The invention discloses a method for simultaneously detecting the content of three photoinitiators in light-cured
denture base resin. The method comprises the following steps: leaching a cured resin sample by using
methanol as a
solvent to obtain a leaching solution; then separating and detecting the liquid to be detected by using an ultra-
high performance liquid chromatography-
mass spectrometry technology; and finally, performing quantitative analysis based on the
standard curve of each target object by adopting an external standard method. The method provided by the invention can be used for synchronously and accurately measuring the contents of three key photoinitiators, namely (2, 4, 6-trimethylbenzoyl) diphenyl
phosphine oxide, 2, 4, 6-trimethylbenzoyl-di (p-tolyl)
phosphine oxide and 3, 5-di-tert-butyl-4-
hydroxybenzoic acid hexadecyl ester, namely, (2, 4, 6-trimethylbenzoyl) diphenyl
phosphine oxide, 2, 4, 6-trimethylbenzoyl-di (p-tolyl)
phosphine oxide and 3, 5-di-tert-butyl-4-hexadecyl benzoate. The method has excellent
repeatability, high sensitivity and accurate quantification capability, the operation process is simple, convenient and rapid, and reliable
technical support is provided for monitoring the
biological safety and quality consistency of the photocuring denture material.