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Selectivity is the degree to which a drug acts on a given site relative to other sites. Relatively nonselective drugs affect many different tissues or organs. For example, atropine, a drug given to relax muscles in the digestive tract, may also relax muscles in the eyes and in the respiratory tract.
A kind of containing spiro compound and its preparation method and application
The application provides a kind of containing spiro compound and its preparation method and application, belong to organic synthesis technical field.The structure formula of containing spiro compound described in the application is as shown in formula 1, formula 2 or formula 3: formula 1, formula 2, formula 3, in formula 1, formula 2 and formula 3, R2It is selected from hydrogen, deuterium, methyl, methoxy, hydroxyl or halogen, R3It is selected from hydrogen, methyl, halogen, cyano or trifluoromethyl, R4It is selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted benzyl, substituted or unsubstituted phenyl, cyclic alkyl containing double bond or deuterated methyl, R5It is selected from substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted naphthyl, unsubstituted phenyl or phenyl substituted by one or more of halogen, methyl, tert-butyl, methoxy, alkyl, n is the positive integer of 0-3.The application realizes excellent site selectivity, avoids C3 position side reaction, and has good chemical selectivity.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE