This invention relates to the field of biomaterials, specifically to the application of an acidic
hydrolysate of a
giant salamander mucus extract in the preparation of a
root surface treatment agent. The
root surface treatment agent comprises a product obtained by reducing lyophilized
powder of salamander
skin secretions with an acidic solution at a concentration of 0.2-0.3 mol / L and a pH of 1-5, wherein the
mass ratio of the lyophilized salamander
skin secretions to the acidic solution is (1-3):1; the resulting
root surface treatment agent, after adjustment with an alkaline solution, has a pH of 6-6.5. This root surface treatment agent demonstrates significant potential in promoting
natural tooth replantation and restoration, with effects including promoting early load stabilization through natural
wet bonding, assisting in the construction of a regenerative microenvironment through active proteins, and promoting adhesion between
periodontal ligament stem cells and the matrix by enhancing adhesion
signal expression.