6 results about "Methyl selenocysteine" patented technology

The invention belongs to the technical field of functional foods and medicines, and particularly discloses application of L-selenium methyl selenocysteine in preparation of a product for targeted regulation of intestinal flora to relieve chemotherapy immune injury. The target regulation is realized by specifically improving the relative abundance of the beneficial bacteria, namely, Bacteroides acdifaciens, in the intestinal tracts of the subject, so that the relative abundance of the beneficial bacteria, namely the Bacteroides acdifaciens, in the intestinal tracts of the subject is improved. Systematic contrast experiments prove that under the condition of equal selenium content, the selenium-enriched milk powder strengthened by taking L-selenium methyl selenocysteine as a unique selenium source has the effect obviously superior to that of contrast milk powder strengthened by selenium-enriched yeast or sodium selenite in the aspect of relieving immunosuppression, intestinal injury and systemic inflammation caused by cyclophosphamide. The core mechanism of the L-selenium methyl selenocysteine is that the L-selenium methyl selenocysteine can be used for efficiently and specifically enriching Bacteroides acdifaciens, and the L-selenium methyl selenocysteine can be used for efficiently and specifically enriching Bacteroides acdifaciens. Based on the discovery, the invention correspondingly provides a selenium-enriched milk powder product with definite targeting property and excellent effects, and a brand new efficient solution is provided for chemotherapy auxiliary nutrition support of tumor patients.

The invention relates to the technical field of food nutrition fortifiers, in particular to L-selenium-methyl selenocysteine and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out group protection on L-serine, then activating hydroxyl of the serine in three modes of iodination, bromination and toluenesulfonate, and respectively carrying out a methylselenylation substitution reaction on the obtained three activated intermediates and a sodium methyl selenol solution prepared in situ, and finally, completing protective group removal and solvent recovery in a rotary evaporation bottle of a rotary evaporator in one pot to obtain the L-selenium-methyl selenocysteine. According to the method, raw materials are economical and easy to obtain, reaction steps are simple, reaction conditions are mild, the product does not need optical resolution, the reaction direct yield is high, the process coupling degree is high, the provided optimal intermediate scheme is high in universality and compatibility, and convenience is provided for industrial production.

This invention discloses the application of selenium-containing carbon quantum dots in enhancing the accumulation of organic selenium in rice grains, belonging to the field of plant growth regulator technology. This invention provides the application of selenium-containing carbon quantum dots in enhancing the accumulation of organic selenium in rice grains, which can significantly increase the organic selenium content in rice grains, including selenocysteine, selenomethionine, and methylselenocysteine. Under high and low temperature conditions during the rice grain-filling stage, the selenium-containing carbon quantum dots significantly increase the accumulation of total organic selenium, thereby stably improving the organic selenium level of rice grains under different temperature stresses, ensuring the nutritional quality and functionality of rice. This invention provides an efficient and stable method for producing selenium-enriched functional rice.

The application discloses a method for preparing L-selenium-methyl selenocysteine by organic phosphine reduction, which is prepared by one-pot method under the reduction of organic phosphine, taking L-serine or L-serine derivative as raw material and dimethyl diselenide as selenium source. Compared with the conventional chemical synthesis method, the method for preparing L-selenium-methyl selenocysteine by organic phosphine reduction can efficiently synthesize L-selenium-methyl selenocysteine and its derivative under the reduction of organic phosphine, can obtain L-selenium-methyl selenocysteine with high yield and high purity, has the advantages of simple synthesis route, no need to use boron hydride reducing agent or Grignard reagent with explosion hazard, mild reaction condition, safe and reliable process, cheap and easily available raw material, high product yield, high purity and the like, and has important promoting effect on realizing large-scale industrial application of L-selenium-methyl selenocysteine.

The invention discloses an optimized formula of natural nano organic plant selenium with higher bioavailability and stronger anti-cancer activity and a preparation method, and belongs to the technical field of functional food and nutrient enrichment. According to the formula, L-sodium ascorbate, selenium-enriched yeast, L-ascorbic acid, D-biotin and L-selenium-methyl selenocysteine are used as core raw materials, and edible corn starch, maltodextrin, magnesium stearate and hydroxypropyl starch empty capsules are compounded to prepare capsules. Organic selenium is converted into a natural nano state with uniform particle size through processes of reduction stabilization, nano dispersion, low-temperature homogenization and step-by-step granulation, so that the solubility, the absorptivity and the bioavailability are remarkably improved; all the active ingredients have a synergistic effect, so that the selenium toxicity is reduced, and the antioxidant and in-vitro anticancer activity is enhanced. The problems of poor absorption, insufficient stability, single activity and the like of traditional organic selenium are solved, and the product is safe and stable, is suitable for long-term administration and can be used for anticancer assistance, immune enhancement and oxidative stress protection.

This invention discloses a method for producing selenium-enriched malt with high methylselenocysteine ​​content in the field of functional foods. The method involves mixing selenium powder with sodium sulfite at a molar ratio of 1:(4.0~8.0), calcining the mixture at 300±10℃ for 2-4 hours, cooling the resulting powder, adding 10-16 times the powder's weight of serine, and then dissolving the mixture in 10-20 times its weight of water to obtain a selenium-enriched solution. This selenium-enriched solution is then mixed with alcohols to form a nutrient solution. The nutrient solution is then soaked with wheat grains at a mass ratio of (2.0~4.0):1 at 10-30℃ until the average length of the malt reaches 1.5 times the length of the wheat grain. After drying and pulverizing, selenium-enriched malt powder is obtained. The product contains up to 1080 ppm of selenium and up to 851 ppm of methylselenocysteine, and can be used as a health product, functional food, or feed additive.