The invention is a space-simulated seed mutagenic device, comprising an X-ray generator (1), a microwave generator (2), an ultraviolet generator (3), an ultrasonic generator (4), a gamma-ray generator (5), a valve (6), an external storehouse (7), an internal storehouse (8), an air blower (9), a fixed frame (10) and a sealing board (11); the external storehouse (7) and the internal storehouse (8) are spheroidal and are provided with an air-tight door which is open and the sealing board (11) is arranged between the external storehouse (7) and the internal storehouse (8); the sealing board (11), the external storehouse (7) and the internal storehouse (8) form a seal cavity; the internal storehouse (8) is provided with a hole; the external storehouse (7) is provided with the valve (6), and the X-ray generator (1), the microwave generator (2), the ultraviolet generator (3), the ultrasonic generator (4) and the gamma-ray generator (5) are arranged in the external storehouse (7); the fixed frame (10) is provided with a cavity, and an air inlet which is connected with the air blower (9) is arranged at the bottom of the fixed frame (10); the external storehouse (8) is arranged in the cavity of the fixed frame (10); therefore, the mutagen can be concentrated in one channel for radiating the seeds in an all-round way and the injury on the seeds is little.