24 results about "Poloxamer 407" patented technology

This application relates to the fields of oral care and biopharmaceutical technology, and discloses an oral antibacterial and repairing film containing a compound lysozyme and its preparation method. The film components include sodium hyaluronate, poloxamer 407, lysozyme, L-arginine, D-trehalose dihydrate, L-methionine, glycerol, deoxygenated purified water, and a pH adjuster. The formulation utilizes L-arginine to competitively bind to the carboxyl group of sodium hyaluronate, blocking the electrostatic complexation and aggregation of polyanions and alkaline lysozyme. Combined with an inorganic salt avoidance design and a poloxamer network, it achieves a rheological response where the storage modulus increases in the opposite direction upon encountering salivary ions, enhancing mucosal retention. The oxygen consumption of L-methionine and the hydration effect of trehalose further preserve enzyme activity. The preparation method employs two-phase isolated formulation and continuous static mixing in tubular tubing to avoid high molecular weight aggregation. This invention solves the problems of easy inactivation and phase separation of lysozyme, improving the physical stability and antibacterial activity of the formulation.

This invention relates to the field of traditional Chinese medicine (TCM) health preservation technology, and discloses a TCM weight loss and health preservation method that combines moxibustion, hair combing, and foot therapy to dispel dampness and promote Yang. The composition comprises a solution made from Artemisia argyi volatile oil, 6-gingerol concentrate, isosorbide dimethyl ether, urea, poloxamer 407, decyl glucoside, pH buffer, and purified water. The preparation method involves heating to form a homogeneous eutectic liquid and mixing it with the oil phase. During cooling, a low-tension aqueous phase is pumped submerged. Based on dilution turbidity feedback, the reserved decyl glucoside is used for dynamic repair, resulting in a stable microemulsion system. The health preservation method uses this composition as a foot bath solution, combined with combing the Du and Gallbladder meridians, moxibustion on specific acupoints on the abdomen, and friction on the Yongquan acupoint on the sole of the foot. By addressing the issue of fat-soluble components of TCM easily precipitating and separating in water, the transdermal absorption efficiency is improved. Combined with the synergistic effect of TCM physical therapy, a good dampness-dispelling and health-preserving effect is achieved.

The invention relates to a device comprising an expandable hollow hydrogel tube encapsulated by an ingestible capsule to enable the targeted delivery of large molecules such as biologics to the gastrointestinal (GI) mucosa. Upon ingestion, the capsule is arranged to release the hydrogel tube in the GI tract, where the hydrogel tube expands from a first configuration to a second configuration upon hydration. In its expanded state, the hydrogel tube exerts an outward radial force on the lining of the GI tract. In some embodiments, the outward-facing surface of the hydrogel tube comprises microneedles. The invention further relates to a hydrogel resin comprising: gelatin or poloxamer 407; a neutralisation agent; acrylic acid or sodium acrylate; a crosslinker; a photoinitiator; and a photoabsorber. The hydrogel tube of the invention may be produced by bioprinting and photo-crosslinking said hydrogel resin.

Formulas for use in enhancing the transduction efficiency of lentiviral vector (LV) particles into various target cells are disclosed herein. For example, a formulation for use in enhancing the transduction of paramyxovirus pseudotype lentiviral vector particles into target cells may comprise a cell-permeable peptide (CPP) comprising at least one of Vectofusion-1 or LAH4-C; and poloxamer 407, wherein the concentration of poloxamer 407 is greater than or equal to the concentration of CPP. Additionally, a method of using such formulations to enhance the transduction of LV particles, including particularly in vivo transduction, is disclosed herein.

The present disclosure relates to a core-shell capsule comprising menthol as a volatile active and an amphiphilic polymer comprising a polyethylene glycol (PEG) segment and a hydrophobic segment, wherein the menthol and the hydrophobic segment form the core of the capsule, encapsulated within a shell comprising the PEG segment and crosslinked with a polyacid, wherein the amphiphilic polymer is Poloxamer 407, and wherein the core-shell capsule has a thermal stability of more than 400 ℃ and is configured to release the menthol in a controlled manner.

This invention relates to the field of nanomaterial dispersion technology, and discloses a nano-hydroxyapatite suspension and its preparation method, comprising nano-hydroxyapatite, thixotropic nanoparticles, N,O-carboxymethyl chitosan, one or two of glycerol and D-sorbitol, poloxamer 407, trisodium citrate dihydrate, xylitol, sodium benzoate, and deionized water. The preparation method includes preparing an A-phase dispersion containing thixotropic nanoparticles and a B-phase suspension containing nano-hydroxyapatite. The B-phase suspension is dropwise added to the A-phase dispersion to react and obtain a three-dimensional composite framework. An auxiliary phase is added for low-shear mixing and vacuum degassing and degassing. This invention constructs a three-dimensional network framework by crosslinking thixotropic nanoparticles with N,O-carboxymethyl chitosan, which hinders the aggregation and gravitational sedimentation of nano-hydroxyapatite particles, giving the system thixotropic properties that are stable at rest and flow under stress, achieving framework dissociation and particle release under slightly acidic conditions.

This invention relates to a compound gel for treating joint inflammation based on a modified ancient Chinese medicine formula, belonging to the fields of pharmaceutical preparations and traditional Chinese medicine. The compound gel consists of active ingredient extracts, a poloxamer thermosensitive gel matrix, a penetration enhancer, a humectant, and deionized water. The active ingredient extracts are obtained from *Terminalia chebula*, *Amla emblica*, lavender, wild watermelon, *Artemisia annua*, and chamomile through ultrasonic-microwave coupling extraction. Using ultrasonic-microwave coupling extraction combined with a low-temperature drying process, small-molecule active ingredients are obtained. A body temperature-responsive gel is constructed based on poloxamer 407 / 188, achieving in-situ phase transition on the skin surface and stable sustained release over 6-8 hours, significantly improving transdermal absorption. The gel is combined with an integrated medication container and biomimetic protective gear to form a synergistic drug delivery system, achieving closed-loop controlled release, leak-proof design, and motion adaptation. This gel is non-irritating and non-allergenic, suitable for topical treatment of osteoarthritis, rheumatoid arthritis, and soft tissue injuries caused by cold and dampness in high-altitude regions.

The application relates to the field of fragrance preparation technology and discloses a layered slow-release fragrance based on wormwood essence and a preparation method thereof. The preparation raw materials of the fragrance include deionized water, polyethylene glycol 400, urea, tannic acid, triethanolamine, poloxamer 407, isopropyl myristate and an acidic eutectic solvent and wormwood extract complex. The preparation method comprises the following steps: dissolving water phase raw materials at low temperature, adding poloxamer 407 and the like to form a liquid precursor through hydration assembly; then pumping in an acidic complex to break the weak alkaline balance of the system, so that the tannic acid restores crosslinking activity and in-situ hydrogen bond crosslinking with the polymer; and finally, a heat-induced phase change is caused through controlled temperature rise to form a gel skeleton. Through in-situ construction of a stable multi-level crosslinking network, volatile components are effectively locked, the technical problems of easy volatilization loss of wormwood extract and easy phase separation of a multi-component system are solved, and smooth and long-lasting release of fragrance components is realized.

The application belongs to the field of daily chemicals, and particularly relates to a season self-adaptive temperature-sensitive hair care composition, which comprises the following components calculated by weight percentage: a temperature-sensitive regulator, an anionic surfactant, a zwitterionic surfactant, a nonionic surfactant, a liquid crystal phase inducing structuring agent, a small molecule peptide supplement, a moisturizing conditioner, a cationic conditioner, a cationic polysaccharide support agent, a non-volatile conditioner, and the balance of pure water; the temperature-sensitive regulator comprises poloxamer 407 and polyurethane-35, and the mass ratio of the poloxamer 407 to the polyurethane-35 is 1:3-3:1. The poloxamer 407 and the polyurethane-35 are compounded in a specific ratio, so that the composition realizes continuous and smooth transition of performance in a wide range of ambient temperature, and realizes excellent effects of cross-season self-adaptive hair care by a single product.

The application belongs to the field of drug delivery nanotechnology, and provides a method for preparing cubic lipid nanoparticles encapsulating small interfering ribonucleic acid and application thereof. The application adopts a trinity design of ion complex pre-assembly of succinylated glycerol monooleate and cationic lipids, space stabilization of poloxamer 407, and rapid particle formation by microfluidics, realizes stable construction of internal nanostructure of inverse bicontinuous cubic phase, encapsulation of small interfering ribonucleic acid in water channel network with high drug loading, long-term stability of colloids under physiological ion strength conditions, and excellent batch consistency, solves the technical contradictions of existing lipid nanometer delivery systems, such as difficulty in giving consideration to low polydispersion and batch consistency, mutual restraint of cationic complex strength and colloidal stability, and difficulty in synergistic optimization of high drug loading and stability of cubic phase structure under high solid content microfluidic conditions, and has wide application value in gene therapy and nucleic acid drug delivery.

This invention discloses a method for preparing and applying magnetically responsive gel microspheres for rapid drug release controlled by magnetothermal stimulation, belonging to the fields of biomedical materials and tumor treatment technology. The method includes: preparing magnetic beads conjugated with targeting antibodies and antitumor drugs; dispersing the magnetic beads and an immune environment modulator in a thermosensitive gel precursor solution containing poloxamer 407; and preparing gel microspheres with uniform particle size using microfluidic technology. The microspheres obtained by this invention possess magnetically induced targeting and thermosensitive properties. Under the action of an external alternating magnetic field, they can rapidly generate a magnetothermal effect, triggering the thermal melting and liquefaction of the gel microspheres at the tumor site, achieving on-demand, rapid, and controllable drug release, and simultaneously exerting a synergistic effect of magnetothermal killing and chemotherapy killing, suitable for the treatment of HER2-positive tumors.

The present application relates to a kind of miR-124 nasal cavity in-situ gel spray and its preparation method.The miR-124 nasal cavity in-situ gel spray thereof is aqueous solution containing miR-124 lipid nanoparticle, poloxamer 407, poloxamer 188 and sodium alginate;The concentration of poloxamer 407 in the miR-124 nasal cavity in-situ gel spray is 145mg / mL-155mg / mL;The concentration of poloxamer 188 in the miR-124 nasal cavity in-situ gel spray is 9.5mg / mL-10.5mg / mL;The concentration of sodium alginate in the miR-124 nasal cavity in-situ gel spray is 1mg / mL-5mg / mL.The spray can effectively improve the olfactory area deposition of drug miR-124, extend the nasal cavity retention time of drug miR-124, improve the nasal-brain delivery efficiency of miR-124.

This invention discloses a mussel protein anti-breakage and soothing scalp care essence and its preparation method, relating to the field of chemical pharmaceutical manufacturing technology. The mussel protein anti-breakage and soothing scalp care essence is composed of the following components in parts by weight: 20-35 parts modified mussel protein; 150-180 parts poloxamer 407; 20-30 parts poloxamer 188; 5-10 parts vitamin C glucoside; 0.5-1 part ergothioneine; 10-20 parts β-alanine betaine; and pharmaceutical-grade polyethylene glycol 400. 50-80 parts; the remainder is purified water, and the total weight is made up to 1000 parts; the modified mussel protein is a protein peptide obtained by directional enzymatic hydrolysis and phosphorylation. This invention uses directional enzymatic hydrolysis and low-temperature plasma-assisted phosphorylation for modification, combined with precise ingredient formulation and refined temperature control process, to take into account both hair breakage prevention and scalp soothing effects, improve product stability and skin feel, and improve the problems of efficacy decay and system instability of traditional products.

The invention relates to a Ziconotide temperature-sensitive nasal spray, which comprises a solvent, and Ziconotide, a first matrix, a second matrix, an absorption enhancer, a pH buffer system and a polypeptide stabilizer dispersed in the solvent, the first matrix is poloxamer 407, and the second matrix is poloxamer 188; the temperature-sensitive nasal spray comprises the following components in percentage by mass: 5%-20% of the first substrate, 0-5% of the second substrate, 0.01%-10% of the absorption enhancer, and the balance of the temperature-sensitive nasal spray, the pH buffer system is an acetic acid-acetate system or a lactic acid-lactate system. The ziconotide temperature-sensitive nasal spray can form a good spray form through a nasal spray device, the viscosity has a temperature-sensitive characteristic, and the ziconotide temperature-sensitive nasal spray is not easy to lose and has good stability.

This invention relates to the field of pharmaceutical formulation technology, and more particularly to an injectable bupivacaine-meroxicam sustained-release solution, its preparation method, and its application. The sustained-release solution comprises the following components in the indicated mass fractions: bupivacaine or a pharmaceutically acceptable salt thereof 1.5%–3.5%; meloxicam or a pharmaceutically acceptable salt thereof 0.03%–0.15%; poloxamer 407 15%–25%; poloxamer 188 1%–8%; hydroxypropyl methylcellulose 0.5%–5%; an osmotic pressure regulator 0.7%–5%; a buffer salt 0.1%–1%; and the balance being water. This invention constructs a thermosensitive in-situ gel system, enabling the formulation to be a flowable solution at room temperature, which rapidly transforms into a semi-solid gel reservoir at body temperature after injection, achieving a long-lasting and stable sustained release of bupivacaine and meloxicam for over 24 hours. All components are safe pharmaceutical excipients with good biocompatibility; the preparation process is simple.

This invention discloses a thermosensitive hydrogel loaded with anti-inflammatory small molecules, its preparation method, and its applications, relating to the field of biomedical technology. It comprises mesenchymal stem cell-derived exosomes loaded with anti-inflammatory small molecules, sodium hyaluronate, a thermosensitive hydrogel matrix, and an enzymatic debridement agent. This invention encapsulates papain with enzymatic debridement function, anti-inflammatory small molecules, and mesenchymal stem cell-derived exosomes as the main body of repair activity within a thermosensitive hydrogel matrix composed of a fixed ratio of poloxamer 407 and poloxamer 188. This composition is liquid at low temperatures, making it easy to apply, and transforms in situ into a semi-solid gel upon contact with oral temperature, achieving wound adhesion and long-term residence. Papain is used for initial debridement, creating conditions for subsequent repair; the bioaffinity between the anti-inflammatory small molecules and exosomes enables controlled and sustained release of the active ingredients; and finally, mesenchymal stem cell-derived exosomes promote wound repair.

The present disclosure relates to a core-shell capsule comprising a hydrophobic core comprising ferulic acid, encapsulated within a hydrophilic shell formed of a poly(ethylene glycol)- containing amphiphilic polymer crosslinked by a polyacid having at least one carboxylic acid group, wherein the poly(ethylene glycol)-containing amphiphilic polymer is Poloxamer 407; and wherein the loading of the ferulic acid in the core-shell capsule ranges from 8 to 11%, relative to the total weight of the core-shell capsule. The present disclosure also relates to a method of producing the core-shell capsule of the present disclosure.

This invention discloses a thermosensitive hydrogel loaded with anti-inflammatory small molecules, its preparation method, and its applications, relating to the field of biomedical technology. It comprises mesenchymal stem cell-derived exosomes loaded with anti-inflammatory small molecules, sodium hyaluronate, a thermosensitive hydrogel matrix, and an enzymatic debridement agent. This invention encapsulates papain with enzymatic debridement function, anti-inflammatory small molecules, and mesenchymal stem cell-derived exosomes as the main body of repair activity within a thermosensitive hydrogel matrix composed of a fixed ratio of poloxamer 407 and poloxamer 188. This composition is liquid at low temperatures, making it easy to apply, and transforms in situ into a semi-solid gel upon contact with oral temperature, achieving wound adhesion and long-term residence. Papain is used for initial debridement, creating conditions for subsequent repair; the bioaffinity between the anti-inflammatory small molecules and exosomes enables controlled and sustained release of the active ingredients; and finally, mesenchymal stem cell-derived exosomes promote wound repair.

This invention discloses a thermosensitive hydrogel burn dressing based on a honeysuckle-Lithospermum erythrorhizon compound extract and its preparation method, belonging to the technical field of medical burn dressings. The thermosensitive hydrogel burn dressing includes a thermosensitive gel matrix and active ingredients dispersed in the thermosensitive gel matrix; the thermosensitive gel matrix is ​​composed of poloxamer 407, poloxamer 188, and water for injection; the active ingredients are composed of a dry powder of a traditional Chinese medicine compound extract and alum-borneol complex powder. This invention obtains the dry powder of the traditional Chinese medicine compound extract through dynamic reflux extraction with ethanol and alcohol precipitation purification, and obtains the alum-borneol complex powder through a melt dispersion-solidification-ball milling process. The active ingredients are dispersed in a specific ratio in a thermosensitive gel matrix without chemical cross-linking agents. The product of this invention is a flowing liquid at room temperature and spontaneously forms a gel upon contact with the wound at body temperature, exhibiting strong antibacterial, sustained-release, and healing-promoting effects.

The application provides a multi-layer penetration controlled-release acid preparation and a preparation method thereof, and belongs to the field of cosmetics. The preparation is composed of Aspergillus oryzae fermentation substrate freeze-dried powder, composite alpha-hydroxy acid, salicylic acid, poloxamer 407, polyhydric alcohol and non-ionic surfactant. The freeze-dried powder is obtained by co-fermenting olea europaea leaves and curcuma and refining through ultrafiltration. A temperature-sensitive phase change system is constructed by using poloxamer, so that the product is changed from a liquid state to a gel state at body temperature, and the synergistic controlled release of acid components and bioactive substances is realized. The preparation process adopts low-temperature swelling and vacuum freeze-drying technology, so that the stability of the system and the efficiency of the active substances are ensured. The application significantly reduces the irritation of high-concentration acid, improves the black suppression and repair effect, and is suitable for precise improvement of hyperpigmentation problems such as chloasma.

The present application provides a temperature-sensitive hydrogel system for intranasal delivery of mesenchymal stem cells and application, which comprises a poloxamer hydrogel as a carrier and mesenchymal stem cells loaded on the carrier; the poloxamer hydrogel as a carrier comprises poloxamer 407 and poloxamer 188, and further comprises at least one of epidermal growth factor and fibroblast growth factor. The present application solves the problems of low efficiency of mesenchymal stem cells into the brain and poor survival ability of mesenchymal stem cells in the nasal cavity in the treatment of ischemic stroke under the current technology, improves the accumulation and activity of mesenchymal stem cells in the lesion site, and improves the prognosis of stroke treatment. The cell preparation in the present application can target the brain ischemic site, and can be administered by non-invasive intranasal administration, avoiding the risk of secondary trauma caused by invasive administration.

This invention relates to the field of surgical wound treatment materials and related instruments, and discloses an injectable hydrogel and injection method for wounds after tophi removal surgery, comprising a thermosensitive hydrogel matrix, a uric acid-lowering active ingredient, and an anti-inflammatory active ingredient; the thermosensitive hydrogel matrix is ​​selected from one or more of polylactic acid-polyethylene glycol-polylactic acid block copolymer, polylactic acid-glycolic acid copolymer-polyethylene glycol-polylactic acid-glycolic acid copolymer block copolymer, and poloxamer 407; the mass percentage concentration of the thermosensitive hydrogel matrix in the injectable hydrogel for wounds after tophi removal surgery is 15%-30%. Compared with existing oral or intravenous systemic drug administration regimens, the local sustained-release drug administration method of this invention avoids systemic drug side effects and improves the local drug utilization efficiency of the surgical cavity.

The application discloses a low-stimulus and high-safety benzoyl aconine original base temperature-sensitive analgesic gel injection as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The injection takes benzoyl aconine original base as a core analgesic component, constructs a triple heart protection system of'sub-anesthetic dose lidocaine + ammonium glycyrrhizinate + magnesium sulfate', cooperates with a poloxamer 407 temperature-sensitive gel matrix, and is supplemented with a cosolvent and an antioxidant, has a pH value of 5.5-6.5, can be injected at room temperature, and is quickly gelled at body temperature to realize long-acting controlled release. The preparation has high analgesic intensity, no addiction, slight injection pain, controllable cardiotoxicity, and can maintain analgesia for more than 12 hours after single administration, is suitable for local targeted treatment of moderate and severe chronic pain, neuropathic pain and the like, and has significant clinical advantages and popularization value.

The present disclosure relates to a method of preparing nanocapsules of ursolic acid. The method comprises mixing ursolic acid with a poly(ethylene glycol)-containing polymer at ambient temperature to form a mixture, adding an aqueous carrier to the mixture, and homogenizing the mixture with the aqueous carrier under high-shear conditions to obtain an emulsion comprising a hydrophobic core consisting of the ursolic acid, encapsulated by a shell consisting of the poly(ethylene glycol)-containing polymer, wherein the poly(ethylene glycol)- containing polymer is Poloxamer 407, and wherein the method is performed without heating and without organic solvents. The present disclosure also relates to a core-shell capsule prepared by the method of the present disclosure.