46 results about "Silver sulfadiazine" patented technology
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This medication is used with other treatments to help prevent and treat wound infections in patients with serious burns.
Topical spray for burn treatment and anti-infection
InactiveUS6987133B2Function increaseReduce disadvantagesBiocideCosmetic preparationsCross-linkAntimicrobial drug
This invention relates to a topical spray preparation for burn treatment and microbial infections on human being or animals. This non-aerosol preparation contains an antimicrobial drug, i.e., silver sulfadiazine, as is dispersed or solubilized in a cream or lotion base matrix which can be sprayed directly from a common trigger spray device. The key component of the matrix can be characterized by it having a suitable molecular weight polymer of cross-linked acrylic acid, such as Carbomers or non-ionic surfactants such as polyoxyethylene alkyl ethers, or any combination of the above materials.
Owner:SAGE PHARMA
External-use ointment for treating empyrosis and preparation method thereof
InactiveCN101703603ASimple recipeSimple preparation processHydroxy compound active ingredientsAerosol deliveryMyrrhBaical Skullcap Root
The invention provides external-use ointment for treating empyrosis and a preparation method thereof. The external-use ointment is empyrosis humectation ointment prepared from Chinese medicaments and Western medicaments through processing, and comprises the following components in part by weight: 10 to 30 parts of Chinese angelica, 10 to 25 parts of golden thread, 10 to 25 parts of amur corktree bark, 10 to 25 parts of baical skullcap root, 10 to 20 parts of prepared frankincense, 20 to 25 parts of prepared myrrh, 1 to 3 parts of musk, 10 to 20 parts of borneol, 150 to 270 parts of silver sulfadiazine powder, 500 to 1,000 parts of Vaseline and 40 to 80 parts of bees wax. The ointment adopts the Chinese angelica, the frankincense and the myrrh which have the effects of activating blood circulation, relieving pain and promoting tissue regeneration; the golden thread, the amur corktree bark and the baical skullcap root have the effects of clearing away heat and toxic materials and eliminating dampness; the borneol has bitter and cold properties, can clear away heat to be cool when in external use, and has the lasting effect of constringency, tissue regeneration and odynolysis when being compatible with the musk; and the silver sulfadiazine powder has the effects of sterilization and antiphlogosis. The whole medicament has the effects of promoting blood circulation by removing blood stasis, diminishing inflammation and relieving pain, changing rot and promoting tissue, inhibiting exudation and promoting wound healing, and has low incidence rate of scar.
Owner:朱广波
Novel synergistic pharmaceutical composition for topical applications
ActiveUS20130085103A1Increasing antibacterial effectiveness of antibacterial agentImprove breathabilityAntibacterial agentsOintment deliveryDiseaseAdditive ingredient
A synergistic pharmaceutical composition for the preparation of topical formulations for use in prophylaxis and treatment of wounds, burn wounds, skin grafts, pressure ulcers, diabetic foot ulcers and other skin diseases is provided. The composition may include one or more synergistically active ingredients and one or more inactive ingredients. The synergistically active ingredients may include Recombinant Human Epidermal Growth Factor (rh-EGF) (REGEN-D™ of Bharat Biotech International Limited) and / or Platelet Derived Growth Factor (rh-PDGF-BB), silver sulfadiazine (SSD) and chlorhexidine gluconate (CHG). One or more inactive ingredients may comprise carriers, preservatives, emulsifiers, skin emollients and soothers and one or more other constituents.
Owner:BHARAT BIOTECH INTERNATIONAL
Silver sulfadiazine thermosensitive gel as well as preparation method and application thereof
The invention discloses silver sulfadiazine thermosensitive gel as well as a preparation method and application thereof. The silver sulfadiazine thermosensitive gel is prepared from the following rawmaterials: silver sulfadiazine nanocrystalline, 11 to 20 weight percent of poloxamer 407, 0 to 4 weight percent of temperature regulator, 3 to 13 weight percent of humectant and the balance of water.The gel nanocrystallizes silver sulfadiazine so as to increase the surface area of the silver sulfadiazine and enhance the antibacterial effects; by taking the poloxamer as a gel substrate and utilizing the thermosensitive gelling properties, effective fitting and easiness in removal of wound are realized; meanwhile, the gel can be used as a drug reservoir, and further slow release and long-term effects of antibacterial drugs are achieved. The gel can be directly used on the surfaces suffering from trauma, bedsore and ulceration so as to realize the effects of isolating, resisting bacteria, promoting wound healing and the like. The gel provided by the invention has the advantages that a substrate and components of the gel are both safe and non-toxic biomaterials and can be widely used in treatment and repair of clinical acute and chronic wound infection.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Silver/polydiguanide complex, preparation method thereof, and antibacterial composition containing the same as an active ingredient
InactiveCN102573859AHigh antibacterial activityLow minimum inhibitory concentration (MIC) valuesAntibacterial agentsOrganic active ingredientsSolubilityZeta potential
The present invention relates to a silver / polydiguanide complex and derivatives thereof including silver and polydiguanide having at least two biguanide moieties, wherein the silver is stabilized in an oxidation state of an integer of 0 to 4, a mole ratio between the silver and the polydiguanide is 1: 1-4, an average particle diameter of the complex is micrometer or nanometer, and zeta potential of the complex is greater than or equal to zero, a preparation method thereof, and an antibacterial composition for burns or wounds treatment including the same as an active ingredient. A silver / polydiguanide complex according to the present invention is different from conventional silver / polydiguanide complexes in carbon, hydrogen, and nitrogen contents as well as in structure of silver and polydiguanide, and solubility, is a material that exhibits a very good antibacterial activity due to a much lower minimal inhibitory concentration (MIC) value by 10 to 100 folds or more compared to silver sulfadiazine which is a conventional therapeutic agent for burns, and may be usefully used as an antibacterial composition for burns or wounds treatment.
Owner:SEOUL NAT UNIV R&DB FOUND
Preparation method of composite antibacterial dressing loaded with silver sulfadiazine
ActiveCN104784739AOvercoming poor adhesionOvercome brittleness and other problemsAbsorbent padsBandagesFreeze-dryingSilver sulfadiazine
The invention discloses a preparation method of a composite antibacterial dressing loaded with silver sulfadiazine. The preparation method comprises steps as follows: (1), bacterial cellulose is obtained through static fermentation of acetobacter xylinum; (2), the bacterial cellulose is beat after alkali washing to be prepared into a homogeneous-phase suspension liquid; (3), a sodium alginate solution is prepared; (4), silver sulfadiazine is subjected to ultrasonic treatment in water; (5), the sodium alginate solution, the bacterial cellulose homogeneous-phase suspension liquid and a silver sulfadiazine suspension liquid are mixed and prepared into a homogeneous-phase mixed liquid; the homogeneous-phase mixed liquid is poured into a die and cured with a 5% CACl2 solution, and the sodium alginate and bacterial cellulose composite antibacterial dressing loaded with silver sulfadiazine can be obtained after freeze drying. The preparation method is simple and easy to operate, the obtained composite antibacterial dressing keeps good moisture retention performance and biocompatibility, has a better inhibition function on escherichia coli, candida albicans and staphylococcus aureus and facilitates wound healing and skin regeneration, and the production process is simple.
Owner:NANJING FORESTRY UNIV
Topical medications for bruises and burns
ActiveUS20160022676A1Reduce physical impactBiocideHydroxy compound active ingredientsTransdermal patchPhenylephrine hcl
Topical medications to treat the physical effects of bruises and burns. For bruises, the topical medication preferably includes therapeutically effective amounts of vasoconstrictor, such as phenylephrine HCL USP, an anti-inflammatory, such as Arica, and compounding agents. In one embodiment, the compounding agents are a Versabase® gel which includes water, ammonium acryloyldimethyltaurate copolymer, aloe barbadensis leaf juice powder, allatoin, disodium EDTA, methylchloroisothiazolinone and methylisothiazolinone. For burns, the topical medication preferably combines therapeutically effective amounts of an active anti-bacterial compound, such as silver sulfadiazine, an anesthetic, such as lidocaine, and a histamine blocker, such as diphenhydramine, with suitable compounding agents, such as Versabase® gel. Both the anti-bruise and anti-burn medications of the present invention can advantageously be formulated in solutions, lotions, creams, ointments, gels, foams or transdermal patches.
Owner:MERIDIAN RES & DEV
Antimicrobial material and method for making the same
InactiveUS8367094B2Reduce infectionSubstantial unmet needInorganic active ingredientsCatheterPolyethylene vinyl acetateSilver iodate
Owner:SZYCHER MICHAEL
Topical pharmaceutical composition comprising nanonized silver sulfadiazine
The invention relates to a topical pharmaceutical composition for burn treatment and microbial infections on human beings or animals. The pharmaceutical composition comprises 0.1% w / w to 1.0% w / w of an antimicrobial drug, i.e., silver sulfadiazine and 0.2% w / w antiseptic, i.e., chlorhexidine gluconate, wherein silver sulfadiazine is in nanonized form.
Owner:SUN PHARMA INDS
Liquid wound spray dressing and preparation method thereof
ActiveCN111166932AAntibacterialHas hemostatic and pain-relieving effectsPharmaceutical delivery mechanismBandagesWound dressingSilver sulfadiazine
The invention belongs to the field of medical dressings, and particularly relates to a liquid wound spray dressing and a preparation method thereof. The liquid wound spray dressing comprises raw material components of silver sulfadiazine, lidocaine, chitosan, polyvinyl alcohol, ethanol, a preservative, purified water and the like. By optimal design of the component types, proportion and preparation method, long-term bacteriostasis and hemostasis of the liquid wound dressing can be improved, invasion of bacteria can be resisted for a long time, orderly growth and texture repair of wound tissuecan be prompted, and the wound healing process can be accelerated. The liquid wound dressing has definite curative effect, is safe and reliable to use and non-irritant to skin, and has better practical value and popularization and application significance, and the preparation method is quick and simple.
Owner:海南妙音春制药有限公司
Silver-containing medical hydrocolloid dressing and preparation method thereof
ActiveCN109395155AOvercome stabilityOvercome bacteriostasisAbsorbent padsMicrocapsulesPolyrotaxaneIrritation
The invention belongs to the technical field of medical and sanitary auxiliary materials and particularly relates to a silver-containing medical hydrocolloid dressing and a preparation method thereof.The hydrocolloid dressing includes CMC / PEG / PAA particles, thermoplastic rubber, liquid paraffin, tackifying resin, a plasticizer, alpha-cyclodextrin polyrotaxane / silver sulfadiazine serving as an antibacterial agent and the like. In general, by optimizing and adjusting relevant components, the hydrocolloid dressing which is safe, free of irritation, uniform in liquid absorption, excellent in antibacterial performance and lasting in antibacterial effect is prepared, and the antibacterial agent is uniformly dispersed. The dressing is great in waterproof and antibacterial performance and capableof absorbing a large amount of exudate and toxic substances of a wound and maintaining a wet healing environment for the wound for a long time without being bonded to the wound and has other excellent performance. Therefore, the dressing has a high practical value for wound repairing and wound healing.
Owner:HENAN HUIBO MEDICAL CO LTD
Otic microbial combination for treatment of animals with ruptured tympanic membrane
InactiveUS7011839B2Easy to useSimple compositionAntibacterial agentsBiocideSilver sulfadiazineTreated animal
Owner:ELANCO US INC
Traditional Chinese medicine for treating burns and scalds
InactiveCN103845461AGood effectPain reliefHydroxy compound active ingredientsDermatological disorderMyrrhSilver sulfadiazine
The invention relates to a traditional Chinese medicinal preparation for treating burns and scalds. The first choice of western medicines for treating burns and scalds at present is silver sulfadiazine, and traditional Chinese medicines for treating burns and scalds adopt burn and scald medicine preparations, and the above medicines have a high price and are suitable for specific people. The above traditional Chinese medicine for treating burns and scalds is composed of Medicine Terminalia Fruit, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Boswellia carteri, myrrh and borneol. The traditional Chinese medicinal preparation is prepared by using pure traditional Chinese medicines, has the characteristics of simple preparation technology, use convenience, low price, fast pain relieving, quick drying of wounds, short treatment course, no scars after curing, smooth wounded surface, strong infection resistance and the like, can be stored in a sealed and shady place at normal temperature for several years, is unconstrained by time, does not deteriorate, has no people limit, and is suitable for the old, the young and pregnant women.
Owner:李国庆
Topical medications for bruises and burns
InactiveUS20160296576A1Reduce physical impactHydroxy compound active ingredientsInorganic active ingredientsTransdermal patchPhenylephrine hcl
Owner:MERIDIAN RES & DEV
Medicament for treating scald
InactiveCN101647957APromote circulationConvergence woundOrganic active ingredientsDermatological disorderDiseaseTreatment effect
The invention discloses a production formula of a medicament for treating scald and a manufacture method thereof. The medicament for treating scald is prepared from the following raw materials: angelica, hemlock parsley, rhubarb, sanguisorba, radix scutellariae, rhizoma coptidis, safflower, corydalis tuber, bletilla striata, water and silver sulfadiazine by the following steps: firstly, preparinga traditional Chinese medicine extract; sterilizing the extract at high pressure for standby; then, adding silver sulfadiazine to a sterilized mortar by an aseptic operation method; adding the traditional Chinese medicine extract sterilized at high pressure to the mortar; and grinding the silver sulfadiazine and the traditional Chinese medicine extract into an even solution, i.e. the medicament for treating scald. The medicament for treating scald promotes the blood circulation by removing blood stasis, diminishes inflammation, relieves pain, diminishes a wound, takes partial anti-inflammatoryeffect, rapidly stops wound water after being scalded, enables the wound to scald rapidly, avoids wound infection and has unique treatment effect on various scald diseases, burn disease, old rotten legs, and the like.
Owner:王蔚
Medicinal preparation for promoting healing of body surface injury and method for preparing medicinal preparation
ActiveCN107198776AAvoid depositionFunctionalDermatological disorderHeterocyclic compound active ingredientsHypopigmentationSilver sulfadiazine
The invention relates to a medicinal preparation for promoting healing of body surface injury and a method for preparing the medicinal preparation. Silver sulfadiazine (a), pain killers (b), asiaticoside (c) and other pharmaceutically acceptable carriers (d) are compatible with one another according to suitable proportions to obtain the medicinal preparation. The medicinal preparation and the method have the advantages that the medicinal preparation has double synergistic antibacterial and pain alleviating functions, accordingly, healing of wound surfaces can be promoted, epidermis hyperpigmentation due to the silver sulfadiazine can be prevented, and scar can be reduced; the shortcomings of poor hydrophilicity after existing pain killers and existing silver sulfadiazine are directly compatible with one another and easiness in volatilizing moisture in wound surfaces can be overcome.
Owner:SHANGHAI INST OF PHARMA IND CO LTD +1
Degradable medical hemostatic material and preparation method thereof
InactiveCN109395150AImprove solubilityImprove spinnabilitySurgical adhesivesBiochemical fibre treatmentFiberFreeze-drying
Owner:CHTC JIAHUA NONWOVEN CO LTD
Pharmaceutical composition for treating animal body surface trauma and preparation technology thereof
InactiveCN104825474AAntibacterial and anti-inflammatoryWith astringent hemostasisOrganic active ingredientsAntiinfectivesDiseaseMeloxicam
The invention discloses a pharmaceutical composition for treating animal body surface trauma. The pharmaceutical composition is composed of silver sulfadiazine, methoxybenzyl aminopyrimidine, and meloxicam according to a mass ratio of (4-6):1:(1-3.5). The provided pharmaceutical composition can be made into medicine sticking for treating various body surface traumas such as dairy cow udder trauma, hoof disease, and the like, the total cure rate can reach 78.0%, the total effective rate can reach 87.9%, and the curative effect is prominently better than that of clinical common treatment methods.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
Sterilization film coating agent for burn and scald wound
InactiveCN1927210AAvoid spreadingOrganic active ingredientsDermatological disorderSilver sulfadiazineEther
The invention relates to a sterilization type film coating agent for the treatment of burns and scalds, wherein the main constituents include white Vaseline, cellulose glycollic ether, silver sulfadiazine, Tween-80, distilled water and highly effective germicidal agent.
Owner:TIANJIN SHIXIONG TECH DEV
Topical pharmaceutical composition comprising nanonized silver sulfadiazine
Owner:SUN PHARMA INDS
Prevention and treatment for microbial infections
ActiveUS20180236000A1Improve efficacyInhibiting and reducingAntibacterial agentsBiocideSodium PyrithioneMedicine
The present invention features a composition comprising zinc pyrithione and silver sulfiadizine, a formulation thereof and a method of treating microbial infection using the composition.
Owner:UNIVERSITY OF ROCHESTER
Polyurethane foam with synergistically enhanced antibacterial effect
InactiveCN106221658AHigh oxygen indexImprove flame retardant performanceNon-macromolecular adhesive additivesPolyureas/polyurethane adhesivesDiethyl phosphateSilver sulfadiazine
The invention discloses polyurethane foam with a synergistically enhanced antibacterial effect. The polyurethane foam is prepared from, by weight, 150-160 parts of diphenylmethane diisocyanate, 100-105 parts of propoxylated glycerin, 100-110 parts of castor oil, 5-6 parts of glycerin, 40-43 parts of diethyl phosphate, appropriate amount of 1mol / L sodium hydroxide solution, 13-15 parts of diatomite, 5-6 parts of distilled water, 2-3 parts of triethanolamine, 3-4 parts of dibutyltin dilaurate, 2.5-3.5 parts of TX-10, 3-4 parts of carboxymethyl cellulose, 4-5 parts of sulfanilamide, 3-4 parts of silver sulfadiazine, 8-10 parts of anatase nano titania and appropriate amount of deionized water. The polyurethane foam is low in cost, simple in preparation process, available for onsite foaming and excellent in sealing effect on switch cabinets and has antibacterial and bactericidal effects, remarkable antibacterial effects can be kept for a long time even in a humid environment, and the service life of seal glue is prolonged.
Owner:HEFEI E CHON METAL PLATE TECH CO LTD
A kind of sulfadiazine silver thermosensitive gel and its preparation method and application
The invention discloses a silver sulfadiazine temperature-sensitive gel and its preparation method and application. The raw material composition includes silver sulfadiazine nanocrystals, 11wt%-20wt% poloxamer 407, 0wt%-4wt% temperature regulator and 3wt% %‑13 wt% humectant and balance water. The gel nanometerizes silver sulfadiazine to increase its surface area to enhance the antibacterial effect; uses poloxamer as the gel matrix, and uses its temperature-sensitive gelling properties to achieve effective adhesion to the wound and easy removal; The glue acts as a drug reservoir to achieve slow-release and long-acting effects of antibacterial drugs. The gel can be directly used on the surface of various wounds, bed sores and ulcers to play the roles of isolation, antibacterial, wound healing and the like. The matrix and components of the gel provided by the invention are safe and non-toxic biological materials, and can be widely used in the treatment and repair of clinical acute and chronic wound infections.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Energy-saving real stone paint and preparation method thereof
InactiveCN107383962AEasy to prepareEasy to controlAntifouling/underwater paintsPaints with biocidesFiberTriclosan
The invention relates to an energy-saving real stone paint and a preparation method thereof, and belongs to the field of building materials. Raw materials of the energy-saving real stone paint include 25-30 parts by weight of resin, 20-26 parts by weight of a filler, and assistants. The filler includes Danqiangsi fibers, calcium sulfate whiskers, zeolite powder and slag powder, and the assistants include an organic phosphine / bromine complex, sodium tripolyphosphate, water glass, acrylamide, attapulgite, a binder, a coupling agent, an antifoaming agent and an insect repellent. The insect repellent includes triclosan, chitin, anthraquinone and silver sulfadiazine. The energy-saving real stone paint can kill bacteria and repel insects, and has the advantages of excellent crack resistance, low heat conductivity and good heat insulation effect. A preparation method of the energy-saving real stone paint comprises the following steps: mixing the resin with the organic phosphine / bromine complex, curing the obtained mixture to obtain cured00 resin, and mixing the cured resin with the filler and the remaining assistants to prepare the energy-saving real stone paint. The preparation method has the advantages of simplicity, easiness in process control, short time, and suitableness for industrial production.
Owner:重庆索利特涂料有限公司
Heparin sodium lotion and method for preparing same
InactiveCN105520956AEasy to prepareEasy to useHydroxy compound active ingredientsInorganic active ingredientsSilver sulfadiazineGlycerol
The invention discloses heparin sodium lotion and a method for preparing the same. The heparin sodium lotion comprises principle compositions and pharmaceutical excipients. The principle compositions include heparin and silver sulfadiazine, and the pharmaceutical excipients include sodium hyaluronate, zinc oxide, glycerin, menthol and purified water. The heparin sodium lotion and the method have the advantages that the method for preparing the heparin sodium lotion is simple, the heparin sodium lotion is convenient to use, and excellent curative effects of resisting inflammation, inhibiting germs and relieving pain can be realized by the heparin sodium lotion.
Owner:KAMP PHARMA
Medicinal preparation for promoting body surface wound healing and preparation method thereof
ActiveCN107198776BAvoid depositionFunctionalDermatological disorderHeterocyclic compound active ingredientsSilver sulfadiazineSulfanilamide
Owner:SHANGHAI INST OF PHARMA IND CO LTD +1
Preparation method for preparing cysteine oligopeptide and membrane dressing through enzyme catalysis
PendingCN110607336AMild reaction conditionsLess side effectsAbsorbent padsFermentationFiltration membraneFreeze-drying
The invention relates to a preparation method for preparing cysteine oligopeptide and membrane dressing through enzyme catalysis. The preparation method comprises the following steps of adding L-cysteine methyl ester hydrochloride, perfluoro-tert-butanol and proteases to a disodium hydrogen phosphate-citrate buffer solution, and performing a stirring reaction; filtering and concentrating a reaction mixture through an ultra filtration membrane; and performing vacuum distillation on filtrate after being concentrated through the ultra filtration membrane, and performing freeze drying to obtain the cysteine oligopeptide. The cysteine oligopeptide, diglycid ethyl ether and silver sulfadiazine are mixed, and coated to form the membrane so as to obtain a cysteine oligopeptide membrane dressing. The method has the advantages of being mild in reaction condition, environmental-friendly, small in side effects and the like, and can omit the steps of tedious protection and protection removal. The membrane dressing prepared by the method adopts the cysteine oligopeptide as a substrate, and the properties of microorganism resistance, biocompatibility, degradability and the like are excellent.
Owner:JIANGNAN UNIV
A kind of silver-containing medical hydrocolloid dressing and preparation method thereof
ActiveCN109395155BImprove and enhance antibacterial propertiesEvenly dispersedAbsorbent padsMicrocapsulesPolymer scienceSilver sulfadiazine
Owner:HENAN HUIBO MEDICAL CO LTD
A film spraying agent for shallow burns and its preparation method
ActiveCN105251011BHydroxy compound active ingredientsPeptide/protein ingredientsSilver sulfadiazineGlycerol
Owner:海宁经开产业园区开发建设有限公司
Silver sulfadiazine film formation spray and preparation method thereof
InactiveCN107485605AGood suspensionReduce dosageAntibacterial agentsOrganic active ingredientsDual effectSilver sulfadiazine
The invention relates to a silver sulfadiazine film formation spray and a preparation method thereof. A combined film formation material is used to realize film forming and suspending aiding dual effects, so the solution suspending property of the film formation spray is improved, the spraying effect is guaranteed, the film forming performance is good, the speed is fast, and the silver sulfadiazine film formation spray is a promising silver sulphadiazine treatment dosage form.
Owner:南京泽恒医药技术开发有限公司
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