48results about How to "Improve long-term efficacy" patented technology

Disclosed are a macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof. The bone restoration comprises a macroscopic pore metal structural body, a microscopic pore structural body and nanofibers. The appearance of the macroscopic pore metal structural body is consistent with an anatomic form of defect part bone tissues, the size of internal macroscopic pores is 300-1500 micrometers, porosity ranges from 50% to 90%, microscopic roughness Ra of pore walls is 5-30 micrometers, all the macroscopic pores are communicated with one another completely, mechanical property of the macroscopic pore metal structural body is compatible with that of the defect part bone tissues, compressive strength is 60-300MPa, and elasticity modulus is 0.5-30GPa. The microscopic pore structural body is positioned in the macroscopic pore metal structural body, internal microscopic pores are uniform in structure and are communicated with one another completely, the pore size is 50-250 micrometers, and pore walls of the microscopic pores consist of the nanofibers which are made of biodegradable polymer materials. The bone restoration perfectly integrates the anatomic form, the mechanical property and biological property and can be applied to treatment of large segmental bone defects of bearing parts clinically.

The invention discloses application of dihydromyricetin in preparing a medicine for preventing and treating untoward reactions in radiotherapy and chemotherapy of tumor. In particular, the application is to prepare medicines for preventing and treating untoward reactions in radiotherapy and chemotherapy of tumor, preventing and treating arrest of bone marrow and baldness, resisting mutation, preventing and treating the generation of secondary tumors, preventing and treating tumor transfer, and preventing and treating breast cancer, cervical carcinoma, intestinal cancer and the like. The invention creatively finds that the dihydromyricetin has the effects of removing free radicals, inhibiting reaction chains of the free radicals, resisting the mutation, inhibiting the expression of the tumor gene, causing the death of tumor cells, preventing and treating the tumor generation, preventing and treating the secondary tumors and the transfer of the secondary tumors and preventing and treating infection. Therefore, as the medicine for preventing and treating untoward reactions in radiotherapy and chemotherapy of tumor, the dihydromyricetin can inhibit and alleviate chemical damage, prevent and treat damage of a mutagen and further prevent gene mutation or the secondary tumors; and by combination with the radiotherapy and chemotherapy, the effects of preventing untoward reactions in radiotherapy and chemotherapy of tumor and preventing generation of tumors are achieved.

The invention discloses a medicine for treating esophageal cancer. The medicine comprises the following raw materials in part by weight: 9 to 15 parts of astragalus, 10 to 15 parts of tangerine peel, 8 to 13 parts of cinnamomvine, 16 to 20 parts of stir-fried chicken's gizzard-membrane with vingar, 8 to 12 parts of muscone, 6 to 10 parts of scorpion, 5 to 8 parts of centipede, and 7 to 10 parts of borneol. Active pharmaceutical ingredients are prepared from the Chinese medicines, and capsule is prepared by mixing the active pharmaceutical ingredients and starch. The medicine can soothe liver and regulate qi, promote blood circulation and remove blood stasis, and clear heat and remove toxicity, has an anticancer and pain-relieving effect and does not have toxic or side effect; and clinical experiment proves that the medicine has a good effect of treating the esophageal cancer.

The invention relates to a biliary tract support, which comprises tubular main body made from the material matched with body; the first protruded ring, the second protruded ring, and the extending part far away the second protruded ring, wherein the invention can avoid stitching match open, to save time, avoid directly function biliary tract match open with bile, without leakage, confirm enough blood supply, confirm successful flow of bile, and improve treatment effect.

The invention relates to a medicament for treating vascular headache, in particular to a medicament for treating vascular headache and a preparation method thereof. The medicament is prepared from the following raw material medicaments in part by weight: 12 to 15 parts of hemlock parsley, 12 to 15 parts of gastrodia tuber, 10 to 13 parts of chastetree fruit, 15 to 18 parts of white peony root, 10 to 13 parts of corydalis tuber, 15 to 18 parts of angelica root, 12 to 15 parts of red-rooted salvia, 13 to 16 parts of ligusticum, 9 to 12 parts of bupleurum, 2 to 5 parts of whole worm, 13 to 16 parts of jasmine, 10 to 13 parts of curcuma zedoary, and 3 to 5 parts of licorice root. The method for preparing the medicament comprises the following steps of: 1) preparing the raw material medicaments according to the proportion, removing impurities, and crushing into particles of about 100 meshes by using a traditional Chinese medicine crusher; 2) uniformly mixing the crushed medicinal powder and high quality honey with water; and 3) conglutinating the medicinal powder by using a traditional Chinese medicinal pill molding machine to prepare honey pills with weight of about 0.2g, drying by using a drier, and filling into a dry closed container. The traditional Chinese medicine is a medicament special for treating the vascular headache, is completely prepared from pure traditional Chinese medicines without toxic or side effect, and has quick response and long duration.

A nanoglue is formed with one or more bioadhesive polymers, one or more dendrimers, and optionally one or more therapeutic, prophylactic, or diagnostic agents. The bioadhesive polymers and dendrimers are modified with functional groups to permit crosslinking upon one or more stimuli, e.g., ultraviolet irradiation, and form hydrogel in situ at tissue sites. In the repair of corneal wounds, the nanoglue leads to improved rate of healing with less scarring and less inflammation, compared to non-treated cornea or ones treated with sutures. Therapeutic agents can be covalently conjugated to the precursor components and be delivered to specific eye compartments, providing a more efficacious treatment formulation of ocular disorders than delivering drugs in their free forms. Methods of making and using the hydrogel and hydrogel precursor compositions are also provided.

The invention discloses a gradually-expanding intravascular stent, which comprises a stent substrate constructed by a shape memory alloy and a mechanical impedance system formed by a biodegradable material, wherein the stent substrate is formed by weaving a shape memory alloy wire or formed by cutting and welding a shape memory alloy sheet, is extended along the axial direction, is shortened along the radial direction and is compounded with a biodegradable material to form an integrated compound structure. Due to the adoption of the gradually-expanding intravascular stent, gradual expansion of the intravascular stent and accurate control over an expansion process are realized, high mechanical adaptability is achieved for blood vessels in an expansion process, vessel injuries caused by intravascular stent expansion are relieved and eliminated to the maximum extent, the occurrence of restenosis in the intravascular stent is inhibited, and long-term curative effect of the intravascular stent is effectively enhanced; and the gradually-expanding intravascular stent can be applied to interventional therapy of cardiovascular diseases.

The invention provides a method for enabling bone cement to generate heat subsequently, which is used for enabling the bone cement to achieve the temperature, at which peripheral tumour cells are killed. The method for enabling the bone cement to generate heat subsequently disclosed by the invention comprises the following steps of: uniformly mixing powder of nano-gold and acrylic resin bone cement to form a mixture; pouring material liquid of the acrylic resin bone cement into the mixture, and sufficiently stirring till a drawing period or an early dough period; and, after the acrylic resin bone cement is solidified, irradiating a bone cement block by utilizing infrared ray according to survival or development conditions of the tumour cells. According to the invention, the bone cement and the nano-gold are mixed, so that the effects of strengthening and treating damaged bone tissue are taken; furthermore, by means of subsequent infrared irradiation, the internal bone cement achieves a certain temperature to kill the peripheral tumour cells; and thus, the long-term effect for treating bone tumours is improved.

The invention relates to uses of different positions of Salvia miltiorrhiza Bunge and Panax Notoginseng and combinations thereof in smooth muscle cell proliferation inhibition and coronary artery restenosis control, and concretely relates to Salvia miltiorrhiza Bunge and Panax Notoginseng extraction technologies, and uses of different positions of Salvia miltiorrhiza Bunge and Panax Notoginseng and combinations thereof in vascular smooth muscle cell proliferation inhibition and coronary artery expanding formation restenosis control. Experiments prove that 50%, 95%, a 50%+95% combination and a 50%+80%+95% combination in extract products of Salvia miltiorrhiza Bunge and Panax Notoginseng can effectively inhibit the proliferation of vascular smooth muscles and control the incrassation of balloon injury postoperative endangium; and the vascular smooth muscle proliferation inhibition and balloon injury postoperative endangium incrassation control effects of the 50%+95% combination and the 50%+80%+95% combination are better than that of the individual dosing of each of the positions.

The invention discloses a nano composition as well as a preparation method and application thereof. The nano composition comprises a biological surfactant, active ingredients, lipid and water. The biological surfactant is adopted in the nano composition, so that various high-concentration water-soluble active ingredients and / or non-water-soluble active ingredients can be effectively wrapped, so that the transdermal delivery of various active ingredients can be realized, multiple effects and / or synergistic interaction are realized, the transdermal absorption rate and bioavailability of the active ingredients are improved, the transdermal action time is shortened, the skin retention volume is increased, and the instant and long-acting effects are achieved.

The invention discloses application of total flavone of ampolopsis grossedentata in preparing medicines for preventing and treating untoward reaction in tumor radiation treatment and chemo-treatment, and in particular relates to application of the total flavone of ampolopsis grossedentata in preparing medicines for preventing and treating the untoward reaction in tumor radiation treatment and chemo-treatment, preventing and treating arrest of bone marrows and alopecia, having anti-mutagenic function, preventing and treating generation of secondary tumor and tumor metastasis, and preventing and treating breast carcinoma, cervical carcinoma, intestinal carcinoma and the like. The invention creatively finds out that the total flavone of ampolopsis grossedentata eliminates free radicals, inhibits free radical reaction chains, uses THT for anti-mutation, inhibits tumor gene expression and initiates tumor cell apoptosis so as to prevent and treat tumor generation, secondary tumor and tumor metastasis, uses the THT to inhibit virus transfection so as to prevent and treat infection, and realizes prevention, control or elimination of hazards or toxic hazards of chemical medicines and radiation on histiocyte and organs.

The invention discloses a vibrating device for urethral repair. The device comprises a metal probe and a machine body. The machine body comprises a shell, a power switch and a strength adjusting switch are installed on the surface of the shell, and a driver, a motor, a lithium battery and a circuit board are arranged in the shell. The lithium battery is used for supplying power to the motor. The circuit board, the power switch and the strength adjusting switch are matched and used for controlling starting and rotation frequency of the motor. The driver is connected with the motor and the metal probe and used for driving the metal probe to vibrate when the motor rotates. The vibrating device has the following advantages that the non-surgical urethral dilatation process is standardized, the treatment effect is guaranteed, automatic operation is achieved, treatment strength is adjusted according to types of patients, the long-term treatment effect of urethral stricture dilatation is improved, and the effect of gradually repairing the urethra is achieved. The learning curve of urethral dilatation is shortened and work efficiency is improved. By means of the device, non-surgical urethral dilatation treatment and repair serve as long-term means so as to achieve the aim of the long-term effect of non-surgical urethral stricture treatment.

The invention discloses an intelligent system preparation for dialectically conditioning physiques and preventing and treating various psoriasis and a preparation method. For different physiques and etiology, pathogenesis and skin lesion characteristics of various psoriasis, 62 traditional Chinese medicines such as astragalus mongholicus and the like are respectively adopted and are subjected to steps of decocting and the like to prepare different formula preparations; by external application to related acupoints of the upper part (the Dazhui acupoint), the middle part (the Danzhong acupoint,the Shenque acupoint and the Guanyuan acupoint), the lower part (double Xuehai acupoints, double ZuSanli acupoints, double Sanyinjiao acupoints and double Yongquan acupoints) and an affected part (theashi acupoint) and oral administration, a five-in-one integral conditioning and preventing-treating integrated system is formed; and the intelligent system preparation is depended on an automatic dynamic integral regulation and control mechanism of a five-organ-in-one system of a human body, and implements intelligent dialectical physique conditioning and prevention and treatment. The intelligentsystem preparation disclosed by the invention has the effects of dispersing and descending, regulating lung and skin, clearing heat and dispelling cold, relieving exterior syndromes and removing freckles, warming yang and strengthening kidney, promoting water circulation and removing dampness, activating blood and dissolving stasis, detoxifying and dredging collaterals, reinforcing qi and nourishing blood, and dispelling wind and arresting itching, and is used for conditioning physiques and preventing and treating various psoriasis.

An antalgic ointment for treating the rheumatalgia and the pain caused by lumber intervertebral disk protrusion and hyperosteogeny is composed of the ointment A prepared from 4 Chinese-medicinal materials including realgar, calomelas, etc. the ointment B prepared from 6 Chinese-medicinal materials including calcined gypsum, bormeol, menthol, etc, and the ointment C prepared from 8 Chinese-medicinal materials including Dragon's blood, myrrh, cloves, musk, etc.

PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.

The invention discloses a traditional Chinese medicine fuming and washing solution for treating external piles. The traditional Chinese medicine fuming and washing solution is prepared from, by weight, 6-9 parts of rhizoma alismatis, 3-7 parts of omei mountain bamboo juvenile leaves, 11-14 parts of herba euonymi, 4-7 parts of big rattlesnake plantain herb, 2-5 parts of roots or leaves or fruits of solanum incanum, 1-4 parts of perfoliote knotweed herb, 4.5-7.5 parts of roots of adenophora trachelioides, 3-6 parts of rhizomes of fagopyrum cymosum, 7-13 parts of clethra loosestrife herb, 6-12 parts of fruits of dahurian rose, 5-9 parts of centipedaplant herb, 6-11 parts of radix sophorae flavescentis, 4-7 parts of zostera marina and 3-7 parts of common ammannia herb. The traditional Chinese medicine fuming and washing solution has the advantages that medicine sources are easy to obtain, no adverse effect is caused after a person takes the traditional Chinese medicine fuming and washing solution, clinical use is safe, and the effects of radical cure, overall repair, treatment on both symptoms and root causes and no relapse after curing are truly achieved.

The invention discloses a purely natural external-applied Chinese medicinal medicine for curing anoxemic thighbone necrosis, comprising the following components in weight shares: S 75-100 shares, Cassia Bark 75-100 shares, Dahurian Angelica Root 30-50 shares, Ground Beetle 30-50 shares, Paniculate Swallowwort Root 30-50 shares, Cortex Acanthopanacis 30-50 shares, Dragon's Blood 30-50 shares, Frankincense 30-50 shares, Myrrha 30-50 shares, Rhubarb 30-50 shares, Radix Ampelopsis 30-50 shares, and Rice bean 30-50 shares. And the preparing steps comprise: crushing sulphur into 100-120 mesh powder at 20 deg.C-60 deg.C; crushing Dragon's Blood, Frankincense, and Myrrha into 100-120 mesh powder at-10 deg.C-0 deg.C; crushing Cassia Bark, Dahurian Angelica Root, Ground Beetle, Paniculate Swallowwort Root, Cortex Acanthopanacis, Rhubarb, Radix Ampelopsis, and Rice bean into 100-120 mesh powder at 60 deg.C-80 deg.C; mixing their powder, and mixing the mixed powder with prepared honey into plaster. The product is externally applied without being orally taken, absorbed through the skin, convenient, no-damage, fast curing, having short period of treatment, high-cure rate, good-curative effect for long time, no-toxicity and -side effect, and low cost. And the preparing process and devices are simple and easy to master.

The invention provides a method for enabling bone cement to generate heat subsequently, which is used for enabling the bone cement to achieve the temperature, at which peripheral tumour cells are killed. The method for enabling the bone cement to generate heat subsequently disclosed by the invention comprises the following steps of: uniformly mixing powder of nano-gold and acrylic resin bone cement to form a mixture; pouring material liquid of the acrylic resin bone cement into the mixture, and sufficiently stirring till a drawing period or an early dough period; and, after the acrylic resin bone cement is solidified, irradiating a bone cement block by utilizing infrared ray according to survival or development conditions of the tumour cells. According to the invention, the bone cement and the nano-gold are mixed, so that the effects of strengthening and treating damaged bone tissue are taken; furthermore, by means of subsequent infrared irradiation, the internal bone cement achieves a certain temperature to kill the peripheral tumour cells; and thus, the long-term effect for treating bone tumours is improved.

The present invention describes compounds of the formula: wherein R 芳基 is an aryl group; R 1 C is a straight or branched chain 2 -C 40 Hydrocarbyl group; R 2 for C 1 -C 4 Alkyl; R f is a perfluorinated group having an average of 3 to 5 carbon atoms; and the subscript x is 1 to 3.

Described are compounds of the formula shown in the specification, wherein RAryl is an aryl group; R1 is a linear or branched C2-C40 hydrocarbyl group; R2 is a C1-C4 alkyl; Rf is a perfluorinated group of having an average of 3 to 5 carbon atoms; and the subscript x is 1 to 3.

The invention provides a self-expanding tapered vascular stent applied to multiple stenosis of a tapered blood vessel, comprising a plurality of plaque contact areas and blood vessel contact areas; Both the plaque contact area and the blood vessel contact area respectively include multiple groups of corrugated supports, and the diameters of adjacent corrugated supports are reduced in equal proportions, so that the stent is tapered along the axial direction; each group of corrugated supports includes a plurality of unit waves; the present invention The sub-regional design is adopted to reduce the damage to the blood vessel after stent implantation. Compared with the blood vessel contact area, the plaque contact area has a shortened peak-to-valley length, increased rib thickness and rib width, and increased unit wave length. The number of waves is increased to enhance the radial support force. In addition, the stents in the plaque contact area are connected by rigid connectors, which enhances the circumferential rigidity of the stents. At the same time, there are several semicircular grooves in contact with blood on the inner surface of the vascular stent, so as to improve the blood flow in the vascular stent and prevent the occurrence of restenosis.

The present disclosure relates to treatment of topical lesion diseases by topical administration, uses of non-pathogenic cell-related components, and pharmaceutical compositions comprising non-pathogenic cell-related components. Specifically, the present disclosure relates to the application of a cell-related component as an active ingredient capable of providing a therapeutic effect including a synergistic effect in the treatment of a local lesion disease, a pharmaceutical composition comprising the cell-related component, and a pharmaceutical kit.

The invention provides a balloon-expandable vascular stent applied to multiple stenosis of round and straight blood vessels, comprising a plurality of plaque contact areas and blood vessel contact areas; the plaque contact areas and the blood vessel contact areas are staggered along the axial direction, and the plaque contact areas It includes multiple groups of corrugated supports and rigid connectors, the blood vessel contact area includes multiple groups of corrugated supports and flexible connectors, and each area is connected by flexible connectors to improve the flexibility of the stent. The invention adopts a sub-regional design to reduce the damage to blood vessels after stent implantation, and compared with the blood vessel contact area, the length of the unit wave peak to the trough in the plaque contact area is shortened, and the rib thickness and rib width are increased. And the number of unit waves is increased to enhance the radial support force. In addition, the stents in the plaque contact area are connected by rigid connectors, which enhances the circumferential rigidity of the stents. At the same time, there are several semicircular grooves in contact with blood on the inner surface of the vascular stent, so as to improve the blood flow in the vascular stent and prevent the occurrence of restenosis.

The present invention relates to the combination of the HDM2-p53 interaction inhibitor drug (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one [HDM201] and an anti-TIM-3 antibody molecule as TIM-3 inhibitor. The present invention further relates to the use of said combination in the treatment of cancer, in particular hematological tumors. The present invention further relates to dose and dosing regimen related to this combination cancer treatment.

The invention relates to a traditional Chinese medicine composition for treating brain tumor. The traditional Chinese medicine composition consists the following components by mass: 1-5 parts of arisacma consanguineum, 1-5 parts of pinellia ternata, 2-8 parts of seaweed, 2-8 parts of sea-tangle, 1-6 parts of rhizoma gastrodiae, 1-6 parts of fructus viticis, 1-6 parts by weight of pericarpium citrireticulatae, 2-8 parts of white atractylodes rhizome, 2-8 parts of poria cocos and 1-5 parts of rhizoma alismatis. The traditional Chinese medicine composition provided by the invention takes the arisacma consanguineum, the pinellia ternate, the seaweed and the sea-tangle as monarch drugs; through the pericarpium citri reticulatae, the white atractylodes rhizome, the poria cocos and the rhizoma alismatis, the spleen is tonified to guide clear Yang Qi to rise, and the dampness is eliminated to lead turbid Yin Qi to decline; and through enabling the gastrodia elata and the fructus viticis to dispel wind and leading the gastrodia elata and the fructus viticis to rise up, the traditional Chinese medicine composition acting on the brain tumor enters a brain through channel tropism so as to reach a lesion.

The invention provides a tibia intercondyloid spine fracture reduction fixing device which comprises reduction fixing pincers, a plurality of bone tunnel machining limiting plates and a fracture sheet pressing plate. The reduction fixing pincers are provided with a limiting frame used for being matched with the limiting plates. The fracture sheet pressing plate is provided with a guiding hole used for guiding a kirschner wire. A fracture sheet is provided with a limiting hole matched with the reduction fixing pincers. Compared with the similar design, the small and practical restoring and fixing pincers effectively improve the anatomical reduction efficiency and accuracy of the intercondyloid spine fracture sheet, the fracture sheet is pressed when bone tunnels are machined, and secondary dislocation is avoided when the bone tunnels are machined; moreover, the reduction fixing pincers provide inlets of the multiple bone tunnels and angle locating devices for surgeons to select, the generality of the reduction fixing pincers is improved, and the reduction fixing pincers can deal with tibia anatomic variation of multiple situations.