Periodontitis is a common chronic inflammatory disease featured the destruction of connective tissue and osseous tissue, which often influences the supportive tissues around gingiva, periodontal membrane, alveolar bone and cementum and brings inflammatory damage to them which finally results in tooth loss, indigestion and systemic infection etc. This invention discloses a formula of health-care food for antibiotics, anti-inflammation, bone growth and prevention of periodontitis and its preparation method. The product consists of dried tangerine peel and hawthorn with effect of antibiotics, anti-inflammation and promoting bone growth, especially suitable for prevention and treatment of oral diseases such as periodontitis. It can be used to make hawthorn slices, hawthorn peels, gums, fructose, drinks and other hawthorn health-care products. It can also improve digestion, relieves cough, removes phlegm,reduces blood-lipid and blood-sugar, protects liver and heart. It is a health-care product applicable for people with sub health like indigestion, pulmonary heart disease, coronary heart disease, liver cirrhosis, diabetes and osteoporosis.