Pharmaceutical composition for treating periodontitis, and preparation method and application thereof

A composition and periodontitis technology, applied in the field of pharmaceutical preparations, can solve problems such as unfavorable treatment, poor patient compliance, patient discomfort, etc., and achieve the effects of improving medication compliance, prolonging release time, and reducing medication frequency

Active Publication Date: 2011-11-16
SHENZHEN SOUTH CHINA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1) Inconvenient medication
Periodontal tablets and periodontal strips need to be placed in periodontal pockets with special devices, which is inconvenient to operate;
[0007] 2) Foreign body sensation and poor patient compliance
Periodontal tablets and periodontal strips are solid preparations. After being placed in the periodontal pocket, there is an obvious foreign body sensation, which causes discomfort to the patient and poor drug compliance;
[0008] 3) Ointment is a semi-solid preparation with high viscosity and poor fluidity. It is not easy to spread after use, which affects the curative effect and is unfavorable for treatment.
But can only play a preventive role, can not reach the therapeutic effect of the present invention for treating periodontitis

Method used

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  • Pharmaceutical composition for treating periodontitis, and preparation method and application thereof
  • Pharmaceutical composition for treating periodontitis, and preparation method and application thereof
  • Pharmaceutical composition for treating periodontitis, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The pharmaceutical composition for the treatment of periodontitis of the present invention has the following compositions, all in mass percent:

[0052]

[0053] Preparation:

[0054] (1) Take purified water, add Carbomer 974P to it in batches under stirring condition, stir until dispersed evenly, then add hypromellose K4M while stirring, stir until completely swollen to obtain gel solution A;

[0055] (2) Add poloxamer 407 evenly to the gel solution A obtained in step (1), stir and mix to completely wet the poloxamer 407 to obtain gel solution B;

[0056] (3) Then get glycerin, polyethylene glycol 400, the chlorhexidine gluconate solution that mass concentration is 20%, banana essence, the peppermint oil that volume ratio is 4% to join in the gel solution B, stir and mix, low temperature 4 Place overnight at ℃ to fully swell the gel to obtain gel solution C;

[0057] (4) Use 0.2mol / l sodium hydroxide solution to adjust the pH of the gel solution C to 6.50, and add...

Embodiment 2

[0060] The pharmaceutical composition for the treatment of periodontitis of the present invention has the following compositions, all in mass percent:

[0061]

[0062] The preparation method of the pharmaceutical composition for the treatment of periodontitis of the present invention, the steps are as follows:

[0063] (1) Take purified water, add chitosan to it in portions under stirring condition, stir until dispersed evenly, then add carboxymethyl cellulose while stirring, stir until completely swollen to obtain gel solution A;

[0064] (2) Add poloxamer 407 evenly to the gel solution A obtained in step (1), stir and mix to completely wet the poloxamer 407 to obtain gel solution B;

[0065] (3) Add glycerin, Tween 80, chlorhexidine acetate, peppermint oil with a volume ratio of 4%, and phosphate buffer to the gel solution B obtained in step (2), stir and mix, and heat at a low temperature of 4°C Leave it overnight to make the gel fully swell to obtain gel solution C; ...

Embodiment 3

[0069] The pharmaceutical composition for the treatment of periodontitis of the present invention has the following compositions, all in mass percent:

[0070]

[0071]

[0072] The preparation method of the pharmaceutical composition for the treatment of periodontitis of the present invention, the steps are as follows:

[0073] (1) Take purified water, add chitosan to it in stages under stirring condition, stir until dispersed evenly, then add polyvinylpyrrolidone while stirring, stir until completely swollen to obtain gel solution A;

[0074] (2) Add poloxamer 407 evenly to the gel solution A obtained in step (1), stir and mix to completely wet the poloxamer 407 to obtain gel solution B;

[0075] (3) Add glycerin, Tween 80, chlorhexidine hydrochloride, peppermint oil with a volume ratio of 4%, and apple essence to the gel solution B obtained in step (2), stir and mix, and place at a low temperature of 4°C overnight , to make the gel fully swell to obtain gel solution ...

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Abstract

The invention relates to a pharmaceutical composition for treating periodontitis and a preparation method thereof, wherein the pharmaceutical composition comprises chlorhexidine or derivatives thereof, poloxamer 407, a release speed adjusting agent, a stabilizer and other additives. The pharmaceutical composition has particular physical characteristics; when the temperature reaches the gel point, the composition can undergo phase transition from liquid to semisolid gel; the composition is liquid at the room temperature; after being used, the composition changes into semisolid gel quickly under the human body temperature condition and then is adhered on the surface of periodontal mucosa to release the medicine, thus a therapeutic effect is obtained; the composition has specific controlled-release property, and can achieve a controlled-release effect of 4 to 5 days of sustained medicine release by adjusting types and dosages of the release speed adjusting agents, thereby reducing the medicine using times, and improving the medication compliance of patients; and the composition is good in stability, and convenient to produce, transport and store.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating periodontitis and a preparation method thereof. Background technique [0002] Periodontitis is the "number one killer" of oral health, and some early symptoms of periodontitis have also become the main feature of the deterioration of oral "sub-health". Periodontitis is a chronic inflammation that invades the gums and periodontal tissues. It is a destructive disease. Its main features are the formation of periodontal pockets and inflammation of the pocket walls, alveolar bone resorption and gradual loosening of teeth. It is the leading cause of adult Leading cause of tooth loss. The disease is mostly caused by bacterial plaque, calculus, food impaction, bad restorations, bite trauma, etc. The gums are inflamed and swollen, and the plaque accumulation is aggravated at the same time, and spread from supragingival to subg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61K9/06A61P1/02
Inventor 卢锦华苏宏瑞颜红冯永兵柳忠义
Owner SHENZHEN SOUTH CHINA PHARMA
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