57 results about "Seleno methionine" patented technology

The five component composition consisting essentially of: (1) Water soluble antioxidant vitamin C or ascorbic acid, or any of its forms or derivatives, or mixtures thereof. (2) Oil soluble antioxidant vitamin E or Alpha-tocophorol, or any of its forms or derivatives, or mixtures thereof. (3) The element selenium, or a chemical (or composition) containing it, or mixtures thereof. The most preferred chemical containing selenium is dimethyl selenide and mixtures thereof. The words "dimethyl selenide" here and hereinafter mean dimethyl selenide and / or it's oxidation products, including dimethyl selenoxide. (4) A sulfur amino acid, in any form, or a sulfur peptide, or a sulfur protein, or any of their derivatives, or mixtures thereof. The mixture of methionine and cysteine, which contains as impurities some seleno-methionine and some selenocysteine, is preferred,-the tripeptide glutathione containing cysteine is also preferred. (5) Another antioxidant, other than vitamin C and other than vitamin E, which is synthetic or natural and water soluble or oil soluble, or a mixture of such antioxidants, or a combination of such forms thereof. The mixtures of butylated hydroxyanisole and ethoxyquin is preferred.

A method for administering an antioxidant composition to humans according to their age and sex is disclosed wherein the method comprises administering to said humans a daily dose of a multiple antioxidant micronutrient composition comprising vitamin A (palmitate), beta carotene (from natural d. salina), vitamin C (calcium ascorbate), vitamin D-3 (cholecalciferol), natural source vitamin E including both d-alpha tocopheryl and d-alpha tocopheryl acid succinate, thiamine mononitrate, riboflavin, niacinamide ascorbate, d-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, folic acid (folacin), d-biotin, selenium (1-seleno methionine), chromium picolinate, zinc glycinate, calcium citrate, and magnesium citrate. For persons over the age of about 51, the composition preferably further comprises one or more of co-enzyme Q10, N-acetyl cysteine, and alpha lipoic acid. Preferably, also, vitamin D is added for women over the age of about 36.

The purpose of this invention is:new selenohydroxy acid compounds and their derivatives;their process for the preparation;use of the new compounds as precursors of L(+)-selenomethionine and / or source of selenium in human or animal nutrition, in cosmetics and pharmaceutics;and nutritional, cosmetic and pharmaceutical compositions containing them.The new compounds that are the subject of this invention satisfy the general formula (I):in whichn=0, 1 or 2,R1=OH, OCOR3, OPO3H2, OPO(OR4)(OR5), or OR6,R2=OH, R3, or NHR7,R3=particularly alkoxyl (C1-C26), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols,OR4=OR5=particularly alkoxyl (C1-C26), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols,OR6=pyruvate, lactate, citrate, fumarate, maleate, myristate, palmitate, stearate, palmitoleate, oleate, linoleate, natural fatty acids, or 13-cis retinoate,R7=H, alkyl, natural amino acids, or natural amines.

The invention discloses selenium-rich feed for cultivating selenium-rich fish, which is characterized in that the content of total selenium in the selenium-rich feed is 1.5-20mg / kg, wherein selenomethionine accounts for 60%-80% of the total selenium, and selenocysteine accounts for 1%-10% of the total selenium. The selenium content of the selenium-rich fish cultivated by the selenium-rich feed is stable and controllable (the meat selenium content can reach to 1.5-10.0mg / kg, and the proportion of organic selenium is larger than or equal to 80 %), the selenium is safe in form and good in absorption effect, and patients lack of the selenium can improve the condition of lack of the selenium in a short time by eating the selenium-rich fish. In addition, a selenium-rich method is easy to popularize, and large-scale production can be achieved.

The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of using the same (e.g., as a therapeutic and / or prophylactic treatment for neurodegenerative disease). Additionally, the present invention demonstrates that specific forms of selenium (e.g., SEL-PLEX) possess the ability to alter expression of genes associated with disease and / or aging while other forms of selenium (e.g., selenomethionine) do not.

The invention relates to a method for extracting selenocystine and selenomethionine from selenium-gathered plant Cardamine hirsuta. The method comprises the following steps: after crushing a dried poly-selenium plant Cardamine hirsute material, extracting selenocystine by adding hydrochloric acid, extracting selenomethionine by adding sodium hydroxide, regulating the pH value of a filtrate to be nearly neutral, separating by using a high pressure preparation column, removing inorganic salt ions of an eluent containing selenocystine and selenomethionine by respectively using cellulose ester dialysis bags, and then, carrying out freeze drying to obtain high-quality selenocystine and selenomethionine products. The technical process is simple; the product extraction rate is high; the produced selenocystine and selenomethionine products can act as crude drugs for producing injections or food additives, are wide in use, and meanwhile can promote the development of Cardamine hirsuta planting industry, so that the industrial chain is extended.

The invention relates to an environmentally-friendly method for synthesizing selenomethionine. The method comprises the following steps of: reducing alpha-amido-protected aspartate beta-alkyl grease into alpha-amido-protected homoserine, then carrying out acid catalysis for ring closing to obtain inner grease of the homoserine, then reacting with metal selenide to generate homocystine selenide, obtaining the alpha-amido-protected homoserine, and finally eliminating protection and obtaining a selenomethionine product. The environmentally-friendly method has the advantages that the highly-toxic and rotten dimethyl diselenide is prevented from being used, so that the damage to the environment and operators are greatly reduced; the yield is high, the production cost is lower, the product purity is high, and optical and pure selenomethionine can be produced by large batch; and the obtained product can be used for preparing the intermediate of a selenium-containing medicine, and solves the difficulty that the selenomethionine and the related medicines can not be popularized.

The invention discloses an organic microelement premix for an egg chicken, which comprises methionine hydroxyl-copper, ferrous fumarate, methionine hydroxyl-iron, methionine hydroxyl-zinc, methionine hydroxyl-manganese, seleno methionine and chromium picolinate. The organic microelement premix is used for feeding the egg chicken; when in use, the premix is added into a complete feed in a proportion of 0.1%-0.15%. In the invention, the utilization rate of microelements is greatly improved; experiments prove that the utilization rate of organic microelements is improved by about 5 times compared with inorganic microelements; as absorption and utilization rates are improved, the waste of resources is reduced, the discharge of the microelements is obviously reduced, and adverse effects on the environment are relieved; moreover, the immunity of the organism is improved, the disease resistance is enhanced, and the mortality is reduced; therefore, the quality of an eggshell is improved, the eggshell is smooth, and has bright color, and the nutritive value of a chicken egg is improved.

The invention discloses a duck feed rich in organic selenium. If the feed is fed from young ducks, the production performance, the meat selenium content and the duck meat quality of meat ducks can be effectively improved. The total selenium content of the duck feed rich in organic selenium is 300-1000 microgrammes / kg, wherein selenomethionine accounts for 60-80% of the total selenium ratio, and selenocysteine accounts for 1-10% of the total selenium ratio. According to the feed, the immunity, the production performance, the meat selenium content and the duck meat quality of the meat duck can be effectively improved, and the duck feed can be widely applied to the cultivation of the meat duck.

The invention discloses a pharmaceutical composition useful for treatment and prevention of medical disorders and ailments. The aforesaid composition comprises active ingredients comprising; Turmeric extract, Turmeric powder, optionally, Selenium or source of Selenium, especially Selenomethionine, optionally, Green tea extract. The pharmaceutical composition further comprises enteric coating encapsulating the same. The disclosed pharmaceutical composition is especially adapted for treatment of inflammatory bowel disease (IBD) and colorectal cancer (CRC).

The invention provides a preparation method and application of a selenium-enriched fertilizer dedicated to tea. The preparation method comprises the following steps: dissolving sodium selenite in water to prepare an original mother solution, wherein the sodium selenite concentration is 80 to 120g / l; mixing the original mother solution and an amino acid solution of which the mass concentration is 15% to 20%, and then carrying out vibration chelation to obtain a chelated solution; mixing an aluminum chloride solution with a 3 to 8% cystine solution uniformly to obtain a nutrient solution; mixing the chelated solution with the nutrient solution uniformly to obtain a chelated nutrient solution; adding sodium alkyl benzene sulfonate into the chelated nutrient solution, and carrying out secondary chelation with an alcoholic fermentation filtrate under a 25 to 35 DEG C stirring condition, so as to obtain the selenium-enriched fertilizer dedicated to tea. According to the selenium-enriched fertilizer dedicated to tea, 90% or more of inorganic selenium is converted into organic selenium such as selenomethionine and selenocystine, so that the risk of poisoning is eliminated, the absorption and conversion rates of selenium are improved, and the consumption of sodium selenite as well as the cost is reduced.

The invention relates to an application of selenomethionine in preparation of a medicine for treating Alzheimer's disease. Specifically, selenomethionine has efficacy of improving learning and memory ability of an animal, inhibiting accumulation of Abeta in a brain and Tau protein and phosphorylation level of Tau protein, reducing GSK (glycogen synthase kinase)-3beta expression in the brain of the animal, reducing inflammatory response in the brain, reliving synaptic injury of nerve cells, improving activity of SOD (superoxide dismutase) in the brain and increasing content of glutathione with reducibility. Selenomethionine has an obvious therapeutical effect on Alzheimer's disease, and the therapeutical effect is stable; therefore, selenomethionine is a good choice for treating Alzheimer's disease clinically.

The invention discloses a pharmaceutical composition useful for treatment and prevention of medical disorders and ailments. The aforesaid composition comprises active ingredients comprising; Turmeric extract, Turmeric powder, Selenium or source of Selenium, especially Selenomethionine, and Green tea extract. The disclosed pharmaceutical composition is especially adapted for treatment of inflammatory bowel disease (IBD) and colorectal cancer (CRC).

The invention relates to a selenium yeast hydrolysate and a preparation method and application thereof. The selenium yeast hydrolysate contains protein, amino acid nitrogen, acid soluble protein and selenomethionine, wherein the amino acid nitrogen content is 2-3 wt%, and the acid soluble protein content is 35-45 wt%. The method includes adding citric acid into selenium yeast milk for autolysis treatment and enzymolysis treatment, and enzymes added in enzymolysis treatment include papain, neutral protease, alkaline protease and flavourzyme. The product of the method can be produced in large scale industrially easily. The selenium yeast hydrolysate prepared by the method has high contents of functional components, the selenium absorption rate in animal bodies is greatly increased, and the selenium yeast hydrolysate can be used as a feed additive.

The present invention discloses an additive premix for improving pork quality. The additive premix includes a carrier and an additive composition. The additive composition comprises selenomethionine, isoflavone, lutein, vitamin E or / and vitamin C, wherein the components of the composition are added as follows: 10 to 25 mg / kg of selenomethionine, 8 to 28 mg / kg of isoflavone, 5 to 10 mg / kg of lutein and 30 to 70 mg / kg of vitamin E or 5 to 20 mg / kg of vitamine C. The present invention also provides a method for using the additive. According to the invention, the additive premix contains the composition including biological active substances, and better effects can be achieved by adding the additive premix than adding any single component, so that the use of each additive is reduced, and the cost is saved. By using the additive premix, the loin area can be significantly increased, the intramuscular fat is reduced, and the pork quality is greatly improved in the aspects of marbling, water holding capacity, tenderness, shearing force, colority and drip loss.

A radioactive protection micronutrient formulation system is provided and the system comprises: a formulation consisting essentially of antioxidants, the antioxidants are selected from the group consisting essentially of vitamin C, vitamin E, N-acetyl cysteine, natural mixed carotenoids, and alpha-lipoic acid, vitamin A (palmitate), vitamin D-3 (cholecalciferol), thiamine mononitrate, riboflavin, niacinamide ascorbate, d-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, folic acid, D-Biotin, selenium (1-seleno-methionine), chromium picolinate, zinc glycinate, calcium citrate and magnesium citrate and mixtures thereof; and plus a booster formulation selected from a group consisting essentially of vitamin C, d-alpha tocopheryl acid succinate, alpha tocopherol, N-acetyl cysteine, natural mixed carotenoids and alpha lipoic acid, the formulation is designed to reduce the risk in humans exposed to doses of ionizing radiation of becoming subjected to at least one condition selected from the group consisting essentially of radiation-induced acute leukemia, breast cancer, thyroid cancer and other somatic and heritable mutations.

The invention discloses a human immunity enhancer for cancer prevention and treatment. The human immunity enhancer comprises components in parts by weight as follows: 111-222 parts of Echinacea phenol, 144-288 parts of astragaloside, 111-177 parts of chrysin, 333-666 parts of coriolus versicolor polysaccharide, 22-33 parts of diindolymethane, 60-111 parts of resveratrol, 80-111 parts of curcumin,111-222 parts of dihydroquercetin, 111-222 parts of tea polyphenols, 2.22-11.1 parts of L-selenomethionine, 80-130 parts of phosphatidylcholine, 90-140 parts of phosphatidylserine, 444-888 parts of methionine and 3000-4000 parts of a lipidosome matrix emulsion. The natural traditional Chinese medicine extracts and multiple active compounds are matched in proportion, a lipidosome matrix convenientto absorb is adopted, the immunity of the human body can be improved, and cancer, AIDS and other immunodeficiency diseases can be resisted effectively.

The invention relates to an additive feed for fattening beef cattle and a use method of the additive feed. The additive feed is prepared from the following components in parts by weight: 0.05-0.2 parts of Vitamin A, 0.03-0.1 parts of vitamin D3, 0.5-1.5 parts of vitamin E, 0.5-1 part of vitamin B1, 10-15 parts of guanidinoacetic acid, 3-8 parts of glycine betaine, 0.05-0.2 parts of selenomethionine, 0.5-1 part of rumen bypass choline, 1-2 parts of ferroporphyrin, 2-5 parts of zinc sulfate, 15-20 parts of magnesium oxide, 20-30 parts of sodium sulfate, 10-18 parts of hay vinasse, 2-5 parts of potassium chloride, 1-3 parts of clostridium butyricum, 0.1-0.5 parts of an antioxidant and 20-30 parts of rice hull powder. The additive feed has the effects of promoting the rumen health of cattle and increasing the lean meat percentage of beef cattle.

The invention relates to a integrated method for preparing seleno chromium methionine (III) through hrdantoin and its application. The intermediate seleno acimetion with multiple biological activity and usage can be prepared with said method. The Cr3+ in chromium trichloride hexahydrate can produce three modifications of different construction with one to three acid molecules, which are named as I-seleno chromium methionine, II-seleno chromium methionine and seleno chromium methionine (containing three acid molecules). The difference in performance and effect of three modifications is favorable for controlling content and proportion of selenium and chromium in compound. The compound can be widely used in medicine, health care product, feed addictive and cosmetics, especially used to produce capsule, tablet and oral liquid prevent and treating diabetes.

The invention discloses a method for analyzing the selenium form of selenium-rich proteoglycan based on HPLC-ICP-MS. Protease K and a Tris-HCl buffer solution are added into the selenium-enriched proteoglycan, enzymolysis is performed for 18 hours at the constant temperature of 37 DEG C, and high performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) is applied to analyze selenium compounds in enzymolysis supernatant: sodium selenite (Na2SeO3), selenocystine (SeCys2), selenium methyl selenocysteine (SeMeCys) and selenomethionine (SeMet). According to the method, only four selenium compounds are obtained through enzymolysis and are highly matched with a standard substance, and quantification is accurate; and the recovery rate is 78.35-111.42%, and the method is high in recovery rate, mild in condition and good in stability.

The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., Sel-Plex) and methods of using the same (e.g., as a therapeutic and / or prophylactic treatment for neurodegenerative disease). Additionally, the present invention demonstrates that specific forms of selenium (e.g., Sel-Plex) possess the ability to alter expression of genes associated with disease and / or aging while other forms of selenium (e.g., selenomethionine) do not.

The invention provides a method for applying L-selenomethionine to animal cell antioxidation and a product thereof, which relate to the technical field of animal cell culture. The method comprises thefollowing step of adding an L-selenomethionine working solution into a culture system of animal cells so that the final concentration of L-selenomethionine in the culture system of animal cells is 0.5-1.5 mu M; wherein the concentration of the L-selenomethionine working solution is 5-15 [mu] M. The application method of L-selenomethionine in animal cell antioxidation alleviates the lack of an animal cell antioxidation method which can effectively reduce cell oxidative damage and maintain cell activity, and is low in cytotoxicity, simple and convenient to operate and low in cost in the prior art. The invention also provides an animal cell antioxidant containing the L-selenomethionine, an animal cell culture medium containing the L-selenomethionine or the animal cell antioxidant containingthe L-selenomethionine, and a medicine or a feed additive containing the L-selenomethionine or the animal cell antioxidant containing the L-selenomethionine.

The invention discloses application of selenomethionine in preparation of skin care products, particularly relates to mask liquid containing selenomethionine or mask liquid containing selenomethionine and brooklet anemone root extract, and belongs to the technical field of skin care products. The mask liquid also comprises an antioxidant, a humectant, glycerol, methyl ester and phenoxyacetic acid, the brooklet anemone root extract is obtained by adopting an ethanol ultrasonic extraction method, and selenomethionine is organic selenium with high bioavailability, low toxicity and low price, and can effectively scavenge free radicals, prevent skin aging and delay aging. The scheme has the advantages that the mask liquid which is safe and effective and has the anti-oxidation effect is provided, the optimal selenomethionine adding amount of the mask liquid is determined, double-path oxidation resistance of superoxide anion free radicals and hydroxyl free radicals is achieved, meanwhile, the brooklet anemone root extract is added, and the anti-inflammatory and antibacterial effects are achieved.

The invention discloses a method for preparing L-selenomethionine and belongs to the field of additives. The method comprises the following steps: A. subjecting L-methionine and iodomethane to a reaction in water, so as to obtain an intermediate; and B. subjecting the intermediate and selenium sodium methoxide to a reaction in an alcoholic solvent, carrying out quenching with glacial acetic acid after the reaction ends up, adjusting a pH value of a reaction system to 5 to 6, and carrying out filtering and baking, thereby obtaining the L-selenomethionine. The method has the beneficial technicaleffects that the intermediate is simpler in preparation and lower in cost; the preparation operation of the intermediate is simpler; and employed raw materials and reagents are commercially available, a reaction process is free of production of fetid and hypertoxic byproduct, and thus, the method is more beneficial to labor protection and environments.

The invention discloses a preparation method of L-selenomethionine, and belongs to the field of additives. The preparation method comprises the following steps of A. reacting a compound 1 with a compound 2 in a solvent, and filtering after reaction to obtain a green solid compound 3; B. firstly, reacting the compound 3 with sodium borohydride in a protic solvent for 1-10 hours, dripping dimethyl sulfate after the reaction time is reached, continuing to react for 1-5 hours, quenching by using acetic acid, filtering and drying to obtain the L-selenomethionine. The preparation method disclosed bythe invention has the beneficial effects that: 1. the compound 1 has mild condition and high yield; 2. the reaction condition of the compound 3 is mild, virulent and malodorous selenium sodium methoxide cannot be generated, and the labor protection and the environmental protection are facilitated; 3. the compound 3 is simple to separate and only needs to be centrifugally subjected to spin filtration, and the obtained product has high purity; and 4. the raw materials and reagents are commercially available, and the intermediate does not need to be separated in the preparation process of the L-selenomethionine, so that the operation is simple.

Compositions are disclosed that include undenatured whey protein and glycine. The undenatured whey protein is preferably included at a final concentration of about 20%-80%, while the glycine is present at a final concentration of about 5%-35%. The whey protein has not been exposed to acid hydrolysis and, preferably, includes cold cross-flow membrane filtrate. The glycine is preferably 20-80 mesh in size, and exhibits a U.S. Pharmacopeia (USP) 28 grade. The composition further includes several vitamin and mineral cofactors, namely, selenomethionine, nicotinamide adenine dinucleotide (NADH), and Vitamin B3.

The invention discloses an additive pre-mixing material capable of improving the quality of pork. The additive pre-mixing material comprises a carrier and an additive composition, wherein the additivecomponent consists of 1:1 type selenomethionine metal chelate, 4' 7-dyhydroxy isoflavone and vitamin E, and metals in the 1:1 type selenomethionine metal chelate are divalent metal copper, zinc, manganese and ferrum, and negative ions are minus univalent fluorions, chloridions, bromide ions and hydrogen sulfate ions; and the addition amount of each ingredient in the composition is as follows: 1-100 mg / kg of 1:1 type selenomethionine metal chelate, 1-100 mg / kg of 4' 7-dyhydroxy isoflavone and 10-100 mg of vitamin E. The invention also provides a use method of the additive pre-mixing material. The additive pre-mixing material can be prepared into the pre-mixing material, a concentration material and a full-valent material. The additive pre-mixing material composition formed by bioactive substances has a better effect that a situation that any one single ingredient is singly added, an eye muscle area can be obviously enlarged, intramuscular fat is reduced, and aspects, including marbling, water-holding capacity, tenderness, shearing force, chromaticity, drip loss and the like, can be obviously improved so as to improve the quality of the pork.