23 results about "Complex formation" patented technology

The invention provides preparation and application of an ethylene selective oligomerization catalyst composition. The ethylene selective oligomerization catalyst composition comprises a transition metal compound a, a ligand b and an auxiliary c. The novel indole onium iodized salt ligand is synthesized for the first time, and when an ethylene oligomerization catalyst system taking the ligand compound as the ligand is used for catalyzing ethylene oligomerization reaction, the ligand compound has the advantages of high coordination capability, proper electrical property and capability of forming a stable complex with transition metal; the ligand can resist high temperature, reduces influence on 1-octene selectivity and catalyst activity as much as possible, and has an excellent application prospect.

The present invention discloses a fracturing and sealing device and method based on supercritical CO2 injection into basalt. The fracturing and sealing device includes: a test body module, including a basalt sample; an injection module, which injects the required gas, liquid or gas-liquid mixture into the test body module; a pressure loading module, which is connected to the test body and applies axial pressure and / or confining pressure to the test body module; wherein the injection module and the pressure loading module are configured to achieve fracturing of the basalt sample, as well as the radial permeability of the basalt sample after fracturing and the sealing of CO2 by the basalt sample after fracturing. It can overcome the limitations of the single function of traditional indoor test devices and achieve a comprehensive understanding of the fracturing and sealing process under complex formation environmental conditions; it is also convenient for analyzing the formation law of basalt fracture networks, evaluating the permeability of fracture networks, and comparing the feasibility and effectiveness of basalt mineralization and CO2 storage under different injection modes.

The present invention discloses an experimental device and method for studying the wax deposition law in porous media in near-wellbore areas, belonging to the technical field of wax deposition experiments. The experimental device comprises a wax deposition visualization model, a multi-stage temperature control module, a liquid injection and cleaning module, a confining pressure adjustment module, a back pressure control module, a product recovery module and an image acquisition module; a natural core slice with a pore throat structure is simulated by a wax deposition visualization model, a multi-stage temperature control module is used to perform graded local heating to simulate complex formation temperature conditions, a confining pressure adjustment module is used to provide confining pressure, a back pressure control module is used to adjust the model outlet pressure to simulate bottom hole flow pressure, a liquid injection and cleaning module is used to inject crude oil and cleaning fluid therein, and an oil displacement experiment and subsequent cleaning are completed; an image acquisition module and a visualization clamping module are used to intuitively observe the wax deposition process in the model, and the wax crystal phase change process during the experiment is analyzed, and the wax deposition formulas of different parts of the model are used to characterize the step-by-step precipitation law of wax.

Described are affinity purification system that includes a carrier / surface that is non-cellular, and sliding clamp (SC) protein, and methods for purifying proteins that bind to the SC. The SC is associated with the carrier / surface via covalent / non-covalent interactions. To attain control of coupling site, the SC can be mutated via site-directed mutagenesis to introduce an exogenous residue and, the exogenous internal residue is conjugated to the non-cellular surface through the linker. The SC can also be coupled to the carrier via non-covalent interactions such as the affinity interactions involved in ligand / binding partner complex formation.The SC-based affinity purification system are used in a purification column as bait proteins, to isolate SC binding partners or non SC-binding proteins engineered to contain a SC binding site prior to its purification.

The technology provided herein relates to multiplex methods and kits for detecting different analytes in a sample simultaneously, in particular by using premixed macromolecule complexes like complexes having a primary and a secondary antibody, wherein the primary antibodies contain identical identifier elements.

A method produces an aqueous liquid preparation for magnetic resonance contrast that contains a complex of a lanthanide and a macrocyclic chelate together with free chelate. A solution of the macrocyclic chelate in water is prepared, lanthanide and meglumine are added, and complex formation proceeds in the presence of meglumine at a pH between 6.5 and 8.0 with lanthanide in molar excess over meglumine and meglumine in molar excess over the chelate. The pH is then reduced to a target value below 5.0 by incremental addition of an acid such as further chelate, optionally followed by addition of a fixed chelate amount. The pH is subsequently raised above 6.5 with meglumine and the solution is diluted to a final volume, providing an industrial-scale single-vessel process that yields a preparation containing a defined low amount of free lanthanide.

Provided is a method for recovering an organic fluorine compound which requires only a small amount of acid and base for recovery treatment. A metal cation is added to an aqueous phase containing an organic fluorine compound to cause a complex formation reaction with molecules of the organic fluorine compound, and an electrically neutral chemical species generated thereby is solvent-extracted into an organic phase forming a two-liquid system with the aqueous phase.

This invention belongs to the field of pharmaceutical technology, specifically relating to a method for improving the water solubility of drugs by mutually solubilizing rosiglitazone and ibuprofen. The method involves co-dissolving rosiglitazone and ibuprofen in an aqueous solution, resulting in an increase in the water solubility of both drugs due to the presence of the other. This method is simple to operate, low in cost, and the solubilizing effect is due to intermolecular interactions between the two drugs within the solution system; no chemical reaction or co-crystal complex formation occurs between the two drugs.

This invention relates to an ultra-micro associative emulsion modifier, belonging to the technical field of chemical flooding agents used in oilfield chemistry to enhance oil recovery. It addresses the problems of insufficient interfacial activity, poor emulsion stability, and limited permeability in formation pores caused by improper surfactant formulation in existing modifiers. The key technical point is to provide a composite system composed of water, polyether-modified polysiloxane, sodium α-olefin sulfonate, and sodium dodecyl sulfate in specific weight proportions. Through molecular synergy and association among the components, this system spontaneously forms ultra-fine and stable emulsion droplets, effectively reducing the oil-water interfacial tension and enhancing the long-term stability of the system in complex formation environments. Its main application is as a modifier in oilfield water injection development, adjusting the water flow profile by injecting it into the formation, emulsifying and carrying residual oil, thereby improving oil displacement efficiency and increasing the ultimate oil recovery rate.

The present invention discloses an monoclonal antibody, which can bind to HyIL-6 with the binding constant 2.86×10−10 and significantly inhibit IL-6 / IL-6R / gp130 complex formation. In addition, the monoclonal antibody of the present invention effectively inhibits HyIL-6-stimulated signal transducer and activator of transcription 3 (STAT3) activation and related vascular endothelial growth factor (VEGF) induction. Data from hydrogen deuterium exchange mass spectrometry (HDX-MS) demonstrate that the antibody of the present invention mainly binds to site IIIa of IL-6 and blocks the final step in the interaction between gp130 and IL-6 / IL-6R complex. Additionally, data from ELISA binding assays and kinetics assays indicate that the antibody of the present invention interacts simultaneously with IL-6 and IL-6R, while it does not interact with IL-6R alone. The unique features of the antibody of the present invention offer a novel alternative for IL-6 blockade and illuminate a better therapeutic intervention targeting IL-6.

This invention discloses a method for preparing amphoteric electrodeposition photoresist on a metal surface, specifically including the following steps: Step 1, synthesizing cashew nut shellac monomer; Step 2, preparing an amphoteric resin; Step 3, preparing an electrophoretic coating; Step 4, electrophoretically depositing photoresist on a conductive substrate. This invention also discloses the preparation method and application of amphoteric electrodeposition photoresist on a metal surface. This invention solves the problems of existing photoresists causing complex formation due to strong alkalis, corrosion of metal circuits by strong acids, and swelling of the photoresist film.

The invention provides a thermal response type phase change microcapsule, a preparation method thereof and a water-based drilling fluid. The thermal response type phase change microcapsule comprises a core material and a shell layer, the core material is an eutectic substance containing carboxylated carbon nanotubes, the shell layer is silicon dioxide containing graphene oxide, and the carboxylated carbon nanotubes and the graphene oxide are directionally arranged to form a continuous heat conduction path from the core material to the shell layer. The thermal response type phase change microcapsule prepared by the invention can be directly compatible in an existing drilling fluid system, shows good dispersity and suspension property, is fast in thermal response and strong in adaptability, is suitable for extreme drilling environments such as underground temperature control, complex formation thermal management and the like, and has less damage to rheology and filtration performance.

This method for carbon dioxide fixation comprises: a step in which a metal complex of a metallic element with a chelating agent is formed in an aqueous alkali solution containing hydrogen carbonate ions or the like, the chelating agent, and a raw material including both the metallic element, which is capable of forming a carbonate with the hydrogen carbonate ions or the like and capable of reacting with the chelating agent to form a complex, and ions unnecessary for the formation of the metal carbonate or for the formation of the metal complex of the metallic element with the chelating agent; a step in which the aqueous alkali solution is heated to react the hydrogen carbonate ions or the like with the metal complex, thereby forming a metal carbonate; and a step in which carbon dioxide is injected into the aqueous alkali solution containing the formed metal carbonate to thereby form hydrogen carbonate ions or the like. The raw material is supplied and the metal complex formation step, the metal carbonate formation step, and the step for forming hydrogen carbonate ions or the like are performed. The method for carbon dioxide fixation further includes a step in which the unnecessary ions are removed.

This invention discloses a high-temperature resistant and calcium-sensitive cementing fluid loss reducing agent. This fluid loss reducing agent is a copolymer with a micro-crosslinked stable structure, prepared by free radical copolymerization of sulfonic acid-containing olefin monomers, tertiary amine ester functional monomers, amide-containing olefin monomers, cyclic functional monomers, and crosslinked monomers. The cyclic monomers lock the main chain conformation, and the crosslinked network provides spatial protection, significantly enhancing the stability of the ester side chains at the physical level. This fundamentally inhibits the formation of harmful carboxyl groups, improving the product's calcium sensitivity resistance and high-temperature resistance. This fluid loss reducing agent exhibits excellent high-temperature and strong alkali resistance, suitable for application in a wide temperature range of 80℃ to 220℃, alkaline environments with pH 8 to 12, and high calcium ion concentrations. It also shows good compatibility with cement slurry, without adversely affecting its rheological properties or thickening time. It can be widely used in cementing operations in complex formations such as deep onshore wells, high-temperature and high-pressure offshore wells, and salt-gypsum layers.

The invention relates to the field of oilfield chemistry, in particular to a low-loss oilfield blocking remover and a using method thereof. Comprising the following raw materials in parts by weight: 5-30 parts of a modified flaky ferric hydroxide material, 1-10 parts of 3-hydroxy-2-[(phosphono formyl) amino] sodium propionate, 0.5-5 parts of a surface regulating agent, 0.5-3 parts of a slow release regulator, 0.2-2 parts of a pH buffer agent, 0.5-3 parts of a biodegradable stabilizer and 47-92.3 parts of deionized water, and through interface regulation and control and structural stability design, the blockage removal treatment on the reservoir blockage is effectively realized. The system can reduce secondary damage to strata while maintaining a good permeability improvement effect, has excellent viscosity retentivity and mineralized water stability, and is outstanding in emulsification and dispersion performance, and the overall performance shows higher applicability and persistence under complex stratum conditions.

The application discloses a non-denaturing mass spectrometry detection method for determining interaction between aptamer and small molecule target, comprising a spray needle coated with conductive coating; preparation of aptamer and target molecule stock solution; first mass spectrometry analysis of mixed solution, obtaining combination ratio of both; analysis on stability of complex ion in tandem mass spectrometry mode; in the detection method, on one hand, a nano-sized electrospray emission spray needle is used, for sample solution containing high concentration of non-volatile salt, which significantly reduces adduct and ion cluster of complex formation, improves resolution and signal-to-noise ratio, and is simple in operation and small in sample consumption; on the other hand, through non-denaturing mass spectrometry detection, stoichiometric relationship of combination and stability change of aptamer before and after combination can be directly obtained; the method can quickly and accurately identify interaction between nucleic acid aptamer and target molecule, and is expected to be further applied to rapid screening and sequence optimization of nucleic acid aptamer.

To provide a method for simply and selectively separating and recovering high-purity dysprosium from a solution containing neodymium ion and dysprosium ion whose simple separation is difficult.SOLUTION: A dysprosium complex is created by allowing a tripod-type Schiff ligand to react with neodymium ion and dysprosium ion in a mixed solvent of an aprotic polar solvent and a protic polar solvent. By fractionally precipitating the dysprosium complex, a separation condition for precipitating the dysprosium complex as a crystal in 1 step is determined, and dysprosium is separated at purity of 99% or more.SELECTED DRAWING: None

This invention provides an oilfield tracer and a method for evaluating the oil production contribution of different sections of a horizontal well, belonging to the field of oilfield development technology. The oilfield tracer provided by this invention comprises white oil, a nonionic surfactant, sodium 3-allyloxy-2-hydroxypropanesulfonate, and alcohols; wherein the rare earth metal salt forms a complex with a complexing agent and sodium 3-allyloxy-2-hydroxypropanesulfonate; the complexing agent is a mixture of glycolic acid, triethylenetetramine, and sodium dimercaptopropanesulfonate in a mass ratio of 10:(3-5):(1-2). This oilfield tracer is stable under complex formation conditions and can withstand high salinity. In evaluating the oil production contribution of different sections of a horizontal well using this oilfield tracer, different types and amounts of tracers can be selected for different sections, enabling the evaluation of the oil production contribution of each section of the horizontal well and providing a valid basis for subsequent repeated fracturing.

The present invention relates to nanostructure-bonding partner conjugates, as well as reaction mixtures, analyte detection devices, and methods for fabricating and using conjugates. [Solution] In particular, the present invention provides a method for detecting a target analyte in a sample, comprising the step of mixing the sample with a first detection conjugate and a second detection conjugate in a solution, wherein the first and second detection conjugates include metal nanostructures linked to binding partners that can specifically bind to the target analyte when it is present in the sample, forming a complex between the first detection conjugate and the analyte and the second detection conjugate, and the change in optical signal during complex formation indicates the presence of the target analyte in the sample.

A method of manufacturing a semiconductor device in a semiconductor body having a first surface and a second surface is proposed. Semiconductor device elements are formed in the semiconductor body by processing the semiconductor body at the first surface. A wiring area is formed over the first surface of the semiconductor body. The semiconductor body is attached to a carrier via the wiring area. Thereafter, ions are implanted through the second surface into the semiconductor body. The ions are ions of a doping element, or ions, which induce doping by complex formation, or ions of a heavy metal. A surface region of the semiconductor body at the second surface is irradiated with a plurality of laser pulses. Thereafter, the carrier is removed from the semiconductor body.

The invention relates to the field of oilfield chemicals, and discloses polyacrylamide suitable for oilfield reinjection sewage preparation and a preparation process thereof, the composition comprises the following components by mass: 74-78% of an acrylamide monomer, 10-20% of an initiator, 10-20% of an initiator, 10-20% of a crosslinking agent, 1-3% of a crosslinking agent, 1-3% of a crosslinking agent, 1-3% of a crosslinking agent, and the balance of water. 12%-16% of a 2-acrylamide-2-methyl propane sulfonic acid monomer; 0.1%-3% of a sulfobetaine type acrylamide monomer; 0.05% to 0.5% of a long-chain alkyl acrylamide monomer; the total addition amount of the initiator accounts for 0.1%-0.14% of the total mass of the monomers; the adding amount of the stabilizer accounts for 0.02%-0.04% of the total mass of the monomers; and the balance of deionized water. The sulfobetaine type acrylamide monomer is adopted, so that the polymer can still maintain good viscosity retention ability and solution stability under the condition of extremely high salinity, especially under the condition of a complex stratum with high content of high-valence metal ions.

Compositions and methods for the selective extraction of rare molecular species from a mixture containing a predominance of related molecular species, and their subsequent release are provided. Compositions include a segregating probe having a target-specific targeting portion, a protecting portion, a scissile or cleavable site or portion, and a capture portion. Complex formation between the targeting portion and the target rare species results in protection of the cleavable site. Such complexes remain intact through a cleavage step directed to the cleavable site or portion of the segregating probe. While complex formation can occur between a segregating probe and a related, but non-target, species the cleavable site is not protected in such complexes. A subsequent capture step directed to the capture portion selectively captures or segregates the target rare species from the general milieu, which can be removed by washing. Subsequent release of the target rare species from the segregating probe provides a solution enriched in the target rare species.

The invention provides a volatile component characterization method of agilawood koji, which comprises the following steps: carrying out initial data acquisition on an agilawood sample, obtaining concentration distribution information of heavy metal pollution in the sample and initial signal characteristics of volatile components, and carrying out lossless scanning on the sample to obtain an original data set of heavy metal pollution degree and volatile component signals; classifying the heavy metal pollution degree aggravating characteristics, dividing the sample into different pollution grade intervals, and determining a matrix effect change range corresponding to each grade; based on the matrix effect change range, analyzing the influence of chemical reaction enhancement on complex formation, obtaining a quantitative index of complex formation on volatilization characteristic change, and if the quantitative index exceeds a preset threshold range, dynamically optimizing the pretreatment process to obtain a treatment scheme adapted to the current pollution degree.