130 results about "Membrane integrity" patented technology

Stress of a silicon nitride layer may be enhanced by deposition at higher temperatures. Employing an apparatus that allows heating of a substrate to substantially greater than 400° C. (for example a heater made from ceramic rather than aluminum), the silicon nitride film as-deposited may exhibit enhanced stress allowing for improved performance of the underlying MOS transistor device. In accordance with alternative embodiments, a deposited silicon nitride film is exposed to curing with ultraviolet (UV) radiation at an elevated temperature, thereby helping remove hydrogen from the film and increasing film stress. In accordance with still other embodiments, a silicon nitride film is formed utilizing an integrated process employing a number of deposition / curing cycles to preserve integrity of the film at the sharp corner of the underlying raised feature. Adhesion between successive layers may be promoted by inclusion of a post-UV cure plasma treatment in each cycle.

Stress of a silicon nitride layer may be enhanced by deposition at higher temperatures. Employing an apparatus that allows heating of a substrate to substantially greater than 400° C. (for example a heater made from ceramic rather than aluminum), the silicon nitride film as-deposited may exhibit enhanced stress allowing for improved performance of the underlying MOS transistor device. In accordance with some embodiments, a deposited silicon nitride film is exposed to curing with plasma and ultraviolet (UV) radiation, thereby helping remove hydrogen from the film and increasing film stress. In accordance with other embodiments, a silicon nitride film is formed utilizing an integrated process employing a number of deposition / curing cycles to preserve integrity of the film at the sharp corner of the underlying raised feature. Adhesion between successive layers may be promoted by inclusion of a post-UV cure plasma treatment in each cycle.

The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of biguanides (metformin) and / or sulfonylureas in the prevention and treatment of insulin resistance and diabetes mellitus, alone or in combination, as a nutrient for humans. The carefully chosen active ingredients of the invention are designed in a modular fashion to prevent and rectify adverse events associated with insulin resistance syndrome and diabetes mellitus, and with the clinical use of biguanides (metformin) and / or the sulfonylureas. These modules are: (1) Mitochondrial Metabolic Group, (2) Plasma and Mitochondrial Membrane Integrity Group, (3) Nocturnal Group and, (4) Insulin Alternative Group. When used in concert with a biguanide, a sulfonylurea or with a combination of both, the invention will broaden the clinical usefulness of these drugs. The invention will retard the progression of insulin resistance to type 2 diabetes, and reduce the serious microvascular and macrovascular complications commonly associated with insulin resistance syndrome and diabetes mellitus.

The invention relates to a gas sensor and its method of manufacture.Electrochemical gas sensors usually comprise an external housing, which acts as a reservoir for electrolyte; a wick to keep electrodes wetted with the electrolyte and external electrical terminals, for making electrical contact with the electrodes. Typically a gas permeable / microporous membrane has been used to seal a gas sensor in order to prevent leakage of electrolyte. A problem with existing sensors has been that there was a risk of electrolyte leaking through the membrane around the region where electrical connectors passed therethrough.The present invention overcomes this by providing a method of urging conductive polymer through the membrane under controlled conditions of heat and pressure, thereby ensuring the integrity of the membrane remains in tact while defining an electrically / conductive pathway therethrough.

The invention provides a sulfur-nitrogen dual-doped graphene nano material. A preparation method of the sulfur-nitrogen dual-doped graphene nano material comprises the following steps: mixing a sulfur nitrogen precursor and graphene oxide to obtain a mixture I, adding the mixture I into ethanol, ultrasonically and uniformly dispersing, and drying at 40 to 90 DEG C, thus obtaining a composite of the graphene oxide and the sulfur nitrogen precursor; and standing the composite of the graphene oxide and the sulfur nitrogen precursor at a high temperature of 800 to 1000 DEG C for 1 to 5 hours under the protection of inert gas, then naturally cooling to the room temperature, and obtaining a final product. The preparation method is low in cost; by combining a two-dimensional structure of the graphene and doping-induced polarity active site, the conductivity of a positive electrode of a lithium sulfur battery is remarkably improved, the loss and reutilization of polysulfide are improved, and when the prepared sulfur nitrogen dual-doped graphene nano material is used as a multifunctional interlayer material to be applied to the lithium sulfur battery, the conductivity of the sulfur positive electrode and the completeness of a protection diaphragm under large current can be remarkably improved, and the applicability is high.

The invention relates to a production method of a hollow fiber membrane, in particular to a hollow fiber membrane in an asymmetric network pore structure and the preparation method thereof. According to the technical proposal of the invention, the hollow fiber membrane of the asymmetric network pore structure comprises an endodermis, an exodermis and a support layer between the endodermis and the exodermis. The hollow fiber membrane is characterized in that: the hollow fiber membrane is the hollow fiber membrane of an inter compression type with the aperture of the exodermis being 0.5 to 20 times more than that of the endodermis; or the hollow fiber membrane is the hollow fiber membrane of an outside-in type with the aperture of the endodermis being 0.5 to 20 times more than that of the exodermis. The preparation method of the hollow fiber membrane in the asymmetric network pore structure employs a dry-wet spinning process. The hollow fiber membrane prepared by the method is characterized in the high working pressure bearing capacity, good membrane integrity, high membrane flux, high separation accuracy and so on.

The invention relates to a diluent of frozen semen of a milk goat, and a preparation method and a diluting method thereof as well as a preparation method of frozen semen of the milk goat in a thin pipe. In an existing frozen semen storage method, sperms are struck by low temperature to cause structure change of plasmalemma, so that the integrity of the plasmalemma and the survival rate and the fertility of the sperms after resuscitation are seriously influenced. The preparation method is characterized in that thin-pipe freezing treatment with two-step dilution and balancing and two-step cooling is carried out on fresh semen, wherein a basic diluent is prepared from Tris, citric acid, glucose, trehalose, Vc, GSH, BSA, ATP, compound antibiotic, yolk and water; a frozen diluent is prepared from the basic diluent and glycerinum; the diluent is utilized for diluting and balancing the fresh semen, and the fresh semen is sub-packaged in thin pipes and is stored in liquid nitrogen. According to the invention, the effects of low-temperature storage and freezing storage of the frozen semen of the milk goat is good, the survival rate, the integration rate of acrosome and the integrity of the plasmalemma of the semen after unfreezing are effectively increased, the aberration rate is reduced and the production efficiency and the quality of the frozen semen of the milk goat are improved.

The present invention relates to a novel nasal formulation for the treatment and prophylaxis of nasal congestion. When an infant is born, its nasal passages are relatively sterile, in time the nasal passages are colonized by fungi, molds and other organisms which compromise the integrity of the nasal and paranasal mucosa. The presence of these organisms elicits a mild chronic inflammatory reaction of the nasal and paranasal mucosa, in some cases leading to congestion and excess production of mucus. This chronic inflammatory process compromises the integrity of the nasal and paranasal mucosa, making it more vulnerable to binding with allergens and other invading organisms such as the rhinovirus. The purpose of this invention is to establish a treatment and prophylaxis of nasal congestion, which will control the presence of the invading organisms in the nasal and paranasal mucosa, reducing congestion as well as mucus production. By reducing the mild chronic inflammation in the nasal passages, prophylaxis with this nasal formulation passively reestablishes the integrity of the nasal and paranasal mucosa, thereby reinforcing the body's defenses against the implantation of allergens and of organisms such as the rhinovirus.

The present invention relates to a multiparticulate tablet with improved gastro-protection comprising at least a pharmaceutically active substance in the form of enteric coated particles, and a mixture of tableting excipients, wherein the said mixture of excipients comprising xylitol and / or maltitol, each in a directly compressible form, a disintegrating agent, a lubricant and at least one other diluent and the ratio of a) the xylitol and / or the maltitol to b) the other diluent(s) is less than 5 / 95 (weight / weight) and the result of the “test of integrity of the film” is greater than 95%, preferably greater than 97% and more preferably still greater than 99% and the result of the “release test” is greater than 90%, preferably greater than 95%. According to one embodiment of the invention, the active substance is omeprazole or esomeprazole. According to another embodiment the tablet is a disintegratable tablet, which disintegrate in the mouth with or without chewing. The invention also comprises a process for preparing the claim tablet and its use in medicine.

The invention discloses a tobacco half-film-covering cultivation method. According to the method, a mulching film is covered on the top of a ridge, and then planting holes for cultivation of tobacco seedlings are punched on the edges of the mulching film on the shoulder part of the ridge. The tobacco half-film-covering cultivation method has the advantages that tobacco is planted in a one ridge and double-line mode, and therefore transplanting between a wide line and a narrow line is achieved, ventilation and photopermeability of the tobacco at later stage are benefited, and tobacco leaf quality is improved; in the later stage growing process of the tobacco, the root system is located in the film and outside the film at the same time, and therefore characteristics of moisture preservation in the droughty situation and drainage in the rain-waterlogging situation are combined, and normal growing of the tobacco is benefited; the edges of the mulching film are connected with base fertilizer, the root system of the tobacco is close to and in contact with the mulching film and the base fertilizer, and therefore rain water can flow to the periphery of the root system easily along the film to dissolve the fertilizer and moisten the root system of the tobacco, the utilizing rate of the fertilizer is improved, and root system development and tobacco growing are promoted; and as the edges of the mulching film is adjacent to the basal part of the stem of the tobacco, when people stand on the ridge to uncover the film, the completeness of the mulching film is guaranteed, recycling efficiency of the mulching film is improved, and white pollution is effectively reduced.

The integrity test method applied to hollow-fibre filtration membranes are of the type with an internal skin, the concentrate compartment (J) being formed by the lower part of the hollow fibres and the permeate compartment (K) being formed by the part on the outside of the hollow fibres; a pressurized gas is made to flow through the concentrate compartment (J) for draining the hollow fibres, which are open at their ends; the method starts by leaving the permeate compartment (K) to the atmosphere, so as to allow the liquid on the surface of the membrane to migrate through the membrane; the permeate compartment (K) is then isolated; the pressure rise in the permeate compartment (K), caused by the circulation of gas in the concentrate compartment (J) and the flow of gas towards the permeate compartment, is measured; and, after a defined time, the pressure rise is compared with that observed when an integral membrane is used.

The invention relates to accelerated mixed gas integrity testing methods, devices, and systems for integrity testing wetted single and multi-layered porous materials, whereby the testing method is non-destructive to the porous materials being tested. The accelerated mixed gas integrity test method includes one or more of the following components: i) a permeate side gas purge component; ii) a permeate side volume reduction component; and iii) a permeate side circulation component. The invention is directed towards reducing the length of time necessary to complete the integrity testing of single and multi layered porous materials, elements and membranes.

The invention discloses a lithium battery diaphragm and a preparation method, and belongs to the technical field of a battery diaphragm and a manufacturing method. The lithium battery diaphragm is a three-layer composite diaphragm, a track etch membrane is used as a base material, a high-temperature-resisting layer is compounded on the track etch membrane, a hot closed layer is compounded on the high-temperature-resisting layer, the high-temperature-resisting layer can resist the high temperature of more than 200 DEG C, and a melting point of the hot closed layer is 100 to 130 DEG C. The method comprises the following steps of blade coating the high-temperature material on the track etch membrane, and standing the track etch membrane; and quickly blade coating the hot closed material at a molten state outside the high-temperature-resisting material, and continuously solidifying the material at the room temperature to obtain the lithium battery diaphragm. The composite diaphragm is heated to 200 DEG C, the track etch membrane layer is basically molten, the high-temperature-resisting layer still can form a film, so that high heat stability can be realized; and moreover, in the charging and discharging process, even when the organism bottom membrane is molten, the high-temperature-resisting layer still can maintain the completeness of the diaphragm, the large-area positive / negative electrode short-circuit phenomenon can be prevented, and the safety of the battery can be improved.

A method for recombinantly expressing a macromolecule in a host cell is disclosed which involves culturing a host cell which contains two nucleic acid sequences, i.e., a first nucleic acid sequence encoding a membrane-permeabilizing agent and a second nucleic acid sequence encoding a desired macromolecule under the operative control of an inducible promoter, to a selected cell density that permits accumulation of the agent. Thereafter the host cell is exposed to an environmental condition that induces the agent to disrupt the integrity of the cell membrane without complete lysis of the cell membrane. The host cell thereby allows transport through the membrane of small molecular weight compounds. These resulting host cells are cultured in the presence of a nutrient cocktail that contains components that can transport through the disrupted cell membrane, e.g., an inducing agent that induces the tightly regulated promoter and metabolic requirements that permit expression of the macromolecule.

A multi-purpose contact lens care solution having high antimicrobial activity comprising, in an aqueous liquid medium, cetylpyridinium chloride and a non-ionic surfactant. In one embodiment of the invention, the non-ionic surfactant is a poly(oxypropylene)-poly(oxyethylene) block copolymer. The solution may optionally also include additional antimicrobial components, a buffer component, a viscosity inducing component, a surfactant, taurine, propylene glycol and / or a tonicity component. This solution additionally prevents losses in ocular tissue membrane integrity during contact lens wear.

With only 19 amino acids, Duramycin is the smallest known polypeptide that has a defined 3-dimmensional binding structure. Duramycin binds Phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. As an abundant binding target, PtdE is a major phospholipid and accounts for about 20 % of the phospholipid content in mammalian cellular membranes. PtdE is externalized to the surface of apoptotic cells, and also becomes accessible in necrotic cells due to compromised plasma membrane integrity. Given the unique physicochemical properties of Duramycin and the availability of PtdE in acute cell death, the goal of this study is to develop and evaluate 99mTc-HYNIC-Duramycin as a novel molecular probe for imaging PtdE. 99mTc-HYNIC-Duramycin is a low-molecular weight, fast-clearing radiopharmaceutical that detects apoptosis / necrosis by binding to PtdE. The goal was to quantify the uptake of 99mTc-HYNIC-Duramycin in the area-at-risk after myocardial ischemia and reperfusion, and to determine the window of detection.

The invention relates to a bacterial capsule staining method, comprising the steps: 1) dropping a droplet of sterile water on a glass slide; 2) bacteria culturing for 24 to 48 hours, selecting the bacteria with a transfering loop, and slowly coating the glass slide in water moisture state spirally from the center to the outside to keep the capsule complete; 3) natural drying or blow drying with electric wind; 4) dropping 2-3 droplets of pure methanol, fixing for 1-2 minutes, and inclining to remove the methanol; 5) dropping carbolic acid fuchsin to stain for 1-3 minutes, and covering a cover glass; and 6) absorbing the liquid surrounding the cover glass with a piece of absorbent paper, inclining the slide glass to absorb partial staining liquid under the cover glass. By improvement on the slide making method, the staining method and the operation steps, the completeness of bacterial capsule is effectively kept, the growing state of all the bacterial capsule in the specimen can be clearly displayed, the operation difficulty of capsule staining is obviously reduced, and the reliability of bacterial capsule recognition is improved.

An underground water guiding and draining system under an impermeable membrane of an industrial waste residue storage yard is arranged in a mountain body (20) below a impermeable membrane (10) in a storage yard, and comprises a main guiding-leaking blind ditch (30), a branch guiding-leaking blind ditch (40) and a water guiding blind ditch (50), wherein the main guiding-leaking blind ditch is arranged at the lowest position of a valley, and the length of the main guiding-leaking blind ditch extends to the downstream of the storage yard along the tail end of the storage yard; the branch guiding-leaking blind ditch is arranged by surrounding the storage yard along the hillside surrounding the storage yard, a plurality of leaking water grooves for containing water leaking from the hillside are arranged on a guiding-leaking pipe in the branch guiding-leaking blind ditch, and a water outlet is arranged at one end of the branch guiding-leaking blind ditch positioned at the downstream of the storage yard; and the branch guiding-leaking blind ditch and the main guiding-leaking blind ditch are communicated with each other by a plurality of water guiding blind ditches or solid-wall HDPE (High-Density Polyethylene) water guiding pipes, which are arranged at intervals. The underground water guiding and draining system forms spider net shape under the impermeable membrane of the waste residue storage yard, so that underground water can be drained effectively, the support force on the impermeable membrane caused by underground water can be reduced, the upheaval and cracking of the impermeable membrane can be prevented, so that the completeness of the impermeable membrane can be kept, and the impermeable function of the impermeable membrane can be guaranteed.

The invention relates to a difunctional coated diaphragm for lithium ion batteries and a preparation method thereof. With a porous polyolefin diaphragm as a substrate, inorganic matter particles witha cation exchange function and high-temperature stability are used for being coated on one side or both sides of the porous polyolefin diaphragm. The coated lithium ion battery diaphragm has the following advantages: on one hand, because of the high thermal stability of the inorganic matter, a polymer is melted under high temperature, while the existence of the inorganic matter keeps the integrityof the lithium ion battery diaphragm, and therefore the high-temperature resistance of the diaphragm can be improved; in addition, the inorganic matter coated on the surface can adsorb divalent ironions released in the cyclic process of the lithium iron phosphate of the anode of a lithium ion battery, preventing the divalent iron ions from being diffused into the cathode and reduced into iron element to cause battery micro-short-circuiting, consequently, the capacity of the lithium ion battery can be kept for a long time, and safety problems, such as spontaneous combustion, which can be possibly caused by micro-short-circuiting are prevented.

The invention relates to the field of metal surface treatment, and particularly relates to a process of silane-zirconium salt conversion treatment before metal cathode electrophoresis coating. A technology of silane-zirconium salt conversion treatment before cathode electrophoresis coating is adopted, i.e. a silanization treatment technology and a zirconium salt conversion technology are successfully fused, so that silane and a zirconium salt conversion film are hybridized, thus forming a silane-zirconium salt conversion hybrid film on the metal surface. Compared with the simple zirconium salt conversion film, the corrosion resistance (especially the alkali resistance) of the hybrid film is greatly enhanced, thereby ensuring the integrity of the zirconium salt conversion film under an alkaline environment in the electrophoresis process and further ensuring the adhesive force between the paint and the matrix. The hybrid film has the advantages of high corrosion resistance, compactness, uniformity, low resistance, good adhesive force and the like.

Modified fusion enhanced erythrocytes (or other cell types and synthetic cells) including human viral receptor proteins, human viral coreceptor proteins and viral derived proteins capable of mediating entry of respective viruses into the modified erythrocytes, cells or pseudo-cells and the method of using the fusion enhanced modified erythrocytes, cells or pseudo-cells for the treatment or prevention of viral infections. The fusion enhanced modified erythrocytes comprises CD4 and at least one HIV coreceptor, such as CXCR4 or CCR5 and as well, at least one of cholesterol rafts, fusin, actin, a viral derived protein such as fusion peptide derived from HIV GP120 or HIV GP41 or a shorter protein derived from a long viral protein, such as a portion of HIV derived GP120, or HIV GP41 such as the 23 N-terminal peptide of the HIV-1 gp 41 protein (AVGIGALFLGFLGAAGSTMGARS) called FP23 (Fusion Peptide). These viral-fusion enhanced cells may also be electrostatic charge enhanced through further additions named in this invention. The modified erythrocytes, when administered to an HIV patient, bind to the plasma virus and induce the injection of the HIV ribonucleoprotein complex into the cells. The entrapped viral content is sequestered within said cell for at least the period of time that the cell maintains its outer membrane integrity. The virus is thereafter either degraded or deactivated within the erythrocytes, cells or pseudo-cells, or destroyed by erythrophagocytosis.

The invention discloses nutritive feed for supplying vitamins, amino acids and oligosaccharides for pigs. The nutritive feed is prepared from raw materials of 200 to 280 parts by weight of one or more vitamins, 80 to 160 parts by weight of one or more amino acids and 15 to 30 parts by weight of oligosaccharides, and 550 to 750 parts by weight of auxiliary materials, wherein the one or more vitamins are selected from vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin D3, vitamin E and biotin; and the one or more amino acids are selected from lysine, glutamic acid, aspartic acid, leucine, glycine, alanine and threonine. The nutritive feed can protect integrity of skin and mucosa, improve a color and brightness of fur, improve immunity of a sow, reduce embryonic mortality, avoid diseases such as mastitis and lactescence deficiency in a lactation stage, reduce a weak piglet rate and obviously improve weight in a week.

A package for a medical device having an elongated shaft and a proximal luer fitting, the package includes a one-piece body formed as a single structure. The one-piece body includes at least a spiral casing formed therein, the spiral casing defining a spiral lumen configured to receive the elongated shaft of the medical device. The package includes a luer retaining portion at one end of the spiral casing with barrier film sealed to the luer retaining portion to maintain the sterility of the medical device. The package further including a cap placed over the luer retaining portion and barrier film to protect the integrity of the barrier film and prevent perforation of the barrier film which would compromise the sterility of the medical device.

An automatic on-line tester for detecting the integrity of the separating hollow fibre membrane is disclosed. A pressure sensor is fixed on the separating membrane module and connected to PLC control system. The perssure air is pumped in the separating membrane module untile all water in it is discharged. The pressures at different time are measured. Their pressure difference can be used to judge the membrane integrity. When said pressure difference is greater than 5Kpa, the membrane must be exchanged. Its advantages are high correctness and efficiency and low cost.

The invention provides a high graphitization three-dimensional carbon nanotube graphene composite material and a preparation method and an application thereof. The preparation method comprises the steps of performing mixing on carbon nanotubes and graphene, and adding ethyl alcohol and performing ultrasonic uniform dispersion, and putting the mixture into a drying oven to be dried at 50 DEG C to obtain a compound of carbon nanotubes and graphene; and putting the compound into a high-temperature graphitization furnace, and under high-purity argon protection, heating to 2,850 DEG C by a programheating method and continuing for 2h to obtain the high graphitization three-dimensional carbon nanotube graphene composite material. The preparation method is simple and large-scale production can berealized easily; meanwhile, by virtue of high temperature graphitization processing, the surface defect structure of the carbon material can be repaired effectively, and the oxygen-containing functional groups can be removed from the surface, so that electrical conductivity and thermal conductivity of the material are greatly improved; and a sulfur-bearing positive electrode obtained by using thehigh-temperature material shows extremely high advantage in the charging-discharging circulation at a high-rate high current, and diaphragm completeness can be protected effectively.