Preparation method of composition for inhibiting cicatricial healing of wound

A composition and scar technology, which can be used in drug combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of lack of skin, harmless scar removal products, etc., and reduce pigmentation. , Inhibition of pathological scar fibrous hyperplasia, the effect of repairing trauma scar

Active Publication Date: 2020-03-20
河南希百康健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is a lack of scar removal products t

Method used

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  • Preparation method of composition for inhibiting cicatricial healing of wound
  • Preparation method of composition for inhibiting cicatricial healing of wound
  • Preparation method of composition for inhibiting cicatricial healing of wound

Examples

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Effect test

Embodiment 1

[0071] The preparation method of the composition for inhibiting wound cicatrix healing comprises the following steps:

[0072](1) Weigh 10mg L-selenium-methylselenocysteine ​​and 3g hyaluronic acid, and measure 500mL ultrapure water, and weigh the L-selenium-methylselenocysteine Dissolve in the measured ultrapure water to obtain the L-selenium-methylselenocysteine ​​aqueous solution to be stirred, and stir and shear the L-selenium-methylselenocysteine ​​aqueous solution to be stirred by an ultrasonic mixer Cut, shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water to obtain an aqueous solution of L-selenium-methylselenocysteine, and then weigh the transparent Hyaluronic acid is added to an aqueous solution of L-selenium-methylselenocysteine, and the composition stock solution is obtained after swelling at room temperature for 1-2 days;

[0073] (2) Under sterile conditions, pass the stock solution of the composition prepared in ste...

Embodiment 2

[0076] The preparation method of the composition for inhibiting wound cicatrix healing comprises the following steps:

[0077] (1) Weigh 5mg L-selenium-methylselenocysteine ​​and 3g hyaluronic acid, and measure 500mL ultrapure water, and weigh the L-selenium-methylselenocysteine Dissolve in the measured ultrapure water to obtain the L-selenium-methylselenocysteine ​​aqueous solution to be stirred, and stir and shear the L-selenium-methylselenocysteine ​​aqueous solution to be stirred by an ultrasonic mixer Cut, shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water to obtain an aqueous solution of L-selenium-methylselenocysteine, and then weigh the transparent Hyaluronic acid is added to an aqueous solution of L-selenium-methylselenocysteine, and the composition stock solution is obtained after swelling at room temperature for 1-2 days;

[0078] (2) Under sterile conditions, pass the stock solution of the composition prepared in ste...

Embodiment 3

[0081] The preparation method of the composition for inhibiting wound cicatrix healing comprises the following steps:

[0082] (1) Weigh 3mg L-selenium-methylselenocysteine ​​and 3g hyaluronic acid, and measure 500mL ultrapure water, and weigh the L-selenium-methylselenocysteine Dissolve in the measured ultrapure water to obtain the L-selenium-methylselenocysteine ​​aqueous solution to be stirred, and stir and shear the L-selenium-methylselenocysteine ​​aqueous solution to be stirred by an ultrasonic mixer Cut, shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water to obtain an aqueous solution of L-selenium-methylselenocysteine, and then weigh the transparent Hyaluronic acid is added to an aqueous solution of L-selenium-methylselenocysteine, and the composition stock solution is obtained after swelling at room temperature for 1-2 days;

[0083] (2) Under sterile conditions, pass the stock solution of the composition prepared in ste...

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Abstract

The invention discloses a preparation method of composition for inhibiting cicatricial healing of wound. The method includes the following steps of (1) weighing L-selenium-methyl selenocysteine and hyaluronic acid according to the ratio, respectively and measuring ultrapure water according to the ratio, dissolving the weighed L-selenium-methyl selenocysteine into the ultrapure water and conductingstirring, conducting shearing, conducting shaking or conducting vortexing by an ultrasonic mixer until the L-selenium-methyl selenocysteine is completely dissolved in the ultrapure water, and then adding the weighed hyaluronic acid and conducting swelling at room temperature for 1-2 days to obtain a composition stock solution; (2) Passing the composition stock through a 0.22 mum micro-porous filter under sterile conditions, conducting packaging under sterile conditions after sterilization, and conducting storing by placing the solution at 2-8 DEG C to obtain the composition for inhibiting cicatricial healing of the wound. The composition for inhibiting cicatricial healing of the wound prepared by the invention can effectively reduce cicatricial healing of the wound, and can reduce pigmentation of the wound site at the stage of wound shaping.

Description

technical field [0001] The invention belongs to the technical field of wound scar repair, and in particular relates to a preparation method of a composition for inhibiting wound scar healing. Background technique [0002] Scar refers to the appearance, morphology and histopathological changes of normal skin tissue caused by trauma. Its formation is due to the severe damage of human skin and soft tissue, which cannot be completely repaired normally by itself, and is replaced by fibrous tissue, leaving a scar that affects both function and appearance. Abnormal and unsound organization. Scars bother most people's normal study and life, especially when the scars are exposed, it will seriously affect people's self-esteem and self-confidence. The current treatment methods are basically performed in two ways: surgical repair and drug softening. Surgical repair is generally to flatten the scar that is higher than the normal skin, and for the sunken scar, the method of paving the s...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/198A61K47/36A61P17/02
CPCA61K9/0014A61K31/198A61K47/36A61P17/02A61K2300/00
Inventor 张继业李清清司佩茹杨显伟王梦涵莫菲马佳王阳李霁宇
Owner 河南希百康健康产业有限公司
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