4results about How to "Delayed healing" patented technology

The invention discloses magnesium-based hydrogen-rich bone cement as well as a preparation method and application thereof. The magnesium-based hydrogen-rich bone cement is prepared by mixing and curing powder and curing liquid, the powder comprises the following components in parts by mass: 50-80 parts of structural powder, 10-15 parts of a bonding consumable, 5-10 parts of a healing accelerant and 15-40 parts of an auxiliary agent, the structural powder comprises reinforcing powder and compatible powder, the reinforcing powder comprises at least one of calcium silicate and calcium phosphate, and the compatible powder comprises at least one of magnesium silicate and magnesium phosphate; the healing accelerant comprises a biodegradable polymer and a magnesium-based material embedded in the biodegradable polymer; and after the powder and the curing liquid are mixed and cured, surface activation treatment is applied, and at least part of the bonded consumables are removed. The magnesium-based hydrogen-rich bone cement disclosed by the invention can be applied to preparation of bone defect repair materials, can relieve local tissue inflammatory response, and is high in oxidation resistance, long in oxidation resistance duration, few in organic residues on the ceramic surface of the bone cement and good in biocompatibility.

The invention provides a drainage disc with a shape memory surface pattern, a preparation method and a drainage valve, and relates to the technical field of medical devices for eyes, the drainage disc is made of shape memory polymer, the drainage disc has an initial shape and a temporary shape, the initial shape comprises a groove structure facing the direction of the eyes, and the temporary shape comprises a groove structure facing the direction of the eyes. The temporary shape comprises a flat structure, the temporary shape is configured to be converted into the initial shape from the flat structure under temperature stimulation, and the cell surface morphology of the eye is restrained through the groove structure. The drainage disc is made of the shape memory polymer material, the drainage disc made of the shape memory polymer material recovers to the initial shape under temperature stimulation, the drainage disc with the groove structure is formed, the groove structure generates surface appearance constraint on eye cells, formation of scar tissue is reduced, and therefore the eye cells can be effectively protected. And the operation success rate of implanting the glaucoma drainage device is improved.

The invention discloses application of oridonin in preparation of an external preparation for treating skin scald, and belongs to the technical field of medicines. It is found for the first time that oridonin can effectively relieve the injury degree of skin scald and promote wound healing, the content of oridonin in the external preparation is 0.1-1% w / w, the dosage form can be selected from oil-in-water emulsion, plaster or hydrogel, and after the oridonin is matched with auxiliary materials such as a gel matrix and a transdermal enhancer, animal experiments prove that the oridonin can be used for preparing the external preparation. The 0.1% oridonin external preparation and the 1% oridonin external preparation can improve the symptoms of mice with scalded skin and promote wound healing, and the treatment effect of the oridonin external preparation is superior to that of asiaticoside ointment. According to the invention, the medicinal application of oridonin is expanded, a new effective medicine choice is provided for treating skin scald, and the oridonin has good clinical application value and popularization prospect.

The utility model discloses a medullary cavity flushing device which comprises a flushing pipe, a water absorption piece, dressing, a water outlet pipe, a positive pressure device and a negative pressure device, the water absorption piece is used for covering a wound, the dressing is used for being pasted on human body soft tissue around the wound to seal the water absorption piece, and one end of the flushing pipe penetrates through the dressing and the water absorption piece to be placed in a patient body. One end of the water outlet pipe is communicated with the water absorption piece, and the other end of the water outlet pipe is connected with the negative pressure device. A wound is covered with the water absorption part, the negative pressure device and the positive pressure device are opened at the same time, the water absorption part can absorb a large amount of seepage and blood flushed out of a marrow cavity, continuous drainage is achieved, soft tissue bacterial colonization is reduced, and soft tissue healing is facilitated; the water absorption piece can relieve edema of a wound surface except for osteomyelitis, improve local blood perfusion, reduce physical stimulation on the wound surface and draw and shrink the cavity; the water absorption piece can stretch soft tissue cells, promote granulation tissue production and promote blood vessel growth; the water absorption piece prevents the water outlet pipe from being blocked.