Temperature-sensitive nasal spray gel for treating rhinitis
A sensitive, gel-based technology for medical applications that can address issues such as lack of site selectivity, detachment, and non-specific adhesion
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Embodiment 1
[0024] prescription:
[0025] Poloxamer 40718g
[0026] PLGA-PEG-PLGA0.5g
[0027] Glucomannan 0.2g
[0028] Epidermal growth factor 0.05g
[0029] Benzalkonium Chloride 0.1g
[0030] Add water to 100g
[0031] Preparation
[0032] 1. Add the prescribed amount of PLGA-PEG-PLGA, glucomannan, epidermal growth factor and benzalkonium chloride to the prescribed amount of water while stirring, dissolve and cool to 10±1°C;
[0033] 2. Weigh the prescribed amount of poloxamer 407, add it into the above-mentioned cooled solution while stirring, and store it at 10±1°C until a clear and bubble-free solution is formed, and pump air if necessary;
[0034] 3. Use sodium hydroxide solution (10% aqueous solution) to adjust the pH of the thermosensitive gel to 6.0;
[0035] 4. Fill the above solution into the spray device, control the filling volume to 5-10ml, control the liquid storage room of the filling machine, and the temperature is 10±1°C;
[0036] 5. After ray sterilization, pa...
Embodiment 2
[0038] prescription:
[0039] Poloxamer 40722g
[0040] PLGA-PEG-PLGA1g
[0041] Glucomannan 0.5g
[0042] Epidermal growth factor 0.05g
[0043] Methylparaben, propylparaben (weight ratio 1:1) 0.1g
[0044] Add water to 100g
[0045] Preparation:
[0046] 1. Add the prescribed amount of PLGA-PEG-PLGA, glucomannan, epidermal growth factor, methylparaben and propylparaben to the prescribed amount of water while stirring, dissolve and cool to 10±1°C;
[0047]2. Weigh the prescribed amount of poloxamer 407, add it into the above-mentioned cooled solution while stirring, and store it at 10±1°C until a clear and bubble-free solution is formed, and pump air if necessary;
[0048] 3. Use sodium hydroxide solution (10% aqueous solution) to adjust the pH of the thermosensitive gel to 6.0;
[0049] 4. Fill the above solution into the spray device, control the filling volume to 5-10ml, and control the liquid storage room and system temperature of the filling machine to 10±1°C;
...
Embodiment 3
[0052] prescription:
[0053] Poloxamer 40724g
[0054] PLGA-PEG-PLGA0.5g
[0055] Glucomannan 0.5g
[0056] Epidermal Growth Factor 0.1g
[0057] Benzalkonium Bromide 0.2g
[0058] Add water to 100g
[0059] Preparation:
[0060] 1. Add the prescribed amount of PLGA-PEG-PLGA, glucomannan, epidermal growth factor and benzalkonium bromide into the prescribed amount of water while stirring, dissolve and cool to 10±1°C;
[0061] 2. Weigh the prescribed amount of poloxamer 407, add it into the above-mentioned cooled solution while stirring, and store it at 10±1°C until a clear and bubble-free solution is formed, and pump air if necessary;
[0062] 3. Use sodium hydroxide solution (10% aqueous solution) to adjust the pH of the thermosensitive gel to 6.0;
[0063] 4. Fill the above solution into the spray device, control the filling volume to 5-10ml, control the liquid storage room of the filling machine, and the temperature is 10±1°C;
[0064] 5. After ray sterilization, pa...
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