44 results about "Silver sulfadiazine" patented technology

This invention relates to a topical spray preparation for burn treatment and microbial infections on human being or animals. This non-aerosol preparation contains an antimicrobial drug, i.e., silver sulfadiazine, as is dispersed or solubilized in a cream or lotion base matrix which can be sprayed directly from a common trigger spray device. The key component of the matrix can be characterized by it having a suitable molecular weight polymer of cross-linked acrylic acid, such as Carbomers or non-ionic surfactants such as polyoxyethylene alkyl ethers, or any combination of the above materials.

The invention provides external-use ointment for treating empyrosis and a preparation method thereof. The external-use ointment is empyrosis humectation ointment prepared from Chinese medicaments and Western medicaments through processing, and comprises the following components in part by weight: 10 to 30 parts of Chinese angelica, 10 to 25 parts of golden thread, 10 to 25 parts of amur corktree bark, 10 to 25 parts of baical skullcap root, 10 to 20 parts of prepared frankincense, 20 to 25 parts of prepared myrrh, 1 to 3 parts of musk, 10 to 20 parts of borneol, 150 to 270 parts of silver sulfadiazine powder, 500 to 1,000 parts of Vaseline and 40 to 80 parts of bees wax. The ointment adopts the Chinese angelica, the frankincense and the myrrh which have the effects of activating blood circulation, relieving pain and promoting tissue regeneration; the golden thread, the amur corktree bark and the baical skullcap root have the effects of clearing away heat and toxic materials and eliminating dampness; the borneol has bitter and cold properties, can clear away heat to be cool when in external use, and has the lasting effect of constringency, tissue regeneration and odynolysis when being compatible with the musk; and the silver sulfadiazine powder has the effects of sterilization and antiphlogosis. The whole medicament has the effects of promoting blood circulation by removing blood stasis, diminishing inflammation and relieving pain, changing rot and promoting tissue, inhibiting exudation and promoting wound healing, and has low incidence rate of scar.

A synergistic pharmaceutical composition for the preparation of topical formulations for use in prophylaxis and treatment of wounds, burn wounds, skin grafts, pressure ulcers, diabetic foot ulcers and other skin diseases is provided. The composition may include one or more synergistically active ingredients and one or more inactive ingredients. The synergistically active ingredients may include Recombinant Human Epidermal Growth Factor (rh-EGF) (REGEN-D™ of Bharat Biotech International Limited) and/or Platelet Derived Growth Factor (rh-PDGF-BB), silver sulfadiazine (SSD) and chlorhexidine gluconate (CHG). One or more inactive ingredients may comprise carriers, preservatives, emulsifiers, skin emollients and soothers and one or more other constituents.

The invention discloses silver sulfadiazine thermosensitive gel as well as a preparation method and application thereof. The silver sulfadiazine thermosensitive gel is prepared from the following rawmaterials: silver sulfadiazine nanocrystalline, 11 to 20 weight percent of poloxamer 407, 0 to 4 weight percent of temperature regulator, 3 to 13 weight percent of humectant and the balance of water.The gel nanocrystallizes silver sulfadiazine so as to increase the surface area of the silver sulfadiazine and enhance the antibacterial effects; by taking the poloxamer as a gel substrate and utilizing the thermosensitive gelling properties, effective fitting and easiness in removal of wound are realized; meanwhile, the gel can be used as a drug reservoir, and further slow release and long-term effects of antibacterial drugs are achieved. The gel can be directly used on the surfaces suffering from trauma, bedsore and ulceration so as to realize the effects of isolating, resisting bacteria, promoting wound healing and the like. The gel provided by the invention has the advantages that a substrate and components of the gel are both safe and non-toxic biomaterials and can be widely used in treatment and repair of clinical acute and chronic wound infection.

The invention discloses a preparation method of a composite antibacterial dressing loaded with silver sulfadiazine. The preparation method comprises steps as follows: (1), bacterial cellulose is obtained through static fermentation of acetobacter xylinum; (2), the bacterial cellulose is beat after alkali washing to be prepared into a homogeneous-phase suspension liquid; (3), a sodium alginate solution is prepared; (4), silver sulfadiazine is subjected to ultrasonic treatment in water; (5), the sodium alginate solution, the bacterial cellulose homogeneous-phase suspension liquid and a silver sulfadiazine suspension liquid are mixed and prepared into a homogeneous-phase mixed liquid; the homogeneous-phase mixed liquid is poured into a die and cured with a 5% CACl2 solution, and the sodium alginate and bacterial cellulose composite antibacterial dressing loaded with silver sulfadiazine can be obtained after freeze drying. The preparation method is simple and easy to operate, the obtained composite antibacterial dressing keeps good moisture retention performance and biocompatibility, has a better inhibition function on escherichia coli, candida albicans and staphylococcus aureus and facilitates wound healing and skin regeneration, and the production process is simple.

The invention relates to a topical pharmaceutical composition for burn treatment and microbial infections on human beings or animals. The pharmaceutical composition comprises 0.1% w/w to 1.0% w/w of an antimicrobial drug, i.e., silver sulfadiazine and 0.2% w/w antiseptic, i.e., chlorhexidine gluconate, wherein silver sulfadiazine is in nanonized form.

The invention belongs to the field of medical dressings, and particularly relates to a liquid wound spray dressing and a preparation method thereof. The liquid wound spray dressing comprises raw material components of silver sulfadiazine, lidocaine, chitosan, polyvinyl alcohol, ethanol, a preservative, purified water and the like. By optimal design of the component types, proportion and preparation method, long-term bacteriostasis and hemostasis of the liquid wound dressing can be improved, invasion of bacteria can be resisted for a long time, orderly growth and texture repair of wound tissuecan be prompted, and the wound healing process can be accelerated. The liquid wound dressing has definite curative effect, is safe and reliable to use and non-irritant to skin, and has better practical value and popularization and application significance, and the preparation method is quick and simple.

The invention belongs to the technical field of medical and sanitary auxiliary materials and particularly relates to a silver-containing medical hydrocolloid dressing and a preparation method thereof.The hydrocolloid dressing includes CMC/PEG/PAA particles, thermoplastic rubber, liquid paraffin, tackifying resin, a plasticizer, alpha-cyclodextrin polyrotaxane/silver sulfadiazine serving as an antibacterial agent and the like. In general, by optimizing and adjusting relevant components, the hydrocolloid dressing which is safe, free of irritation, uniform in liquid absorption, excellent in antibacterial performance and lasting in antibacterial effect is prepared, and the antibacterial agent is uniformly dispersed. The dressing is great in waterproof and antibacterial performance and capableof absorbing a large amount of exudate and toxic substances of a wound and maintaining a wet healing environment for the wound for a long time without being bonded to the wound and has other excellent performance. Therefore, the dressing has a high practical value for wound repairing and wound healing.

Disclosed herein is an improved composition that is useful in treating otic infections comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat otic infections in animals, the improvement comprising the composition which can be used safely to treat animals with a ruptured tympanic membrane.

The invention relates to a traditional Chinese medicinal preparation for treating burns and scalds. The first choice of western medicines for treating burns and scalds at present is silver sulfadiazine, and traditional Chinese medicines for treating burns and scalds adopt burn and scald medicine preparations, and the above medicines have a high price and are suitable for specific people. The above traditional Chinese medicine for treating burns and scalds is composed of Medicine Terminalia Fruit, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Boswellia carteri, myrrh and borneol. The traditional Chinese medicinal preparation is prepared by using pure traditional Chinese medicines, has the characteristics of simple preparation technology, use convenience, low price, fast pain relieving, quick drying of wounds, short treatment course, no scars after curing, smooth wounded surface, strong infection resistance and the like, can be stored in a sealed and shady place at normal temperature for several years, is unconstrained by time, does not deteriorate, has no people limit, and is suitable for the old, the young and pregnant women.

The invention discloses a production formula of a medicament for treating scald and a manufacture method thereof. The medicament for treating scald is prepared from the following raw materials: angelica, hemlock parsley, rhubarb, sanguisorba, radix scutellariae, rhizoma coptidis, safflower, corydalis tuber, bletilla striata, water and silver sulfadiazine by the following steps: firstly, preparinga traditional Chinese medicine extract; sterilizing the extract at high pressure for standby; then, adding silver sulfadiazine to a sterilized mortar by an aseptic operation method; adding the traditional Chinese medicine extract sterilized at high pressure to the mortar; and grinding the silver sulfadiazine and the traditional Chinese medicine extract into an even solution, i.e. the medicament for treating scald. The medicament for treating scald promotes the blood circulation by removing blood stasis, diminishes inflammation, relieves pain, diminishes a wound, takes partial anti-inflammatoryeffect, rapidly stops wound water after being scalded, enables the wound to scald rapidly, avoids wound infection and has unique treatment effect on various scald diseases, burn disease, old rotten legs, and the like.

The invention relates to a medicinal preparation for promoting healing of body surface injury and a method for preparing the medicinal preparation. Silver sulfadiazine (a), pain killers (b), asiaticoside (c) and other pharmaceutically acceptable carriers (d) are compatible with one another according to suitable proportions to obtain the medicinal preparation. The medicinal preparation and the method have the advantages that the medicinal preparation has double synergistic antibacterial and pain alleviating functions, accordingly, healing of wound surfaces can be promoted, epidermis hyperpigmentation due to the silver sulfadiazine can be prevented, and scar can be reduced; the shortcomings of poor hydrophilicity after existing pain killers and existing silver sulfadiazine are directly compatible with one another and easiness in volatilizing moisture in wound surfaces can be overcome.

The invention discloses a preparation method of a degradable medical hemostatic material. The preparation method comprises the following steps: (1) mixing polyethylene glycol, hyaluronic acid and deionized water according to a certain volume ratio; (2) dividing the solution in the step (1) into three parts which are identical, then adding gelatin, polylactic acid and chitosan to the three parts ofthe solution separately and stirring, and then stirring and sonicating the three parts of the solution; (3) carrying out electrospinning on the mixed solution obtained in the step (2) to obtain gelatin/polylactic acid/chitosan composite ultrafine fiber, and vacuum drying the fiber; (4) adding the ultrafine fiber obtained in the step (3) to a solution of silver sulfadiazine for soaking, then freeze drying the fiber, and hot pressing the fiber on a hot pressing plate to obtain the degradable medical hemostatic material. The raw materials used in the hemostatic material are all harmless raw materials with good biocompatibility and biodegradability, have good bioadhesion, can well control the continuous bleeding of the tissue, and have high hemostatic capacity.

The invention discloses a pharmaceutical composition for treating animal body surface trauma. The pharmaceutical composition is composed of silver sulfadiazine, methoxybenzyl aminopyrimidine, and meloxicam according to a mass ratio of (4-6):1:(1-3.5). The provided pharmaceutical composition can be made into medicine sticking for treating various body surface traumas such as dairy cow udder trauma, hoof disease, and the like, the total cure rate can reach 78.0%, the total effective rate can reach 87.9%, and the curative effect is prominently better than that of clinical common treatment methods.

The invention relates to a sterilization type film coating agent for the treatment of burns and scalds, wherein the main constituents include white Vaseline, cellulose glycollic ether, silver sulfadiazine, Tween-80, distilled water and highly effective germicidal agent.

The invention discloses polyurethane foam with a synergistically enhanced antibacterial effect. The polyurethane foam is prepared from, by weight, 150-160 parts of diphenylmethane diisocyanate, 100-105 parts of propoxylated glycerin, 100-110 parts of castor oil, 5-6 parts of glycerin, 40-43 parts of diethyl phosphate, appropriate amount of 1mol/L sodium hydroxide solution, 13-15 parts of diatomite, 5-6 parts of distilled water, 2-3 parts of triethanolamine, 3-4 parts of dibutyltin dilaurate, 2.5-3.5 parts of TX-10, 3-4 parts of carboxymethyl cellulose, 4-5 parts of sulfanilamide, 3-4 parts of silver sulfadiazine, 8-10 parts of anatase nano titania and appropriate amount of deionized water. The polyurethane foam is low in cost, simple in preparation process, available for onsite foaming and excellent in sealing effect on switch cabinets and has antibacterial and bactericidal effects, remarkable antibacterial effects can be kept for a long time even in a humid environment, and the service life of seal glue is prolonged.

The invention relates to an energy-saving real stone paint and a preparation method thereof, and belongs to the field of building materials. Raw materials of the energy-saving real stone paint include 25-30 parts by weight of resin, 20-26 parts by weight of a filler, and assistants. The filler includes Danqiangsi fibers, calcium sulfate whiskers, zeolite powder and slag powder, and the assistants include an organic phosphine/bromine complex, sodium tripolyphosphate, water glass, acrylamide, attapulgite, a binder, a coupling agent, an antifoaming agent and an insect repellent. The insect repellent includes triclosan, chitin, anthraquinone and silver sulfadiazine. The energy-saving real stone paint can kill bacteria and repel insects, and has the advantages of excellent crack resistance, low heat conductivity and good heat insulation effect. A preparation method of the energy-saving real stone paint comprises the following steps: mixing the resin with the organic phosphine/bromine complex, curing the obtained mixture to obtain cured00 resin, and mixing the cured resin with the filler and the remaining assistants to prepare the energy-saving real stone paint. The preparation method has the advantages of simplicity, easiness in process control, short time, and suitableness for industrial production.

The invention relates to a silver sulfadiazine film formation spray and a preparation method thereof. A combined film formation material is used to realize film forming and suspending aiding dual effects, so the solution suspending property of the film formation spray is improved, the spraying effect is guaranteed, the film forming performance is good, the speed is fast, and the silver sulfadiazine film formation spray is a promising silver sulphadiazine treatment dosage form.