Pharmaceutical composition for treating periodontitis, and preparation method and application thereof
A composition and periodontitis technology, applied in the field of pharmaceutical preparations, can solve problems such as unfavorable treatment, poor patient compliance, patient discomfort, etc., and achieve the effects of improving medication compliance, prolonging release time, and reducing medication frequency
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Embodiment 1
[0051] The pharmaceutical composition for the treatment of periodontitis of the present invention has the following compositions, all in mass percent:
[0052]
[0053] Preparation:
[0054] (1) Take purified water, add Carbomer 974P to it in batches under stirring condition, stir until dispersed evenly, then add hypromellose K4M while stirring, stir until completely swollen to obtain gel solution A;
[0055] (2) Add poloxamer 407 evenly to the gel solution A obtained in step (1), stir and mix to completely wet the poloxamer 407 to obtain gel solution B;
[0056] (3) Then get glycerin, polyethylene glycol 400, the chlorhexidine gluconate solution that mass concentration is 20%, banana essence, the peppermint oil that volume ratio is 4% to join in the gel solution B, stir and mix, low temperature 4 Place overnight at ℃ to fully swell the gel to obtain gel solution C;
[0057] (4) Use 0.2mol / l sodium hydroxide solution to adjust the pH of the gel solution C to 6.50, and add...
Embodiment 2
[0060] The pharmaceutical composition for the treatment of periodontitis of the present invention has the following compositions, all in mass percent:
[0061]
[0062] The preparation method of the pharmaceutical composition for the treatment of periodontitis of the present invention, the steps are as follows:
[0063] (1) Take purified water, add chitosan to it in portions under stirring condition, stir until dispersed evenly, then add carboxymethyl cellulose while stirring, stir until completely swollen to obtain gel solution A;
[0064] (2) Add poloxamer 407 evenly to the gel solution A obtained in step (1), stir and mix to completely wet the poloxamer 407 to obtain gel solution B;
[0065] (3) Add glycerin, Tween 80, chlorhexidine acetate, peppermint oil with a volume ratio of 4%, and phosphate buffer to the gel solution B obtained in step (2), stir and mix, and heat at a low temperature of 4°C Leave it overnight to make the gel fully swell to obtain gel solution C; ...
Embodiment 3
[0069] The pharmaceutical composition for the treatment of periodontitis of the present invention has the following compositions, all in mass percent:
[0070]
[0071]
[0072] The preparation method of the pharmaceutical composition for the treatment of periodontitis of the present invention, the steps are as follows:
[0073] (1) Take purified water, add chitosan to it in stages under stirring condition, stir until dispersed evenly, then add polyvinylpyrrolidone while stirring, stir until completely swollen to obtain gel solution A;
[0074] (2) Add poloxamer 407 evenly to the gel solution A obtained in step (1), stir and mix to completely wet the poloxamer 407 to obtain gel solution B;
[0075] (3) Add glycerin, Tween 80, chlorhexidine hydrochloride, peppermint oil with a volume ratio of 4%, and apple essence to the gel solution B obtained in step (2), stir and mix, and place at a low temperature of 4°C overnight , to make the gel fully swell to obtain gel solution ...
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