22 results about "Methyl selenocysteine" patented technology

The invention relates to the technical field of veterinary chemical drugs, and provides an application of a selenium-rich composition in a drug for preventing bone marrow suppression after chemotherapy of dogs, and the selenium-rich composition comprises nano-selenium-beta-glucan chelate and L-selenium-methyl selenocysteine, the mass ratio of the nano-selenium-beta-glucan chelate to the L-selenium-methyl selenocysteine is 1: (0.3-0.6), and the mass ratio of the nano-selenium-beta-glucan chelate to the L-selenium-methyl The molar ratio of the astragaloside IV to the cobamamide is (5 to 8): 1. Through the synergistic effect of the nano-selenium-beta-glucan chelate and the L-selenium-methyl selenocysteine and in combination with the loading technology of the silicon dioxide mesoporous carrier, the absorption rate of selenium is greatly improved.

The invention provides application of methyl selenocysteine in improving insect resistance of rice and a method, belongs to the technical field of agricultural plant protection, and particularly relates to application of methyl selenocysteine in treating rice in a root irrigation or stem and leaf spraying mode. During root irrigation, the concentration of the methyl selenocysteine is 2-10 [mu] M; when the stem leaves are sprayed, the concentration of the methyl selenocysteine is 20-100 [mu] M; the invention discloses that methyl selenocysteine has an excellent prevention and control effect on main piercing-sucking type pests, namely brown planthopper and sogatella furcifera, on rice for the first time, the survival rate of rice planthopper nymphs can be reduced to 10% or below, and the methyl selenocysteine has very high economic benefits.

The application provides a synthesis method of L-selenium-methyl selenocysteine, which comprises the following steps: mixing dimethyl diselenide with sodium borohydride, then adding a sodium hydroxide solution to react, to obtain a sodium methyl selenide solution; preparing 3-chloro-L-alanine methyl ester hydrochloride, stirring the prepared 3-chloro-L-alanine methyl ester hydrochloride with the sodium methyl selenide solution to react; acidifying the solution after the stirring reaction, then extracting, removing impurities, heating the water phase, and reducing pressure distillation to obtain solid crystals; using methanol to extract the solid crystals twice, then adding triethylamine to stir and crystallize, to obtain L-selenium-methyl selenocysteine solid crude product; hydrating the L-selenium-methyl selenocysteine solid crude product, then recrystallizing to obtain L-selenium-methyl selenocysteine solid; the L-selenium-methyl selenocysteine synthesized by the application has the advantages of simple process route, mild conditions, high purity and high yield.

The invention discloses a ferroptosis inhibitor for improving liver toxicity of a GPR40 agonist TAK-875. The ferroptosis inhibitor comprises an iron complexing agent, an antioxidant, a lipoxygenase (LOX) inhibitor, an ACSL4 inhibitor, nitrogen oxide and selenium supplement, the iron complexing agent comprises deferoxamine, deferiprone, Deferasirox, curcumin and hepcidin, so that unstable iron in cells can be reduced, and a Fenton reaction can be inhibited; the antioxidant is prepared from Ferrostain-1, Liproxstain-1, Trolox and XJB-5-131, and the antioxidant is prepared from the following raw materials: sodium alginate, sodium alginate and sodium alginate; the lipoxygenase (LOX) inhibitor comprises Zileuton, AA861, PD146176 and baicalin, the ACSL4 inhibitor comprises Troglitazole, Rosiglitazole and Pioglitazole, the nitrogen oxides comprise TEMPO and PHOXNO, the Fenton reaction can be blocked, and the generation of hydroxyl free radicals can be inhibited; the selenium supplement comprises selenium, methyl selenocysteine and selenocystamine, the abundance of GPX4 is supplemented, and the lipid peroxide removing capacity is enhanced. Compared with the prior art, the invention has the advantage that the iron inhibitor is effectively proved to treat hepatotoxicity.

The invention provides a hair-growing traditional Chinese medicine preparation and a preparation method thereof. The hair-growing traditional Chinese medicine preparation is prepared from the following components in parts by weight: 400 to 500 parts of fermented radix polygoni multiflori, 100 to 200 parts of radix rehmanniae preparata, 100 to 200 parts of radix angelicae sinensis, 20 to 30 parts of fructus chaenomelis lagenariae, 20 to 30 parts of flos carthami, 1 to 5 parts of rhizoma zingiberis recens, 0.03 to 0.05 part of L-selenium-methyl selenocysteine, 50 to 100 parts of inulin and 60 to 90 parts of matrine-chitosan conjugate. Uniformly mixing the fermented polygonum multiflorum, prepared rehmannia root, angelica sinensis, pawpaw, safflower carthamus, ginger, L-selenium-methyl selenocysteine, inulin and matrine-chitosan conjugate to obtain the hair-growing traditional Chinese medicine preparation which has the effects of preventing hair loss and growing hair.

The invention discloses a selenium vitamin E capsule composition for resisting cancer and assisting in protecting chemical liver injury, and belongs to the technical field of health food. The composition is prepared from active ingredients and pharmaceutic adjuvants, wherein the active ingredients comprise L-selenium-methyl selenocysteine, vitamin E, vitamin C and vitamin B3. All the active ingredients generate a synergistic effect through scientific proportioning, so that the composition not only can effectively inhibit cancer cell proliferation and play an anti-cancer role, but also can relieve damage of chemical toxins to the liver through a strong anti-oxidation mechanism and assist in protecting the liver function. The product disclosed by the invention is high in bioavailability and good in safety, and has remarkable beneficial effects.

The application discloses a kind of plant selenium-rich nutrient solution, it is with full formula nutrient solution as foundation culture solution, add the nutrient solution of final concentration 0.90~2.0mg / L selenium-methyl selenocysteine;The full formula nutrient solution is by volume ratio 1~3:1~3:198~208 A liquid, B liquid and water are mixed into.The plant selenium-rich nutrient solution of the application, through specific component and amount, under the condition that not affecting the yield of vegetables, the selenium content of vegetables reaches the requirement in DBS 42 / 002-2014 selenium content requirement of selenium-rich organic food standard.The plant selenium-rich nutrient solution of the application does not add phosphorus, and the methyl selenocysteine therein can still be efficiently absorbed and utilized by vegetables, improves the utilization rate of selenium, reduces the cost of selenium-rich vegetable planting, while reducing phosphorus pollution, with practical popularization and application value.

The preparation method comprises the following steps: weighing 15g of selenomethionine and 5g of selenium methyl selenocysteine, dissolving the selenomethionine and the selenium methyl selenocysteine in 800ml of water for injection, and stirring until the solution is clear; adding 20g of beta-cyclodextrin and 3g of L-ascorbic acid, and adjusting the pH value to 7.2 + / -0.2; supplementing the water for injection to 1000ml, and sterilizing and filtering through a 0.22 mu m filter membrane to obtain the injection. And subpackaging the injection, and sterilizing in a water bath at the temperature of 60 DEG C for 30 minutes to obtain a final product. The invention belongs to the technical field of medicines, and particularly provides a preparation method of a non-toxic high-selenium injection which takes organic selenium as a core component, supplements selenium for patients who cannot eat and drink and need large-dose selenium supplementation, and adopts a composite stable system and a low-temperature sterilization technology.

The invention belongs to the technical field of functional foods and medicines, and particularly discloses application of L-selenium methyl selenocysteine in preparation of a product for targeted regulation of intestinal flora to relieve chemotherapy immune injury. The target regulation is realized by specifically improving the relative abundance of the beneficial bacteria, namely, Bacteroides acdifaciens, in the intestinal tracts of the subject, so that the relative abundance of the beneficial bacteria, namely the Bacteroides acdifaciens, in the intestinal tracts of the subject is improved. Systematic contrast experiments prove that under the condition of equal selenium content, the selenium-enriched milk powder strengthened by taking L-selenium methyl selenocysteine as a unique selenium source has the effect obviously superior to that of contrast milk powder strengthened by selenium-enriched yeast or sodium selenite in the aspect of relieving immunosuppression, intestinal injury and systemic inflammation caused by cyclophosphamide. The core mechanism of the L-selenium methyl selenocysteine is that the L-selenium methyl selenocysteine can be used for efficiently and specifically enriching Bacteroides acdifaciens, and the L-selenium methyl selenocysteine can be used for efficiently and specifically enriching Bacteroides acdifaciens. Based on the discovery, the invention correspondingly provides a selenium-enriched milk powder product with definite targeting property and excellent effects, and a brand new efficient solution is provided for chemotherapy auxiliary nutrition support of tumor patients.

The invention relates to the technical field of food nutrition fortifiers, in particular to L-selenium-methyl selenocysteine and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out group protection on L-serine, then activating hydroxyl of the serine in three modes of iodination, bromination and toluenesulfonate, and respectively carrying out a methylselenylation substitution reaction on the obtained three activated intermediates and a sodium methyl selenol solution prepared in situ, and finally, completing protective group removal and solvent recovery in a rotary evaporation bottle of a rotary evaporator in one pot to obtain the L-selenium-methyl selenocysteine. According to the method, raw materials are economical and easy to obtain, reaction steps are simple, reaction conditions are mild, the product does not need optical resolution, the reaction direct yield is high, the process coupling degree is high, the provided optimal intermediate scheme is high in universality and compatibility, and convenience is provided for industrial production.

This invention discloses the application of selenium-containing carbon quantum dots in enhancing the accumulation of organic selenium in rice grains, belonging to the field of plant growth regulator technology. This invention provides the application of selenium-containing carbon quantum dots in enhancing the accumulation of organic selenium in rice grains, which can significantly increase the organic selenium content in rice grains, including selenocysteine, selenomethionine, and methylselenocysteine. Under high and low temperature conditions during the rice grain-filling stage, the selenium-containing carbon quantum dots significantly increase the accumulation of total organic selenium, thereby stably improving the organic selenium level of rice grains under different temperature stresses, ensuring the nutritional quality and functionality of rice. This invention provides an efficient and stable method for producing selenium-enriched functional rice.

The application discloses a method for preparing L-selenium-methyl selenocysteine by organic phosphine reduction, which is prepared by one-pot method under the reduction of organic phosphine, taking L-serine or L-serine derivative as raw material and dimethyl diselenide as selenium source. Compared with the conventional chemical synthesis method, the method for preparing L-selenium-methyl selenocysteine by organic phosphine reduction can efficiently synthesize L-selenium-methyl selenocysteine and its derivative under the reduction of organic phosphine, can obtain L-selenium-methyl selenocysteine with high yield and high purity, has the advantages of simple synthesis route, no need to use boron hydride reducing agent or Grignard reagent with explosion hazard, mild reaction condition, safe and reliable process, cheap and easily available raw material, high product yield, high purity and the like, and has important promoting effect on realizing large-scale industrial application of L-selenium-methyl selenocysteine.

The invention provides a selenium-rich composite tablet and a preparation method and application thereof, and belongs to the technical field of biological medicine preparations, the tablet takes selenium-rich yeast, L-selenium-methyl selenocysteine, compound protein peptide and soybean protein hydrolysate as main components, and the bioavailability and synergistic effect of selenium are remarkably improved by optimizing the raw material ratio. Wherein the compound protein peptide is modified by combining a step enzymolysis technology with selenylation, so that the activity and the stability of the peptide are enhanced; the soybean protein hydrolysate is subjected to a specific enzymolysis process, the nutritional value and the absorption efficiency of the tablet are further improved, the selenium-rich composite tablet has the remarkable effects of improving the immunity of the human body and resisting oxidation and aging, and the defects that a traditional selenium supplementing preparation is low in absorption rate and poor in stability are overcome.

The invention discloses a three-selenium composition for promoting proliferation of beneficial bacteria and a preparation method thereof, the three-selenium composition is characterized in that the three-selenium composition is prepared from selenoprotein prepared from mulberry leaves, selenium-rich tea leaves and cardamine violifolia as raw materials, nano selenium-rich yeast and L-selenium-methyl selenocysteine, the components of the three-selenium composition are unique in preparation, the three-selenium composition can generate a synergistic interaction effect under a specific ratio, and the composition has a good effect on promoting proliferation of beneficial bacteria. The selenium-enriched yeast is an organic selenium component, the obtained product not only can safely supplement selenium, but also has the effects of promoting proliferation of beneficial bacteria and enhancing immunity, and the technical requirements of symbolic components, pesticide residues and heavy metal content of the product are ensured by adopting an ultrasonic enzymolysis and biotransformation method and a process of nanocrystallizing the selenium-enriched yeast and adsorbing and filtering an extracting solution. The product provided by the invention has the advantages of large market demand, wide market demand, wide application prospect, facilitation of promotion of popularization and application of precise selenium supplement, facilitation of promotion of development of agricultural product planting and processing industry, and substantial social and economic benefits.

The invention provides an L-selenium methyl modified oligopeptide compound for monascus fermentation as well as a preparation method and application thereof, and relates to the technical field of biological fermentation, the amino acid sequence is H2N-Arg-Gly-Asp-L-selenium methyl selenocysteine-OH, the L-selenium methyl modified oligopeptide compound is used as a fermentation accelerant, the compound is added into a monascus fermentation culture medium, the addition amount is 0.1-1.0 g / L, and the fermentation time is 1-2 hours; the growth rate of monascus can be improved, and the fermentation period is shortened; the synthesis of the monascus pigment and Monacolin K can be promoted, so that the yield of the monascus pigment is increased by 20-30%, and the yield of the Monacolin K is increased by 15-25%; the adaptability of monascus to environmental factors (such as temperature and pH value) can be enhanced, and the fluctuation in the fermentation process is reduced.

The invention relates to the technical field of organic synthesis, in particular to L-selenium-methyl selenocysteine and a continuous production method and system thereof. The production method comprises the following steps: S1, conveying a reducing agent, selenium powder and an acid solution into a dynamic tubular reactor for reaction to obtain hydrogen selenide gas; s2, the hydrogen selenide gas reacts with a bicarbonate solution to obtain selenium hydride salt, the selenium hydride salt reacts with a methylation reagent to obtain methyl selenol salt, and the methyl selenol salt reacts with a chloro-alanine salt solution to obtain L-selenium-methyl selenocysteine salt; s3, the L-selenium-methyl selenocysteine salt is subjected to acidification, and L-selenium-methyl selenocysteine is obtained; wherein the reaction in the step S2 is carried out in the microchannel reactor. According to the method disclosed by the invention, continuous production of the L-selenium-methyl selenocysteine can be realized, the reaction efficiency is improved, and possibility is provided for mass production.

The invention discloses a method for simultaneously detecting the contents of selenomethionine and selenomethylselenocysteine ​​in black garlic. The method comprises the following steps: extracting black garlic by ultrasonic-assisted extraction to obtain an extract; subjecting the obtained extract to solid phase extraction and then PITC derivatization to obtain a sample solution; and subjecting the obtained sample solution to UPLC-MS detection to obtain the contents of selenomethionine and selenomethylselenocysteine ​​in the black garlic through calculation.

The invention provides an anti-aging theaflavin composition as well as a preparation method and application thereof, and belongs to the technical field of biology. The composition comprises a coated and modified nanocrystalline theaflavin-metal organic framework compound and a mitochondrial targeting coenzyme Q10-L-selenium-methyl selenocysteine compound. The nanocrystalline theaflavin-metal organic framework is prepared by adopting a special method, the stability and the bioavailability of theaflavin are improved by adopting the gamma-cyclodextrin-tannic acid copolymer for coating, and the stability and the bioavailability of theaflavin are improved by being matched with the mitochondrial targeting coenzyme Q10-L-selenium-methyl selenocysteine compound for reasonable compatibility and use, so that the anti-aging effect can be well realized; the effect of theaflavin is effectively improved.

The invention discloses an optimized formula of natural nano organic plant selenium with higher bioavailability and stronger anti-cancer activity and a preparation method, and belongs to the technical field of functional food and nutrient enrichment. According to the formula, L-sodium ascorbate, selenium-enriched yeast, L-ascorbic acid, D-biotin and L-selenium-methyl selenocysteine are used as core raw materials, and edible corn starch, maltodextrin, magnesium stearate and hydroxypropyl starch empty capsules are compounded to prepare capsules. Organic selenium is converted into a natural nano state with uniform particle size through processes of reduction stabilization, nano dispersion, low-temperature homogenization and step-by-step granulation, so that the solubility, the absorptivity and the bioavailability are remarkably improved; all the active ingredients have a synergistic effect, so that the selenium toxicity is reduced, and the antioxidant and in-vitro anticancer activity is enhanced. The problems of poor absorption, insufficient stability, single activity and the like of traditional organic selenium are solved, and the product is safe and stable, is suitable for long-term administration and can be used for anticancer assistance, immune enhancement and oxidative stress protection.

This invention discloses a method for producing selenium-enriched malt with high methylselenocysteine ​​content in the field of functional foods. The method involves mixing selenium powder with sodium sulfite at a molar ratio of 1:(4.0~8.0), calcining the mixture at 300±10℃ for 2-4 hours, cooling the resulting powder, adding 10-16 times the powder's weight of serine, and then dissolving the mixture in 10-20 times its weight of water to obtain a selenium-enriched solution. This selenium-enriched solution is then mixed with alcohols to form a nutrient solution. The nutrient solution is then soaked with wheat grains at a mass ratio of (2.0~4.0):1 at 10-30℃ until the average length of the malt reaches 1.5 times the length of the wheat grain. After drying and pulverizing, selenium-enriched malt powder is obtained. The product contains up to 1080 ppm of selenium and up to 851 ppm of methylselenocysteine, and can be used as a health product, functional food, or feed additive.

The present application relates to L-selenium-methyl selenocysteine extraction technical field, disclose a kind of selenium-enriched supplement special dietary food, specifically: template molecule L-selenium-methyl selenocysteine carboxyl and the pyridyl of functional monomer acryloyloxy bipyridyl amine monomer is self-assembled into polymeric molecule by ionic interaction, by free radical polymerization method, preparation magnetic L-selenium-methyl selenocysteine extractant;Magnetic L-selenium-methyl selenocysteine extractant is added to selenium-containing amino acid free type selenium-enriched rice protein solution, oscillation extraction, magnetic separation magnetic L-selenium-methyl selenocysteine extractant, using mixed solvent oscillation precipitation, obtain L-selenium-methyl selenocysteine.The present application provides a kind of extraction L-selenium-methyl selenocysteine in selenium-enriched rice protein, L-selenium-methyl selenocysteine prepared as selenium supplement, supplemented with other nutrient substance preparation selenium-enriched supplement special dietary food.

The invention provides a method for detecting alpha-acetamido methyl acrylate and impurities, which adopts high performance liquid chromatography, adopts a Shim-pack GIST C18-AQ column as a chromatographic column, adopts water-acetonitrile as a mobile phase according to a volume ratio of 98: 2-90: 10, and adopts isocratic elution; the chromatographic conditions are as follows: the column temperature is 25-35 DEG C, the flow velocity of a mobile phase is 0.8-1.2 mL / min, the detection wavelength of an ultraviolet detector is 200-230 nm, and the sample size is 5-20 [mu] L; the impurities comprise an impurity I and an impurity II; the impurity I is alpha, alpha '-diacetamido methyl propionate, the molecular formula of the impurity I is C8H14N2O4, and the impurity II is 2-(N-methyl acetamido) methyl acrylate, and the molecular formula of the impurity II is C7H11NO3. Accurate, sensitive, convenient, fast and low-cost detection can be realized, so that high-quality production of downstream products such as L-selenium-methyl selenocysteine and the like is guaranteed.