18 results about "Seleno methionine" patented technology

The invention belongs to the technical field of agricultural compositions, and discloses a composition for improving low temperature resistance of rice. The composition is prepared from the following effective components in percentage by mass: 0.001 to 0.1 percent of 24-epibrassinolide, 0.1 to 10 percent of trehalose and 0.01 to 5 percent of selenomethionine. According to the invention, 24-epibrassinolide is utilized to activate a BR signal channel, and trehalose is utilized to maintain cell osmotic equilibrium and selenomethionine has an antioxidant protection effect, so that the low-temperature protection effect is enhanced together. Besides, a nano delivery technology is combined with plant hormone regulation and control, so that the low-temperature adaptive capacity of the rice in the seedling stage is remarkably improved, and an innovative scheme is provided for solving the problem of frequent occurrence of extreme low temperature under the global warming background.

The application belongs to the field of functional food and nanotechnology, and particularly relates to a preparation method of peanut protein polysaccharide composite nanoparticles loaded with selenomethionine. The application combines peanut protein isolate with low methoxyl pectin and sodium alginate composite polysaccharide, and introduces selenomethionine to prepare a high-performance composite nanoparticle with a core-shell structure. The components of the application have good compatibility, the prepared nanoparticles have excellent performance, the nanoparticles have a wide application field, the preparation method is simple and mild, and the application has practical application value. The preparation method provided by the application not only provides a new way for high-value utilization of peanut protein, but also develops a nutrient delivery system with high stability and bioavailability, and provides a theoretical basis and practical reference for the innovative research and development of functional food.

The application discloses selenium-rich rice with multiple amino acids and a preparation method and application thereof, and belongs to the technical field of cross between agricultural planting and deep processing of agricultural products. The rice meets four core indexes: the proportion of organic selenium is greater than or equal to 80% (of which the proportion of selenomethionine is greater than or equal to 70%), the index of human essential amino acids is greater than or equal to 0.95, the content of leucine and arginine is significantly strengthened, and the content of characteristic aroma substance 2-AP is greater than or equal to 200 mu g / kg. The preparation method comprises the following steps: at the booting stage of rice, a first nutrient solution with a specific ratio of four kinds of amino acids is sprayed to optimize the metabolic basis; at the early stage of grain filling, a second nutrient solution containing selenomethionine and proline is sprayed to realize synergistic transport; and finally, the harvested rice is subjected to specific temperature and humidity after-ripening treatment. Through unique time sequence design and material combination, the method improves the selenium nutrition, amino acid quality and "roasted nut aroma" flavor of the product, and provides technical support for the development of high-quality rice.

This invention discloses a selenium-enriched feed additive for beef cattle and its feeding method, belonging to the field of animal nutrition and feed technology. It comprises the following raw materials in parts by weight: 12-22 parts yeast selenium, 5-10 parts nano selenium, 8-15 parts L-selenomethionine, 3-8 parts methionine o-selenoclidinium, 300-400 parts fermented puffed corn flour, 150-200 parts fermented wheat bran, 10-15 parts vitamin E, 20-30 parts L-lysine salt, 15-25 parts DL-methionine, 150-200 parts compound minerals, 0.5-1.5 parts antifungal agent, and 0.1-0.5 parts antioxidant. This invention uses methionine o-selenoclidinium to bind and target the selenium source, synergistically combining the advantages of three selenium sources to solve the problems of low selenium bioavailability, poor digestive tract stability, and insufficient targeted deposition in muscle, thereby improving absorption efficiency, ensuring processing stability, and optimizing selenium deposition and safety in meat products.

The invention discloses a processing method of selenium-enriched rice, and relates to the technical field of grain processing. The method comprises the steps of raw material chemical modification pretreatment, chelating type composite selenium source preparation, complexing auxiliary soaking, chemical selenium fixation treatment, segmented humidity control drying, tempering balance and graded grinding. Sodium dihydrogen phosphate and citric acid are compounded to modify a rice structure, sodium selenite and selenomethionine are compounded and chelated by L-lysine to form a stable selenium source, sodium pyrophosphate is matched for assisting permeation and calcium chloride is used for fixing selenium, and follow-up drying and grinding processes are cooperated, so that the problems of low selenium absorption efficiency, high loss rate and non-uniform distribution in the prior art are solved. The product is stable in selenium content, low in cooking loss, high in bioavailability, low in broken rice rate, uniform in quality, simple and controllable in process and suitable for industrial standardized production.

The invention discloses a zero-addition selenium-rich milk production mode based on yeast selenium feeding and milk selenium regulation and control. The method is realized through two stages of precise regulation and control: in the first stage, a specific dose of yeast selenium is added into daily ration of cows in the lactation period, and the content of natural organic selenium in raw milk is increased through biotransformation; in the second stage, the fresh milk is subjected to low-temperature milk selenium stability regulation and control, under the condition that no exogenous selenium compound is added, the stability and bioavailability of the selenium form in the milk are kept, the problems that in traditional selenium-rich milk production, selenium additive residues exist, the selenium form is unstable, and product safety is low are solved, and the selenium-rich milk is suitable for large-scale production. The invention provides the production method of the selenium-enriched milk which is free of chemical addition in the whole process, stable and controllable in selenium content, and high-bioavailability selenomethionine is taken as the main selenium form. The obtained product accords with the development trend of natural and safe functional dairy products, and is suitable for large-scale dairy product processing.

This invention proposes a method for preparing selenomethionine, comprising the following steps: S1. Inoculating selenium-resistant Bacillus subtilis into a culture medium containing sodium selenite for activation, and selecting seed culture in the logarithmic growth phase; S2. Inoculating the seed culture into a fermentation medium, providing carbon and nitrogen sources for cell proliferation in the early stage of fermentation, and adding inorganic selenium source and exogenous methionine precursor in the middle and late stages of fermentation, while adjusting dissolved oxygen and pH to reduce inorganic selenium into selenomethionine within the cells; S3. After fermentation, subjecting the fermentation broth to cell disruption, solid-liquid separation, and drying to obtain a product rich in selenomethionine. This preparation method, through staged fermentation, balances cell growth and selenium conversion efficiency, achieving efficient synthesis of selenomethionine from Bacillus subtilis. The product contains selenium primarily in the form of selenomethionine, with a high proportion of organic selenium. The strains used are highly safe, the process is mature, and the application value is significantly improved, making it suitable for industrial-scale production.

The application relates to application of L-selenomethionine oligopeptide in preparation of an antitumor drug, and L-selenomethionine oligopeptide (III) is further prepared by using synthesized L-selenomethionine (II). The L-selenomethionine oligopeptide has good antitumor activity, and (II-1) to (II-10) in the application have good inhibitory activity on cervical cancer cells. The results obtained by the application show that the L-selenomethionine oligopeptide has wide application prospects in a drug development system, a new and wider idea is provided for synthesizing and screening the L-selenomethionine oligopeptide, and a more effective way is provided for treating related diseases.

The invention discloses a selenium nutrition prediction and process optimization method for selenium-rich pork processing, which is applied to a cloud server and comprises the following steps: receiving a first process parameter sent by a terminal; the method comprises the following steps of: preprocessing a first process parameter to obtain a second process parameter by utilizing actual measurement values at different time points in a multi-time processing process of a preprocessed selenium-enriched pork sample in an optimal processing mode, classifying the second process parameter in time and space, and performing decomposition, feature screening and fusion on the classified data to obtain a selenium-enriched pork sample; and obtaining fused features, inputting the fused features into a plurality of initial prediction models to obtain an initial prediction result under a second process parameter, and inputting the initial prediction result into a fusion model to obtain a target prediction result comprising a target total selenium retention rate, a target selenomethionine proportion and a target bioavailability. And then substituting the optimal process parameters into a target optimization function to obtain a total optimization value, and after obtaining target optimal process parameters through the total optimization value, sending the target optimal process parameters and a corresponding target prediction result to a terminal.

The present application relates to the technical field of biological fermentation, and particularly relates to a corynebacterium glutamicum and a method for preparing L-selenomethionine by fermentation using the bacterial strain. The screened corynebacterium glutamicum is subjected to steps of (1) plate activation, (2) seed culture, (3) fermentation culture and biological conversion, and is subjected to one-stage or multi-stage culture, so as to generate L-selenomethionine by taking L-homoserine, sodium methylselenide or methylselenol as a substrate. The prepared L-selenomethionine has a content higher than 70 g / L in the fermentation liquor, has a higher yield, and has a higher market customer acceptance as a biological fermentation product.

The invention belongs to the technical field of biology, and particularly relates to selenium-containing yolk immunoglobulin with neuroprotection activity and a preparation method and application thereof, and the selenium-containing yolk immunoglobulin contains organic selenium selenocysteine and / or organic selenium selenomethionine. The invention provides selenium-containing egg yolk immunoglobulin and a preparation method thereof, the selenium-containing egg yolk immunoglobulin is screened from selenium-rich egg yolk, the selenium-containing egg yolk immunoglobulin contains selenium, contains organic selenium selenocysteine and selenomethionine, does not contain inorganic selenium and has neuroprotective activity, a secondary structure of the selenium-containing egg yolk immunoglobulin mainly adopts beta folding, and the secondary structure of the selenium-containing egg yolk immunoglobulin mainly adopts beta folding. The protein extract plays a protection role by reducing the NO content and ROS content of BV-2 cells and increasing the GPx content, the SOD content and the CAT content. The selenium-containing yolk immunoglobulin provided by the invention is from food sources, is safe and low-sensitive, and has good neuroprotective activity, a high dose of peptide is suitable for patients with moderate and severe diabetes, and a low dose of peptide is suitable for daily diet supplement of the patients with diabetes in an early stage or a stable stage.

This invention belongs to the field of health food and discloses a preparation process and application of a compound peptide that enhances immunity. The peptide is composed of the following components: 5-15 parts yak bone peptide, 3-10 parts marine collagen oligopeptides, 2-8 parts soybean protein peptide, 1-5 parts cordyceps peptide, 1-5 parts wolfberry peptide, 0.5-3 parts sea cucumber intestinal ovum peptide, 0.3-2 parts yeast β-glucan, 0.01-0.1 parts selenomethionine, 0.2-1.5 parts shiitake mycelium polysaccharide, 0.1-1 parts elderberry extract, 0.1-1 parts echinacea extract, 0.05-0.5 parts zinc-lactalbumin complex, and 0.03-0.3 parts ferrous lactate. This invention proposes a preparation process and application of a compound peptide that enhances immunity. By using specific component ratios and manufacturing processes, it not only has excellent immune activation capabilities but also comprehensively regulates the body's immune function. It can be used to prepare foods or health products that enhance immunity.

The invention relates to a combination therapy for treating liver cancer. The combination therapy mainly comprises combined application of L-selenomethionine and an immune checkpoint inhibitor (especially an anti-PD1 antibody). The composition can effectively inhibit tumor growth and enhance the tumor killing ability of an immune system. By reducing the number of tumor infiltration neutrophils and weakening the immunosuppression function of the neutrophils, the L-selenomethionine significantly improves the anti-tumor immune response. The invention provides a safe and effective treatment choice, the curative effect of the immune checkpoint inhibitor is remarkably improved, and a new treatment hope is brought to patients.

The invention relates to the field of food processing, and discloses a processing method of selenium-rich and zinc-rich low-salt salted eggs, which comprises the following steps: selecting zinc-rich and selenium-rich raw material eggs, cleaning, carrying out ice-temperature pretreatment at-1-0 DEG C, and destroying a lipoprotein structure by using low-temperature stress; the method comprises the following steps: taking selenium-enriched wheat seedling water boiling liquid as a substrate, adding D-sorbitol, sodium chloride, potassium citrate, zinc lactate and L-selenomethionine dispersed in ethanol to prepare a three-phase composite pickling liquid, and constructing a metastable-state complex by utilizing potassium citrate and zinc lactate to prevent zinc precipitation; immersing the pretreated poultry eggs in the pickling liquid for constant-temperature pickling and circulating homogenization; and finally, curing through two-stage heat treatment. According to the method, the problem of difficulty in oil extraction of low-salt pickled egg yolk is solved through ice-temperature pretreatment, stable permeation and reinforcement of zinc and selenium in a low-salt system are realized by utilizing a complexing and dispersing technology, and the obtained salted egg is low in salt content, high in oil extraction rate and rich in nutrition.

Process for the preparation of 3-methylselenopropanal. The invention relates to a process for the preparation of 3-methylselenopropanal (MSeP), characterized in that it comprises the following steps: a) a solution of CH3SeLi and a solution of acrolein are made available; b) the CH3SeLi solution and the acrolein solution are mixed to obtain a reaction medium in which the acrolein is converted to MSeP; c) optionally, the MSeP thus obtained is isolated and / or purified in the reaction medium. The invention also relates to the manufacture of 2-hydroxy-4-methylselenobutyric acid and selenomethionine from the MSeP thus prepared.

The invention relates to a fusion protein containing selenomethionine and application of the fusion protein in treating acute pancreatitis, and belongs to the technical field of biological medicines. The fusion protein is prepared from a TAT-14-PTD-p65 fusion protein and organic selenium (selected from selenomethionine) through an in-vivo biochelation method, the fusion protein adopts an Nrf2 activation-NF-kappa B inhibition-selenium donor three-in-one design, and comprises an Nrf2 activation element (TAT-14 peptide), an NF-kappa B inhibition element (PTD-p65-P1) and a selenium donor element (selenomethionine) which are connected through a (Gly4Ser) 2 connecting peptide so as to avoid spatial interference. Experiments show that the fusion protein and the selenium chelate thereof can significantly reduce serum lipase and amylase levels of C57 mice with acute pancreatitis, inhibit inflammatory response and oxidative stress and relieve pancreatic tissue damage by inhibiting pancreatic tissue NF-kB inflammatory pathway activation and up-regulating pancreatic Nrf2 / HO-1 antioxidant pathway, and the selenium chelate has a better effect.

The invention discloses a feed rape fermentation compound, a preparation method and a fermentation application method. The feed rape fermentation compound comprises the following components: feed rape, modified beta-cyclodextrin, modified starch, a complex microbial inoculant, potassium iodide and selenomethionine, wherein the complex microbial inoculant comprises aspergillus niger, lactobacillus plantarum and bacillus subtilis. When the glucosinolate of the feed rape is converted into sulforaphene by the aspergillus niger, the modified beta-cyclodextrin and the modified starch have a synergistic effect through electrostatic attraction in an acidic fermentation environment, the sulforaphene is embedded in the modified beta-cyclodextrin, and the modified beta-cyclodextrin-sulforaphene inclusion compound is wrapped by a gel network of the modified starch, so that the glucosinolate of the feed rape is converted into the sulforaphene. The sulforaphene is prevented from being exposed to sulfinyl outside the cavity to be attacked, oxygen is isolated, meanwhile, hydroxyl free radicals are blocked from approaching the sulforaphene, oxidation of the sulforaphene is prevented, and the retention rate of the sulforaphene is increased. Potassium iodide and selenomethionine are added, so that the high-retention-rate sulforaphene is prevented from competitively combining with a sodium-iodine co-transporter of a thyroid cell membrane.

The purpose of the present invention is to provide a composition for treating or preventing an infection (COVID19) caused by SARS-CoV-2. A method for screening for a drug having an inhibitory activity against a protease of SARS-CoV2 is established, and it is found that selenoneine has an inhibitory activity against the protease of SARS-CoV2. On the basis of this finding, a composition for treating or preventing COVID19 which contains selenoneine is provided.