39 results about "Exanthem" patented technology

A once-a-day oral milnacipran modified release formulation has been developed. The formulation comprises an extended release dosage unit (optionally containing the immediate release portion) coated with delayed release coating. The milnacipran composition, when administered orally, first passes through the stomach releasing from zero to less than 10% of the total milnacipran dose and then enters the intestines where drug is released slowly over an extended period of time. The release profile is characterized by a 0.05-4 hours lag time period during which less than 10% of the total milnacipran dose is released followed by a slow or extended release of the remaining drug over a defined period of time. The composition provides in vivo drug plasma levels characterized by Tmax at 4-10 hours and an approximately linear drop-off thereafter and Cmax below 3000 ng / ml, preferably below 2000 ng / ml, and most preferably below 1000 ng / ml. The composition provides a therapeutic effect over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.

The invention provides a pharmaceutical composition with a pure plant origin and application thereof. Pharmacological studies show that the medicament can treat acne from multiple aspects and ensure that propionibacterium acnes do not generate drug resistance. Clinical experiment shows that the medicament has quick response, can cure the acne in a short time, obviously reduces the recurrence, has good safety and does not have obvious adverse reaction. Compared with single use of a tanshinone extract (such as a tanshinone capsule), the medicament reduces the dosage, improves the treatment effect and avoids the allergic reaction, such as rash, lip rash and the like. Simultaneously the quality of the medicament and the stability of the healing efficacy are ensured by effectively controlling active ingredients.

The invention provides a traditional Chinese medicinal composition for external use for treating rash. The traditional Chinese medicinal composition is prepared from the following raw medicines: 10 to 50 weight parts of radix scutellariae, 10 to 60 weight parts of herba portulacae, 10 to 60 weight parts of cortex dictamni, 10 to 50 weight parts of radix sophorae flavescentis, and 10 to 60 weight parts of herba taraxaci. The traditional Chinese medicinal composition disclosed by the invention has a remarkable effect on the aspect of improving acne-like rash and itch degree related to EGFRIs (Epidermal Growth Factor Receptor Inhibitors); moreover, an obvious adverse effect is avoided.

The invention discloses a traditional Chinese medicine composition for treating variability measles. The traditional Chinese medicine composition comprises the following bulk drugs by weight: 4-9 parts of Platycodon grandiflorum, 10-15 parts of dandelion, 4-6 parts of Adenophora, 4-9 parts of ephedra, 5-12 parts of almond, 4-9 parts of licorice and 12-25 parts of gypsum. The traditional Chinese medicine composition is used for treating measles and can obviously reduce incidence rate of complications. The medicine provided by the invention has reliable effects of abating fever, promoting eruption, cooling diaphragm and detoxifying, and the advantages of easy material acquisition, low price convenience for manufacturing and wide scope of application. Through years of research and clinic observation on hundreds of patients, the traditional Chinese medicine composition for treating variability measles has obvious clinic treatment effect. In the treatment of measles, the medicine provided by the invention can realize stationary fever ablation, no obvious surge or drop; and from fever to normal temperature, 0.5-3 days can be saved. In addition, the medicine can turn the rash into smooth and stable state, and realizes reliable effects of promoting eruption, clearing lung, cooling diaphragm and detoxifying.

The invention discloses a combination drug of curing rash and burn and preparation method thereof. The combination drug is composed of carbonized hair, astragalus membranaceus, rehmannia glutinosa libosch, Chinese angelica, plaster stone, raw calamine, beewax, elephant hide, sesame oil and cuttle bone. A production method includes that the carbonized hair is purified by water containing soda and dried, impurities of the carbonized hair are removed, the elephant hide is cut into blocks and porphyrized, the astragalus membranaceus, the rehmannia glutinosa libosch and the Chinese angelica are cut into slices, the raw calamine and the plaster stone are porphyrized, then the sesame oil is put in an iron pan and heated to 250 DEG C, the carbonized hair is added into the iron pan for 10-15min, then the carbonized hair is fished out, the astragalus membranaceus, the rehmannia glutinosa libosch and the Chinese angelica are added into the iron pan, after 5 minutes, the astragalus membranaceus, the rehmannia glutinosa libosch and the Chinese angelica are together fished out, the sesame oil in the iron pan is filtered and conducts deslag, then the sesame oil is heated to 220 DEG C, the plaster stone, the raw calamine, cuttle bone powder and melting beewax are added into the sesame oil, and after filtered, elephant hide powder is added to be blended to be pasty to form paste. The combination drug is reasonable in combination, and clear in curative effect, and has the efficacy of promoting granulation and removing necrotic tissue, stopping pain and removing stasis, activating blood and dispersing blood stasis, and promoting granulation growth.

The invention belongs to the technical field of drugs, mainly relates to a preparation formula for treating aids (Acquired Immune Deficiency Syndrome) and specifically relates to a traditional Chinese medicine preparation for assisting to treat aids. The traditional Chinese medicine preparation comprises such components as codonopsis pilosula, astragalus membranaceus, rhizoma anemarrhenae, radices trichosanthis, scutellaria baicalensis, amomum tsao-ko, rhizoma atractylodis, raw semen coicis, stiff silkworm, periostracum cicada, herba violae, radix paeoniae rubra, angelica sinensis, wolfberry fruit and herba epimedii. The invention aims at providing a traditional Chinese medicine preparation for assisting to treat aids without negative effect; the traditional Chinese medicine preparation for aids has auxiliary treatment effect on early-stage symptoms of aids, such as emaciation and weakness, deficient breath and laziness to speak, interrupted or lasting low-grade fever, spontaneous perspiration and night sweating, frequent scrofulosis or abdominal pain and diarrhea, watery stool or thin sloppy stool, bad mood, or cough, white sputum, multiple rash, depression, tender-red tongue or dull-red tongue, tongue coating as white as powder deposited, or pale tongue nature and few tongue coating, mostly vire and slippery pulse and weakness under press, and especially weak Chi parts.

The invention provides a preparation method of a traditional Chinese medicine for treating red urine type acute contagious conjunctivitis, and belongs to the technical field of preparation methods of traditional Chinese medicines. Currently, sulfonamides and antibiotics are generally adopted to treat red urine type acute contagious conjunctivitis, but gastrointestinal reaction, crystalluria, hematuresis, rash, drug fever and leucopenia are caused to a patient who administrates sulfamethoxazole. The preparation method is characterized by comprising the following steps of immersing the following 27 traditional medicines in water, namely coix seed, exocarpium benincasae, rice bean, zanthoxylum bungeanum maxim, corn stigma, calabash, dayflower, polygonum aviculare, dianthus superbus, akebiaquinata, ricepaper pith, rush, patrinia, changium smyrnioides, hemsleya macrosperma, rhizoma anemarrhenae, arrowshaped tinospora root, trollflower, honeysuckle, spanishneedles herb, cordate houttuynia, Japan clover herb, hyperforin perforatum, sedum sarmentosum, common leafflower herb with root, lophatherum gracile and liquorice; decocting with slow fire; and filtering and removing slag to obtain decoction, which is the traditional Chinese medicine for treating red urine type acute contagious conjunctivitis. The Chinese medicine lotion has the advantages of small toxic and side effect of prepared Chinese medicine decoction, short course of treatment and high cure rate.

The invention discloses an anti-inflammatory ointment containing cannabis flavone and a preparation method thereof, and belongs to the technical field of preparation of external medicines. The anti-inflammatory ointment containing the cannabis flavone is prepared from the following original auxiliaries in parts by weight: 15 parts to 25 parts of purified water, 15 parts to 30 parts of paraffin wax, 5 parts to 20 parts of vaseline, 20 parts to 40 parts of beewax, 1 part to 10 parts of cannabis flavone, 1 part to 10 parts of wintergreen oil, 0.5 part to 5 parts of penetration enhancer, 1 part to10 parts of emulsifying agent, 5 parts to 15 parts of moisturizer, 0.1 part to 1 part of essence, and 0.1 part to 1 part of preservative. Effective active ingredients, such as ephedrin and luteolin in the anti-inflammatory ointment have obvious inhibition effects on arthritis pain, gout, rheumatoid arthritis and rash, also has a good inflammation elimination effect on inflammation caused by bacteria and virus, and also has the effects of resisting allergy, bacteria and virus. The ointment is safe and green, has no side effects, is simple in process, and is suitable for industrialized production.

The invention discloses a preparation method of a Chinese medicine irrigation solution for treating liver-fire excess type trichomonas vaginitis, belonging to the technical field of preparation method of Chinese medicines. At present, generally, antibiotics and sulfanilamide medicines are used for treating liver-fire excess type trichomonas vaginitis, such as ampicillin, excessive use always causes gastrointestinal intolerance, intramuscular injection causes local pains, oral administration or intramuscular injection can cause allergic reaction, and the most manifestation is rash. The Chinese medicine irrigation solution disclosed herein is prepared by putting 16 kinds of herbs consisting of celosia seeds, butterflybush flower, pipewort, scouring rush, chrysanthemum, mint, periostracum cicadae, Dictamnus dasycarpus Turcz, sophora flavescens, balsam pear, ilex latifolia thumb, Elephantopus scaber, polygonum cuspidatum, saxifrage, gentian and licorice in water for soaking, then decocting with slow fire, filtering and removing the residues to obtain a liquid medicine. The Chinese medicine irrigation solution disclosed herein has the advantages of small toxic and side effect, short treatment course and high cure rate, and can avoid the adverse effects of applying western medicines.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine gel for preventing and treating mosquito bites and a preparation method of the traditional Chinese medicine gel for preventing and treating mosquito bites, and the traditional Chinese medicine gel for preventing and treating mosquito bites is composed of a traditional Chinese medicine extract composition and a gel matrix, the traditional Chinese medicine extract composition is prepared from clove oil, cinnamon oil, eucalyptus oil, camphor, methyl salicylate, menthol and peppermint oil according to a certain weight part ratio. The traditional Chinese medicine gel for preventing and treating mosquito bite has a rapid and effective elimination effect on swelling, rash, pruritus and other symptoms caused by bite or contact of mosquitoes, caterpillars and the like. The traditional Chinese medicine gel for preventing and treating mosquito bite also has a good disinfection effect on symptoms caused by bite of malignant toxic organisms such as poisonous bees, poisonous snakes and scorpions with certain toxicity; in addition, the traditional Chinese medicine gel for preventing and treating mosquito bite also has a good prevention effect on mosquito bite.

The invention provides a traditional Chinese medicine composition for treating skin rash caused by antineoplastic drugs, which comprises the following components by weight: 9-18 parts by weight of Taxus chinensis, 10-30 parts by weight of coix seed, and 10-30 parts by weight of honeysuckle , 10-30 parts by weight of reed stem, 10-20 parts by weight of angelica, 9-15 parts by weight of trichosanthes, 9-20 parts by weight of Scrophulariaceae, 3-9 parts by weight of Angelica dahurica, and 5-15 parts by weight of licorice. The invention can significantly improve and cure skin rashes caused by antitumor drugs in a short period of time, is safe to use, has definite curative effect, and obviously improves the quality of life of patients without reducing the intensity of antitumor treatment.

The present disclosure provides a biosignature that distinguishes Lyme disease, including early Lyme disease, from STARI. The present disclosure also provides methods for detecting Lyme disease and STARI, as well as methods for treating subjects diagnosed with Lyme disease or STARI.

The invention relates to application of omeprazole in relieving toxic and side effects of a tyrosine kinase inhibitor TKIs. Omeprazole and the tyrosine kinase inhibitor are combined to find that omeprazole not only can enhance the proliferation inhibition effect and apoptosis effect of the TKIs on cancer cells, but also can greatly relieve diarrhea and rash adverse reactions of patients caused bytaking the TKIs. The invention has the advantages of good economy and high safety, and can relieve the toxic and side effects of targeted drugs, improve the living quality of patients and reduce the economic burden of patients.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a radix bupleuri, os draconis and oyster soup in preparing a medicine capableof treating a first-phase and second-phase adiaphoresis hand-foot-and-mouth disease, a radix bupleuri, os draconis and oyster soup variation in preparing the medicine capable of treating the first-phase and second-phase adiaphoresis hand-foot-and-mouth disease, and a self-designed radix bupleuri and radix puerariae lobatae soup in preparing the medicine capable of treating the first-phase and second-phase adiaphoresis hand-foot-and-mouth disease. A clinic experiment indicates that the invention has an obvious advantage on the aspects of recovery, effect performing and a number of qualified voters, and a difference is a statistic difference. From specific symptoms, an experimental group has statistical significance for the advantages on three symptom aspects, including a rash distribution situation, appetite loss and dry mouth and lips, and has the advantages but does not have the statistic difference on the aspects of salivation, tired expression, dysphoria, skittishness, vomiting, dysphoria, limb shaking and myasthenia.

Disclosed herein is an albumin pharmaceutical composition, comprising albumin and at least one amino acid having a relative molecular mass of 145-175. Clinically, the albumin pharmaceutical composition can effectively reduce undesirable responses, such as rash, urticaria, anaphylaxis and possible immune responses in the human body caused by albumin polymers and dimers, thereby further ensuring the safety in clinical medication.

The invention provides an anti-allergic composition and an application of the anti-allergic composition in preparation of an anti-allergic preparation. The traditional Chinese medicine effective components and the composition thereof comprise amygdalin, cimicifugin, a composition of the amygdalin and the cimicifugin, a composition of the amygdalin and the 5-O-methylvisammioside, and a composition of the cimicifugin and the 5-O-methylvisammioside, which have obvious interaction with macrophage migration inhibition factors. The migration quantity of zebrafish macrophages can be obviously inhibited; the application of the anti-allergic composition in the preparation of the anti-allergic preparation is characterized in that the anti-allergic pharmaceutical composition can be used for treating allergy-related diseases caused by macrophage infiltration, migration and inflammatory factor release caused by allergy, including allergic rhinitis, allergic asthma, allergic rash and allergic purpura, as well as allergic rhinitis, allergic asthma, allergic rash and allergic purpura. And important drug guidance is provided for treatment of allergic diseases.

Disclosed herein is an albumin pharmaceutical composition, comprising albumin and at least one amino acid having a relative molecular mass of 145-175. Clinically, the albumin pharmaceutical composition can effectively reduce undesirable responses, such as rash, urticaria, anaphylaxis and possible immune responses in the human body caused by albumin polymers and dimers, thereby further ensuring the safety in clinical medication.

The invention provides a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 5-7 parts of eucommia ulmoides, 5-7 parts of loranthus parasiticus, 6-8 parts of radix clematidis, 5-7 parts of salviae miltiorrhizae, 4-6 parts of earthworm, 7-9 parts of radix rehmanniae recen, 5-7 parts of pawpaw, 5-7 parts of zaocys dhumnade, 4-6 parts of pseudo-ginseng, 4-6 parts of radix angelicae pubescentis, 4-6 parts of safflower carthamus, 5-7 parts of radix paeoniae alba, 5-7 parts of spatholobus suberctu, 6-8 parts of angelica sinensis and 2.5-3.5 parts of centipedes. The traditional Chinese medicine composition can be used for effectively treating rheumatoid arthritis inshort treatment time. A gel-type preparation prepared from the traditional Chinese medicine composition has a better treatment effect than that of conventional paste and patch, and can act on skin, mucous membranes and tracts, so that first pass elimination caused by oral administration can be avoided, and slow and irregular absorption and other defects and adverse response, such as allergy and rash, generated in the applying process in traditional paste can be relieved. The traditional Chinese medicine composition has the advantages of being convenient and comfortable in use, good in biocompatibility, non-strict in process condition and the like, is suitable for production condition of traditional Chinese medicinal compound preparations, is convenient for popularization and application, and can be used as first choice for improving traditional external preparations of traditional Chinese medicines.

The invention discloses a purely traditional Chinese medicine facial mask capable of relieving rash relevant to tumor target medicines. The traditional Chinese medicine ingredients of the facial maskcomprise the following components in parts by mass of 30-40 parts of dandelions, 20-30 parts of radix sophorae flavescentis, 15-25 parts of honeysuckle flowers, 15-20 parts of fructus forsythiae, 20-25 parts of radix rehmanniae, 15-20 parts of radix lithospermi and 10-12 parts of fresh licorice roots. The purely traditional Chinese medicine facial mask disclosed by the invention is designed in accordance with the characteristic that target medicines cause excessive dampness and heat in bodies of rash patients through diagnosis of experts in department of traditional Chinese medicines of tumor,and after early stage test, favorable effects are obtained, so that the purely traditional Chinese medicine facial mask is more suitable for rash caused by the target medicines. The purely traditional Chinese medicine facial mask is mainly applied to faces of patients, so that long-term effects after treatment need to be considered. Compared with traditional hormones and traditional antibacterialointment, the purely traditional Chinese medicine facial mask disclosed by the invention is prepared from purely traditional Chinese medicine ingredients, so that adverse reactions of allergy, pigmentation and the like cannot be caused, and worry of the patients can be avoided. The purely traditional Chinese medicine facial mask disclosed by the invention is easy to decoct, low in price and suitable for more patients to use.

The invention discloses a system and equipment for cognitive diseases based on cross-modal medical biological characteristics of fever with rash and a storage medium, and the system comprises: a preprocessing module which is used for obtaining and preprocessing multi-modal medical biological samples of multiple patients with fever with rash; a feature extraction module which is used for extracting feature information of each sample, performing feature screening and disease cause classification, and constructing a sample data set according to disease causes; a model building module which is used for training the sample data sets by using an AdaBoost algorithm and building a disease cognitive system model; and an etiological analysis module which is used for performing etiological analysis on the to-be-identified multi-modal medical biological sample of the fever and rash through the disease cognition system model. According to the method, the disease cognitive system model is constructed to perform etiological analysis on the cross-modal medical biological characteristics of the fever with rash, so that the advantages of the medical biological characteristic indexes of each modal can be brought into full play, and the effect and capability of cognizing the fever with rash diseases are improved.

The present disclosure provides a biosignature that distinguishes Lyme disease, including early Lyme disease, from STARI. The present disclosure also provides methods for detecting Lyme disease and STARI, as well as methods for treating subjects diagnosed with Lyme disease or STARI.

The invention discloses a traditional Chinese medicine mask for treating rash related with molecular targeted anti-tumor drugs and a preparation method thereof, and relates to the field of traditional Chinese medicine masks. The traditional Chinese medicine mask is prepared from the following raw materials in parts by mass: 15-20 parts of yam rhizome, 15-20 parts of fructus cnidii, 15-20 parts of herba violae, 15-20 parts of polygonum aviculare, 15-20 parts of coptis chinensis, 15-20 parts of cortex phellodendri, 15-20 parts of scutellaria baicalensis, 12-22 parts of indigo naturalis, 15-20 parts of sanguisorba officinalis, 15-20 parts of rhizoma atractylodis, 15-20 parts of chrysanthemum, 15-20 parts of rhizoma smilacis glabrae, 15-20 parts of radix isatidis, 15-20 parts of fructus kochiae, and 15-20 parts of radix sophorae flavescentis. The traditional Chinese medicine mask is prepared from pure traditional Chinese medicine components. The yam rhizome and the polygonum aviculare have the effects of promoting diuresis and removing turbidity; the coptis chinensis, the cortex phellodendri and the scutellaria baicalensis have the main effect of clearing heat of tri-jiao; the indigo naturalis, the chrysanthemum and the radix isatidis have the effects of clearing away heat and toxic materials; and the fructus cnidii, the fructus kochiae and the radix sophorae flavescentis have the effects of destroying parasites and relieving itching. The medicines are combined to achieve the purpose of treating rash by clearing away heat and toxic materials, removing dampness, relieving itching, healing sore and promoting tissue regeneration on the basis of tonifying spleen and eliminating dampness.

The invention relates to a new dosage form of selumetinib and a derivative of the selumetinib, and belongs to the field of medicine. According to the new dosage form of the selumetinib and the derivative of the selumetinib, the adverse reactions of leucopenia, rash, diarrhea and fatigue after use of the selumetinib are reduced. The new dosage form is a preparation prepared from an ordinary releasepart containing the selumetinib and the derivative of the selumetinib as active ingredients and a slow-release part containing the selumetinib and the derivative of the selumetinib as active ingredients; and the molar ratio of the selumetinib and the derivative of the selumetinib contained by the ordinary release part to the selumetinib and the derivative of the selumetinib contained by the slow-release part is (10-90) to (10-90). The invention further provides a preparation method of the pharmaceutical composition. A clinical test shows that the incidence rate of adverse reactions of the newdosage form is obviously lower than that of conventional tablets of selumetinib, and a safe new dosage form is provided for the clinical application of the selumetinib and the derivative of the selumetinib.

The invention discloses a traditional Chinese medicine compound preparation for treating rash caused by a targeted drug. The traditional Chinese medicine compound preparation is prepared from the following raw materials by weight of15g of radix stemonae, 15g of fructus xanthii, 10g of flos caryophylli, 10g of fructus liquidambaris, 10g of flos campsis, 10g of fructus forsythiae, 15g of radix sophorae flavescentis, 10g of nidus vespae, 15g of fructus tribuli and 30g of radix ophiopogonis. The traditional Chinese medicine compound preparation solves the problems that at present, western medicineonly treats rash with hormones and antibiotic ointment, and existing treatment medicine is poor in curative effect, not suitable for large-area use and the like; and the traditional Chinese medicinecompound preparation is suitable for treating rash pruritus caused by targeted medicine, and has the advantages of being exact in curative effect, convenient to use, light in adverse reaction and widein market prospect through years of clinical application.

The invention provides a toad male ointment, which, in parts by weight, comprises the following raw material components: 20-40 parts by weight of toad venom, 20-40 parts by weight of realgar, 20-40 parts by weight of borneol, 20-40 parts by weight of lead dan, 20-40 parts by weight of Glauber's salt, 50-150 parts by weight of frankincense and myrrh in total, 40-60 parts by weight of dried dragon's blood, 5-20 parts by weight of sap, 1-2 parts by weight of musk, 50-150 parts by weight of rhubarb, A total of 50-150 parts by weight of Radix vulgaris and Caowu, 20-40 parts by weight of Curcuma Radix, and 5-20 parts by weight of Asarum. The present invention also provides the Babu ointment and application of the above-mentioned Chanxiong ointment. The Chanxiong ointment and the Babu ointment of the present invention can treat various cancer pains, have obvious effect of labor pain, reduce adverse reactions, improve the quality of life of patients, and effectively reduce the occurrence of allergic rashes.

The invention relates to a method for extracting Acanthopanax, which comprises the following steps: 1) crushing; 2) enzymatic hydrolysis; 3) ultrasonic extraction; 4) filtering; 5) alcohol precipitation; 6) macroporous resin adsorption; 7) Non-polar resin adsorption; 8) Chromatographic column separation; 9) Sterile ultrafiltration. This process makes the extraction efficiency of Acanthopanax more efficient, and can also significantly reduce the polar and non-polar impurities in the extract of Acanthopanax, and reduce the number of patients who are injected with the extract of Acanthopanax senticosus injection. Symptoms such as skin rash, itching, dizziness, headache and heart palpitations, improve the safety of injection drugs.

The invention provides a traditional Chinese medicine composition for treating rash and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 to 18 parts of herba portulacae, 8 to 10 parts of green prickleyash, 6 to 12 parts of rhizoma atractylodis, 7 to 11 parts of radix saposhnikoviae, 28 to 32 parts of mirabilite, 8 to 12 parts of alum, 14 to 16 parts of fructus forsythiae, 8 to 10 parts of raw cacumen biotae and 3 to 7 parts of fistular onion stalk.The traditional Chinese medicine composition disclosed by the invention is simple and convenient in preparation process and has a good effect of treating rash caused by cetuximab.