105 results about "Poloxamer 407" patented technology

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.

The invention discloses a waterproof long-lasting oil-control gel composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition comprises 4-6 parts of an oil absorption compound A, 9-13 parts of an oil absorption compound B and 70-95 parts of a gel matrix, wherein the oil absorption compound A is prepared from mesoporous silica and poloxamer 407, and the aperture of the oil absorption compound A is 5-10 nm; the oil absorption compound B is prepared from polymethyl methacrylate microspheres, isododecane and polyglycerol-3 diisostearate, and the pore diameter of the oil absorption compound B is 150 to 300 nm. According to the invention, through dual mechanisms of temperature response and volatilization driving, a dynamic gradient structure of bottom layer small aperture-surface layer large aperture is formed at skin temperature, and directional migration of grease is realized; meanwhile, the surface property transformation of the material after oil absorption is creatively utilized, a hydrophobic membrane is formed on the surface of the polymethyl methacrylate microsphere, a self-enhanced waterproof barrier is constructed, the unique effect that the more oil is absorbed, the more water is resisted is achieved, the problem of makeup removal caused by sebum and sweat can be effectively solved, and the makeup lasting time is remarkably prolonged.

The invention relates to injectable temperature-sensitive hydrogel loaded with traditional Chinese medicine active exosomes, and belongs to the technical field of clinical treatment of diabetic foot refractory wounds, and the injectable temperature-sensitive hydrogel is obtained by poloxamer 407 hydrogel and a hyaluronic acid loaded composite carrier; the composite carrier body is formed by coating a traditional Chinese medicine active exosome with a coating solution; the traditional Chinese medicine active exosome is obtained by inducing adipose-derived mesenchymal stem cells with a modified astragalus extract. The injectable temperature-sensitive hydrogel is obtained by loading a composite carrier with poloxamer 407 hydrogel and hyaluronic acid, the poloxamer 407 and the hyaluronic acid quickly form a physical barrier on a wound surface after being injected, a moist healing environment is provided, and continuous and slow release of exosome and active ingredients is realized by means of the temperature-sensitive characteristic and the network structure of the poloxamer 407 and the hyaluronic acid, so that the wound healing effect is improved. And over-high local concentration or premature loss caused by sudden release of the medicine is avoided.

The invention discloses a temperature-sensitive hydrogel loaded with mesenchymal stem cell exosome as well as a preparation method and application of the temperature-sensitive hydrogel, and belongs to the technical field of biological medicines. The method comprises the following steps: (1) adding poloxamer 407 into a pre-cooled dispersion medium to enable the final mass concentration to be 20-30%, and oscillating and dissolving at 4 DEG C overnight to obtain poloxamer hydrogel; (2) collecting a mesenchymal stem cell culture supernatant, and then centrifuging, wherein the centrifuging condition is 200 * g * 15 minutes to 2000 * g * 20 minutes to 12000 * g * 20 minutes; filtering the supernatant, concentrating by using an ultrafiltration tube, further performing ultracentrifugation on the concentrated solution, re-suspending the precipitate by using DPBS, centrifuging again, and re-suspending the finally obtained exosome precipitate by using DPBS to obtain an exosome suspension; the ultracentrifugation condition is as follows; and (3) taking the poloxamer hydrogel prepared in the step (1), adding the exosome suspension obtained in the step (2) under an ice-water bath condition, and uniformly mixing to obtain the poloxamer temperature-sensitive hydrogel.

The invention provides a dotenorad solid dispersion, a solid dispersion pharmaceutical composition, a preparation method and application and a medicine containing the solid dispersion, and belongs to the technical field of pharmaceutical preparations. The preparation method of the dotenorad solid dispersion provided by the invention comprises the following steps: dissolving dotenorad, povidone K90 and poloxamer 407 in water and a medicinal organic solvent to obtain a mixed solution; the mass ratio of the povidone K90 to the poloxamer 407 is gt; 1; and carrying out spray drying on the mixed solution to obtain the dotenorad solid dispersion. The dotenorad solid dispersion prepared by the method provided by the invention has the advantages of fast dissolution of dotenorad and good stability, and is suitable for large-scale production.

The invention relates to the technical field of medical gel preparation, in particular to propolis temperature-sensitive in-situ gel as well as a preparation method and application thereof. A gel matrix is screened by adopting a single factor test, a prescription is optimized by adopting a star point design-effect surface method, and the quality of the propolis temperature-sensitive gel is evaluated. The optimal prescription of the propolis temperature-sensitive vaginal gel obtained through experimental optimization is as follows: 22.9% of poloxamer 407, 1.8% of poloxamer P188, 5.4% of polyethylene glycol 400 and 5% of propolis, the gelling temperature before dilution is 25 DEG C, and the gelling temperature after dilution is 37 DEG C. Quality evaluation results show that the antibacterial agent is stable in property, proper in gelling temperature and good in antibacterial activity. The prepared propolis temperature-sensitive vaginal gel is stable in process, uniform in appearance, controllable in quality and good in slow-release effect and antibacterial effect.

The invention discloses a compound fluralab chewable tablet and a preparation method thereof, and relates to the technical field of veterinary drug preparations, the chewable tablet is composed of fluralab, pyrantel and moxidectin solid dispersion constructed by poloxamer 407 / lauryl sodium sulfate (or sodium dodecyl sulfate); preferably, the particle size D50 of the dispersion is 5-30 microns, and D90 is less than or equal to 80 microns. The preparation method comprises the following steps: firstly, dissolving moxidectin in the system to form a clear solution, drying under reduced pressure, and grinding and sieving at low temperature to obtain a dispersed material; premixing with microcrystalline cellulose, then mixing with lactose, adding a disintegrating agent and a lubricating agent, and carrying out prepressing-main pressing two-stage tabletting to obtain the tablet. The system can maintain amorphous distribution of moxidectin in the tablet, the content uniformity and dissolution and acceleration stability are remarkably improved, broad-spectrum synergy is formed by the moxidectin, the fluralasodium and the pyrantel, and the moxidectin tablet is suitable for killing fleas and ticks, treating roundworms and hookworms and preventing canine heart filariasis and tubuloidiasis.

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.

The invention belongs to the technical field of medical instruments, and provides a long-acting moisturizing contact lens eye lotion and a preparation method thereof. The contact lens eye moistening liquid provided by the invention is prepared from the following components in parts by mass: 0.01 to 0.5 part of gamma-polyglutamic acid, 0.5 to 1.2 parts of electrolyte component, 0.1 to 1.0 part of osmotic pressure regulator, 0.01 to 0.1 part of poloxamer 407 and 96 to 99.5 parts of buffer solution. According to the contact lens eye lotion disclosed by the invention, long-acting moisturizing, low irritation, high stability and excellent lens compatibility are realized through structural synergy of the polyglutamic acid and the electrolyte, functional synergy of the polyglutamic acid and the preservative and environmental synergy of the buffer solution and the osmotic pressure regulator, and the physiological function of natural tears is simulated.

This invention discloses a two-photon AIE nanoparticle, the preparation method of which includes the following steps: S1. Mixing tetrahydrofuran, a tetrahydrofuran solution containing AIE material, a tetrahydrofuran solution containing poloxamer 407, and methyl orthosilicate, and homogenizing the mixture to obtain a homogenized solution; S2. Adding the mixture obtained in S1 dropwise to deionized water under stirring, then homogenizing the mixture again, and then stirring; S3. Dialyzing and then filtering to obtain purified two-photon AIE nanoparticles; S4. Modifying the surface of silica with amino groups and then modifying it with dextran to obtain dextran-modified two-photon AIE nanoparticles. The preparation method disclosed in this invention has the advantages of simple preparation and low cost. The obtained nanoparticles have high stability, high safety, and high two-photon performance, and can be used for two-photon imaging of deep biological tissues.

This application relates to the fields of oral care and biopharmaceutical technology, and discloses an oral antibacterial and repairing film containing a compound lysozyme and its preparation method. The film components include sodium hyaluronate, poloxamer 407, lysozyme, L-arginine, D-trehalose dihydrate, L-methionine, glycerol, deoxygenated purified water, and a pH adjuster. The formulation utilizes L-arginine to competitively bind to the carboxyl group of sodium hyaluronate, blocking the electrostatic complexation and aggregation of polyanions and alkaline lysozyme. Combined with an inorganic salt avoidance design and a poloxamer network, it achieves a rheological response where the storage modulus increases in the opposite direction upon encountering salivary ions, enhancing mucosal retention. The oxygen consumption of L-methionine and the hydration effect of trehalose further preserve enzyme activity. The preparation method employs two-phase isolated formulation and continuous static mixing in tubular tubing to avoid high molecular weight aggregation. This invention solves the problems of easy inactivation and phase separation of lysozyme, improving the physical stability and antibacterial activity of the formulation.

The invention relates to the technical field of traditional Chinese medicine extracts and application, and discloses a preparation method of a fresh perfoliote knotweed herb extract and application of the fresh perfoliote knotweed herb extract in preparation of gel for treating herpes zoster. The perfoliote knotweed herb extract is prepared from 5 to 10 percent of perfoliote knotweed herb extract F1 component, 10 to 25 percent of perfoliote knotweed herb extract F2 component, 2 to 10 percent of berberine, 0.1 to 2 percent of herba menthae volatile oil, 0.1 to 2 percent of herba schizonepetae volatile oil, 5 to 10 percent of low-molecular hyaluronic acid, 5 percent of carbomer (940), 2 to 5 percent of poloxamer 407, 2 to 5 percent of Tween (80), 5 to 10 percent of glycerol, 1 to 5 percent of triethanolamine, 2 percent of phenoxyethanol and the balance of pure water. The preparation process of the nanogel has the characteristics of uniform and controllable particle size and excellent skin permeability, the nanogel can accurately target a focus part, the bioavailability of the medicine is remarkably improved, and the stability of a gel system is good; and the preparation process of the active component of the fresh perfoliote knotweed herb for treating the herpes zoster can efficiently retain the active components in the medicinal materials, is high in extraction rate and simple and convenient in process operation, and has a good market prospect.

This invention relates to the field of traditional Chinese medicine (TCM) health preservation technology, and discloses a TCM weight loss and health preservation method that combines moxibustion, hair combing, and foot therapy to dispel dampness and promote Yang. The composition comprises a solution made from Artemisia argyi volatile oil, 6-gingerol concentrate, isosorbide dimethyl ether, urea, poloxamer 407, decyl glucoside, pH buffer, and purified water. The preparation method involves heating to form a homogeneous eutectic liquid and mixing it with the oil phase. During cooling, a low-tension aqueous phase is pumped submerged. Based on dilution turbidity feedback, the reserved decyl glucoside is used for dynamic repair, resulting in a stable microemulsion system. The health preservation method uses this composition as a foot bath solution, combined with combing the Du and Gallbladder meridians, moxibustion on specific acupoints on the abdomen, and friction on the Yongquan acupoint on the sole of the foot. By addressing the issue of fat-soluble components of TCM easily precipitating and separating in water, the transdermal absorption efficiency is improved. Combined with the synergistic effect of TCM physical therapy, a good dampness-dispelling and health-preserving effect is achieved.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a natural polysaccharide temperature-sensitive gel for freeing lung and reducing phlegm for children and a preparation method thereof.The natural polysaccharide temperature-sensitive gel is prepared from, by weight, 3-8 parts of traditional Chinese medicine nano-composites, 16-20 parts of poloxamer 407 and 0.6-1.2 parts of low-acyl gellan gum, the preparation method comprises the following steps: taking traditional Chinese medicine extracts of perilla leaves, bitter apricot kernels, platycodon grandiflorum and liquorice as a core, forming a nano-composite through astragalus polysaccharide and hydroxypropyl-beta-cyclodextrin, and finally loading the nano-composite into a temperature-sensitive gel network constructed by low-acyl gellan gum and poloxamer 407. The constructed natural polysaccharide temperature-sensitive gel not only can effectively mask the unpleasant odor of the medicine and improve the stability of the medicine, but also can remarkably prolong the residence time of the medicine in the nasal cavity, so that the long-acting treatment effect of ventilating the lung and reducing phlegm is realized.

The invention relates to the technical field of medicines, in particular to a multifunctional sustained-release medicine framework material as well as a preparation method and application thereof. The material is hydrophilic and hydrophobic double-segment composite modified carbomer premixed powder and is prepared from a carbomer homopolymer type A 971P NF, a carbomer homopolymer type B 974P NF, poloxamer 407 and a double-molecular-weight polyethylene glycol dextrin compound according to the weight ratio of (20 to 28) to (10 to 14) to (10 to 14) to (9 to 15). The preparation method comprises the following steps: carrying out spray drying to prepare a compound, carrying out acidic dispersion on carbomer, adding a poloxamer solution in batches, adjusting the pH value to 5.2-5.8, and drying to obtain the premix powder. The material is used for a dihydroergoline mesylate oral sustained-release solid preparation, through the design of a pre-neutralization shell layer and a middle skeleton layer, the gel strength and alteration behavior are synergistically regulated and controlled, early burst release is effectively inhibited, later stable release is ensured, 24-hour near-zero-level drug release is realized, and the plasma concentration stability and the curative effect consistency are improved.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The invention provides a thermo-sensitive hydrogel containing alpha-isoterpinene and a preparation method of the thermo-sensitive hydrogel, and the hydrogel comprises the following components: Te with the content of 0.1-5.0% (w / w); the temperature-sensitive matrix is composed of poloxamer 407 (15-25% w / w) and poloxamer 188 (2-10% w / w), and the mass ratio of the poloxamer 407 to the poloxamer 188 is (2.5-7.5): 1; the antioxidant system comprises ascorbyl palmitate (0.05-0.2% w / w), at least one of tocopherol, rosmarinic acid ester or pharmaceutically acceptable derivatives of the rosmarinic acid ester, and the balance of water. The traditional Chinese medicine composition is used for safely and effectively treating acnes. Belongs to the field of pharmaceutical preparations.

The invention relates to the technical field of cosmetics, in particular to application of poloxamer 407 in improving the toughness of a cosmetic film and foundation cosmetics. The poloxamer 407 is dissolved in water, the polyol is added, the mixture is stirred and mixed uniformly to form a mixed solution, the mixed solution is added into a solution or emulsion containing the film-forming agent, the hardness of the formed cosmetic film is similar to that of a cosmetic film formed without adding the mixed solution, and the toughness is improved. The hardness of the formed cosmetic film in a high-temperature and high-humidity environment is similar to that at normal temperature, the hardness is not obviously reduced, and the hardness of the cosmetic film formed without adding the mixed solution is obviously reduced at high temperature and high humidity. When the composition is applied to foundation make-up cosmetics, the completeness and the makeup maintaining effect of makeup can be improved, and particularly, the composition has a more obvious effect under high-temperature and high-humidity conditions.

The invention discloses a composite milk adjuvant, a preparation method and application of the composite milk adjuvant in vaccines, and belongs to the technical field of medicines. The technical problems to be solved are relatively weak cell immunocompetence, relatively poor immunogenicity and relatively weak immunoregulation capability. According to the technical scheme, squalene, polyoxyethylated castor oil 35 and poloxamer 407 are used as raw materials to prepare a basic formula of the milk adjuvant, an immunologic stimulant is added on the basis to prepare the composite milk adjuvant, and the physicochemical properties and safety of the composite milk adjuvant are represented. The synergistic effect of the milk adjuvant on humoral immunity and cellular immunity is further evaluated by being matched with a recombinant tuberculosis antigen Ag85B to immunize mice, and data support is provided for application of the milk adjuvant in development of novel vaccines such as tuberculosis vaccines and the like. The composite milk adjuvant prepared by the invention not only keeps good humoral immunity and induces generation of high-level IgG1 and IgG2a, but also remarkably improves the response level of cellular immunity.

The invention provides a budesonide temperature-sensitive gel preparation as well as a preparation method and application thereof, and the budesonide temperature-sensitive gel preparation is mainly prepared from the following components: budesonide, poloxamer 407, poloxamer 188, propylene glycol, hydroxypropyl methyl cellulose, sodium benzoate and pure water. After the budesonide temperature-sensitive gel drug delivery system based on poloxamer 407, poloxamer 188 and hydroxypropyl methylcellulose is applied to a cavity, semi-solid gel can be quickly formed, and strong retention and slow release effects are shown, so that the bioavailability is increased, the formed semi-solid gel can be retained at a drug delivery part and cannot be lost, and the budesonide temperature-sensitive gel drug delivery system is suitable for clinical application. In addition, budesonide can be gradually released, and a remarkable curative effect is shown in short-term clinical application of recurrent chronic sinusitis with nasal polyp.

The invention relates to a device comprising an expandable hollow hydrogel tube encapsulated by an ingestible capsule to enable the targeted delivery of large molecules such as biologics to the gastrointestinal (GI) mucosa. Upon ingestion, the capsule is arranged to release the hydrogel tube in the GI tract, where the hydrogel tube expands from a first configuration to a second configuration upon hydration. In its expanded state, the hydrogel tube exerts an outward radial force on the lining of the GI tract. In some embodiments, the outward-facing surface of the hydrogel tube comprises microneedles. The invention further relates to a hydrogel resin comprising: gelatin or poloxamer 407; a neutralisation agent; acrylic acid or sodium acrylate; a crosslinker; a photoinitiator; and a photoabsorber. The hydrogel tube of the invention may be produced by bioprinting and photo-crosslinking said hydrogel resin.

The invention relates to the technical field of biological medicines, and discloses a traditional Chinese medicine composition for treating rhinitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 1 to 8 parts of fructus xanthii, 3 to 8 parts of flos magnoliae, 5 to 20 parts of radix saposhnikoviae, 15 to 20 parts of herba menthae, 5 to 10 parts of radix scutellariae, 1 to 10 parts of periostracum cicadae, 1 to 5 parts of fructus arctii, 0.5 to 4 parts of trametes robiniophila mycoplasm, 0.01 to 0.1 part of zinc oxide nanoparticles, 12 to 20 parts of hydroxymethyl chitosan, 2 to 5 parts of poloxamer 407 and 1 to 3 parts of poloxamer 188. According to the traditional Chinese medicine composition for treating rhinitis and the preparation method, the trametes robiniophila mycoplasm and the zinc oxide nanoparticles cooperate with the fructus xanthii, the flos magnoliae, the radix saposhnikoviae, the herba menthae, the radix scutellariae, the periostracum cicada and the fructus arctii to jointly treat allergic rhinitis. The traditional Chinese medicine and western medicine combined method is adopted, inflammatory response is relieved, the immunologic function of a patient is enhanced, meanwhile, medicine use is reduced, and wide application prospects are achieved.

The invention relates to the technical field of gels, in particular to a temperature-sensitive gel for female private part nursing and a preparation method thereof. The invention relates to a pore-foaming agent which is prepared from the following components in parts by mass: 17 to 22 parts of poloxamer 407, 8 to 12 parts of poly N-isopropylacrylamide, 0.5 to 2 parts of carboxymethyl chitosan, 5 to 8 parts of pore-foaming agent, 0.1 to 0.5 part of ionic cross-linking agent and 0.5 to 3 parts of traditional Chinese medicine extract, wherein the poloxamer 407 and the poly (N-isopropylacrylamide) form an interpenetrating polymer network structure, the poloxamer 407 provides basic thermosensitivity, the gel mechanical strength is enhanced by combining the poloxamer 407 with the poly (N-isopropylacrylamide), the low critical solution temperature of the poly (N-isopropylacrylamide) is 32 DEG C, and the low critical solution temperature of the poly (N-isopropylacrylamide) and the gelling temperature (30-34 DEG C) of the poloxamer 407 form complementation; the storage modulus of a mixed system at 35 DEG C breaks through 1500 Pa, and compared with traditional single poloxamer, the mechanical strength is greatly improved.

The invention relates to the technical field of biological medicine, in particular to pogostemon cablin alcohol lipid cubic liquid crystal nanoparticles as well as a preparation method and application thereof. The pogostemon cablin alcohol lipid cubic liquid crystal nanoparticles comprise the following components: glyceryl monooleate, polyethylene glycol 400, poloxamer 407, D (+)-glucose and pogostemon cablin alcohol. The pogostemon cablin alcohol lipid cubic liquid crystal nanoparticle is of a core-shell structure, a shell is of a skeleton structure jointly formed by the glyceryl monooleate, the polyethylene glycol 400, the poloxamer 407 and the D (+)-glucose, and a core is the pogostemon cablin alcohol. The patchouli alcohol lipid cubic liquid crystal nanoparticles are good in in-vitro stability, have a slow release effect compared with free drugs, and have good development and application prospects in the field of chemotherapeutic intestinal injury treatment.

An umbilical cord mesenchymal stem cell and application thereof in treating osteoarthritis. The application discloses a dual-response hydrogel drug delivery system for osteoarthritis treatment and application thereof, and relates to a synergistic design of a bifunctional fusion protein BFP, an epigenetic regulator TSA and a temperature-sensitive-enzyme response hydrogel. The bifunctional protein BFP contains a cartilage induction domain CIP-2 and an anti-inflammatory domain AIP-3, which are connected in series through a rigid connection peptide EAKAK, and can specifically activate the TGF-beta pathway and respond to MMP9 to release the anti-inflammatory fragment. The temperature-sensitive-enzyme dual-response hydrogel is composed of thiolated hyaluronic acid and poloxamer 407, and can rapidly gelate within 3.5±0.5 minutes at 37 DEG C, the gel transition point is 29.2±0.3 DEG C, and the synergistic release of BFP / TSA can be realized in the presence of MMP9, and the 72-hour release rate reaches 86.7%. Experiments prove that the system can make the SOX9 / COL2A1 gene expression of UC-MSCs increase by 6.77 times and 5.9 times respectively, the GAG deposition amount reaches 0.81 OD630, the ICRS score in the rat OA model increases by 267%, and the serum MMP-13 level decreases by 78.3%. Therefore, the technology of the application provides a new direction for the precise treatment of osteoarthritis.

Formulas for use in enhancing the transduction efficiency of lentiviral vector (LV) particles into various target cells are disclosed herein. For example, a formulation for use in enhancing the transduction of paramyxovirus pseudotype lentiviral vector particles into target cells may comprise a cell-permeable peptide (CPP) comprising at least one of Vectofusion-1 or LAH4-C; and poloxamer 407, wherein the concentration of poloxamer 407 is greater than or equal to the concentration of CPP. Additionally, a method of using such formulations to enhance the transduction of LV particles, including particularly in vivo transduction, is disclosed herein.

The invention relates to an oral glucose in-situ gel preparation as well as a preparation method and application thereof, belongs to the technical field of biological medicines, and solves the problem that a glucose preparation in the prior art is not suitable for neonates. The oral glucose in-situ gel preparation comprises glucose, a temperature-sensitive gel matrix, a preservative and a solvent, the temperature-sensitive gel matrix is prepared from poloxamer 407 and poloxamer 188; wherein the poloxamer 407 accounts for 10%-20% by mass, the poloxamer 188 accounts for 2%-8% by mass, and the content of the glucose accounts for 10%-25% by mass. By adjusting the mass percent of poloxamer 407 and poloxamer 188 and optimizing the drug loading capacity, the gel preparation can generate in-situ phase change at the temperature of 31-35 DEG C while increasing the drug loading capacity, so that the glucose gel preparation can be adhered to oral buccal mucosa, dysphagia of newborns caused by swallowing of the preparation is avoided, slow release of glucose can be realized, and the preparation has a good application prospect. And the glucose can be quickly absorbed through oral buccal mucosa.

The invention relates to the technical field of pharmaceutical preparations, and provides a blumea balsamifera oil nano-micelle as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing blumea balsamifera oil, poloxamer 407 and trichloromethane to obtain a mixed solution; and evaporating trichloromethane in the mixed solution to dryness, mixing the remainder with water, and hydrating to obtain the blumea balsamifera oil nano-micelle. The nano preparation is combined with the blumea balsamifera oil which is a superior traditional Chinese medicine extract, so that the drug delivery can be effectively improved, the bioavailability can be improved, meanwhile, the cytotoxicity of the blumea balsamifera oil can be reduced, and the safety can be improved; in-vivo and in-vitro anti-inflammatory activity test results show that the low-concentration blumea balsamifera oil nano-micelle has the best inhibition effect on mouse ear swelling, and the inhibition rate can reach 60.1%; the blumea balsamifera oil nano-micelle has a remarkable inhibition effect on the release of an inflammatory mediator NO and cell factors TNF-alpha and IL-6 generated by RAW264.7 cells induced by LPS (lipopolysaccharide).

The invention discloses a vaginal temperature-sensitive antibacterial gel and a preparation method thereof, the gel is composed of water-soluble chitosan, poloxamer 407, hydroxy propyl cellulose, nano silver, plant polyphenol, a transdermal absorption enhancer, propylene glycol and deionized water, the poloxamer 407 is used as an only thermally induced hydrogel forming agent, and the nano silver, the plant polyphenol, the transdermal absorption enhancer, the propylene glycol and the deionized water are added into the gel; a solvation temperature-sensitive adjusting system is constructed through propylene glycol, and the sol-gel transition temperature is accurately regulated and controlled to 28-32 DEG C. The gel is a low-viscosity fluid (500-1000 mPa.s) at the normal temperature of 15-25 DEG C, and is easy to push and inject; and after contacting with the body temperature of 36 DEG C, the gel is instantly subjected to phase change within 30 seconds to form high-strength gel, and the gel is stably anchored on the vagina wrinkling wall for more than 8 hours by utilizing the synergistic effect of physical chimerism and electrostatic adsorption. The problems that an existing temperature-sensitive preparation is difficult in normal-temperature administration, slow in-vivo solidification and prone to loss are solved, a split-phase sterilization method is adopted in the preparation process, and the preparation method is suitable for industrial production.

The invention provides temperature-sensitive poloxamer gel for preventing vaginal radiation injury and a preparation method of the temperature-sensitive poloxamer gel, and belongs to the technical field of medical gel. The temperature-sensitive type poloxamer gel is prepared from the following components: 6 percent to 18 percent of a poloxamer compound, 3 percent to 8 percent of a functional component, 0.01 percent to 0.08 percent of a penetration enhancer, 0.10 percent to 0.45 percent of a regulator, 0.13 percent to 0.25 percent of a humectant, 0.05 percent to 0.12 percent of a preservative and the balance of water, the poloxamer compound is prepared by compounding poloxamer 407 and poloxamer 188, and the poloxamer compound is prepared by compounding the poloxamer 407 and the poloxamer 188. The temperature-sensitive poloxamer gel for preventing the vaginal radiation injury, disclosed by the invention, is relatively long in retention time at an acting part, has a certain slow release effect, can keep long-time stimulation to vaginal mucosa, is beneficial to rapid healing of a wound surface, can effectively prevent radioactive vaginitis, is convenient to use, and is safe and non-irritant to a human body.