The invention relates to a graphene electronic nose-based reusable breath detector, which includes a breath collection device, an elastic wearable, a left air intake filter box, a right air intake filter box, and a one-way breathable valve. The detector with this structure can not only use the graphene sensor to analyze and judge the abnormal smell produced by the user's breathing, but also the cell mutation and the stretching stress of the oral cavity converted into the change of electricity, so as to realize the abnormality of the user's health. Conditions, as well as the detection of respiratory conditions, and can be used for clinical large data sample analysis. At the same time, the accumulation of low-cost, high-throughput, and large-sample data is conducive to the discovery of new disease biomarkers. The detector provides users with a portable, non-invasive, fast, sensitive, accurate, cheap, and repeatable wearable The detection equipment can monitor the air externally, detect diseases including early cancer internally, and accurately perceive and store the user's health data, which has a wider range of applications.