56 results about "Seleno methionine" patented technology

The invention discloses a recombinant bacterium for high-yield production of selenomethionine and a preparation method of the recombinant bacterium, and belongs to the technical field of genetic engineering. According to the invention, selenium-rich region (Enshi) soil and withered grass are taken as materials, a bacillus subtilis strain with high selenomethionine synthesis capability is separated and screened, the bacillus subtilis strain is taken as an original strain, and a recombinant strain of high-expression SeMet synthesis key gene thioredoxin reductase (TrxRB) is constructed by utilizing an expression vector pHT43, so that high-yield SeMet engineering bacteria are obtained. The bacillus subtilis rich in selenomethionine and the recombinant bacteria thereof can be used as feed additives, and can be used for supplementing SeMet and improving the feed conversion rate in the production of livestock and poultry and aquatic animals.

The invention relates to the technical field of medical preparations, and particularly discloses a selenium-based anti-postmenopausal osteoporosis medicine and a preparation method and application thereof.The selenium-based anti-postmenopausal osteoporosis medicine comprises a main active component, a secondary active component and an auxiliary active component, the main active component is a nano-selenium-phytoestrogen compound and is formed by covalent coupling of selenomethionine and soy isoflavone, the particle size of the main active component is 50-200 nm, and the particle size of the auxiliary active component is 100-200 nm; the mass of the selenium element accounts for 5-30% of the mass of the compound; the auxiliary active component is a collagen peptide-calcium chelate and is prepared from marine collagen peptide and calcium citrate through chelation reaction, and the mass ratio of the calcium element to the collagen peptide is (1: 3)-(1: 5); the targeted delivery carrier is folic acid modified chitosan nanoparticles and is used for loading the main active component and the auxiliary active component; the auxiliary materials comprise a disintegrating agent, a lubricating agent and a pH-sensitive enteric coating material; through the synergistic effect of the main active ingredient nano-selenium-phytoestrogen compound and the auxiliary active ingredient collagen peptide-calcium chelate, bone formation can be promoted and bone resorption can be inhibited at the same time, and dual-function treatment is achieved.

The invention discloses a selenium-rich microecological preparation. The selenium-rich microecological preparation is prepared by the following steps: S1, activating strains; s2, preparing a selenomethionine premixed solution; s3, co-culture of bacteria and selenium; s4, forming a selenoprotein complex; s5, preparing a coating material; s6, coating with an emulsion; s7, acid-resistant layer coating; and S8, enteric activation treatment. According to different growth stages of the meat geese in the antibiotic-free breeding, a daily ration formula is directionally intervened: in the brooding period of the meat geese, the selenium-rich microecological preparation and daily ration feed are mixed in a dry mode, and conventional feeding is carried out; in the growth period of the meat geese, acidifying the selenium-rich microecological preparation, preparing the selenium-rich microecological preparation into a solution, and feeding the meat geese with the solution in the form of drinking water; in the fattening period of the meat geese, the premix containing the selenium-enriched microecological preparation is mixed with daily ration, and the meat geese are fed in an intensified mode. According to the invention, selenium-rich breeding of meat geese can be realized, economic benefits are increased, antibiotics can be replaced, and the eating safety and edible value of meat geese are improved.

The invention relates to the technical field of pig feeds, and particularly discloses a special compound feed for weaning sows, the feed comprises a functional additive, the functional additive comprises the following raw materials in parts by weight: 1-3 parts of a plant extract compound, 2-5 parts of conjugated linoleic acid, 0.0003-0.0005 part of selenomethionine, 0.15-0.35 part of vitamin E, and 0.15-0.3 part of vitamin C; the plant extract compound is prepared from the following components: astragalus polysaccharide, icariin, epigallocatechin gallate and a carrier, and the mass ratio of the astragalus polysaccharide to the icariin to the epigallocatechin gallate is 1 to (1 to 4) to (0.2 to 0.8). The special compound feed for the weaned sows is used for feeding the weaned sows through a scientific and reasonable formula, can promote follicular development of the sows after weaning, improve the oestrus rate and reduce the proportion of non-oestrus sows, and can solve the problem of slow ovarian function recovery of the sows in summer high-temperature seasons.

The present invention discloses a selenium-loaded photocross-linked alginate hydrogel and a preparation method thereof, and relates to the technical field of polymer gels. The preparation method is as follows: first, alginate is dissolved in deionized water, sodium chloride and a buffer are added and stirred until completely dissolved, the pH is adjusted to weak acidity, N-hydroxy-sulfosuccinimide and a condensing agent are added, and after stirring evenly, 2-aminoethyl methacrylate hydrochloride is added to carry out a methacrylate reaction to obtain methacrylated alginate. The alginate and a photoinitiator are separately dissolved in deionized water to prepare a storage solution, and selenomethionine is dissolved in the photoinitiator storage solution. Finally, a photoinitiator solution containing selenomethionine and a methacrylated alginate storage solution are mixed, and a photocross-linking reaction is initiated by ultraviolet irradiation to obtain a selenium-loaded photocross-linked alginate hydrogel. The present invention introduces selenomethionine into a photocross-linked alginate hydrogel scaffold, which has good cell biocompatibility and promotes osteogenesis.

The invention discloses an anti-radiation organic selenium salt and a preparation method and application thereof in the field of functional food additives. The anti-radiation organic selenium salt is prepared from the following components in percentage by weight: basic salt: 80-95% of lake salt, rock salt, bamboo salt, sea salt or refined table salt; the organic selenium active ingredients comprise 0.1 to 2 percent of L-selenomethionine, and / or 1 to 3 percent of selenium-enriched yeast extract, and / or 0.5 to 2 percent of selenized carrageenan. Through fluidized bed coating and microcapsule technologies, the six-month selenium retention rate is greater than or equal to 95%, the problem that organic selenium is easy to degrade is solved, the stability is high, L-selenomethionine and vitamin E cooperate, and simulated digestion experiments show that the selenium bioavailability is greater than or equal to 80% and is superior to that of inorganic selenium (lt); 50%); the organic selenium scavenges free radicals, the vitamin E protects cell membranes, and the zinc and the astragalus extract enhance immunity, so that all-around radiation protection is realized; the amino acid mixture covers the bitter taste of the organic selenium, the delicate flavor score is greater than or equal to 7.5 / 10, and the palatability is good; the method can be directly integrated to an existing salt production line, and is suitable for industrial production.

The present application relates to an organic selenium nutrient solution for crops and a preparation method thereof. The nutrient solution comprises, by mass percentage, selenomethionine 0.1-0.5%, complex amino acids 2.0-5.0%, potassium humate 1.0-3.0%, plant extracts 0.5-1.0%, EDTA chelated calcium, magnesium and zinc 0.05-0.5%, potassium sorbate 0.05-0.2%, and purified water as the remainder. Preferably, the selenomethionine is L-type selenomethionine with a three-layer coating, the inner layer of which is formed by cross-linking chitosan and citric acid, the middle layer is hydroxypropyl methyl cellulose, and the outer layer is a sodium alginate-gelatin matrix cross-linked by Ca 2+ / Zn 2+ complex ions. The preparation method comprises adding and chelating each component under specific pH conditions, and stabilizing to form a stable multi-component synergistic system. The nutrient solution has the advantages of high bioavailability, good controlled release performance, high plant absorption efficiency, and strong component stability.

The invention belongs to the technical field of agricultural compositions, and discloses a composition for improving low temperature resistance of rice. The composition is prepared from the following effective components in percentage by mass: 0.001 to 0.1 percent of 24-epibrassinolide, 0.1 to 10 percent of trehalose and 0.01 to 5 percent of selenomethionine. According to the invention, 24-epibrassinolide is utilized to activate a BR signal channel, and trehalose is utilized to maintain cell osmotic equilibrium and selenomethionine has an antioxidant protection effect, so that the low-temperature protection effect is enhanced together. Besides, a nano delivery technology is combined with plant hormone regulation and control, so that the low-temperature adaptive capacity of the rice in the seedling stage is remarkably improved, and an innovative scheme is provided for solving the problem of frequent occurrence of extreme low temperature under the global warming background.

The invention discloses a bionic nano-vesicle preparation method, which comprises: dissolving epigallotein gallate and selenomethionine in deionized water, adding a formaldehyde solution, stirring in a dark environment, and carrying out centrifugal purification to obtain spherical nano-particles; extracting exosomes from the stem cells; and adding the spherical nano-particles and the exosome into deionized water, and stirring to obtain the bionic nano-vesicle. The bionic nano vesicles prepared by the invention can regulate and control macrophages and T cells, have anti-inflammatory and immune network regulation and control effects, and are applied to the protection effect on acute kidney injury.

The application belongs to the field of functional food and nanotechnology, and particularly relates to a preparation method of peanut protein polysaccharide composite nanoparticles loaded with selenomethionine. The application combines peanut protein isolate with low methoxyl pectin and sodium alginate composite polysaccharide, and introduces selenomethionine to prepare a high-performance composite nanoparticle with a core-shell structure. The components of the application have good compatibility, the prepared nanoparticles have excellent performance, the nanoparticles have a wide application field, the preparation method is simple and mild, and the application has practical application value. The preparation method provided by the application not only provides a new way for high-value utilization of peanut protein, but also develops a nutrient delivery system with high stability and bioavailability, and provides a theoretical basis and practical reference for the innovative research and development of functional food.

The invention discloses a preparation method of silkworm selenium-rich eggs, and belongs to the technical field of functional egg production. The preparation method of the silkworm selenium-rich eggs provided by the invention comprises the four steps of preparation of nano-selenium mulberry leaves, selenium-rich breeding of silkworms, preparation of silkworm selenoprotein and feeding management of laying hens. According to the method disclosed by the invention, the defects of low selenium utilization rate, high cost, serious pollution and the like in the traditional technology are overcome through collaborative optimization of a biological chain, efficient conversion and directional enrichment of selenium resources are realized, the selenium content of the obtained eggs is stabilized at 36.8 + / -1.9 mu g / egg, the proportion of selenomethionine is as high as 87.9%, the nutritional value and safety of the eggs are remarkably improved, and the method is suitable for industrial production. The method is suitable for industrial production.

The application discloses selenium-rich rice with multiple amino acids and a preparation method and application thereof, and belongs to the technical field of cross between agricultural planting and deep processing of agricultural products. The rice meets four core indexes: the proportion of organic selenium is greater than or equal to 80% (of which the proportion of selenomethionine is greater than or equal to 70%), the index of human essential amino acids is greater than or equal to 0.95, the content of leucine and arginine is significantly strengthened, and the content of characteristic aroma substance 2-AP is greater than or equal to 200 mu g / kg. The preparation method comprises the following steps: at the booting stage of rice, a first nutrient solution with a specific ratio of four kinds of amino acids is sprayed to optimize the metabolic basis; at the early stage of grain filling, a second nutrient solution containing selenomethionine and proline is sprayed to realize synergistic transport; and finally, the harvested rice is subjected to specific temperature and humidity after-ripening treatment. Through unique time sequence design and material combination, the method improves the selenium nutrition, amino acid quality and "roasted nut aroma" flavor of the product, and provides technical support for the development of high-quality rice.

This invention discloses a selenium-enriched feed additive for beef cattle and its feeding method, belonging to the field of animal nutrition and feed technology. It comprises the following raw materials in parts by weight: 12-22 parts yeast selenium, 5-10 parts nano selenium, 8-15 parts L-selenomethionine, 3-8 parts methionine o-selenoclidinium, 300-400 parts fermented puffed corn flour, 150-200 parts fermented wheat bran, 10-15 parts vitamin E, 20-30 parts L-lysine salt, 15-25 parts DL-methionine, 150-200 parts compound minerals, 0.5-1.5 parts antifungal agent, and 0.1-0.5 parts antioxidant. This invention uses methionine o-selenoclidinium to bind and target the selenium source, synergistically combining the advantages of three selenium sources to solve the problems of low selenium bioavailability, poor digestive tract stability, and insufficient targeted deposition in muscle, thereby improving absorption efficiency, ensuring processing stability, and optimizing selenium deposition and safety in meat products.

The invention discloses a processing method of selenium-enriched rice, and relates to the technical field of grain processing. The method comprises the steps of raw material chemical modification pretreatment, chelating type composite selenium source preparation, complexing auxiliary soaking, chemical selenium fixation treatment, segmented humidity control drying, tempering balance and graded grinding. Sodium dihydrogen phosphate and citric acid are compounded to modify a rice structure, sodium selenite and selenomethionine are compounded and chelated by L-lysine to form a stable selenium source, sodium pyrophosphate is matched for assisting permeation and calcium chloride is used for fixing selenium, and follow-up drying and grinding processes are cooperated, so that the problems of low selenium absorption efficiency, high loss rate and non-uniform distribution in the prior art are solved. The product is stable in selenium content, low in cooking loss, high in bioavailability, low in broken rice rate, uniform in quality, simple and controllable in process and suitable for industrial standardized production.

The disclosed invention relates to a chemical composition that can be taken orally and supplements an unhealthy diet and lifestyle. In one aspect of the invention the chemical composition includes Retinol Palmitate, Thiamine, Riboflavin, Niacin, Nicotinamide mononucleotide (NMN), Pyridoxal, Folic Acid, Cyanocobalamin, Cholecalciferol, Zinc, Manganese, Copper, Calcium, Magnesium, Iron, L-Selenomethionine, Lysine, Phenylalanine, L-Threonine, L-Methionine, L-Histidine, L-Tryptophan, L-Leucine, L-Isoleucine, L-Valine, Cinnamon Bark Powder, and Curcumin.

The invention relates to the technical field of food science, and provides a selenium-rich compound formula with an anti-aging function for dogs. Comprising the following components: 5-12% of selenium-enriched yeast powder, 8-15% of compound probiotic freeze-dried powder, 25-30% of euphausia superba powder, 2-5% of a yucca extract, 4-8% of cranberry polyphenol, 5-10% of xylooligosaccharide, 10-15% of trehalose, 1-3% of carboxymethyl cellulose and 0.5-2% of phospholipid. The selenium-enriched yeast powder is used as a source of selenium, and the selenium exists in the form of selenomethionine, so that the bioavailability of the selenium is improved, and the toxicity risk is remarkably reduced. Compared with the prior art, the selenium-enriched yeast powder is added, so that the activity of an Nrf2 pathway in a dog body is up-regulated, the activity of superoxide dismutase (SOD) is further improved to 2.3 times of the original activity, free radicals are more efficiently removed, and senescence is delayed.

The invention provides a selenium form standard quality control sample in a nut matrix as well as a preparation method and application thereof, and belongs to the technical field of standard substances. The method comprises the following steps: performing primary crushing on seed kernels of Brazil nuts to obtain seed kernel particles; sequentially performing degreasing treatment and secondary crushing on the seed kernel particles to obtain degreased powder; spraying a selenite solution on the degreased powder to obtain composite powder; the composite powder is sequentially subjected to freeze drying, third crushing and mixing, and the selenium form standard quality control sample in the nut matrix is obtained. The standard quality control sample for the selenium form in the nut matrix, prepared by the method disclosed by the invention, has good uniformity and stability, and by adopting the standard quality control sample, the accuracy and the reliability of a content detection result of the selenium form (selenite and / or selenomethionine) in plant products such as nuts can be improved.

The invention discloses a high-selenium-content sea cucumber processing technology, and belongs to the technical field of sea cucumber processing, and the high-selenium-content sea cucumber processing technology comprises the following steps: 1, pretreating a sea cucumber raw material, 2, preparing a basic seasoning liquid, and carrying out fermentation treatment on the prepared basic seasoning liquid to obtain a fermented seasoning liquid, 3, dissolving selenomethionine and tea polyphenol in deionized water together, uniformly stirring to form a mixed solution, mixing the mixed solution with a fermentation seasoning liquid, and fully stirring to obtain an enrichment liquid, 4, mixing the pretreated sea cucumbers with the enrichment liquid, and carrying out an ultrasonic treatment-assisted permeation process, and 5, carrying out compound enzyme enzymolysis and curing twice, so as to obtain the selenium-enriched sea cucumbers. Step 6, microwave inactivation and shaping; and step 7, soaking to obtain a sea cucumber finished product with high selenium content. Through the mode, the fermentation seasoning liquid, the tea polyphenol and the enrichment liquid taking selenomethionine as a selenium source are synergistically compounded, and the high-selenium sea cucumber is prepared through a treatment mode of step-by-step enzymolysis of the compound enzyme.

The invention relates to the technical field of feed additives, and particularly discloses a selenomethionine feed additive and a preparation method thereof.The preparation method of the feed additive comprises the steps that wheat flour, a synthetic precursor, KH2PO4 and MgSO4 are added into navel orange residues and mixed to be uniform, then a fermentation substrate is obtained, the moisture content of the fermentation substrate is controlled, and the fermentation substrate is fermented under the condition that the pH ranges from 4 to 8; the preparation method comprises the following steps: inoculating a composite strain capable of producing glutathione reductase, uniformly mixing, controlling the fermentation temperature, fermenting for 10-20 days, inoculating bacillus capable of producing methionine synthetase, fermenting for 10-15 days, drying and crushing to obtain the selenomethionine feed additive. The prepared feed additive is high in organic selenium content, selenomethionine accounts for more than 50% of the total selenium content, the highest selenomethionine accounts for 73.11%, the standard of the feed additive is met, the preparation method is environmentally friendly, and the requirement for production environment conditions is low.

The preparation method comprises the following steps: weighing 15g of selenomethionine and 5g of selenium methyl selenocysteine, dissolving the selenomethionine and the selenium methyl selenocysteine in 800ml of water for injection, and stirring until the solution is clear; adding 20g of beta-cyclodextrin and 3g of L-ascorbic acid, and adjusting the pH value to 7.2 + / -0.2; supplementing the water for injection to 1000ml, and sterilizing and filtering through a 0.22 mu m filter membrane to obtain the injection. And subpackaging the injection, and sterilizing in a water bath at the temperature of 60 DEG C for 30 minutes to obtain a final product. The invention belongs to the technical field of medicines, and particularly provides a preparation method of a non-toxic high-selenium injection which takes organic selenium as a core component, supplements selenium for patients who cannot eat and drink and need large-dose selenium supplementation, and adopts a composite stable system and a low-temperature sterilization technology.

The invention discloses a zero-addition selenium-rich milk production mode based on yeast selenium feeding and milk selenium regulation and control. The method is realized through two stages of precise regulation and control: in the first stage, a specific dose of yeast selenium is added into daily ration of cows in the lactation period, and the content of natural organic selenium in raw milk is increased through biotransformation; in the second stage, the fresh milk is subjected to low-temperature milk selenium stability regulation and control, under the condition that no exogenous selenium compound is added, the stability and bioavailability of the selenium form in the milk are kept, the problems that in traditional selenium-rich milk production, selenium additive residues exist, the selenium form is unstable, and product safety is low are solved, and the selenium-rich milk is suitable for large-scale production. The invention provides the production method of the selenium-enriched milk which is free of chemical addition in the whole process, stable and controllable in selenium content, and high-bioavailability selenomethionine is taken as the main selenium form. The obtained product accords with the development trend of natural and safe functional dairy products, and is suitable for large-scale dairy product processing.

The application relates to the technical field of feed additives, and particularly discloses a selenium-methionine feed additive and a preparation method thereof. The preparation method of the feed additive is as follows: adding wheat powder, a synthetic precursor, KH2PO4 and MgSO4 into navel orange residues, uniformly mixing, obtaining a fermentation substrate, controlling the moisture content of the fermentation substrate, inoculating a complex strain producing glutathione reductase at pH 4-8, uniformly mixing, controlling the fermentation temperature, fermenting for 10-20 days, inoculating bacillus producing methionine synthetase again, fermenting for 10-15 days, drying, crushing, and obtaining the selenium-methionine feed additive. The prepared feed additive has high organic selenium content, selenium-methionine accounts for more than 50% of the total selenium content, and the highest content reaches 73.11%, which meets the standard of the feed additive, and the preparation method is environment-friendly and has low requirements on production environment conditions.

This invention proposes a method for preparing selenomethionine, comprising the following steps: S1. Inoculating selenium-resistant Bacillus subtilis into a culture medium containing sodium selenite for activation, and selecting seed culture in the logarithmic growth phase; S2. Inoculating the seed culture into a fermentation medium, providing carbon and nitrogen sources for cell proliferation in the early stage of fermentation, and adding inorganic selenium source and exogenous methionine precursor in the middle and late stages of fermentation, while adjusting dissolved oxygen and pH to reduce inorganic selenium into selenomethionine within the cells; S3. After fermentation, subjecting the fermentation broth to cell disruption, solid-liquid separation, and drying to obtain a product rich in selenomethionine. This preparation method, through staged fermentation, balances cell growth and selenium conversion efficiency, achieving efficient synthesis of selenomethionine from Bacillus subtilis. The product contains selenium primarily in the form of selenomethionine, with a high proportion of organic selenium. The strains used are highly safe, the process is mature, and the application value is significantly improved, making it suitable for industrial-scale production.

The invention relates to the technical field of aquatic feed, and discloses an oyster shell feed additive and an application of the oyster shell feed additive in shellfish breeding, and the additive comprises the following raw materials in parts by weight: 80-90 parts of oyster shell powder; 1-4 parts of a vitamin composition; 0.5 to 0.9 part of iron glycinate; 0.5 to 1.5 parts of zinc lysine; 0.2 to 0.9 part of manganese methionine; 0.22 to 0.45 part of copper lysine; the preparation method comprises the following steps: cleaning oyster shells, performing staged high-temperature calcination and crushing to obtain oyster shell powder, mixing the oyster shell powder with other raw materials under set conditions, and drying to obtain the oyster shell feed additive, the addition amount of the oyster shell feed additive in a crustacean animal feed is 1-5%, the oyster shell feed additive is fed 2-4 times every day, and the oyster shell feed additive is continuously fed until the culture is finished. By adding the oyster shell feed additive into the feed, the activity of immune enzyme in hepatopancreas is enhanced, the survival rate of crustaceans is effectively improved, and the mineral content of muscles and shells of the crustaceans is increased.

The application relates to application of L-selenomethionine oligopeptide in preparation of an antitumor drug, and L-selenomethionine oligopeptide (III) is further prepared by using synthesized L-selenomethionine (II). The L-selenomethionine oligopeptide has good antitumor activity, and (II-1) to (II-10) in the application have good inhibitory activity on cervical cancer cells. The results obtained by the application show that the L-selenomethionine oligopeptide has wide application prospects in a drug development system, a new and wider idea is provided for synthesizing and screening the L-selenomethionine oligopeptide, and a more effective way is provided for treating related diseases.

The invention discloses a diluent for normal-temperature preservation of boar semen and a preservation method. Selenomethionine is selected as a protective agent in the diluent for preserving the boar semen at the normal temperature to improve the semen quality, the diluent for preserving the semen at the low temperature is a Modena basic diluent, and the addition amount of the selenomethionine in the diluent for preserving the semen at the normal temperature is 0.1-10 mg / L, preferably 1 mg / L. According to the invention, selenomethionine is added into the diluent for preserving the boar semen at normal temperature, so that the motility, motility rate, plasma membrane integrity rate and acrosome integrity rate of the boar semen can be remarkably improved. If the method is applied to actual production, the normal-temperature preservation time of the boar semen can be prolonged, the semen preservation quality is improved, and the production cost is reduced.

The invention discloses a preparation method and application of EGCG (epigallocatechin gallate) organic selenium nanoparticles with tumor cell growth inhibition activity, and belongs to the field of functional nano materials. The nano-particles are organic nano-particles (ESNPs) which are formed by combining epigallocatechin gallate (EGCG) and organic selenium (selenocystine or selenomethionine) through chemical bonds by taking a C2-C6 aldehyde compound or hexamethylenetetramine (HMTA) as a cross-linking agent. The nanostructure has relatively high stability, and can induce oxidative stress in cells to further stimulate ferroptosis and apoptosis, so that the nanostructure shows remarkable inhibitory activity on various tumor cells. The invention provides a new technical approach and theoretical basis for the application of the natural polyphenol and organic selenium composite material in the field of tumor prevention and treatment.

The invention discloses targeted selenium-coupled anti-inflammatory fusion protein and application thereof in acute coronary syndrome reperfusion injury repair, and belongs to the technical field of biomedicine. A GPIb-Annexin A1 fusion protein is constructed firstly, specifically, a human GPIb active fragment serving as an N-terminal targeting element and a human Annexin A1 active fragment serving as a C-terminal anti-inflammatory element are connected in series through a (Gly4Ser) 3 flexible linker, the fusion protein sequence is shown as SEQ ID NO: 3, and the GPIb-Annexin A1 fusion protein is obtained through gene synthesis, vector construction, prokaryotic expression and Ni-NTA purification; and chelating selenomethionine serving as a selenium source with the fusion protein according to the mass ratio of 3: 1 in a phosphate buffer solution with the pH value of 7.5, and dialyzing, freezing and drying to obtain the selenium chelate. Experiments prove that the selenium chelate can significantly improve the left ventricular ejection fraction and the left ventricular shortening fraction of MI / RI mice, reduce the myocardial infarction area, inhibit the expression of TNF-alpha, IL-1beta and IL-6, and reduce the long-term myocardial collagen volume fraction, and can be used for preparing acute coronary syndrome reperfusion injury repair drugs.

The present invention provides an application of selenolysine, and the selenomethionine is applied to resist plant viruses. Specifically, selenomethionine is applied to prepare a drug for preventing and treating plant viruses. The plant virus is tobacco mosaic virus (TMV). Selenomethionine is also applied to prepare a pharmaceutical composition. The pharmaceutical composition is applied to prevent and treat plant viruses; in the present invention, selenomethionine is used to effectively inhibit the proliferation of tobacco mosaic virus, and 0.5 mmol / L of selenomethionine inhibits the passivation activity of TMV by 72.15%, the protective activity by 65.39%, and the therapeutic activity by 45.26%. After tobacco is treated with selenomethionine, the growth state of tobacco is good, and there is no obvious inhibition or poor growth phenomenon, indicating that selenomethionine is safe for host plants and has no phytotoxic effect, indicating that selenomethionine has the potential to be developed into a plant virus inhibitor.

The invention discloses a selenium nutrition prediction and process optimization method for selenium-rich pork processing, which is applied to a cloud server and comprises the following steps: receiving a first process parameter sent by a terminal; the method comprises the following steps of: preprocessing a first process parameter to obtain a second process parameter by utilizing actual measurement values at different time points in a multi-time processing process of a preprocessed selenium-enriched pork sample in an optimal processing mode, classifying the second process parameter in time and space, and performing decomposition, feature screening and fusion on the classified data to obtain a selenium-enriched pork sample; and obtaining fused features, inputting the fused features into a plurality of initial prediction models to obtain an initial prediction result under a second process parameter, and inputting the initial prediction result into a fusion model to obtain a target prediction result comprising a target total selenium retention rate, a target selenomethionine proportion and a target bioavailability. And then substituting the optimal process parameters into a target optimization function to obtain a total optimization value, and after obtaining target optimal process parameters through the total optimization value, sending the target optimal process parameters and a corresponding target prediction result to a terminal.