Anti-radiation organic selenium salt as well as preparation method and application thereof

Abstract

The invention discloses an anti-radiation organic selenium salt and a preparation method and application thereof in the field of functional food additives. The anti-radiation organic selenium salt is prepared from the following components in percentage by weight: basic salt: 80-95% of lake salt, rock salt, bamboo salt, sea salt or refined table salt; the organic selenium active ingredients comprise 0.1 to 2 percent of L-selenomethionine, and / or 1 to 3 percent of selenium-enriched yeast extract, and / or 0.5 to 2 percent of selenized carrageenan. Through fluidized bed coating and microcapsule technologies, the six-month selenium retention rate is greater than or equal to 95%, the problem that organic selenium is easy to degrade is solved, the stability is high, L-selenomethionine and vitamin E cooperate, and simulated digestion experiments show that the selenium bioavailability is greater than or equal to 80% and is superior to that of inorganic selenium (lt); 50%); the organic selenium scavenges free radicals, the vitamin E protects cell membranes, and the zinc and the astragalus extract enhance immunity, so that all-around radiation protection is realized; the amino acid mixture covers the bitter taste of the organic selenium, the delicate flavor score is greater than or equal to 7.5 / 10, and the palatability is good; the method can be directly integrated to an existing salt production line, and is suitable for industrial production.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of functional food additives, in particular to an anti-radiation organic selenium salt, a preparation method and application thereof. BACKGROUND

[0002] With the development of nuclear technology application and space exploration, the opportunities for human beings to contact ionizing radiation (such as gamma / X-ray) and non-ionizing radiation (such as ultraviolet) have significantly increased. Radiation exposure can cause DNA damage, hematopoietic function inhibition and oxidative stress, and safe and effective daily protection means are urgently needed.

[0003] The existing radiation protection functional food (especially edible salt carrier) has the following technical bottlenecks:

[0004] 1) Selection dilemma of selenium form: inorganic selenium salt has low bioavailability (usually <50%), and is easy to cause selenium poisoning; ordinary organic selenium has poor temperature resistance, and the activity loss rate is >30% during high-temperature processing, and is easy to produce odor affecting palatability.

[0005] 2) Single protection mechanism: mainly depends on a single active ingredient, which cannot cope with the combined damage of multiple types of radiation.

[0006] 3) Insufficient process compatibility: direct mixing leads to uneven distribution of active ingredients (selenium content fluctuation >15%); conventional embedding technology is difficult to adapt to the high-temperature and high-humidity processing environment of salt.

[0007] Therefore, the anti-radiation organic selenium salt and the preparation method and application thereof are provided by the person skilled in the art to solve the problems raised in the above background. SUMMARY

[0008] The purpose of the present application is to provide an anti-radiation organic selenium salt and a preparation method and application thereof to solve the problems raised in the above background.

[0009] To achieve the above purpose, the present application provides the following technical scheme:

[0010] The anti-radiation organic selenium salt is made of the following components by weight percentage:

[0011] Basic salt: 80-95% of lake salt, rock salt, bamboo salt, sea salt or refined salt;

[0012] Organic selenium active ingredient: 0.1-2% of L-selenomethionine, and / or 1-3% of selenium-rich yeast extract, and / or 0.5-2% of seleniumized carrageenan;

[0013] Antioxidant stabilizer: 0.5-1% of vitamin E microcapsule;

[0014] Flavor synergist: 2-5% of amino acid mixture;

[0015] The L-selenomethionine and vitamin E microcapsules are coated on the surface of the base salt particles by fluidized bed to form an anti-radiation-antioxidation dual functional active layer, and the amino acid mixture is dispersed in the gap of the coated salt particles by dry mixing process.

[0016] As a further scheme of the present application, the sodium chloride content of the base salt is ≥ 94%, and naturally contains 0.1-0.5% of potassium and magnesium minerals; the bamboo salt is roasted salt containing calcium, magnesium, and zinc minerals; the particle size of the lake salt or rock salt is 100-300 μm, and the surface roughness (Ra) is 0.5-2.0 μm, so as to enhance the adhesion of the active ingredients.

[0017] As a further scheme of the present application, the particle size of the selenium carrageenan is 50-100 nm, and the selenium content is ≥ 10%; the coating material of the vitamin E microcapsule is gelatin-arabic gum composite wall material, the particle size is 10-50 μm, the mass ratio of gelatin to arabic gum is 1:1-1:2, and the encapsulation rate is ≥ 90%.

[0018] As a further scheme of the present application, the amino acid mixture is composed of sodium glutamate, glycine, and alanine in a mass ratio of 3:1:1, and contains 0.1-0.3% of 5'-inosinic acid disodium or 5'-guanylic acid disodium.

[0019] As a further scheme of the present application, it further contains at least one auxiliary ingredient selected from the following:

[0020] a) 0.05-0.2% of nano-silicon dioxide;

[0021] b) 0.1-0.5% of water-soluble zinc compound (zinc citrate);

[0022] c) 0.5-2% of natural polysaccharide stabilizer (β-glucan);

[0023] d) 3-8% of prebiotic (fructooligosaccharide);

[0024] e) 3-5% of calcium supplement (nano-calcium carbonate);

[0025] f) 2-10% of astragalus extract (total flavonoid content ≥ 5%);

[0026] Among them, the water-soluble zinc compound is zinc citrate, the natural polysaccharide stabilizer is β-glucan, the prebiotic is fructooligosaccharide, the calcium supplement is nano-calcium carbonate, and the total flavonoid content of the astragalus extract is ≥ 5%.

[0027] As a further scheme of the present application, the total selenium content is 5-20 μg / g, the bioavailability of selenium is ≥ 80% as determined by simulated digestion experiment, and the selenium retention rate is ≥ 95% after 6 months of storage.

[0028] The preparation method of the anti-radiation organic selenium salt comprises the following steps:

[0029] Step S1, coating liquid preparation: disperse the organic selenium active ingredient and the antioxidant stabilizer in a 30-40% ethanol aqueous solution, and ultrasonic treatment until completely dissolved to obtain a coating liquid;

[0030] Step S2, fluidized bed coating: place the base salt particles in a fluidized bed, control the inlet air temperature to be 50-60℃, the atomization pressure to be 0.2-0.3MPa, spray the coating liquid, and the coating weight gain rate is 1-3%;

[0031] Step S3, flavoring agent mixing: mix the coated salt particles and the flavor synergist in a three-dimensional mixer at a low speed for 20-30min, and the temperature is ≤40℃;

[0032] Step S4, post-treatment: pass through a 80-100 mesh sieve and package under nitrogen;

[0033] In step S2, the fluidized bed coating adopts a gradient spraying method:

[0034] First stage: the spraying rate is 5-8mL / min, so that the active ingredient is preferentially adsorbed on the micropores on the surface of the salt particles;

[0035] Second stage: the spraying rate is increased to 10-15mL / min, and a continuous coating layer is formed.

[0036] As a further scheme of the present application, the adding step of the auxiliary ingredient is:

[0037] A: in step S1, 0.05-0.2% of nano-silicon dioxide and / or 0.1-0.5% of a water-soluble zinc compound are added to the coating liquid preparation, and are dispersed in the ethanol aqueous solution together with the organic selenium active ingredient and the antioxidant stabilizer, and the coating liquid is formed by ultrasonic treatment;

[0038] B: in step S3, the coated salt particles, the flavor synergist, 0.5-2% of a natural polysaccharide stabilizer and / or 3-8% of a prebiotic are mixed together, the conditions are 20-30rpm and the temperature is ≤40℃, and the time is 20-30min;

[0039] C: after step S3, 2-10% of an astragalus extract and / or 3-5% of a calcium supplement are added, and mixed for 10-20min to ensure uniform dispersion and not to damage the coating layer.

[0040] As a further scheme of the present application, the ultrasonic treatment in step S1 adopts a pulse mode, that is, working for 2s, interval for 1s, power of 200W, and time of 10min.

[0041] As a further scheme of the present application: the food is seasoning salt with daily intake ≤6g, which is suitable for radiation exposed population; when used, it is mixed with common salt at a ratio of 1:3-1:5, and the daily selenium intake is controlled in the range of 30-60ug.

[0042] Compared with the prior art, the present application has the following beneficial effects:

[0043] The present application solves the problem of easy degradation of organic selenium by fluidized bed coating and microcapsule technology, with a selenium retention rate ≥95% for 6 months, high stability, L-selenomethionine and vitamin E synergy, simulation digestion experiment shows that the selenium bioavailability ≥80%, better than inorganic selenium (<50%); organic selenium scavenges free radicals, vitamin E protects cell membranes, zinc and astragalus extract enhances immunity, realizes all-round radiation protection; amino acid mixture masks the bitter taste of organic selenium, umami score ≥7.5 / 10, good palatability; whole process low temperature (≤60℃) preparation, can be directly integrated into the existing salt production line, suitable for industrial production. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the embodiments of the present application.

[0045] Example 1 (basic formula)

[0046] 1) Formula (weight percentage):

[0047] Basic salt: 95% lake salt (NaCl 96%, Mg 0.2%, K 0.3%, particle size 100-300um, Ra 0.5-2.0um);

[0048] Organic selenium active ingredient: 1.5% L-selenomethionine (purity ≥98%);

[0049] Antioxidant stabilizer: 0.5% vitamin E microcapsule (gelatin: gum arabic = 1:1, particle size 10-50um);

[0050] Flavor synergist: 3% amino acid mixture (sodium glutamate: glycine: alanine = 3:1:1).

[0051] 2) Preparation steps:

[0052] S1: disperse 1.5% L-selenomethionine and 0.5% vitamin E microcapsule in 35% aqueous ethanol solution, pulse ultrasonic treatment (200W, 2s on / 1s off) for 10min, to obtain a coating liquid;

[0053] S2: Lake salt was placed in a fluidized bed, the inlet air temperature was 55°C, the atomization pressure was 0.25 MPa, gradient spraying: the first stage was 6 mL / min x 5 min, the second stage was 12 mL / min x 10 min, and the coating weight gain was 2%;

[0054] S3: After coating, the salt particles were mixed with 3% amino acid mixture in a three-dimensional mixer at 25 rpm for 25 min, and the temperature was ≤40°C;

[0055] S4: Sieved through a 90-mesh sieve and packaged under nitrogen.

[0056] 3) Experimental data:

[0057] Test item Result Total selenium content 12.4 μg / g HPLC method (GB5009.93-2017) Bioavailability Simulated gastrointestinal digestion model 80.2％ 6-month selenium retention rate Accelerated test (40℃ / 75%RH) 89.7％ Radiation resistance cell survival rate Jurkat cells + 2Gy γ-rays (CCK-8 method) 78.5％ Sensory score Blind test by 10 people (bitterness inhibition effect is obvious) 8.1 / 10 Test item

[0058] Example 2 (containing nano-silicon dioxide)

[0059] 1) Formulation (weight percentage):

[0060] Base salt: 93.8% lake salt (same as in Example 1);

[0061] Organic selenium active ingredient: 0.8% L-selenomethionine;

[0062] Antioxidant stabilizer: 0.7% vitamin E microcapsule (encapsulation rate 92%);

[0063] Flavor synergist: 4.5% amino acid mixture (same as in Example 1);

[0064] Auxiliary ingredient: 0.2% nano-silicon dioxide (30 nm).

[0065] 2) Preparation steps:

[0066] S1: Disperse 0.8% L-selenomethionine, 0.7% vitamin E microcapsule, and 0.2% nano-silicon dioxide in 35% aqueous ethanol solution, and pulse ultrasonic treatment for 10 min;

[0067] S2: Fluidized bed coating parameters were the same as in Example 1, and the coating weight gain was 2%;

[0068] S3: Mixed with 4.5% amino acid mixture at 25 rpm for 25 min (≤40°C);

[0069] S4: Sieved and packaged under nitrogen.

[0070] 3) Experimental data:

[0071] Result Total selenium content 10.2 μg / g (determined by HPLC method) Bioavailability 83.5% (simulated digestion experiment) 6-month selenium retention rate 95.1% (40℃ / 75%RH) Cellular radiation resistance survival rate (2Gy γ-rays) Sensory score (full score 10) 81.7％ 8.6 (no bitterness, umami taste prominent) Test item

[0072] Example 3 (containing zinc and prebiotics)

[0073] 1) Formulation (weight percentage):

[0074] Base salt: 87% rock salt (NaCl 94%, natural selenium 0.1 μg / g);

[0075] Organic selenium active ingredient: 2% L-selenomethionine;

[0076] Antioxidant stabilizer: 1% vitamin E microcapsule;

[0077] Flavor synergist: 5% amino acid mixture (containing 0.3% 5'-inosine disodium);

[0078] Auxiliary ingredient: 0.5% zinc citrate, 4.5% fructo-oligosaccharide.

[0079] 2) Preparation procedure:

[0080] S1 : Dissolve 2% L-selenomethionine, 1% vitamin E microcapsule, 0.5% zinc citrate in 35% aqueous ethanol solution, and ultrasonicate for 10 min;

[0081] S2: Rock salt fluidized bed coating (parameters same as Example 1);

[0082] S3: Mix with 5% amino acid mixture, 4.5% fructo-oligosaccharide at 25 rpm for 25 min;

[0083] S4: Sieving, nitrogen filling and packaging.

[0084] 3) Experimental data:

[0085] Result Total selenium content 20 μg / g Bioavailability 6-month selenium retention rate 85.2％ Cellular radiation resistance survival rate (2Gy γ-rays) 93.8％ Sensory score (full score 10) 84.3％ 8.2 (slight metallic taste, but acceptable) Test item

[0086] Example 4 (selenium-rich yeast formula)

[0087] 1) Formula (weight percentage):

[0088] Base salt: 92.5% refined salt (NaCl 99%);

[0089] Organic selenium active ingredient: 3% selenium-rich yeast extract (selenium content 1000 μg / g);

[0090] Antioxidant stabilizer: 0.5% vitamin E microcapsule;

[0091] Flavor synergist: 3% amino acid mixture;

[0092] Auxiliary ingredient: 1% β-glucan.

[0093] 2) Preparation procedure:

[0094] Coating liquid preparation:

[0095] S1: Disperse 3% selenium-rich yeast extract and 0.5% vitamin E microcapsules in 35% aqueous ethanol solution, and use pulse ultrasonic treatment (power 200 W, work 2 s / interval 1 s) for 10 minutes until completely dissolved to form a uniform coating solution.

[0096] S2: Fluidized bed coating: Place 92.5% refined salt particles (particle size 150-250 μm) in a fluidized bed, control the inlet air temperature to 52°C and the atomization pressure to 0.22 MPa, and use gradient spraying method:

[0097] First stage: Spray rate 7 mL / min, last for 6 minutes, to make active ingredients adsorbed on the surface micropores of salt particles;

[0098] Second stage: Spray rate increased to 13 mL / min, last for 12 minutes, to form a continuous coating layer, coating weight gain rate 2.5%.

[0099] S3: Mix flavoring agents and auxiliary ingredients: Mix the coated salt particles with 3% amino acid mixture and 1% β-glucan in a three-dimensional mixer at a low speed of 22 rpm for 28 minutes, control the temperature ≤38°C, and ensure uniform dispersion.

[0100] S4: Post-processing: Remove particles with abnormal particle size through a 90-mesh sieve, and seal the package with nitrogen-filled aluminum foil bag to avoid oxidation and moisture absorption

[0101] 3) Experimental data:

[0102] Result Total selenium content 8.7 μg / g Bioavailability 78.1% (yeast selenium is slightly lower than pure product) 6-month selenium retention rate 96.3% (β-glucan synergistic effect) Cellular radiation resistance survival rate (2Gy γ-rays) Sensory score (full score 10) 76.5％ 7.9 (slight yeast taste) Test item

[0103] Example 5 (containing Astragalus extract)

[0104] 1) Formula (weight percentage):

[0105] Base salt: 80% bamboo salt (roasted salt containing Ca / Mg / Zn);

[0106] Organic selenium active ingredient: 1.5% L-selenomethionine + 2% seleniumized carrageenan;

[0107] Antioxidant stabilizer: 0.5% vitamin E microcapsules;

[0108] Flavor synergist: 3% amino acid mixture;

[0109] Auxiliary ingredients: 8.5% Astragalus extract (total flavonoids ≥5%), 4.5% fructooligosaccharides.

[0110] 2) Preparation method:

[0111] S1: Coating liquid preparation: 1.5% L-selenomethionine, 2% selenized carrageenan, 0.5% vitamin E microcapsule were dispersed in 32% ethanol aqueous solution, and treated with pulse ultrasonic (200W, 2s on / 1s off) for 10 minutes to form a uniform dispersed coating liquid.

[0112] S2: Fluidized bed coating: 80% bamboo salt particles (particle size 100-300μm, Ra1.2μm) were placed in a fluidized bed, and the inlet air temperature was controlled at 58℃, the atomization pressure was 0.28MPa, and gradient spraying was performed:

[0113] First stage: spray rate 5mL / min, lasting 8 minutes, targeting adsorption on the surface micropores of bamboo salt;

[0114] Second stage: spray rate 15mL / min, lasting 15 minutes, forming a dense coating layer, coating weight gain rate 3%.

[0115] S3: Flavor and prebiotic mixture: the coated salt particles were mixed with 3% amino acid mixture and 4.5% fructooligosaccharide in a three-dimensional mixer at a low speed of 28rpm for 20 minutes, with the temperature controlled below 35℃.

[0116] S4: Add Astragalus extract: add 8.5% Astragalus extract to the above mixing system and continue mixing for 15 minutes (speed 25rpm) to ensure uniform dispersion of the extract without damaging the coating layer.

[0117] S5: Post-processing: pass through an 80-mesh sieve and package in a nitrogen-filled light-proof package (oxygen residual amount ≤3%) to complete the preparation

[0118] 3) Experimental data:

[0119] Result Total selenium content 15.8 μg / g Bioavailability 6-month selenium retention rate 80.6％ 97.5% (stable in alkaline environment of bamboo salt) Cellular radiation resistance survival rate (2Gy γ-rays) 88.4% (synergistic effect of radix astragali) Sensory score (full score 10) 7.5 (herbal flavor is obvious) Test item

[0120] Example 6 (containing calcium supplement)

[0121] Formulation (weight percentage):

[0122] Base salt: 85% sea salt (NaCl 95.7%);

[0123] Organic selenium active ingredient: 1.5% L-selenomethionine;

[0124] Antioxidant stabilizer: 1% vitamin E microcapsule;

[0125] Flavor synergist: 5% amino acid mixture (containing 0.2% 5'-guanylate disodium);

[0126] Auxiliary ingredient: 5% nano calcium carbonate, 2.5% Astragalus extract.

[0127] Preparation method:

[0128] S1: Coating liquid preparation: 1.5% L-selenomethionine, 1% vitamin E microcapsule were dispersed in 38% aqueous ethanol solution, and treated with pulse ultrasonic (200W, 2s on / 1s off) for 10 minutes until completely dissolved to obtain a clear coating liquid.

[0129] S2: Fluidized bed coating: 85% sea salt particles (particle size 200-300 μm, Ra 1.8 μm) were placed in a fluidized bed, and the inlet air temperature was controlled at 50°C, the atomization pressure was 0.3 MPa, and gradient spraying was performed:

[0130] First stage: spray rate 8 mL / min, lasting 5 minutes, quickly adsorbed on the surface of sea salt;

[0131] Second stage: spray rate 11 mL / min, lasting 10 minutes, forming a continuous coating layer, coating weight gain rate 1.5%.

[0132] S3: Flavor mixing: the coated salt particles were mixed with 5% amino acid mixture in a three-dimensional mixer at a low speed of 30 rpm for 25 minutes, and the temperature was ≤40°C.

[0133] S4: Adding calcium supplement and astragalus extract: 5% nano calcium carbonate and 2.5% astragalus extract were added to the above system, and the mixing was continued for 18 minutes (rotation speed 20 rpm) to ensure that the ingredients were uniform and the coating layer was complete.

[0134] S5: Post-processing: sieved through a 100-mesh sieve, and packaged under nitrogen (nitrogen purity ≥99.9%), to obtain the finished product.

[0135] 3) Experimental data:

[0136] Result Total selenium content 18.3 μg / g Bioavailability 6-month selenium retention rate 82.9％ 91.2% (KCl hygroscopicity is slightly higher) Cellular radiation resistance survival rate (2Gy γ-rays) Sensory score (full score 10) 79.8％ 7.0 (potassium salt bitterness needs to be adapted) Test item

[0137] Comparative Example 1: Inorganic selenium salt (traditional process)

[0138] 1) Formula: 95% lake salt + 0.1% sodium selenite (inorganic selenium) + 0.5% vitamin E (not microencapsulated) + 4.4% sodium chloride (to make up the balance).

[0139] 2) Preparation method: direct mixing, no fluidized bed coating, and drying at room temperature.

[0140] 3) Experimental data:

[0141] Result Comparison with Example 1 (gap) Total selenium content 12.1 μg / g Close (difference is due to morphology) Bioavailability Low by 37.9% (Example 1 is 80.2%) 42.3％ 6-month selenium retention rate Low by 21.2% (Example 1 is 89.7%) 68.5％ Radiation resistance cell survival rate Low by 19.3% (Example 1 is 78.5%) 59.2％ Sensory score 4.8 / 10 (bitterness is obvious) Low by 3.3 points (Example 1 is 8.1 / 10) Test item

[0142] Comparative Example 2: Simple mixing of organic selenium (without coating process)

[0143] 1) Formula: same as Example 2 (containing 0.8% L-selenomethionine, 0.2% nano silicon dioxide).

[0144] 2) Preparation method: cancel fluidized bed coating, use three-dimensional mixer to directly dry mix (30 rpm x 30 min).

[0145] 3) Experimental data:

[0146] Result Comparison with Example 2 (gap) Total selenium content 10.0 μg / g Close Bioavailability Low by 17.8% (Example 2 is 83.5%) 65.7％ 6-month selenium retention rate Low by 22.8% (Example 2 is 95.1%) 72.3％ Radiation resistance cell survival rate Low by 14.2% (Example 2 is 81.7%) 67.5％ Selenium content RSD between batches High by 5.5% (Example 2 is 3.1%) 8.6％ Test item

[0147] Comparative Example 3: without vitamin E microcapsule (lack of antioxidant synergy)

[0148] 1) Formula: same as Example 3 (containing 2% L-selenomethionine, 0.5% zinc citrate), remove vitamin E microcapsule.

[0149] 2) Preparation method: same as Example 3.

[0150] 3) Experimental data:

[0151] Result Comparison with Example 3 (gap) Bioavailability Low by 15.1% (Example 3 is 85.2%) 70.1％ 6-month selenium retention rate Low by 11.3% (Example 3 is 93.8%) 82.5％ Radiation resistance cell survival rate Low by 13.1% (Example 3 is 84.3%) 71.2％ Test item

[0152] Comparative Example 4: without amino acid mixture (lack of flavor optimization)

[0153] 1) Formula: same as Example 5 (containing 1.5% L-selenomethionine, 8.5% astragalus extract), remove amino acid mixture.

[0154] 2) Preparation method: same as Example 5.

[0155] 3) Experimental data:

[0156] Result Comparison with Example 5 (gap) Sensory score 4.2 / 10 (heavy bitterness and medicinal taste) Low by 3.3 points (Example 5 is 7.5 / 10) ​ Volunteer acceptance 32% (willing to consume long term) Low 43% (75% for Example 5)

[0157] Comparative Example and Example Comparison Conclusion

[0158] a) Organic selenium vs inorganic selenium: The organic selenium (L-selenomethionine, etc.) used in the example is significantly better than the inorganic selenium (sodium selenite) of Comparative Example 1 in terms of bioavailability, stability, and anti-radiation effect, proving the core advantages of organic selenium form.

[0159] b) Coating process vs simple mixing: The fluidized bed coating process of the example (not used in Comparative Example 2) increases selenium retention rate by more than 20%, improves batch stability, and verifies the key role of coating technology in protecting active ingredients.

[0160] c) Antioxidant synergy: The addition of vitamin E microcapsule (not added in Comparative Example 3) increases selenium retention rate and anti-radiation effect by more than 10%, reflecting the synergistic effect of "organic selenium + vitamin E".

[0161] d) The necessity of flavor optimization: The amino acid mixture (not added in Comparative Example 4) significantly improves the sensory experience, and the acceptance of volunteers is increased by more than 40%, solving the palatability problem of functional salt.

[0162] It can be seen by analysis that:

[0163] The application solves the problem of easy degradation of organic selenium by fluidized bed coating and microcapsule technology, with a selenium retention rate of ≥95% for 6 months, high stability, L-selenomethionine and vitamin E synergy, simulation digestion experiment shows that the selenium bioavailability is ≥80%, better than inorganic selenium (<50%); Organic selenium scavenges free radicals, vitamin E protects cell membranes, zinc and astragalus extract enhances immunity, and achieves all-round radiation protection; Amino acid mixture masks the bitter taste of organic selenium, with a fresh taste score of ≥7.5 / 10, good palatability; The whole process is prepared at low temperature (≤60℃), which can be directly integrated into the existing salt production line and is suitable for industrial production.

[0164] The above is only the preferred specific embodiment of the present application, but the protection scope of the present application is not limited to this, any person skilled in the art can make equivalent replacement or change according to the technical scheme and the inventive concept of the present application within the technical range disclosed by the present application, which should be covered in the protection scope of the present application.

Claims

1. An anti-radiation organoselenium salt, characterized in that, It is made of the following components with the following weight percentages: Base salt: 80-95% lake salt, rock salt, bamboo salt, sea salt or refined salt; Organic selenium active ingredient: 0.1-2% L-selenomethionine, and / or 1-3% selenium-rich yeast extract, and / or 0.5-2% selenium carrageenan; Antioxidant stabilizer: 0.5-1% vitamin E microcapsule; Flavor synergist: 2-5% amino acid mixture.

2. The anti-radiation organoselenium salt of claim 1, wherein: The sodium chloride content of the base salt is ≥94%, and naturally contains 0.1-0.5% potassium and magnesium minerals; bamboo salt is roasted salt containing calcium, magnesium and zinc minerals; the particle size of lake salt or rock salt is 100-300 μm, and the surface roughness is 0.5-2.0 μm.

3. The anti-radiation organoselenium salt of claim 1, wherein: The particle size of the selenium carrageenan is 50-100 nm, and the selenium content is ≥10%; the coating material of the vitamin E microcapsule is gelatin-arabic gum composite wall material, the particle size is 10-50 μm, the mass ratio of gelatin to arabic gum is 1:1-1:2, and the encapsulation rate is ≥90%.

4. The anti-radiation organoselenium salt of claim 1, wherein: The amino acid mixture is composed of sodium glutamate, glycine and alanine in a mass ratio of 3:1:1, and contains 0.1-0.3% 5'-inosinic acid disodium or 5'-guanylic acid disodium.

5. The radiation resistant organoselenium salt of claim 1, wherein, It also contains at least one auxiliary ingredient selected from: a) 0.05-0.2% nano-silicon dioxide; b) 0.1-0.5% water-soluble zinc compound (zinc citrate); c) 0.5-2% natural polysaccharide stabilizer (β-glucan); d) 3-8% prebiotic (fructooligosaccharide); e) 3-5% calcium supplement (nano calcium carbonate); f) 2-10% radix astragali extract (total flavonoid content ≥5%); Among them, the water-soluble zinc compound is zinc citrate, the natural polysaccharide stabilizer is β-glucan, the prebiotic is fructooligosaccharide, the calcium supplement is nano calcium carbonate, and the total flavonoid content of the radix astragali extract is ≥5%.

6. The radiation resistant organoselenium salt according to any one of claims 1 to 5, wherein: The total selenium content is 5-20 μg / g, the selenium bioavailability is ≥80% determined by simulated digestion experiment, and the selenium retention rate is ≥95% after 6 months of storage.

7. A method for the preparation of an anti-radiation organoselenium salt for use in an anti-radiation organoselenium salt as claimed in any one of claims 1 to 6, characterized in that, It includes the following steps: Step S1, coating liquid preparation: disperse the organic selenium active ingredient and the antioxidant stabilizer in 30-40% ethanol aqueous solution, and ultrasonically treat until completely dissolved to obtain a coating liquid; Step S2, fluidized bed coating: place the base salt particles in the fluidized bed, control the inlet air temperature to 50-60℃, the atomization pressure to 0.2-0.3 MPa, spray the coating liquid, and the coating weight gain rate is 1-3%; Step S3, flavoring agent mixing: mix the coated salt particles and the flavor synergist in a three-dimensional mixer at a low speed for 20-30 min, and the temperature is ≤40℃; Step S4, post-treatment: pass through an 80-100 mesh sieve and package under nitrogen; In step S2, the fluidized bed coating adopts gradient spraying method: First stage: spray rate 5-8 mL / min, make the active ingredient preferentially adsorbed on the surface micropores of the salt particles; Second stage: increase the spray rate to 10-15 mL / min to form a continuous coating layer.

8. The method for preparing the anti-radiation organic selenium salt according to claim 7, characterized in that, The addition steps of the auxiliary ingredients are: A: In step S1, 0.05-0.2% nano-silicon dioxide and / or 0.1-0.5% water-soluble zinc compound are added during the preparation of the coating liquid, and are dispersed in an aqueous ethanol solution together with the active ingredient of organic selenium and the antioxidant stabilizer to form a coating liquid through ultrasonic treatment; B: In step S3, the coated salt particles are mixed with the flavor synergist and 0.5-2% natural polysaccharide stabilizer and / or 3-8% prebiotic, under the conditions of 20-30 rpm, temperature ≤40°C, and time 20-30 minutes; C: After step S3, 2-10% radix astragali extract and / or 3-5% calcium supplement are added and mixed for 10-20 minutes to ensure uniform dispersion without damaging the coating layer.

9. The method for preparing the anti-radiation organic selenium salt according to claim 7, characterized in that: The ultrasonic treatment in step S1 uses a pulse mode, i.e., working for 2s, interval for 1s, power for 200W, and time for 10min.

10. Use of the anti-radiation organoselenium salt according to any one of claims 1 to 6 for the preparation of an anti-radiation functional food, characterized in that: The food is a seasoning salt with a daily intake ≤6g, suitable for radiation-exposed populations; when used, it is mixed with ordinary table salt at a ratio of 1:3-1:5, and the daily selenium intake is controlled within the range of 30-60μg.