47results about How to "Improve long-term efficacy" patented technology

Disclosed are a macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof. The bone restoration comprises a macroscopic pore metal structural body, a microscopic pore structural body and nanofibers. The appearance of the macroscopic pore metal structural body is consistent with an anatomic form of defect part bone tissues, the size of internal macroscopic pores is 300-1500 micrometers, porosity ranges from 50% to 90%, microscopic roughness Ra of pore walls is 5-30 micrometers, all the macroscopic pores are communicated with one another completely, mechanical property of the macroscopic pore metal structural body is compatible with that of the defect part bone tissues, compressive strength is 60-300MPa, and elasticity modulus is 0.5-30GPa. The microscopic pore structural body is positioned in the macroscopic pore metal structural body, internal microscopic pores are uniform in structure and are communicated with one another completely, the pore size is 50-250 micrometers, and pore walls of the microscopic pores consist of the nanofibers which are made of biodegradable polymer materials. The bone restoration perfectly integrates the anatomic form, the mechanical property and biological property and can be applied to treatment of large segmental bone defects of bearing parts clinically.

The invention discloses application of dihydromyricetin in preparing a medicine for preventing and treating untoward reactions in radiotherapy and chemotherapy of tumor. In particular, the application is to prepare medicines for preventing and treating untoward reactions in radiotherapy and chemotherapy of tumor, preventing and treating arrest of bone marrow and baldness, resisting mutation, preventing and treating the generation of secondary tumors, preventing and treating tumor transfer, and preventing and treating breast cancer, cervical carcinoma, intestinal cancer and the like. The invention creatively finds that the dihydromyricetin has the effects of removing free radicals, inhibiting reaction chains of the free radicals, resisting the mutation, inhibiting the expression of the tumor gene, causing the death of tumor cells, preventing and treating the tumor generation, preventing and treating the secondary tumors and the transfer of the secondary tumors and preventing and treating infection. Therefore, as the medicine for preventing and treating untoward reactions in radiotherapy and chemotherapy of tumor, the dihydromyricetin can inhibit and alleviate chemical damage, prevent and treat damage of a mutagen and further prevent gene mutation or the secondary tumors; and by combination with the radiotherapy and chemotherapy, the effects of preventing untoward reactions in radiotherapy and chemotherapy of tumor and preventing generation of tumors are achieved.

The invention discloses a medicine for treating esophageal cancer. The medicine comprises the following raw materials in part by weight: 9 to 15 parts of astragalus, 10 to 15 parts of tangerine peel, 8 to 13 parts of cinnamomvine, 16 to 20 parts of stir-fried chicken's gizzard-membrane with vingar, 8 to 12 parts of muscone, 6 to 10 parts of scorpion, 5 to 8 parts of centipede, and 7 to 10 parts of borneol. Active pharmaceutical ingredients are prepared from the Chinese medicines, and capsule is prepared by mixing the active pharmaceutical ingredients and starch. The medicine can soothe liver and regulate qi, promote blood circulation and remove blood stasis, and clear heat and remove toxicity, has an anticancer and pain-relieving effect and does not have toxic or side effect; and clinical experiment proves that the medicine has a good effect of treating the esophageal cancer.

A nanoglue is formed with one or more bioadhesive polymers, one or more dendrimers, and optionally one or more therapeutic, prophylactic, or diagnostic agents. The bioadhesive polymers and dendrimers are modified with functional groups to permit crosslinking upon one or more stimuli, e.g., ultraviolet irradiation, and form hydrogel in situ at tissue sites. In the repair of corneal wounds, the nanoglue leads to improved rate of healing with less scarring and less inflammation, compared to non-treated cornea or ones treated with sutures. Therapeutic agents can be covalently conjugated to the precursor components and be delivered to specific eye compartments, providing a more efficacious treatment formulation of ocular disorders than delivering drugs in their free forms. Methods of making and using the hydrogel and hydrogel precursor compositions are also provided.

The invention relates to uses of different positions of Salvia miltiorrhiza Bunge and Panax Notoginseng and combinations thereof in smooth muscle cell proliferation inhibition and coronary artery restenosis control, and concretely relates to Salvia miltiorrhiza Bunge and Panax Notoginseng extraction technologies, and uses of different positions of Salvia miltiorrhiza Bunge and Panax Notoginseng and combinations thereof in vascular smooth muscle cell proliferation inhibition and coronary artery expanding formation restenosis control. Experiments prove that 50%, 95%, a 50%+95% combination and a 50%+80%+95% combination in extract products of Salvia miltiorrhiza Bunge and Panax Notoginseng can effectively inhibit the proliferation of vascular smooth muscles and control the incrassation of balloon injury postoperative endangium; and the vascular smooth muscle proliferation inhibition and balloon injury postoperative endangium incrassation control effects of the 50%+95% combination and the 50%+80%+95% combination are better than that of the individual dosing of each of the positions.

The invention discloses a nano composition as well as a preparation method and application thereof. The nano composition comprises a biological surfactant, active ingredients, lipid and water. The biological surfactant is adopted in the nano composition, so that various high-concentration water-soluble active ingredients and/or non-water-soluble active ingredients can be effectively wrapped, so that the transdermal delivery of various active ingredients can be realized, multiple effects and/or synergistic interaction are realized, the transdermal absorption rate and bioavailability of the active ingredients are improved, the transdermal action time is shortened, the skin retention volume is increased, and the instant and long-acting effects are achieved.

The invention discloses application of total flavone of ampolopsis grossedentata in preparing medicines for preventing and treating untoward reaction in tumor radiation treatment and chemo-treatment, and in particular relates to application of the total flavone of ampolopsis grossedentata in preparing medicines for preventing and treating the untoward reaction in tumor radiation treatment and chemo-treatment, preventing and treating arrest of bone marrows and alopecia, having anti-mutagenic function, preventing and treating generation of secondary tumor and tumor metastasis, and preventing and treating breast carcinoma, cervical carcinoma, intestinal carcinoma and the like. The invention creatively finds out that the total flavone of ampolopsis grossedentata eliminates free radicals, inhibits free radical reaction chains, uses THT for anti-mutation, inhibits tumor gene expression and initiates tumor cell apoptosis so as to prevent and treat tumor generation, secondary tumor and tumor metastasis, uses the THT to inhibit virus transfection so as to prevent and treat infection, and realizes prevention, control or elimination of hazards or toxic hazards of chemical medicines and radiation on histiocyte and organs.

The invention discloses a vibrating device for urethral repair. The device comprises a metal probe and a machine body. The machine body comprises a shell, a power switch and a strength adjusting switch are installed on the surface of the shell, and a driver, a motor, a lithium battery and a circuit board are arranged in the shell. The lithium battery is used for supplying power to the motor. The circuit board, the power switch and the strength adjusting switch are matched and used for controlling starting and rotation frequency of the motor. The driver is connected with the motor and the metal probe and used for driving the metal probe to vibrate when the motor rotates. The vibrating device has the following advantages that the non-surgical urethral dilatation process is standardized, the treatment effect is guaranteed, automatic operation is achieved, treatment strength is adjusted according to types of patients, the long-term treatment effect of urethral stricture dilatation is improved, and the effect of gradually repairing the urethra is achieved. The learning curve of urethral dilatation is shortened and work efficiency is improved. By means of the device, non-surgical urethral dilatation treatment and repair serve as long-term means so as to achieve the aim of the long-term effect of non-surgical urethral stricture treatment.

The invention discloses an intelligent system preparation for dialectically conditioning physiques and preventing and treating various psoriasis and a preparation method. For different physiques and etiology, pathogenesis and skin lesion characteristics of various psoriasis, 62 traditional Chinese medicines such as astragalus mongholicus and the like are respectively adopted and are subjected to steps of decocting and the like to prepare different formula preparations; by external application to related acupoints of the upper part (the Dazhui acupoint), the middle part (the Danzhong acupoint,the Shenque acupoint and the Guanyuan acupoint), the lower part (double Xuehai acupoints, double ZuSanli acupoints, double Sanyinjiao acupoints and double Yongquan acupoints) and an affected part (theashi acupoint) and oral administration, a five-in-one integral conditioning and preventing-treating integrated system is formed; and the intelligent system preparation is depended on an automatic dynamic integral regulation and control mechanism of a five-organ-in-one system of a human body, and implements intelligent dialectical physique conditioning and prevention and treatment. The intelligentsystem preparation disclosed by the invention has the effects of dispersing and descending, regulating lung and skin, clearing heat and dispelling cold, relieving exterior syndromes and removing freckles, warming yang and strengthening kidney, promoting water circulation and removing dampness, activating blood and dissolving stasis, detoxifying and dredging collaterals, reinforcing qi and nourishing blood, and dispelling wind and arresting itching, and is used for conditioning physiques and preventing and treating various psoriasis.

The invention discloses an artificial crown for a maxillary molar. The crown comprises a combined crown prosthesis, wherein an overflow groove is arranged at the gingival end of the combined crown prosthesis, and is used for cleaning the gingival end of the combined crown prosthesis. During use, a channel with two ends communicating with the oral cavity is formed between the overflow groove and the gingiva. The overflow groove is preferably mesial-distal; and during use, the overflow groove is located between the palatine root and the mesiobuccal and distobuccal roots, and the proximal and distal ends of the overflow groove are both palatally presented. By designing the overflow groove at the gingival end, the artificial crown for the maxillary molar is good for self-cleaning of teeth, canremove hidden plaque and tartar, control periodontitis and prevent root caries, and the long-term curative effect of dental root bisection of the maxillary molar is improved.

The invention discloses a traditional Chinese medicine fuming and washing solution for treating external piles. The traditional Chinese medicine fuming and washing solution is prepared from, by weight, 6-9 parts of rhizoma alismatis, 3-7 parts of omei mountain bamboo juvenile leaves, 11-14 parts of herba euonymi, 4-7 parts of big rattlesnake plantain herb, 2-5 parts of roots or leaves or fruits of solanum incanum, 1-4 parts of perfoliote knotweed herb, 4.5-7.5 parts of roots of adenophora trachelioides, 3-6 parts of rhizomes of fagopyrum cymosum, 7-13 parts of clethra loosestrife herb, 6-12 parts of fruits of dahurian rose, 5-9 parts of centipedaplant herb, 6-11 parts of radix sophorae flavescentis, 4-7 parts of zostera marina and 3-7 parts of common ammannia herb. The traditional Chinese medicine fuming and washing solution has the advantages that medicine sources are easy to obtain, no adverse effect is caused after a person takes the traditional Chinese medicine fuming and washing solution, clinical use is safe, and the effects of radical cure, overall repair, treatment on both symptoms and root causes and no relapse after curing are truly achieved.

Described are compounds of the formula shown in the specification, wherein RAryl is an aryl group; R1 is a linear or branched C2-C40 hydrocarbyl group; R2 is a C1-C4 alkyl; Rf is a perfluorinated group of having an average of 3 to 5 carbon atoms; and the subscript x is 1 to 3.

The invention relates to a traditional Chinese medicine composition for treating brain tumor. The traditional Chinese medicine composition consists the following components by mass: 1-5 parts of arisacma consanguineum, 1-5 parts of pinellia ternata, 2-8 parts of seaweed, 2-8 parts of sea-tangle, 1-6 parts of rhizoma gastrodiae, 1-6 parts of fructus viticis, 1-6 parts by weight of pericarpium citrireticulatae, 2-8 parts of white atractylodes rhizome, 2-8 parts of poria cocos and 1-5 parts of rhizoma alismatis. The traditional Chinese medicine composition provided by the invention takes the arisacma consanguineum, the pinellia ternate, the seaweed and the sea-tangle as monarch drugs; through the pericarpium citri reticulatae, the white atractylodes rhizome, the poria cocos and the rhizoma alismatis, the spleen is tonified to guide clear Yang Qi to rise, and the dampness is eliminated to lead turbid Yin Qi to decline; and through enabling the gastrodia elata and the fructus viticis to dispel wind and leading the gastrodia elata and the fructus viticis to rise up, the traditional Chinese medicine composition acting on the brain tumor enters a brain through channel tropism so as to reach a lesion.

The invention provides a tibia intercondyloid spine fracture reduction fixing device which comprises reduction fixing pincers, a plurality of bone tunnel machining limiting plates and a fracture sheet pressing plate. The reduction fixing pincers are provided with a limiting frame used for being matched with the limiting plates. The fracture sheet pressing plate is provided with a guiding hole used for guiding a kirschner wire. A fracture sheet is provided with a limiting hole matched with the reduction fixing pincers. Compared with the similar design, the small and practical restoring and fixing pincers effectively improve the anatomical reduction efficiency and accuracy of the intercondyloid spine fracture sheet, the fracture sheet is pressed when bone tunnels are machined, and secondary dislocation is avoided when the bone tunnels are machined; moreover, the reduction fixing pincers provide inlets of the multiple bone tunnels and angle locating devices for surgeons to select, the generality of the reduction fixing pincers is improved, and the reduction fixing pincers can deal with tibia anatomic variation of multiple situations.