4 results about "Site selectivity" patented technology

The application provides a kind of containing spiro compound and its preparation method and application, belong to organic synthesis technical field.The structure formula of containing spiro compound described in the application is as shown in formula 1, formula 2 or formula 3: formula 1, formula 2, formula 3, in formula 1, formula 2 and formula 3, R2It is selected from hydrogen, deuterium, methyl, methoxy, hydroxyl or halogen, R3It is selected from hydrogen, methyl, halogen, cyano or trifluoromethyl, R4It is selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted benzyl, substituted or unsubstituted phenyl, cyclic alkyl containing double bond or deuterated methyl, R5It is selected from substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted naphthyl, unsubstituted phenyl or phenyl substituted by one or more of halogen, methyl, tert-butyl, methoxy, alkyl, n is the positive integer of 0-3.The application realizes excellent site selectivity, avoids C3 position side reaction, and has good chemical selectivity.

The application provides a simple and efficient synthesis method for synthesizing a novel binaphthol derivative skeleton phosphorus oxygen ligand, and realizes a method for realizing the enantioselective nickel catalytic aliphatic C(sp 3 )‑H activation of formamide by using a binaphthol derivative phosphorus oxygen ligand connected nickel-aluminum bimetallic catalyst, and belongs to the technical field of asymmetric catalysis application. The key to solving the problem of the application lies in that: 1. A novel binaphthol derivative phosphorus oxygen ligand which is efficient and specific in reaction activity, site selectivity and corresponding selectivity is found, and a method for nickel catalytic aliphatic C(sp 3 )‑H asymmetric activation of formamide is realized; 2. A bimetallic catalyst system is designed by using the characteristics of the ligand, so that the reaction activity is greatly improved, and the efficient preparation is more easy.

The invention provides a simple and efficient synthesis method, in particular to a method for realizing insertion of a formyl compound C-H into intramolecular olefin to construct an indolone compound containing a chiral quaternary carbon center by connecting a phosphorus-oxygen ligand with a nickel-aluminum bimetallic catalyst, and belongs to the technical field of methodology development. The key of the problem solved by the invention is as follows: 1, a formyl compound which is efficient and specific in reaction activity and site selectivity is found; 2, a bimetallic catalytic system is designed by utilizing the characteristics of phosphine oxide ligands, so that the reaction enantioselectivity is greatly improved;

The invention provides an MLM type structure triglyceride rich in DHA (docosahexaenoic acid) at sn-2 site as well as a preparation method and application of the MLM type structure triglyceride. The triglyceride has a glycerin skeleton, the sn-2 site of the glycerin skeleton is esterified with DHA, the sn-1 site and the sn-3 site of the glycerin skeleton are independently esterified with one of C6-C12 saturated medium-chain fatty acids, and at least one of the sn-1 site and the sn-3 site is esterified with lauric acid. The DHA is fixed at the sn-2 position, and lauric acid is introduced at the sn-1 and sn-3 positions, so that the effects of improving the DHA enrichment degree of the colon and cooperatively inhibiting the colorectal cancer are achieved. The triglyceride with the structure belongs to a typical lipid with a middle-long-middle (MLM) type structure. According to the molecular design, DHA is reserved in a monoacylglycerol form in the digestion process and acts on the colon in a positioned manner by utilizing the characteristic that digestive enzyme is selective to a triglyceride part, and meanwhile, lauric acid is rapidly absorbed to play an anti-tumor immunoregulation role, so that complementary advantages of two functional fatty acids are realized on the molecular level.