A kind of sulfadiazine silver thermosensitive gel and its preparation method and application
A technology of silver thermosensitive gel and silver sulfadiazine, which is applied in medical science, bandages, etc., can solve the problems of unfavorable gel form transformation, transient pain, fibroblast toxicity, etc. The number of medicines, the effect of reducing the pain of dressing change
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[0038] 2) Preparation of silver sulfadiazine nanosuspension: take silver sulfadiazine (crude drug) and join in the aqueous solution containing stabilizer (stabilizer can be selected from Poloxamer 407), so that the final concentration of silver sulfadiazine is 20mg / ml~100mg / ml, adopt wet grinding method (2500rpm, 30min) or high-pressure homogeneous method (pressure 1400bar, 50 cycles) to prepare silver sulfadiazine nanosuspension.
[0039] 3) Preparation of silver sulfadiazine-loaded poloxamer thermosensitive gel: add the silver sulfadiazine nanosuspension obtained in step 2) into the gel solution obtained in step 1), and mix evenly to obtain a concentration of silver sulfadiazine nanocrystals The sulfadiazine silver thermosensitive gel is 0.5wt%-1.5wt%. Store at 4°C or below, and spray on the affected area to form a gel when in use.
Embodiment 1
[0042] Example 1: Preparation of thermosensitive gel loaded with 10mg / ml silver sulfadiazine
[0043] 1) Preparation of gel solution: 17.5 g of poloxamer 407 was precisely weighed, and 10 g of glycerol solution was added to 100 ml of distilled water to obtain a gel solution.
[0044] 2) Preparation of silver sulfadiazine nanosuspension: 6g poloxamer 407 was dissolved and dispersed in 194ml deionized water to obtain a 3wt% poloxamer 407 solution; 20g sulfadiazine silver was dispersed in 180ml 3wt% poloxa In the M407 solution, add a ball mill to adjust the rotating speed to 2500rpm and process for 30min to obtain a 100mg / ml silver sulfadiazine nanosuspension.
[0045] 3) Preparation of drug-loaded temperature-sensitive gel: add the sulfadiazine silver nanosuspension in step 2) into the gel solution in a ratio of 10:90 to obtain the sulfadiazine-loaded silver temperature-sensitive gel, sulfadiazine The final concentration of silver in the temperature-sensitive gel is 10mg / ml (in...
Embodiment 2
[0047] Example 2: Preparation of thermosensitive gel loaded with 10mg / ml silver sulfadiazine
[0048] 1) Preparation of gel solution: 25 g of poloxamer 407 powder, 2 g of poloxamer 188 powder and 10 g of glycerol were accurately weighed and added to 100 ml of distilled water to obtain a gel solution.
[0049] 2) Preparation of silver sulfadiazine nanosuspension: 6g poloxamer 407 was dissolved and dispersed in 194ml deionized water to obtain a 3wt% poloxamer 407 solution; 20g sulfadiazine silver was dispersed in 180ml 3wt% poloxa In the M407 solution, use high-pressure homogeneous method (pressure 1400bar, 50 circulations), obtain sulfadiazine silver nano-suspension.
[0050] 3) Preparation of drug-loaded temperature-sensitive gel: add the silver sulfadiazine nanosuspension in step 2) into the gel solution in step 1) according to the volume ratio of 10:90 to obtain the silver-sulfadiazine-loaded temperature-sensitive gel. Glue, the final concentration of silver sulfadiazine in...
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