Temperature-sensitive nasal spray gel for treating rhinitis

A sensitive, gel-based technology for medical applications that can address issues such as lack of site selectivity, detachment, and non-specific adhesion

Inactive Publication Date: 2015-11-11
SUZHOU JIOU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the first-generation mucoadhesive materials have no specificity for substrate adhesion, cannot specifically adhere to the mucous membrane of a specific part of the gastrointestinal tract, and lack site selectivity, such as acrylic acid, cellulose, polysaccharides, etc. Sugars and peptides, etc.
These adhesive materials also have a common disadvantage, that is, they adhere to the mucous membrane through some weak interactions, such as van der Waals force, hydrogen bond, electrostatic and hydrophobic interactions, etc., which are easily affected by metal ions in tissue fluid, pH, etc. value, tissue movement, and clearance effects, it is easier to fall off from the mucosa

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025] Poloxamer 40718g

[0026] PLGA-PEG-PLGA0.5g

[0027] Glucomannan 0.2g

[0028] Epidermal growth factor 0.05g

[0029] Benzalkonium Chloride 0.1g

[0030] Add water to 100g

[0031] Preparation

[0032] 1. Add the prescribed amount of PLGA-PEG-PLGA, glucomannan, epidermal growth factor and benzalkonium chloride to the prescribed amount of water while stirring, dissolve and cool to 10±1°C;

[0033] 2. Weigh the prescribed amount of poloxamer 407, add it into the above-mentioned cooled solution while stirring, and store it at 10±1°C until a clear and bubble-free solution is formed, and pump air if necessary;

[0034] 3. Use sodium hydroxide solution (10% aqueous solution) to adjust the pH of the thermosensitive gel to 6.0;

[0035] 4. Fill the above solution into the spray device, control the filling volume to 5-10ml, control the liquid storage room of the filling machine, and the temperature is 10±1°C;

[0036] 5. After ray sterilization, pa...

Embodiment 2

[0038] prescription:

[0039] Poloxamer 40722g

[0040] PLGA-PEG-PLGA1g

[0041] Glucomannan 0.5g

[0042] Epidermal growth factor 0.05g

[0043] Methylparaben, propylparaben (weight ratio 1:1) 0.1g

[0044] Add water to 100g

[0045] Preparation:

[0046] 1. Add the prescribed amount of PLGA-PEG-PLGA, glucomannan, epidermal growth factor, methylparaben and propylparaben to the prescribed amount of water while stirring, dissolve and cool to 10±1°C;

[0047]2. Weigh the prescribed amount of poloxamer 407, add it into the above-mentioned cooled solution while stirring, and store it at 10±1°C until a clear and bubble-free solution is formed, and pump air if necessary;

[0048] 3. Use sodium hydroxide solution (10% aqueous solution) to adjust the pH of the thermosensitive gel to 6.0;

[0049] 4. Fill the above solution into the spray device, control the filling volume to 5-10ml, and control the liquid storage room and system temperature of the filling machine to 10±1°C;

...

Embodiment 3

[0052] prescription:

[0053] Poloxamer 40724g

[0054] PLGA-PEG-PLGA0.5g

[0055] Glucomannan 0.5g

[0056] Epidermal Growth Factor 0.1g

[0057] Benzalkonium Bromide 0.2g

[0058] Add water to 100g

[0059] Preparation:

[0060] 1. Add the prescribed amount of PLGA-PEG-PLGA, glucomannan, epidermal growth factor and benzalkonium bromide into the prescribed amount of water while stirring, dissolve and cool to 10±1°C;

[0061] 2. Weigh the prescribed amount of poloxamer 407, add it into the above-mentioned cooled solution while stirring, and store it at 10±1°C until a clear and bubble-free solution is formed, and pump air if necessary;

[0062] 3. Use sodium hydroxide solution (10% aqueous solution) to adjust the pH of the thermosensitive gel to 6.0;

[0063] 4. Fill the above solution into the spray device, control the filling volume to 5-10ml, control the liquid storage room of the filling machine, and the temperature is 10±1°C;

[0064] 5. After ray sterilization, pa...

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PUM

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Abstract

The invention belongs to the field of medicine, and relates to temperature-sensitive nasal spray gel for rhinitis treatment and daily protection of the nasal cavity. The temperature-sensitive nasal spray gel contains poloxamer 407, a PLGA-PEG-PLGA (poly(lactic-co-glycolic acid-polyethylene glycol-poly(lactic-co-glycolic acid) three-block polymer, gulcomannan, an epidermal growth factor and water, wherein poloxamer 407 is taken as a temperature-sensitive material, and the using amount of poloxamer 407 is 15 to 25 percent; the PLGA-PEG-PLGA three-block polymer is taken as a phase change temperature regulator, and the using amount of the PLGA-PEG-PLGA three-block polymer is less than 2 percent; the PLGA-PEG-PLGA three-block polymer is the phase change temperature regulator; gulcomannan with a molecular weight of 1 to 3 millions is taken as a mucous adhesive, and the using amount of gulcomannan is 0.2 to 1 percent; the epidermal growth factor is taken as a mucous healing agent, and the using amount of the epidermal growth factor is less than 0.1 percent.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a temperature-sensitive spray gel for nasal cavity. Background technique [0002] The nose is an important organ of the human body, which mainly has functions such as breathing, smell, resonance and reflection. Respiratory function: the nasal cavity is the channel for breathing air, which can regulate the temperature, humidity, filtration and cleaning of the inhaled air, so as to protect the lower respiratory tract mucosa to meet the physiological requirements and facilitate the exchange of oxygen and carbon dioxide in the alveoli; olfactory function: odorous Gas molecules reach the olfactory groove of the nasal cavity with the inhaled airflow, contact the olfactory mucosa, dissolve in the secretion of the olfactory gland, stimulate the olfactory cells to generate nerve impulses, pass through the olfactory nerve to the olfactory bulb, olfactory tract, and then reach the medulla ob...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/12A61K47/34A61P11/02
Inventor 张自强刘宇婧
Owner SUZHOU JIOU BIOTECH CO LTD
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