143 results about "Poloxamer 407" patented technology

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.

The invention discloses a waterproof long-lasting oil-control gel composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition comprises 4-6 parts of an oil absorption compound A, 9-13 parts of an oil absorption compound B and 70-95 parts of a gel matrix, wherein the oil absorption compound A is prepared from mesoporous silica and poloxamer 407, and the aperture of the oil absorption compound A is 5-10 nm; the oil absorption compound B is prepared from polymethyl methacrylate microspheres, isododecane and polyglycerol-3 diisostearate, and the pore diameter of the oil absorption compound B is 150 to 300 nm. According to the invention, through dual mechanisms of temperature response and volatilization driving, a dynamic gradient structure of bottom layer small aperture-surface layer large aperture is formed at skin temperature, and directional migration of grease is realized; meanwhile, the surface property transformation of the material after oil absorption is creatively utilized, a hydrophobic membrane is formed on the surface of the polymethyl methacrylate microsphere, a self-enhanced waterproof barrier is constructed, the unique effect that the more oil is absorbed, the more water is resisted is achieved, the problem of makeup removal caused by sebum and sweat can be effectively solved, and the makeup lasting time is remarkably prolonged.

The invention relates to injectable temperature-sensitive hydrogel loaded with traditional Chinese medicine active exosomes, and belongs to the technical field of clinical treatment of diabetic foot refractory wounds, and the injectable temperature-sensitive hydrogel is obtained by poloxamer 407 hydrogel and a hyaluronic acid loaded composite carrier; the composite carrier body is formed by coating a traditional Chinese medicine active exosome with a coating solution; the traditional Chinese medicine active exosome is obtained by inducing adipose-derived mesenchymal stem cells with a modified astragalus extract. The injectable temperature-sensitive hydrogel is obtained by loading a composite carrier with poloxamer 407 hydrogel and hyaluronic acid, the poloxamer 407 and the hyaluronic acid quickly form a physical barrier on a wound surface after being injected, a moist healing environment is provided, and continuous and slow release of exosome and active ingredients is realized by means of the temperature-sensitive characteristic and the network structure of the poloxamer 407 and the hyaluronic acid, so that the wound healing effect is improved. And over-high local concentration or premature loss caused by sudden release of the medicine is avoided.

The invention discloses a temperature-sensitive hydrogel loaded with mesenchymal stem cell exosome as well as a preparation method and application of the temperature-sensitive hydrogel, and belongs to the technical field of biological medicines. The method comprises the following steps: (1) adding poloxamer 407 into a pre-cooled dispersion medium to enable the final mass concentration to be 20-30%, and oscillating and dissolving at 4 DEG C overnight to obtain poloxamer hydrogel; (2) collecting a mesenchymal stem cell culture supernatant, and then centrifuging, wherein the centrifuging condition is 200 * g * 15 minutes to 2000 * g * 20 minutes to 12000 * g * 20 minutes; filtering the supernatant, concentrating by using an ultrafiltration tube, further performing ultracentrifugation on the concentrated solution, re-suspending the precipitate by using DPBS, centrifuging again, and re-suspending the finally obtained exosome precipitate by using DPBS to obtain an exosome suspension; the ultracentrifugation condition is as follows; and (3) taking the poloxamer hydrogel prepared in the step (1), adding the exosome suspension obtained in the step (2) under an ice-water bath condition, and uniformly mixing to obtain the poloxamer temperature-sensitive hydrogel.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention provides a dotenorad solid dispersion, a solid dispersion pharmaceutical composition, a preparation method and application and a medicine containing the solid dispersion, and belongs to the technical field of pharmaceutical preparations. The preparation method of the dotenorad solid dispersion provided by the invention comprises the following steps: dissolving dotenorad, povidone K90 and poloxamer 407 in water and a medicinal organic solvent to obtain a mixed solution; the mass ratio of the povidone K90 to the poloxamer 407 is gt; 1; and carrying out spray drying on the mixed solution to obtain the dotenorad solid dispersion. The dotenorad solid dispersion prepared by the method provided by the invention has the advantages of fast dissolution of dotenorad and good stability, and is suitable for large-scale production.

The invention relates to a temperature-sensitive gel nose drop and a preparation method and application thereof, and belongs to the technical field of biological medicines.The temperature-sensitive gel nose drop is composed of a temperature-sensitive gel matrix, active ingredients and pharmaceutic adjuvants, the temperature-sensitive gel matrix comprises poloxamer 407 and poloxamer 188, the active ingredients comprise matrine and oxymatrine, and the pharmaceutic adjuvants comprise the temperature-sensitive gel matrix, the active ingredients and the pharmaceutic adjuvants. The pharmaceutic adjuvants comprise one or more of a solvent, a humectant, an antioxidant, a preservative, a wetting agent, a thickening agent, a coloring agent, a wetting agent and a buffering agent. The temperature-sensitive gel nose drop disclosed by the invention is simple in preparation process, controllable in cost and suitable for large-scale production. The thermo-sensitive gel nose drop can improve the expression level of serum IgE, IL-4 and IFN-gamma, improves the symptom of allergic rhinitis by correcting Th1 / Th2 imbalance, is suitable for clinical treatment and prevention of allergic rhinitis, and has a remarkable clinical application prospect.

The invention discloses a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. The invention belongs to the technical field of biological medicine, and relates to a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. According to the method, standard intestinal flora suspension is used as a functional raw material, poloxamer 407 and poloxamer 188 are used as matrixes, and some cryopreservation protective agents and other formulas are used as auxiliary materials, and the preparation method comprises the following steps: (1) preparing standard intestinal flora liquid; (2) gradually adding the following components according to the preparation concentration: 15%-22% of poloxamer 407, 0.5%-4% of poloxamer 188, 5%-20% of glycerol, 0.5%-1% of sodium carboxymethyl cellulose and the balance of 0.9% sodium chloride aqueous solution; (3) mixing and stirring the suspension intestinal bacterial liquid at room temperature, stirring the suspension intestinal bacterial liquid by a method of uniformly stirring the suspension intestinal bacterial liquid by an electric stirring blade until the suspension intestinal bacterial liquid does not have blocks and is uniformly dispersed, continuously stirring the suspension intestinal bacterial liquid until the liquid is viscous and uniform, and converting a viscous solution into a gel state at a corresponding temperature; and (4) sequentially putting the prepared intestinal flora gel preparation into freezing refrigerators at-20 DEG C and-80 DEG C for freezing and storing for later use. The preparation process is simple, the preparation is rapid, the auxiliary materials are medicinal and have good biocompatibility, and the activity of bacteria is not damaged.

The invention discloses pranoprofen temperature-sensitive gel for treating xerophthalmia and a preparation method, the gel takes poloxamer 407 and poloxamer 188 as matrixes, the optimal ratio of the poloxamer 407 to the poloxamer 188 is 23.5%: 2%, and the ratio is optimized and determined by a central composite design-response surface method. During preparation, a blank gel solution is prepared firstly, and then auxiliary materials such as pranoprofen and the like are added for dissolution. The in-vitro release characteristic is good, the accumulated dissolution rate within 210 min exceeds 90%, and the zero-level pharmacokinetic process is achieved. An SD rat xerophthalmia model is established, and it is proved that the xerophthalmia treatment effect of the composition is better than that of eye drops. In eye tissue distribution and aqueous humor pharmacokinetic studies, higher target organ distribution characteristics are shown, the aqueous humor AUC0-t is 1.85 times that of eye drops, and the bioavailability is high. The invention further provides a gel preparation method, a drug effect evaluation method and a related research method, and a new effective dosage form and a new treatment thought are provided for xerophthalmia treatment.

The invention relates to the technical field of medical gel preparation, in particular to propolis temperature-sensitive in-situ gel as well as a preparation method and application thereof. A gel matrix is screened by adopting a single factor test, a prescription is optimized by adopting a star point design-effect surface method, and the quality of the propolis temperature-sensitive gel is evaluated. The optimal prescription of the propolis temperature-sensitive vaginal gel obtained through experimental optimization is as follows: 22.9% of poloxamer 407, 1.8% of poloxamer P188, 5.4% of polyethylene glycol 400 and 5% of propolis, the gelling temperature before dilution is 25 DEG C, and the gelling temperature after dilution is 37 DEG C. Quality evaluation results show that the antibacterial agent is stable in property, proper in gelling temperature and good in antibacterial activity. The prepared propolis temperature-sensitive vaginal gel is stable in process, uniform in appearance, controllable in quality and good in slow-release effect and antibacterial effect.

The invention discloses a kinesio bandage with a slow release function and a preparation process thereof, the kinesio bandage comprises a functional spraying agent, and a contact layer, a slow release layer and a substrate layer which are laminated and compounded in sequence, and the invention relates to the technical field of kinesio. According to the kinesio bandage with the slow release function and the preparation process thereof, a functional spraying agent is independently designed, when the kinesio bandage is used, coupling of the functional spraying agent and a buffer layer is achieved by spraying the functional spraying agent to a contact layer, and under the moisture absorption effect of sodium polyacrylate moisture absorption particles, rapid gelation of the functional spraying agent on the surface of the contact layer is achieved; according to the present invention, the skin surface temperature is responded through the poloxamer 407, such that the rapid formation of the gel state of the contact layer is ensured, the drug release speed is accelerated along with the increase of the skin surface temperature, and the dynamic drug sustained release support condition is provided for the sports personnel;

The invention discloses a compound fluralab chewable tablet and a preparation method thereof, and relates to the technical field of veterinary drug preparations, the chewable tablet is composed of fluralab, pyrantel and moxidectin solid dispersion constructed by poloxamer 407 / lauryl sodium sulfate (or sodium dodecyl sulfate); preferably, the particle size D50 of the dispersion is 5-30 microns, and D90 is less than or equal to 80 microns. The preparation method comprises the following steps: firstly, dissolving moxidectin in the system to form a clear solution, drying under reduced pressure, and grinding and sieving at low temperature to obtain a dispersed material; premixing with microcrystalline cellulose, then mixing with lactose, adding a disintegrating agent and a lubricating agent, and carrying out prepressing-main pressing two-stage tabletting to obtain the tablet. The system can maintain amorphous distribution of moxidectin in the tablet, the content uniformity and dissolution and acceleration stability are remarkably improved, broad-spectrum synergy is formed by the moxidectin, the fluralasodium and the pyrantel, and the moxidectin tablet is suitable for killing fleas and ticks, treating roundworms and hookworms and preventing canine heart filariasis and tubuloidiasis.

An embodiment of the present invention provides a biocompatible, thermosensitive hydrogel composition for subcutaneous or intramuscular injection, the hydrogel comprising a poloxamer, such as poloxamer 338, poloxamer 188, or poloxamer 407, or a mixture thereof, and the composition includes a therapeutic protein or antigen embedded in the composition for sustained release.

The invention discloses low-temperature stable compound temperature-sensitive recombinant humanized collagen gel as well as a preparation method and application thereof. The compound temperature-sensitive recombinant humanized collagen gel comprises the following components in percentage by weight: 17%-20% of poloxamer 407, 0.1%-0.4% of recombinant humanized collagen, 10%-20% of glycerol, 1%-5% of a humectant and the balance of water. The stability of the recombinant humanized collagen gel is improved by adding moisturizers such as glycerol and PEG-8 into a poloxamer 407 gel system, the controllable adjustment of the gel forming temperature of the gel is realized by adjusting the composition proportion, and the gel forming temperature of the gel is regulated and controlled to be 10-30 DEG C. The compound temperature-sensitive recombinant humanized collagen gel disclosed by the invention can stably form gel under different acidic and neutral pH conditions, has good cell compatibility, is free of vaginal irritation and mild implantation reaction, and has wide application prospects in the fields of vaginal in-situ gel medical instruments, biological materials and the like.

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.

The invention belongs to the technical field of medical instruments, and provides a long-acting moisturizing contact lens eye lotion and a preparation method thereof. The contact lens eye moistening liquid provided by the invention is prepared from the following components in parts by mass: 0.01 to 0.5 part of gamma-polyglutamic acid, 0.5 to 1.2 parts of electrolyte component, 0.1 to 1.0 part of osmotic pressure regulator, 0.01 to 0.1 part of poloxamer 407 and 96 to 99.5 parts of buffer solution. According to the contact lens eye lotion disclosed by the invention, long-acting moisturizing, low irritation, high stability and excellent lens compatibility are realized through structural synergy of the polyglutamic acid and the electrolyte, functional synergy of the polyglutamic acid and the preservative and environmental synergy of the buffer solution and the osmotic pressure regulator, and the physiological function of natural tears is simulated.

This invention discloses a two-photon AIE nanoparticle, the preparation method of which includes the following steps: S1. Mixing tetrahydrofuran, a tetrahydrofuran solution containing AIE material, a tetrahydrofuran solution containing poloxamer 407, and methyl orthosilicate, and homogenizing the mixture to obtain a homogenized solution; S2. Adding the mixture obtained in S1 dropwise to deionized water under stirring, then homogenizing the mixture again, and then stirring; S3. Dialyzing and then filtering to obtain purified two-photon AIE nanoparticles; S4. Modifying the surface of silica with amino groups and then modifying it with dextran to obtain dextran-modified two-photon AIE nanoparticles. The preparation method disclosed in this invention has the advantages of simple preparation and low cost. The obtained nanoparticles have high stability, high safety, and high two-photon performance, and can be used for two-photon imaging of deep biological tissues.

The invention relates to preparation of a traditional Chinese medicine nanoemulsion gel spray for treating post-herpes zoster neuralgia. The nanoemulsion gel spray is prepared from the following raw material components: rhizoma corydalis, rhizoma chuanxiong, honeysuckle flowers, radix scutellariae, peach kernels, flos carthami, poloxamer 407, soybean oil, glycerol and pure water. Corydalis tuber, ligusticum wallichii, honeysuckle, radix scutellariae, peach kernel and safflower are adopted as traditional Chinese medicine raw material components, the traditional Chinese medicine raw material components are green, natural, free of hormone and capable of being used for a long time, effective components can effectively relieve and treat neuralgia after herpes zoster, soybean oil, glycerol and pure water are adopted as auxiliary materials, the auxiliary materials and the traditional Chinese medicine components are mixed and subjected to ultrasonic treatment, and the nano-emulsion is obtained. Then the nano-emulsion and poloxamer 407 are fully mixed to prepare nano-emulsion gel, and finally the nano-emulsion gel is canned to obtain the spray.

This application relates to the fields of oral care and biopharmaceutical technology, and discloses an oral antibacterial and repairing film containing a compound lysozyme and its preparation method. The film components include sodium hyaluronate, poloxamer 407, lysozyme, L-arginine, D-trehalose dihydrate, L-methionine, glycerol, deoxygenated purified water, and a pH adjuster. The formulation utilizes L-arginine to competitively bind to the carboxyl group of sodium hyaluronate, blocking the electrostatic complexation and aggregation of polyanions and alkaline lysozyme. Combined with an inorganic salt avoidance design and a poloxamer network, it achieves a rheological response where the storage modulus increases in the opposite direction upon encountering salivary ions, enhancing mucosal retention. The oxygen consumption of L-methionine and the hydration effect of trehalose further preserve enzyme activity. The preparation method employs two-phase isolated formulation and continuous static mixing in tubular tubing to avoid high molecular weight aggregation. This invention solves the problems of easy inactivation and phase separation of lysozyme, improving the physical stability and antibacterial activity of the formulation.

The invention relates to the technical field of traditional Chinese medicine extracts and application, and discloses a preparation method of a fresh perfoliote knotweed herb extract and application of the fresh perfoliote knotweed herb extract in preparation of gel for treating herpes zoster. The perfoliote knotweed herb extract is prepared from 5 to 10 percent of perfoliote knotweed herb extract F1 component, 10 to 25 percent of perfoliote knotweed herb extract F2 component, 2 to 10 percent of berberine, 0.1 to 2 percent of herba menthae volatile oil, 0.1 to 2 percent of herba schizonepetae volatile oil, 5 to 10 percent of low-molecular hyaluronic acid, 5 percent of carbomer (940), 2 to 5 percent of poloxamer 407, 2 to 5 percent of Tween (80), 5 to 10 percent of glycerol, 1 to 5 percent of triethanolamine, 2 percent of phenoxyethanol and the balance of pure water. The preparation process of the nanogel has the characteristics of uniform and controllable particle size and excellent skin permeability, the nanogel can accurately target a focus part, the bioavailability of the medicine is remarkably improved, and the stability of a gel system is good; and the preparation process of the active component of the fresh perfoliote knotweed herb for treating the herpes zoster can efficiently retain the active components in the medicinal materials, is high in extraction rate and simple and convenient in process operation, and has a good market prospect.

This invention relates to the field of traditional Chinese medicine (TCM) health preservation technology, and discloses a TCM weight loss and health preservation method that combines moxibustion, hair combing, and foot therapy to dispel dampness and promote Yang. The composition comprises a solution made from Artemisia argyi volatile oil, 6-gingerol concentrate, isosorbide dimethyl ether, urea, poloxamer 407, decyl glucoside, pH buffer, and purified water. The preparation method involves heating to form a homogeneous eutectic liquid and mixing it with the oil phase. During cooling, a low-tension aqueous phase is pumped submerged. Based on dilution turbidity feedback, the reserved decyl glucoside is used for dynamic repair, resulting in a stable microemulsion system. The health preservation method uses this composition as a foot bath solution, combined with combing the Du and Gallbladder meridians, moxibustion on specific acupoints on the abdomen, and friction on the Yongquan acupoint on the sole of the foot. By addressing the issue of fat-soluble components of TCM easily precipitating and separating in water, the transdermal absorption efficiency is improved. Combined with the synergistic effect of TCM physical therapy, a good dampness-dispelling and health-preserving effect is achieved.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a natural polysaccharide temperature-sensitive gel for freeing lung and reducing phlegm for children and a preparation method thereof.The natural polysaccharide temperature-sensitive gel is prepared from, by weight, 3-8 parts of traditional Chinese medicine nano-composites, 16-20 parts of poloxamer 407 and 0.6-1.2 parts of low-acyl gellan gum, the preparation method comprises the following steps: taking traditional Chinese medicine extracts of perilla leaves, bitter apricot kernels, platycodon grandiflorum and liquorice as a core, forming a nano-composite through astragalus polysaccharide and hydroxypropyl-beta-cyclodextrin, and finally loading the nano-composite into a temperature-sensitive gel network constructed by low-acyl gellan gum and poloxamer 407. The constructed natural polysaccharide temperature-sensitive gel not only can effectively mask the unpleasant odor of the medicine and improve the stability of the medicine, but also can remarkably prolong the residence time of the medicine in the nasal cavity, so that the long-acting treatment effect of ventilating the lung and reducing phlegm is realized.

The invention relates to the technical field of medicines, in particular to a multifunctional sustained-release medicine framework material as well as a preparation method and application thereof. The material is hydrophilic and hydrophobic double-segment composite modified carbomer premixed powder and is prepared from a carbomer homopolymer type A 971P NF, a carbomer homopolymer type B 974P NF, poloxamer 407 and a double-molecular-weight polyethylene glycol dextrin compound according to the weight ratio of (20 to 28) to (10 to 14) to (10 to 14) to (9 to 15). The preparation method comprises the following steps: carrying out spray drying to prepare a compound, carrying out acidic dispersion on carbomer, adding a poloxamer solution in batches, adjusting the pH value to 5.2-5.8, and drying to obtain the premix powder. The material is used for a dihydroergoline mesylate oral sustained-release solid preparation, through the design of a pre-neutralization shell layer and a middle skeleton layer, the gel strength and alteration behavior are synergistically regulated and controlled, early burst release is effectively inhibited, later stable release is ensured, 24-hour near-zero-level drug release is realized, and the plasma concentration stability and the curative effect consistency are improved.

The invention discloses an anti-HPV gel dressing and a preparation method thereof, belonging to the technical field of dressings. The invention comprises the following steps: dissolving lopinavir in methanol to obtain an organic phase, adding poloxamer 407 to deionized water to obtain an aqueous phase, dripping the organic phase into the aqueous phase at a uniform speed while stirring under room temperature, stirring in a fume hood to volatilize methanol after the dripping is completed, and subjecting the obtained solution to particle size treatment using a high-pressure homogenizer to obtain a lopinavir nanoparticle solution; and adding a chitosan-based functional component, poloxamer 407, and poloxamer 188 to the lopinavir nanoparticle solution, stirring at 4°C and 100-200 r / min for 2-4 hours, and placing the dressing in a 4°C refrigerator for treatment for 48 hours to obtain the anti-HPV gel dressing. The anti-HPV gel dressing has good drug sustained-release performance, mucosal adhesion, and viscosity permeability, and greatly improves the bioavailability of lopinavir.

The present invention provides a method for preparing an animal model of insulin resistance and abnormal glucose metabolism caused by mild to moderate hypertriglyceridemia, by injecting poloxamer 407 solution into the mouse peritoneal cavity at a dose of 25-100 mg per kilogram of mouse, administering the drug once every other day for 12 consecutive weeks, and continuously monitoring blood lipid and blood glucose levels. The preferred dose of the present invention is 75 mg per kilogram of mouse. The present invention also provides the use of the animal model in screening and preparing drugs for treating insulin resistance and abnormal glucose metabolism caused by mild to moderate hypertriglyceridemia. The present invention simulates insulin resistance and abnormal glucose metabolism directly caused by mild to moderate hypertriglyceridemia. Compared with traditional high-fat diets or gene knockout models, triglyceride levels are precisely regulated by chemical intervention, avoiding factors such as obesity and inflammation and the risk of genetic manipulation, and having high controllability and efficiency.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The invention provides a thermo-sensitive hydrogel containing alpha-isoterpinene and a preparation method of the thermo-sensitive hydrogel, and the hydrogel comprises the following components: Te with the content of 0.1-5.0% (w / w); the temperature-sensitive matrix is composed of poloxamer 407 (15-25% w / w) and poloxamer 188 (2-10% w / w), and the mass ratio of the poloxamer 407 to the poloxamer 188 is (2.5-7.5): 1; the antioxidant system comprises ascorbyl palmitate (0.05-0.2% w / w), at least one of tocopherol, rosmarinic acid ester or pharmaceutically acceptable derivatives of the rosmarinic acid ester, and the balance of water. The traditional Chinese medicine composition is used for safely and effectively treating acnes. Belongs to the field of pharmaceutical preparations.

The invention relates to the technical field of cosmetics, in particular to application of poloxamer 407 in improving the toughness of a cosmetic film and foundation cosmetics. The poloxamer 407 is dissolved in water, the polyol is added, the mixture is stirred and mixed uniformly to form a mixed solution, the mixed solution is added into a solution or emulsion containing the film-forming agent, the hardness of the formed cosmetic film is similar to that of a cosmetic film formed without adding the mixed solution, and the toughness is improved. The hardness of the formed cosmetic film in a high-temperature and high-humidity environment is similar to that at normal temperature, the hardness is not obviously reduced, and the hardness of the cosmetic film formed without adding the mixed solution is obviously reduced at high temperature and high humidity. When the composition is applied to foundation make-up cosmetics, the completeness and the makeup maintaining effect of makeup can be improved, and particularly, the composition has a more obvious effect under high-temperature and high-humidity conditions.

The invention discloses a composite milk adjuvant, a preparation method and application of the composite milk adjuvant in vaccines, and belongs to the technical field of medicines. The technical problems to be solved are relatively weak cell immunocompetence, relatively poor immunogenicity and relatively weak immunoregulation capability. According to the technical scheme, squalene, polyoxyethylated castor oil 35 and poloxamer 407 are used as raw materials to prepare a basic formula of the milk adjuvant, an immunologic stimulant is added on the basis to prepare the composite milk adjuvant, and the physicochemical properties and safety of the composite milk adjuvant are represented. The synergistic effect of the milk adjuvant on humoral immunity and cellular immunity is further evaluated by being matched with a recombinant tuberculosis antigen Ag85B to immunize mice, and data support is provided for application of the milk adjuvant in development of novel vaccines such as tuberculosis vaccines and the like. The composite milk adjuvant prepared by the invention not only keeps good humoral immunity and induces generation of high-level IgG1 and IgG2a, but also remarkably improves the response level of cellular immunity.