A method for bone cement to subsequently generate heat

A bone cement and follow-up technology, applied in medical science, prosthesis and other directions, can solve the problems of poor treatment effect, lower polymerization heat temperature, and unsatisfactory release effect, so as to improve long-term efficacy and good biocompatibility. Effect

Active Publication Date: 2016-01-20
山东上品医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The heat of polymerization of acrylic resin bone cement in the body decreases quickly, and drops to the temperature of the human body after 1 to 3 minutes, so the therapeutic effect on tumors is limited
Acrylic resin bone cement has no bioactivity and degradability, and acrylic resin bone cement has no bioactivity and degradability, and most antitumor drugs are embedded in the deep part of the bone cement and cannot be released, resulting in the treatment of bone tumors. not effectively
Patent CN101288781B discloses a method for promoting the local drug release of antibiotic-loaded bone cement, and the drug release effect is not satisfactory after verification
and will 125 I is mixed into bone cement, and bone tumors are treated by internal radiation, because 125 The limitation of the irradiation radius of I and the uncertainty of particle distribution, and 125 I has a half-life and the overall therapeutic effect is not good

Method used

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  • A method for bone cement to subsequently generate heat
  • A method for bone cement to subsequently generate heat
  • A method for bone cement to subsequently generate heat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Group 1: Acrylic resin bone cement powder 20g and 0.5mg gold nanorods are fully stirred and mixed, 10ml of liquid material is added, and fully stirred until the late stage of drawing or the early stage of the dough, injected into a cylindrical mold with a diameter of 1.5cm, and the test temperature range is inserted 0~200℃ thermometer.

[0026] Group 2: Another 20g of acrylic resin bone cement powder is directly added to 10ml of acrylic resin bone cement liquid material, then injected into a cylindrical mold with a diameter of 1.5 cm, and inserted into a thermometer with a test temperature range of 0 to 200°C.

[0027] Record the temperature changes of the two separately, see for specific results figure 1 . The results show that there is no difference between bone cement and ordinary bone cement added with gold nanorods, and gold nanorods have no effect on the heat release of bone cement polymerization.

Embodiment 2

[0028] Example 2: In vitro temperature release of gold nanorods of different concentrations

[0029] Mix 20g of acrylic resin bone cement powder with 0.1mg~0.6mg gold nanorods to form a mixture; pour 10ml of acrylic resin bone cement liquid into the above mixture, fully stir until the drawing period or the early stage of the dough, the injection diameter is A 1.5cm cylindrical mold is formed, and a thermometer with a test temperature range of 0~200℃ is inserted; after the acrylic resin bone cement is cured for 24 hours, it is irradiated with infrared rays, and the wavelength of the infrared rays is 550nm~1550nm. The diameter of the gold nanorods is 10-40nm and the length is 30nm-100nm. figure 2 The energy of surface infrared light can be converted into heat by nano-gold, which increases the heat temperature of bone cement polymerization.

Embodiment 3

[0030] Example 3: The mechanical strength of different concentrations of gold nanorods and ordinary bone cement

[0031] Acrylic resin bone cement powder 20g is mixed with 0.1mg, 0.3mg and 0.5mg gold nanorods respectively, and 10ml acrylic resin bone cement powder is added, and it is fully stirred until the late stage of drawing or the early stage of dough, and the injection diameter is 1.5cm cylinder The shaped mold is formed, and a thermometer with a test temperature range of 0~200℃ is inserted. After curing the acrylic resin bone cement for 24 hours, irradiate the infrared laser generator and the acrylic resin bone cement block at a distance of 15cm. The temperature of the three changes can be seen image 3 . The results show that the rate and degree of temperature increase of acrylic resin bone cement are closely related to the amount of gold nanorods added. .

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Abstract

The invention provides a method for enabling bone cement to generate heat subsequently, which is used for enabling the bone cement to achieve the temperature, at which peripheral tumour cells are killed. The method for enabling the bone cement to generate heat subsequently disclosed by the invention comprises the following steps of: uniformly mixing powder of nano-gold and acrylic resin bone cement to form a mixture; pouring material liquid of the acrylic resin bone cement into the mixture, and sufficiently stirring till a drawing period or an early dough period; and, after the acrylic resin bone cement is solidified, irradiating a bone cement block by utilizing infrared ray according to survival or development conditions of the tumour cells. According to the invention, the bone cement and the nano-gold are mixed, so that the effects of strengthening and treating damaged bone tissue are taken; furthermore, by means of subsequent infrared irradiation, the internal bone cement achieves a certain temperature to kill the peripheral tumour cells; and thus, the long-term effect for treating bone tumours is improved.

Description

Technical field [0001] The invention relates to the release of heat from bone cement, in particular to a method for releasing heat from bone cement, which is applied to the fields of primary and secondary malignant bone tumors of vertebral bodies, long bones, and irregular bones. Background technique [0002] The number of patients with tumors is increasing, and the corresponding primary and secondary malignant tumors of the bones correspondingly increase. Bone tumors destroy and dissolve the bone tissues, resulting in the reduction or disappearance of the weight-bearing capacity of the bones, causing severe pain and mobility disorders; the bone tissues are destroyed and formed at the lesions. Soft tissue masses invade normal tissues and nerves through space-occupying effect or direct infiltration, affecting the patient's mobility and even causing paraplegia. Bone tumors seriously affect the quality of life of patients and threaten their lives at all times. Conventional radiothe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/50
Inventor 孙钢刘训伟钟建李敏彭湘涛王志国
Owner 山东上品医疗器械有限公司
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