10 results about "Exanthem" patented technology

Disclosed herein are methods and compositions for preventing or reducing adverse events associated with administration of a RAS(ON) inhibitors. Thus, disclosed are compositions and methods for treating or preventing RAS(ON) inhibitor therapy-associated rash or mucositis. The methods involve administering a compound that binds to cyclophilin A (CypA) to compete with a RAS(ON) inhibitor for CypA binding, thereby reducing tri-complex formation in non-tumor tissues. These approaches may improve the tolerability of RAS(ON) inhibitor therapies without compromising efficacy.

The present disclosure provides recombinant Staphylococcus bacterium (e.g. S. epidermidis) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant Staphylococcus bacterium comprising two inactivated alanine racemase genes (Δalr1 Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant Staphylococcus bacterium. In another aspect, the disclosure features a method of treating or preventing a rash in a subject, comprising administering to the subject a population of the recombinant Staphylococcus bacterium of any one of the aspects or embodiments described herein, in an effective amount to treat or prevent the rash in the subject.

This invention discloses a traditional Chinese medicine composition for treating skin diseases and its preparation method, belonging to the field of traditional Chinese medicine technology. It is made from the following raw materials in parts by weight: 8-12 parts of Phellodendron bark, 8-12 parts of Cnidium monnieri fruit, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Stemona japonica root bark, 8-12 parts of alum, 8-12 parts of Carthamus tinctorius flower, 8-12 parts of dragon's blood, 8-12 parts of Panax notoginseng root bark, 8-12 parts of myrrh, 8-12 parts of frankincense, and 1-3 parts of propolis. This invention also provides an external preparation containing this composition and its preparation method. The preparation method includes pulverizing the raw materials, adding 60%-80% ethanol, soaking at 50-80℃ for 2-7 days, pressing, filtering, and allowing to stand, then collecting the supernatant. Pharmacological experiments show that the composition of this invention has significant antibacterial, anti-inflammatory, and antipruritic effects; clinical observations show a total effective rate of 80%-95% for psoriasis, eczema, rashes, pruritus, herpes, urticaria, and insect bite itching. The formulation of this invention is scientific, the process is stable, and the efficacy is definite, making it suitable for clinical application.

The invention provides a compound external preparation for promoting rash healing and a preparation method thereof, and aims to solve the problems of single target spot, low delivery efficiency, obvious stimulation and easy relapse of the existing rash preparation. The preparation comprises four groups of core active components of antimicrobial, anti-inflammatory and antipruritic, immunoregulation and tissue repair, and is matched with a skin micro-ecological regulator and an antagonist to construct an antibacterial, anti-inflammatory, repair and anti-recurrence full-chain treatment system; liposome formed by negatively charged phospholipid and pegylated cholesterol is used as a carrier and is combined with an azone-propylene glycol composite penetration enhancer, so that the transdermal efficiency and stability of active ingredients are improved; a step-by-step drug loading process is adopted for preparation, differentiated loading is performed according to physicochemical properties of components, and curative effect fluctuation is avoided; the preparation is suitable for various rash types, is non-irritant and anti-relapse, the process is controllable and easy to scale, and an efficient and safe scheme is provided for rash treatment.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving muscles and penetrating rashes, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-30 parts of pachouli, 10-40 parts of kudzu vine, 5-30 parts of notopterygium, 10-40 parts of talc, 5-30 parts of red peony root, 5-30 parts of thin soja bean, 5-30 parts of lophatherum gracile, 5-30 parts of raw rehmannia, and 10-30 parts of forsythia. The traditional Chinese medicine composition has the effects of dispelling dampness and relieving muscles, clearing heat and penetrating rashes, and can effectively improve the symptoms of fever, arthralgia, rash, fatigue, dry mouth and bitter taste, thick and greasy tongue fur and the like of patients with chikungunya fever caused by dampness stagnation in muscles and joints and heat entering the interior.

The application discloses a clinical prediction model for predicting the risk of purpura nephritis and a construction method of a nomogram thereof. Four independent risk factors are obtained through mathematical statistical methods, the risk independent factors include age, rash duration, D-dimer and IgG, four corresponding clinical prediction models are established according to the risk independent factors, and the optimal prediction model containing three prediction factors is obtained through mathematical analysis methods, the three prediction factors are the age of the child, D-dimer and IgG, and the occurrence risk of purpura nephritis can be predicted through the established nomogram. The application provides a convenient and effective tool for clinicians to evaluate the risk of HSPN in children with HSP, and the determination of the IgG and D-dimer levels in blood can be realized in community clinics.

A method of treating and / or preventing a skin toxicity associated with the administration of a therapeutic treatment comprising trametinib, naporafenib, or a combination thereof in a subject in need thereof; the method comprising pre-emptively administering to the subject an effective amount of a rash treatment.

The invention provides a traditional Chinese medicine composition for treating breast cancer and improving adverse reaction, which is prepared from the following raw materials in parts by weight: codonopsis pilosula, bighead atractylodes rhizome, lithospermum, rhizoma cimicifugae, cyrtomium fortunei, pollen typhae, angelica sinensis, golden cypress, radix angelicae, schizonepeta, radix paeoniae rubra, astragalus membranaceus, liquorice, medicated leaven, poria cocos and semen coicis. The traditional Chinese medicine composition can clear away lung heat, tonify heart blood and strengthen the spleen and stomach, and experiments prove that the traditional Chinese medicine composition has a good treatment effect on breast cancer, relieves adverse reactions caused by clinical drugs, especially adverse reactions caused by targeted and immune antitumor drugs and the like, and has a good curative effect on breast cancer. The most common treatment effect on patients with rash, diarrhea, oral mucositis and the like is optimal.

This invention relates to the pharmaceutical technology, and more particularly to a pyridadinopyridone derivative substituted with a nitrogen-containing functional group for use as an SOS1 protein inhibitor, and its use. The compounds provided in this invention exhibit clear inhibitory activity against the SOS1 protein, can be used as SOS1 protein inhibitors, have excellent drug-forming potential, and can be used in the manufacture of therapeutic drugs for diseases such as cancer and pathogenic rash diseases mediated by the SOS1 protein, thus showing promising future applications.

To provide recombinant Staphylococcus bacteria (e.g., S. epidermidis) that are dependent on D-alanine for growth. [Solution] In one aspect, the Disclosure features recombinant Staphylococcus bacteria comprising two inactivated alanine racemase genes (Δalr1Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the Disclosure features a method for producing recombinant Staphylococcus bacteria. In another aspect, the Disclosure provides a method for treating or preventing a rash in a subject, the method comprising the step of administering to the subject an amount effective to treat or prevent a rash in the subject, which is one of the aspects or embodiments described herein.