5 results about "Exanthem" patented technology

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving muscles and penetrating rashes, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-30 parts of pachouli, 10-40 parts of kudzu vine, 5-30 parts of notopterygium, 10-40 parts of talc, 5-30 parts of red peony root, 5-30 parts of thin soja bean, 5-30 parts of lophatherum gracile, 5-30 parts of raw rehmannia, and 10-30 parts of forsythia. The traditional Chinese medicine composition has the effects of dispelling dampness and relieving muscles, clearing heat and penetrating rashes, and can effectively improve the symptoms of fever, arthralgia, rash, fatigue, dry mouth and bitter taste, thick and greasy tongue fur and the like of patients with chikungunya fever caused by dampness stagnation in muscles and joints and heat entering the interior.

The application discloses a clinical prediction model for predicting the risk of purpura nephritis and a construction method of a nomogram thereof. Four independent risk factors are obtained through mathematical statistical methods, the risk independent factors include age, rash duration, D-dimer and IgG, four corresponding clinical prediction models are established according to the risk independent factors, and the optimal prediction model containing three prediction factors is obtained through mathematical analysis methods, the three prediction factors are the age of the child, D-dimer and IgG, and the occurrence risk of purpura nephritis can be predicted through the established nomogram. The application provides a convenient and effective tool for clinicians to evaluate the risk of HSPN in children with HSP, and the determination of the IgG and D-dimer levels in blood can be realized in community clinics.

A method of treating and / or preventing a skin toxicity associated with the administration of a therapeutic treatment comprising trametinib, naporafenib, or a combination thereof in a subject in need thereof; the method comprising pre-emptively administering to the subject an effective amount of a rash treatment.

This invention relates to the pharmaceutical technology, and more particularly to a pyridadinopyridone derivative substituted with a nitrogen-containing functional group for use as an SOS1 protein inhibitor, and its use. The compounds provided in this invention exhibit clear inhibitory activity against the SOS1 protein, can be used as SOS1 protein inhibitors, have excellent drug-forming potential, and can be used in the manufacture of therapeutic drugs for diseases such as cancer and pathogenic rash diseases mediated by the SOS1 protein, thus showing promising future applications.

To provide recombinant Staphylococcus bacteria (e.g., S. epidermidis) that are dependent on D-alanine for growth. [Solution] In one aspect, the Disclosure features recombinant Staphylococcus bacteria comprising two inactivated alanine racemase genes (Δalr1Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the Disclosure features a method for producing recombinant Staphylococcus bacteria. In another aspect, the Disclosure provides a method for treating or preventing a rash in a subject, the method comprising the step of administering to the subject an amount effective to treat or prevent a rash in the subject, which is one of the aspects or embodiments described herein.