174 results about "Emulsion droplet" patented technology

The invention discloses a water-based acrylate pressure-sensitive adhesive emulsion as well as a preparation method and application thereof, and the preparation method comprises the following steps: S1, providing an acrylate pre-emulsion A and an initiator solution B; s2, dropwise adding a part of the acrylate pre-emulsion A into the initiator solution B, and carrying out a heating reaction to obtain a polymer A emulsion; s3, providing a monomer composition B, and mixing the rest of the acrylate pre-emulsion A and the monomer composition B to obtain an acrylate pre-emulsion B; and S4, dropwise adding the acrylate pre-emulsion B into the polymer A emulsion, and heating for reaction to obtain the water-based acrylate pressure-sensitive adhesive emulsion. The water-based acrylate pressure-sensitive adhesive emulsion prepared by the preparation method disclosed by the invention has relatively good adhesiveness, mobility and PVC shrinkage resistance after being coated on a PVC base material.

The utility model provides a double-emulsification high-flux micro-fluidic chip. The double-emulsification high-flux micro-fluidic chip comprises a substrate, a middle layer and a cover plate, according to the utility model, the substrate is not processed, the main micro-channels are processed on the two sides of the middle layer, and the cover plate is punched, so that fluid can be conveniently introduced. A plurality of liquid drop generation units based on the flow focusing technology are designed on one side of the middle layer so as to generate liquid drops for the first time, and a stepped liquid drop generation structure based on interfacial tension is designed on the other side of the middle layer so as to generate liquid drops for the second time. The structures on the two sides of the chip are connected through the through holes. The preparation method comprises the following steps: carrying out photoetching to form a mold, preparing the middle layer by using the mold, forming the required micro-channels on the two sides of the middle layer, punching on the cover plate, and finally bonding the substrate, the middle layer and the cover plate. Through the design of the flow channel and the structure, a large number of double-emulsion droplets can be rapidly prepared, the production efficiency is improved, and the double-emulsion droplet preparation device is suitable for various applications such as drug delivery and biological research.

The invention discloses a dual-mode micro-droplet generation micro-fluidic chip and application thereof in generation of dual-emulsion droplets, and relates to the technical field of micro-fluidic chips. The method comprises the following steps: respectively injecting two different internal phase solutions from the left ends of respective iron tubes, guiding the internal phase solutions to a wedge-shaped tube orifice of a theta-shaped glass capillary tube through respective thin tubes, injecting an intermediate phase solution into a square glass tube through an intermediate phase inlet by using a No.1 needle, and injecting an external phase solution into the square glass tube through an external phase inlet by using a No.2 needle; the two internal phase solutions, the intermediate phase solution and the external phase solution converge at an inlet of the circular glass capillary tube, and after entering the circular glass capillary tube, water-in-oil-in-water double-emulsion droplets are obtained. The invention can obtain the dual-mode micro-droplet generation micro-fluidic chip and the application of the dual-mode micro-droplet generation micro-fluidic chip in generation of dual-emulsion droplets.

The invention relates to the technical field of water-soluble polymers, in particular to a preparation method of a low-temperature-resistant water-in-water emulsion, which comprises the following steps: mixing acrylamide, an anionic monomer, a hydrophobic monomer, a dispersing agent, a chain transfer agent and water, adjusting the pH value, mixing with a stabilizer, introducing nitrogen, sequentially adding an oxidizing agent and a reducing agent to initiate a polymerization reaction, and cooling to obtain the low-temperature-resistant water-in-water emulsion. Quickly adjusting the stirring speed when the viscosity of the mixed system is increased, always keeping vortex at the center of the liquid level in the reaction process, and adjusting the stirring speed to continue the reaction after the polymerization system forms emulsion drops; and when the temperature of the polymerization system begins to reduce, adding an excessive amount of a reducing agent into the reaction system to continue the reaction, and obtaining the low-temperature-resistant water-in-water emulsion after the reaction is finished. The emulsion has the advantages of low apparent viscosity, high dissolution speed, small environmental damage, low temperature resistance and the like.

The invention discloses a mechanical property regulation and control method of an aromatic microcapsule, and belongs to the technical field of microcapsules. The preparation process of the microcapsule comprises the following steps: self-assembling CNC and an amino-functionalized polymer ligand on an oil-water interface to form a stable Pickering emulsion. Wall materials are deposited on the surfaces of emulsion droplets in situ, the CNC interface coverage rate is regulated and controlled by adjusting parameters such as the ligand concentration and the emulsion water phase pH value, and then a series of aromatic microcapsules with different mechanical properties are prepared. In addition, the functional microcapsules can be designed in a customized manner according to different application requirements, and good application prospects are shown.

The application discloses an incubation method of self-assembled organic material crystals based on double emulsion drops, and the method comprises the following steps: preparing W / O / W type double emulsion drops with uniform size through a microfluidic chip; during the preparation of the double emulsion drops, using a self-assembled organic material solution as an inner water phase solution, using a non-water-soluble solution as an intermediate oil phase solution, and using a water phase solution containing a high salt concentration as an outer water phase solution to encapsulate the self-assembled organic material solution, so as to avoid the self-assembled organic material from being free in the outer water phase solution; and incubating the double emulsion drops loaded with the self-assembled organic material solution. By using the concentration difference between the outer water phase solution and the inner water phase solution, under the influence of osmotic pressure, water molecules in the inner water phase solution migrate to the outer water phase, and the concentration of the self-assembled organic material in the double emulsion drops also increases, so as to promote the growth of the self-assembled organic material crystals, and finally, the self-assembled organic material crystals with uniform size are obtained in the double emulsion drops, and each double emulsion drop contains a single self-assembled organic material crystal.

The invention relates to a hydrophilic acrylic pressure-sensitive adhesive. The pressure-sensitive adhesive comprises an acrylic copolymer, polyvinyl alcohol or a derivative thereof, a non-reactive surfactant and a neutralizer according to the solid content of an emulsion, the acrylic copolymer is obtained by copolymerization of n-butyl acrylate, 2-ethylhexyl acrylate, 2-hydroxyethyl acrylate, acrylic acid, methyl methacrylate and a boric acid functional monomer emulsion containing a 2, 1-benzoxaborazole group. The preparation method comprises the following steps: dropwise adding a pre-emulsion, lagging dropwise adding an initiator and carrying out thermal-insulation polymerization to obtain a copolymer emulsion, adding polyvinyl alcohol or a derivative thereof at a specific temperature, neutralizing to a specified pH value, and carrying out segmented drying to form the film. The hydrophilic acrylic pressure-sensitive adhesive disclosed by the invention has both hydrophilicity and wet stability while keeping the adhesion performance.

The invention discloses a preparation method of a sodium alginate / polyphenol Pickering emulsion gel bead adsorbent and an adsorption application of the sodium alginate / polyphenol Pickering emulsion gel bead adsorbent. According to the adsorbent, polyphenol particles serve as a stabilizer, light oil serves as an oil phase, sodium alginate serves as a water phase to construct a low-density Pickering emulsion, then the obtained emulsion is dropwise added into a calcium chloride solution to be cured to form gel beads, and the obtained gel beads serve as the adsorbent with the self-suspension property. The self-suspension gel bead adsorbent designed by the invention is regular and controllable in shape, simple and rapid in preparation process, low in cost and easy for industrial production, has excellent adsorption capacity on various pollutants such as organic dyes, heavy metal ions and antibiotics, is simple and convenient to recycle after adsorption, and has a good application prospect in the field of water treatment.

The application provides a miniemulsion polymer, which is prepared by a miniemulsion polymerization method through controlling pre-emulsion droplet particle size by a high-pressure homogenizer, using specific auxiliary stabilizers and specific primary emulsifiers. After the miniemulsion polymer is incorporated into a base material, an engineering material with high air tightness, high water tightness, high bonding strength and excellent durability can be obtained, which is used for the durability protection or sealing of engineering structures or the bonding between different materials, and has the advantages of simple process, low cost and outstanding comprehensive performance.

Sound-absorbing particles, a method for preparing the same and a related device are provided. The method for preparing the same includes: adding powdered molecular sieve into water and stirring evenly, and adding adhesive and continuing to stir evenly to obtain precursor slurry; adding the precursor slurry, as a dispersed phase, into a microfluidic device, and dispersing, by the microfluidic device, the precursor slurry using a continuous phase into emulsion droplets flowing in a front section of a microchannel of the microfluidic device; extruding the emulsion droplets to have a predetermined shape by adjusting a shape of a rear section of the microchannel of the microfluidic device to obtain deformed emulsion droplets; solidifying the deformed emulsion droplets by setting a temperature in the rear section of the microchannel, to obtain solidified emulsion droplets; and sublimating and drying the solidified emulsion droplets to obtain the sound-absorbing particles.

The application discloses heparin sodium cream and a preparation method thereof, and belongs to the technical field of pharmaceutical preparation production. The heparin sodium cream comprises the following components: heparin sodium, propylene glycol, hydroxyphenyl ethyl ester, sodium dodecyl sulfate, glycerol monostearate and distearate, octadecanol, liquid paraffin, white vaseline and water. The preparation method comprises the following steps: preparing an oil phase and mixing an aqueous phase; taking part of the mixed aqueous phase and the oil phase to form a water-in-oil type primary emulsion; then adding the remaining mixed aqueous phase into the primary emulsion, inducing phase transition into an oil-in-water type cream under mild conditions, and obtaining the finished product after vacuum defoaming and gradient cooling. The application realizes high-efficiency emulsification under mild conditions below 80 DEG C and 3000 rpm through a controlled phase inversion emulsification process, so that the particle size (D99) of the emulsion droplets is less than 5 microns, and the problem that the active substance heparin sodium loses activity under severe conditions is solved completely, and the stability of the product is improved significantly.

This invention discloses a natural antibacterial polydopamine microcapsule and its preparation method. The shell material of the natural antibacterial polydopamine microcapsule is polydopamine, and the core material is Artemisia argyi oil. Using a soft template method with dimethyldiethoxysilane (DMDES) as the raw material, dopamine is in-situ self-polymerized on the surface of polydimethylsiloxane (PDMS) emulsion droplets solubilized with Artemisia argyi oil to prepare natural antibacterial polydopamine microcapsules encapsulating Artemisia argyi oil. The microcapsules prepared by this invention are micrometer-sized, monodisperse, and have high sphericity, with an average size of 1 μm. They exhibit high encapsulation efficiency for Artemisia argyi oil, with the highest encapsulation efficiency reaching 21.5% of the total mass of the microcapsules. This invention overcomes the disadvantages of high cost and environmental pollution caused by the large use of surfactants in classic emulsions. The preparation process is simple; it overcomes the defects of Artemisia argyi oil's volatility and instability; it has good monodispersity and certain antibacterial efficacy; and it can have a potential long-lasting antibacterial effect through the sustained release of Artemisia argyi oil. The preparation of monodisperse natural antibacterial polydopamine microcapsules has broad application potential in the industrial production of aromatic microcapsules.

The application provides a nanoemulsion and a preparation method and application thereof. The total amount of raw materials for preparing the nanoemulsion is 100%, and the raw materials include the following components: 1-40% of a composite surfactant, 1-25% of an oil phase, 1-30% of a co-surfactant, and the balance of a water phase; wherein the mass of the composite surfactant is 100%, and the composite surfactant includes the following components: 5-25% of a biological surfactant, 35-65% of a fatty alcohol polyoxyethylene ether surfactant, 1-20% of dodecyl benzene sulfonic acid and / or sodium salt thereof, 1-20% of oleic acid, and 1-5% of citric acid; the biological surfactant includes one or more than two combinations of sophorolipid, rhamnolipid, trehalose lipid, surfactin, alkyl polyglycoside, phosphatidylcholine, amino acid lipid, saponin, phospholipid, or derivatives thereof; and the average particle size of the emulsion droplets in the nanoemulsion is 1.5-5 nm. The nanoemulsion has excellent recovery performance.

This invention discloses an anionic hydroxyl silicone oil emulsion and its preparation method, relating to the field of polysiloxane emulsion technology, and belonging to patent classification number C08G77 / 04. The preparation method is as follows: Triethanolamine dodecylbenzenesulfonate salt, tridecyl alcohol polyether, and deionized water are mixed and dissolved, heated, and polydimethylsiloxane alcohol is added under high-speed shearing for homogenization. Water is added and the reaction is maintained at a constant temperature to obtain a basic emulsion. γ-(methacryloyloxy)propyltrimethoxysilane is added dropwise to react and obtain an interface-reinforced emulsion. Acrylamide, N-hydroxymethylacrylamide, etc., are pre-emulsified and then added to the interface-reinforced emulsion with ammonium persulfate under nitrogen protection. Polymerization forms a cross-linked polymer shell. After cooling, tert-butylhydroquinone and disodium ethylenediaminetetraacetate are added to obtain an antioxidant emulsion. Phenoxyethanol and octyl glycol are added to obtain the final emulsion. This method significantly improves the thermal stability of the emulsion through the synergistic effects of composite emulsification, interface reinforcement, shell protection, and antioxidant properties, making it suitable for high-temperature environments.

The invention provides camellia oil containing nano squalene and a preparation method thereof, and relates to the technical field of food processing, in particular to camellia oil containing nano squalene. According to the scheme, a high-pressure homogeneous emulsification technology and a lipid-surfactant synergistic stabilization mechanism are adopted; the preparation method comprises the following steps: firstly, beeswax (solid lipid), camellia oil and rice oil (liquid lipid) are fused at high temperature to form a uniform oil phase; the interfacial tension is reduced through high-speed stirring, in the high-pressure homogenizing process, lipid liquid drops are broken to nanoscale through mechanical shearing force and the hole effect, and soybean lecithin molecules rapidly wrap new liquid drops to prevent aggregation. And finally, quickly cooling to recrystallize and solidify the beewax, wherein a crystalline region of the beewax can enhance the rigidity of emulsion droplets, lock a nano structure and uniformly disperse squalene to obtain the nano functional camellia oil. Solid lipid of the nano-carrier can form a physical barrier, the contact rate of squalene and oxygen is reduced, the oxidation rate is reduced, and the preparation method is simple in process, high in operability and suitable for large-scale mass production.

The invention belongs to the field of food engineering, and particularly relates to sphere-like starch-based nanoparticles as well as a preparation method and application thereof. The method comprises the following steps: performing enzymolysis and aging treatment on sweet potato starch gelatinization liquid to obtain rod-like starch nanoparticles, and further performing cooling and aging treatment on the rod-like starch nanoparticles and a small amount of whey protein solution under a hydrothermal condition to obtain the sphere-like starch-based nanoparticles. According to the method provided by the invention, the rod-like nanoparticles which are less than 10 nm and do not have the emulsifying property are further modified and processed to prepare the sphere-like nanoparticles with the scale of 10-30 nm and the high internal phase emulsifying property, the emulsifying effect of the sphere-like nanoparticles can be compared with that of whey protein with the same concentration, and the high internal phase emulsion is small in droplet particle size, good in storage stability, low in cost and wide in application prospect.

A preparation method and an application for an oil-in-water nanoemulsion material are provided, the method is a new method combining sonication-phase inversion composition-phase inversion temperature, S-PIC-T method, i.e., the combined application of the sonication, the phase inversion composition method and the phase inversion temperature develops a new type nano-preparation with small droplet size, high loading hydrophobic small molecule substances, and stable physical and chemical properties. Therefore, in the present disclosure, the sonication in the high-energy method is combined with PIC and PIT in the low-energy method, because the sonication does not produce high heat, the amount of surfactant is reduced, and the size of emulsion droplets is reduced while the energy consumption is low, while PIC and PIT reduce production costs and protect the biological activity of hydrophobic bioactive substances.

The invention relates to the technical field of pesticide preparations, and provides a slow-release pesticide preparation method which comprises the following steps: (1) homogenizing pesticide active ingredients and an emulsifier aqueous solution to form a pesticide-loaded emulsion; (2) dissolving a biodegradable high polymer material in an organic solvent to form a coating phase; (3) dropwise adding the drug-loaded emulsion into the coating phase, and carrying out ultrasonic emulsification to form a W / O emulsion; (4) adding a cross-linking agent under a low-temperature condition for interfacial polymerization; and (5) centrifugally washing and freeze-drying to obtain the sustained-release microcapsule. The particle size of the obtained product is 80-300 [mu] m, the encapsulation efficiency is greater than or equal to 88%, the accumulated release rate in water at 25 DEG C for 30 days is 75-95%, and the lasting period is 3-4 times that of a conventional preparation. The method is suitable for slow-release processing of insecticides, bactericides and herbicides. Through a 4-15 DEG C low-temperature cross-linking process, the decomposition of the heat-sensitive pesticide is effectively inhibited, and the utilization rate of effective components is remarkably improved. A chitosan-PLA composite capsule wall structure is adopted, gradient release is achieved, a chitosan hydrophilic layer is rapidly swelled, 15-20% of the chitosan hydrophilic layer is released within 7 days, and the rapid effect taking requirement is met.

This invention belongs to the field of fire extinguishing materials and their preparation technology, and provides a fire extinguishing microcapsule and its microfluidic controllable preparation method. The preparation method is characterized by the following steps: (1) preparing fluids of each phase, (2) preparing a dual emulsion using a microfluidic device, (3) collecting and sealing the dual emulsion in a collection container, controlling the axis of the collection container to be horizontal, and controlling the collection container to rotate around its axis for 1 to 15 minutes, applying light to solidify the outer shell of the dual emulsion droplets while maintaining the rotation of the collection container, cleaning, and drying to obtain the final product. The fire extinguishing microcapsule prepared by this method consists of an outer shell and a liquid fluorine-containing fire extinguishing agent encapsulated within the outer shell. The outer shell of the fire extinguishing microcapsule has a uniform thickness, and the eccentricity between the outer shell and the core is less than 0.1. The method of this invention can achieve precise customization of fire extinguishing microcapsules according to the differentiated fire characteristics of different application scenarios, and can improve the concentricity between the core and the outer shell of existing fire extinguishing microcapsules.

This invention belongs to the field of microfluidic control technology and discloses a coaxial copolymer microfluidic droplet generation device and method with adjustable focusing distance. The device includes a focusing distance adjustment mechanism, a coaxial premixing module, and a flow focusing module. The coaxial premixing module achieves stable premixing of the inner and middle phase fluids through coaxial arrangement of inner and outer capillaries and a turbulence support structure within the annular gap, forming a core-shell structured preemulsion. The flow focusing module receives the outer phase input and performs hydraulic focusing and shearing on the preemulsion to generate uniform droplets. By precisely adjusting the distance between the two modules through the focusing distance adjustment mechanism, the focusing distance can be continuously changed within the range of 0.0-10.0 mm, achieving fine control over droplet size (260-650 μm) and shell thickness. This invention features a stable structure, precise adjustment, and high pressure resistance, and is suitable for W / O / W multiphase systems, solving the problems of limited adjustment parameters and invariable structure in traditional devices for emulsion droplet control.

The invention discloses an emulsion type movable pressure-sensitive adhesive and a preparation method thereof. The pressure-sensitive adhesive is prepared from the following raw materials: nano polymer microspheres, a soft monomer, an aliphatic ring hard monomer, a fluorine-containing acrylate monomer, a functional monomer, a cross-linking agent, a pH regulator, an emulsifier, an initiator and water. The preparation method of the pressure-sensitive adhesive comprises the following steps: 1, adding nano polymer microspheres, a soft monomer, an aliphatic ring hard monomer, a fluorine-containing acrylate monomer, a functional monomer, a cross-linking agent, an emulsifier and an initiator into 1 / 2-2 / 3 weight of water, and uniformly mixing to obtain a pre-emulsion; and 2, adding the rest water and the pH regulator into a reaction kettle, heating to 80-90 DEG C, slowly dropwise adding the pre-emulsion, continuing to react for 0.5-1.5 hours after dropwise adding is completed, and cooling after the reaction is completed. The removable pressure-sensitive adhesive disclosed by the invention has the advantages of excellent water resistance, good removable performance, energy conservation, environment friendliness, simple preparation process and the like, and has a very good application prospect.

The invention relates to the field of structural color materials, and discloses polymerization-induced phase separation total internal reflection structural color microspheres as well as a preparation method and application thereof. The method comprises the following steps: mixing an epoxy vinyl monomer, a fluorocarbon which cannot be subjected to polymerization reaction and a photoinitiator to obtain an oil-phase mixture; the epoxy vinyl monomer and the fluorocarbon are mutually soluble, and the fluorocarbon does not participate in polymerization; the preparation method comprises the following steps: adding a first surfactant and a second surfactant into water, and mixing to obtain a water-phase mixture; and mixing the oil-phase mixture and the water-phase mixture to form homogeneous-phase emulsion liquid drops, and irradiating the homogeneous-phase emulsion liquid drops under ultraviolet light to obtain the total internal reflection structural color microspheres. The total internal reflection structural color microspheres are prepared by optimizing the composition of two phases of Janus liquid drops and introducing ultraviolet light to initiate monomer polymerization and drive the monomers to be subjected to phase separation from emulsion liquid drops, the preparation process is simplified, cosolvent dissolution is not needed, and the requirements of large-scale industrial production can be met.

The present application belongs to the field of food contact coating materials, and provides a food contact grade silicone emulsion and a preparation method thereof. The silicone intermediate with a core-shell emulsion droplet structure is synergistically compounded with a methyltrimethoxysilane surface modified silica intermediate, and combined with hydrolysis and condensation pre-emulsification, high pressure homogenization, aging, defoaming, filtration and control of emulsion droplet and particle size distribution to obtain a water-based system with stable dispersion and workability. The system still maintains suitable viscosity under higher non-volatile conditions, and after film formation, it has the performances of adhesion, wear resistance, heat resistance and stable release, solving the problem that the existing system cannot simultaneously consider high solid content, low viscosity, processing adaptability, high adhesion, wear resistance and film forming performance, and high heat resistance, stability and low release force. The present application has application value in constructing a silicone release layer on the surface of paper base material and plastic film base material.

This disclosure provides a method for detecting an analyte in a sample, wherein the sample is introduced into an analytical chamber along with emulsion droplets or gel beads. In another aspect, this disclosure provides designs for formulating emulsion droplets or gel beads such that they can be used for the large-scale parallel detection of analytes. Formulations containing specific combinations of fluorescent particles allow for the optical determination of the identity of each fluorescent particle. These combinations are based on the particle fluorescence emission wavelength, fluorescence excitation wavelength, and particle count.

The invention discloses plant essential oil solid slow-release particles for preservation and fresh-keeping of sweet potatoes, and belongs to the technical field of sweet potato fresh-keeping. The preparation method comprises the following steps: compounding clove essential oil, rose essential oil and cinnamon essential oil in proportion, and uniformly stirring and mixing with maltodextrin to form a binary composite emulsion; blending the binary composite emulsion with a sodium alginate solution to form a ternary composite emulsion; and dropwise adding the ternary composite emulsion into a calcium chloride or calcium lactate solution, and freeze-drying to obtain the sweet potato preservative multifunctional slow-release fresh-keeping particles. The plant essential oil is embedded and fixed by adopting a microcapsule nano-emulsification technology and combining the hydrogel characteristic of a calcium alginate three-dimensional network structure, so that the stability of the essential oil is improved, the utilization rate of the essential oil is increased, the control effect of the plant essential oil on germination and rotting of stored sweet potatoes is enhanced, and the logistics shelf time of the sweet potatoes after being delivered from a warehouse is prolonged.

The microporous noise-reducing aerogel coating material is prepared from the following raw materials in parts by weight: 100 to 110 parts of tetraethoxysilane, 1 to 2.5 parts of hydrophilic emulsifier, 5 to 10 parts of pore-foaming agent, 0.5 to 2 parts of initiator, 30 to 40 parts of functional monomer, 5 to 10 parts of cross-linking agent and 2 to 3 parts of lipophilic emulsifier. According to the invention, a hierarchical pore structure from micron to nanoscale is constructed in situ through a one-step method. In the gelation and drying processes, the interface of the emulsion drops is used as a template to guide and form a macroporous skeleton; meanwhile, through a sol-gel process of a silicon source and volatile / reactive pore forming of an organic phase, mesoporous and microporous structures are formed in pore walls. And finally, a three-dimensional through'macropore-mesopore-micropore 'hierarchical pore structure is formed.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a riptacaine cream and a preparation process thereof. A part of water, polyoxyethylene hydrogenated castor oil and a part of carbomer are preferentially mixed to form a water phase, so that the operation temperature in the cream production process can be reduced, hydrogen bonds can be further formed between polyoxyethylene hydrogenated castor oil and carbomer molecules, and meanwhile, carbomer forms a loose three-dimensional structure. When an oil phase and a water phase are mixed, homogenized and emulsified, a hydrogen bond formed between polyoxyethylene hydrogenated castor oil and carbomer molecules can buffer pulling of a homogenized shear force on a stretched carbomer molecular chain to prevent the carbomer molecular chain from being broken. Secondly, after emulsification, a composite interfacial film of a surfactant and macromolecules can be formed on the surface of an oil phase, so that damage to emulsion droplets during collision of the oil droplets can be effectively resisted, and coalescence and flocculation are reduced. The ripropylene dicaine cream prepared by the invention is milk white paste with fine texture, the particle size range is 1-2 microns, and the character, the particle size and the viscosity are basically unchanged after a low-temperature cycle test.

The invention relates to the technical field of deep processing of egg products, in particular to egg white peptide / polyphenol / metal ion ternary synergistically assembled composite particles and application of the egg white peptide / polyphenol / metal ion ternary synergistically assembled composite particles in stable emulsions.The egg white peptide / polyphenol / metal ion ternary synergistically assembled composite particles are prepared by pre-assembling metal ions and polyphenol to form a metal-phenolic network and synergistically assembling the metal-phenolic network and egg white peptide through an anti-solvent coprecipitation method. The egg white peptide / polyphenol / metal ion ternary synergistic assembly composite particles are formed. Compared with unassembled egg white peptide, the colloidal property of the composite particle is regulated and controlled, the absolute value of surface charge is reduced, the interface hydrophobicity is enhanced, and the egg white peptide molecule conformation is promoted to be converted into an ordered secondary structure mainly comprising beta-folding. The composite particle can be used as a novel stabilizer for constructing an emulsion, and the obtained emulsion is uniform in droplet size, good in dispersity and still stable under the environmental stress conditions of heating, freezing and thawing, different pH values, salt ion strength and the like. The invention provides a new technical approach for the application of the egg white source active peptide in emulsion and functional food.

The invention discloses heparin sodium cream and a preparation method thereof, and belongs to the technical field of pharmaceutical preparation production. The heparin sodium cream is prepared from the following components: heparin sodium, propylene glycol, ethylparaben, lauryl sodium sulfate, glyceryl monostearate and glyceryl distearate, octadecanol, liquid paraffin, white vaseline and water. The preparation method comprises the following steps: preparing an oil phase and a mixed water phase; emulsifying a part of the mixed water phase and the oil phase to form a water-in-oil primary emulsion; adding the residual mixed water phase into the primary emulsion, inducing phase transformation into oil-in-water emulsifiable paste under a mild condition, and performing vacuum defoaming and gradient cooling to obtain a finished product. Through a controlled phase inversion emulsification process, efficient emulsification is realized under mild conditions of 80 DEG C or below and 3000 rpm or below, the emulsion droplet particle size (D99) is less than 5 [mu] m, the problem that the active substance heparin sodium loses activity under severe conditions is thoroughly solved, and the product stability is significantly improved.

The application provides a method for preparing hollow non-spherical micro-nanoparticles based on a coaxial micro-reactor, and belongs to the field of droplet microfluidics and polymer materials. A three-channel coaxial micro-reactor is designed to generate a water-in-oil-in-water (W / O / W) double emulsion. The innermost phase is an alkaline electrolyte aqueous solution, the intermediate oil phase is a polymer solution, and the outermost phase is a surfactant aqueous solution. With the volatilization of the intermediate phase solvent, the double emulsion droplets form hollow non-spherical micro-nanoparticles. The double emulsion is placed in a collection liquid with different electrolyte concentrations, water molecules in the collection liquid penetrate into the innermost phase under the action of osmotic pressure, increase the size of the inner droplets of the double emulsion, and then change the morphology of the outer droplets, so that the non-spherical structure required is presented, and the size of the hollow micro-nanoparticles is controllable. The coaxial micro-channel reactor used in the application adopts a flow focusing structure, which is used for controllable generation of double emulsion to prepare multi-chamber hollow non-spherical micro-nanoparticles.