19 results about "Exanthem" patented technology

Disclosed herein are methods and compositions for preventing or reducing adverse events associated with administration of a RAS(ON) inhibitors. Thus, disclosed are compositions and methods for treating or preventing RAS(ON) inhibitor therapy-associated rash or mucositis. The methods involve administering a compound that binds to cyclophilin A (CypA) to compete with a RAS(ON) inhibitor for CypA binding, thereby reducing tri-complex formation in non-tumor tissues. These approaches may improve the tolerability of RAS(ON) inhibitor therapies without compromising efficacy.

The present disclosure provides recombinant Staphylococcus bacterium (e.g. S. epidermidis) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant Staphylococcus bacterium comprising two inactivated alanine racemase genes (Δalr1 Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant Staphylococcus bacterium. In another aspect, the disclosure features a method of treating or preventing a rash in a subject, comprising administering to the subject a population of the recombinant Staphylococcus bacterium of any one of the aspects or embodiments described herein, in an effective amount to treat or prevent the rash in the subject.

The invention relates to a body resistance strengthening and stagnation eliminating prescription for resisting non-small cell lung cancer and a preparation method thereof. The body resistance strengthening and stagnation eliminating prescription is prepared from the following raw material medicines in parts by weight: 2-50g / part of radix fici simplicissimae, 2-50g / part of radix pseudostellariae, 2-50g / part of poria cocos, 2-50g / part of rhizoma atractylodis macrocephalae, 2-50g / part of radix scutellariae, 2-50g / part of oldenlandia diffusa, 2-50g / part of radix ranunculi ternati, 2-50g / part of polygonum cuspidatum, 2-50g / part of curcuma zedoary, 2-50g / part of oyster, 2-50g / part of platycodon grandiflorum, 2-50g / part of edible tulip and 2-50g / part of sculellaria barbata. Cell tests and construction of an NSCLC osimertinib-resistant animal model prove that the body resistance strengthening and stagnation eliminating prescription can regulate a tumor microenvironment (TME) and inhibit growth of osimertinib-resistant non-small cell lung cancer cells. In addition, the formula for strengthening the body resistance and removing stasis can also inhibit growth of common non-small cell lung cancer cells. Meanwhile, clinical observation finds that the body resistance strengthening and stasis removing prescription can improve symptoms such as insomnia, rash and diarrhea of patients with lung accumulation (lung cancer and pulmonary nodule), and improve the life quality of the patients.

This invention discloses a traditional Chinese medicine composition for treating skin diseases and its preparation method, belonging to the field of traditional Chinese medicine technology. It is made from the following raw materials in parts by weight: 8-12 parts of Phellodendron bark, 8-12 parts of Cnidium monnieri fruit, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Stemona japonica root bark, 8-12 parts of alum, 8-12 parts of Carthamus tinctorius flower, 8-12 parts of dragon's blood, 8-12 parts of Panax notoginseng root bark, 8-12 parts of myrrh, 8-12 parts of frankincense, and 1-3 parts of propolis. This invention also provides an external preparation containing this composition and its preparation method. The preparation method includes pulverizing the raw materials, adding 60%-80% ethanol, soaking at 50-80℃ for 2-7 days, pressing, filtering, and allowing to stand, then collecting the supernatant. Pharmacological experiments show that the composition of this invention has significant antibacterial, anti-inflammatory, and antipruritic effects; clinical observations show a total effective rate of 80%-95% for psoriasis, eczema, rashes, pruritus, herpes, urticaria, and insect bite itching. The formulation of this invention is scientific, the process is stable, and the efficacy is definite, making it suitable for clinical application.

The invention discloses a suction type bionic nano particle for monkey pox prevention and a preparation method and application of the suction type bionic nano particle. According to the suction type bionic nano particles, lipid simulating lung surface active substances and macrophage membranes are mixed to form a carrier of the nano particles, monkey pox antigens and cGAMP are wrapped, the suction type bionic nano particles are synthesized, and the suction type bionic nano particles can effectively enhance humoral immunity and cellular immunity of anti-monkey pox viruses. The invention also provides an application of the inhalation type bionic nanoparticle in preparation of a nasal inhalation type vaccine preparation, and the nasal inhalation type vaccine preparation can induce mucosal immunity in lungs and mucosal tissues, effectively protect orthopoxvirus from invading through vagina and enteric cavity, and prevent sexual transmission of the orthopoxvirus; the nasal inhalation type vaccine can completely prevent mice from death caused by infection of attenuated strains of orthopoxvirus VACV by immunizing, rash is completely eliminated, and the nasal inhalation type vaccine has significance on effective prevention of monkey pox.

The invention provides a compound external preparation for promoting rash healing and a preparation method thereof, and aims to solve the problems of single target spot, low delivery efficiency, obvious stimulation and easy relapse of the existing rash preparation. The preparation comprises four groups of core active components of antimicrobial, anti-inflammatory and antipruritic, immunoregulation and tissue repair, and is matched with a skin micro-ecological regulator and an antagonist to construct an antibacterial, anti-inflammatory, repair and anti-recurrence full-chain treatment system; liposome formed by negatively charged phospholipid and pegylated cholesterol is used as a carrier and is combined with an azone-propylene glycol composite penetration enhancer, so that the transdermal efficiency and stability of active ingredients are improved; a step-by-step drug loading process is adopted for preparation, differentiated loading is performed according to physicochemical properties of components, and curative effect fluctuation is avoided; the preparation is suitable for various rash types, is non-irritant and anti-relapse, the process is controllable and easy to scale, and an efficient and safe scheme is provided for rash treatment.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving muscles and penetrating rashes, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-30 parts of pachouli, 10-40 parts of kudzu vine, 5-30 parts of notopterygium, 10-40 parts of talc, 5-30 parts of red peony root, 5-30 parts of thin soja bean, 5-30 parts of lophatherum gracile, 5-30 parts of raw rehmannia, and 10-30 parts of forsythia. The traditional Chinese medicine composition has the effects of dispelling dampness and relieving muscles, clearing heat and penetrating rashes, and can effectively improve the symptoms of fever, arthralgia, rash, fatigue, dry mouth and bitter taste, thick and greasy tongue fur and the like of patients with chikungunya fever caused by dampness stagnation in muscles and joints and heat entering the interior.

The invention discloses a traditional Chinese medicine composition and a preparation method and application thereof.The traditional Chinese medicine composition comprises, by weight, 20-30 parts of dandelion, 20-30 parts of sophora flavescens, 30-100 parts of honeysuckle, 10-30 parts of radix paeoniae rubra and 20-30 parts of fructus kochiae, and the traditional Chinese medicine composition comprises, by weight, 20-30 parts of dandelion, 20-30 parts of sophora flavescens, 30-100 parts of honeysuckle, 10-30 parts of radix paeoniae rubra and 20-30 parts of fructus kochiae. The invention aims to obtain the medicine with the effect of efficiently treating rash caused by cetuximab injection medicine.

The invention provides a traditional Chinese medicine composition for treating infantile anaphylactoid purpura and anaphylactoid purpura rash, which is prepared from the following traditional Chinese medicines: lithospermum, madder, caulis spatholobi, radix rehmanniae recen, moutan bark, scutellaria baicalensis, cynanchum atratum, cacumen biotae, cortex dictamni, ginseng under forest and the like, and is prepared into a pharmaceutical preparation by adopting a traditional preparation method of the traditional Chinese medicine composition. The pharmaceutical composition disclosed by the invention can effectively relieve skin purpura, joint swelling and pain and kidney injury through multi-target regulation of pathological links such as blood heat, blood stasis, body resistance deficiency and the like according to clinical verification; the traditional Chinese medicine composition is reasonable in compatibility, treats both symptoms and root causes, can inhibit vasculitis reaction caused by hyperimmunization, can regulate qi and blood circulation, and reduces recurrence of purpura.

The application discloses a clinical prediction model for predicting the risk of purpura nephritis and a construction method of a nomogram thereof. Four independent risk factors are obtained through mathematical statistical methods, the risk independent factors include age, rash duration, D-dimer and IgG, four corresponding clinical prediction models are established according to the risk independent factors, and the optimal prediction model containing three prediction factors is obtained through mathematical analysis methods, the three prediction factors are the age of the child, D-dimer and IgG, and the occurrence risk of purpura nephritis can be predicted through the established nomogram. The application provides a convenient and effective tool for clinicians to evaluate the risk of HSPN in children with HSP, and the determination of the IgG and D-dimer levels in blood can be realized in community clinics.

Relates to the technical field of medicines, in particular to a pyridazinopyridone derivative used as an SOS1 protein inhibitor and application of the pyridazinopyridone derivative. The compound provided by the invention has an obvious inhibition effect on the activity of the SOS1 protein, can be used as an SOS1 protein inhibitor, is good in druggability, can be used for preparing medicines for treating diseases such as SOS1 protein mediated cancers and pathogenic rash, and has a wide application prospect.

The invention provides a qualitative detection method and application of honey ointment for treating rash. The detection method comprises the following steps: identifying gallic acid, ellagic acid, sennoside A and sennoside B in the honey paste by utilizing a high performance liquid chromatography, and / or identifying the artemisia argyi in the honey paste by utilizing a thin layer chromatography. The method can solve the problem that in the prior art, a qualitative detection method for the Etil filisummer hot honey paste is lacked, and is suitable for the field of qualitative detection of drugs.

A method of treating and / or preventing a skin toxicity associated with the administration of a therapeutic treatment comprising trametinib, naporafenib, or a combination thereof in a subject in need thereof; the method comprising pre-emptively administering to the subject an effective amount of a rash treatment.

The invention discloses a medical medicine smearing device capable of automatically locking the rash position, and belongs to the technical field of medicine smearing devices.The medical medicine smearing device comprises a supporting frame, a guide seat is slidably connected to the top of the supporting frame, a telescopic air cylinder is fixedly installed on the guide seat, and a lead screw is connected between the inner sides of the supporting frame through a bearing; a supporting cylinder is transversely arranged on the lead screw in a sliding mode, a lifting base is fixedly connected to the lower end of the supporting rod, one end of the lifting base can drive a sliding piece and a sliding cover to move up and down, the other end of the lifting base can drive a descending toothed plate to move up and down, and the lifting base can push absorbent cotton. The device can automatically position and lock an affected part and automatically install and discharge absorbent cotton, reduces the difficulty of manual operation, is convenient for doctors and patients to use, ensures accurate application of medicine, effectively improves the treatment effect, and is convenient for uniformly applying the medicine to the absorbent cotton, thereby being beneficial to improving the application effect of the absorbent cotton.

The rapid development of tumor molecular targeting drugs and immunotherapy promotes the progress in the field of tumor treatment, but the treatment means of related adverse reactions are very single, so that the invention discloses a traditional Chinese medicine composition for preventing and treating new-generation targeting and immunotherapy related adverse reactions of tumors and a preparation method of the traditional Chinese medicine composition. The composition is prepared from the following traditional Chinese medicinal materials in parts by mass: 3 to 20 parts of radix astragali seu hedysari, 3 to 18 parts of radix rehmanniae recen, 3 to 15 parts of radix arnebiae seu lithospermi, 3 to 20 parts of herba hedyotidis diffusae, 3 to 20 parts of fructus tribuli, 3 to 18 parts of herba geranii, 3 to 12 parts of gallnut, 3 to 20 parts of fried medicated leaven and 3 to 10 parts of radix glycyrrhizae. The traditional Chinese medicine composition disclosed by the invention has the effects of nourishing yin and tonifying qi, promoting blood circulation and dispelling wind, and detoxifying and dissolving turbidity, and has good effects on preventing and treating rash, gastroenteritis, diarrhea, hypothyroidism, proteinuria, hypertension, pneumonia, myocarditis and the like. The preparation method comprises decoction, granules, pills and capsule preparations. The traditional Chinese medicine composition is simple, convenient, low in cost, free of toxic and side effects and beneficial to prolonging the tolerance period of targeting and immunotherapy and improving the life quality of patients.

The invention provides a quantitative detection method of honey ointment for treating rash and application of the quantitative detection method. The detection method comprises the step of detecting the contents of quercetin and ellagic acid in the honey ointment by using a high performance liquid chromatography. The method can solve the problem of lack of a method for detecting the content of the honey ointment in the prior art, and is suitable for the field of traditional Chinese medicine content detection.

The invention provides a traditional Chinese medicine composition for treating breast cancer and improving adverse reaction, which is prepared from the following raw materials in parts by weight: codonopsis pilosula, bighead atractylodes rhizome, lithospermum, rhizoma cimicifugae, cyrtomium fortunei, pollen typhae, angelica sinensis, golden cypress, radix angelicae, schizonepeta, radix paeoniae rubra, astragalus membranaceus, liquorice, medicated leaven, poria cocos and semen coicis. The traditional Chinese medicine composition can clear away lung heat, tonify heart blood and strengthen the spleen and stomach, and experiments prove that the traditional Chinese medicine composition has a good treatment effect on breast cancer, relieves adverse reactions caused by clinical drugs, especially adverse reactions caused by targeted and immune antitumor drugs and the like, and has a good curative effect on breast cancer. The most common treatment effect on patients with rash, diarrhea, oral mucositis and the like is optimal.

This invention relates to the pharmaceutical technology, and more particularly to a pyridadinopyridone derivative substituted with a nitrogen-containing functional group for use as an SOS1 protein inhibitor, and its use. The compounds provided in this invention exhibit clear inhibitory activity against the SOS1 protein, can be used as SOS1 protein inhibitors, have excellent drug-forming potential, and can be used in the manufacture of therapeutic drugs for diseases such as cancer and pathogenic rash diseases mediated by the SOS1 protein, thus showing promising future applications.

To provide recombinant Staphylococcus bacteria (e.g., S. epidermidis) that are dependent on D-alanine for growth. [Solution] In one aspect, the Disclosure features recombinant Staphylococcus bacteria comprising two inactivated alanine racemase genes (Δalr1Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the Disclosure features a method for producing recombinant Staphylococcus bacteria. In another aspect, the Disclosure provides a method for treating or preventing a rash in a subject, the method comprising the step of administering to the subject an amount effective to treat or prevent a rash in the subject, which is one of the aspects or embodiments described herein.