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Preparing method of nanoscale vitamin microemulsion

A vitamin and microemulsion technology, which is applied in food preparation, food shaping, animal feed, etc., can solve the problems of high production cost, single ingredient, poor water solubility, etc., and achieve low production cost, simple operation, and small particle size.

Inactive Publication Date: 2010-02-17
曹金党
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. At present, all the vitamins used in the domestic and foreign feed industry are micron-sized powder particles, and the fat-soluble vitamins in the water-soluble multivitamins are also emulsified micron-sized oil droplets, which have extremely poor affinity with water and gastrointestinal fluids. The water solubility is also poor, which affects the feeding and drinking effect, the potency is only 7-25%, and the bioavailability is very low
Most of the fat-soluble vitamins fortified in food are directly added or processed into emulsions. Due to poor water solubility, the vitamin content in the unit product is uneven, which affects the fortification effect and reduces the product grade.
[0007] 3. Large differences in absorption and utilization among individuals
[0009] There are some reports about the preparation of vitamin nano-scale microemulsions at present, such as the invention that the application (patent) number is 200410006272.9, the preparation method disclosed by this patent needs to fully emulsify vitamins by a high-pressure homogenizer, and in order to avoid high-pressure homogenization ( 70Mpa, 150Mpa) The high heat generated in the process will destroy vitamins, and a cooling device is required to keep the vitamin liquid at a low temperature, so the production cost is high and the energy consumption is large
The invention patent with application number 200610043053.7 discloses a microemulsion containing vitamin E and vitamin C and its preparation method, but the composition is relatively single

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Heat 1000 mL of purified water to 25°C, weigh 0.5 g of antioxidant sodium sulfite, add it into water, and stir while feeding; when the above raw materials are completely dissolved, add vitamin B in sequence 2 0.2g, vitamin B 1 0.5g, calcium pantothenate 1g, vitamin C 0.6g, niacinamide 2.3g, vitamin K 0.2g, vitamin B 12 0.3g, vitamin B 6 0.1g, folic acid 1g, biotin 0.5g, stirring while feeding; then add antioxidant butylated hydroxyanisole 0.5g, hydrogenated polyoxyethylene castor oil 90g, vitamin A 13g, vitamin D 3 1 g of vitamin E, 2 g of vitamin E, and 15 g of glycerol are stirred while feeding, and stirred at 30° C. for 10 minutes to obtain a clear and transparent microemulsion.

Embodiment 2

[0033] Heat 1000 mL of purified water to 25°C, weigh 0.5 g of sodium salicylate, add it into water, and stir while feeding; when the above raw materials are completely dissolved, add vitamin B in sequence 2 0.5g, vitamin B 1 1g, vitamin C1g, vitamin K0 .2g, vitamin B 12 0.8g, vitamin B 6 1g, 1g of folic acid, 0.5g of biotin, stirring while feeding; then add 0.5g of sodium formaldehyde sulfoxylate, 100g of hydrogenated polyoxyethylene castor oil, 8g of vitamin A, and 8g of vitamin D in turn 3 5 g of vitamin E, 2 g of vitamin E, and 10 g of propylene glycol, stirring while feeding, and stirring at 25° C. for 10 minutes to obtain a clear and transparent microemulsion.

Embodiment 3

[0035] Heat 1000 mL of purified water to 35°C, weigh 0.8 g of antioxidant sodium metabisulfite, add it into water, and stir while feeding; when the above raw materials are completely dissolved, add vitamin B in sequence 1 0.5g, vitamin B 2 0.2g, vitamin B 6 0.1g, vitamin B 12 0.3g, 2g of folic acid, 0.6g of vitamin C, 2.3g of niacinamide, 0.2g of vitamin K, 0.5g of biotin, stir while feeding; then add 0.5g of gallic acid ester, 20g of Span, and polyoxyethylene castor oil in sequence 80g, Vitamin A 13g, Vitamin D 3 1 g of vitamin E, 2 g of vitamin E, and 15 g of glycerin are stirred while feeding, and stirred at 35° C. for 10 minutes to obtain a clear and transparent microemulsion.

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Abstract

The invention relates to a preparing method of nanoscale vitamin microemulsion. The microemulsion is prepared by adding vitamin, emulsifier, co-emulsifier and antioxidant in pure water to form a dispersed system with stable thermodynamics. The preparing technology is mainly characterized in that production process needs no high pressure homogenization processing, and can be finished by simply mechanically stirring, which greatly lowers energy consumption and saves production cost; the average grain diameter of the emulsion droplet of prepared microemulsion is 20 nm. The invention greatly improves bioavailability and stability of vitamin, can be widely used in industries of feed and additive thereof, pet health products, cosmetics, medicine, health products, beverage and the like.

Description

Technical field [0001] The invention relates to a preparation method of vitamins, in particular to a preparation method of nano-scale vitamin microemulsion. Background technique [0002] Vitamins are a class of biologically active low-molecular-weight organic compounds, which are essential nutrients for humans and animals to maintain normal physiological functions. Vitamins generally cannot be synthesized in the body or in sufficient amounts, and most vitamins must be supplied from food or other in vitro supplements. [0003] In the past 20 years, human vitamin supplementation has been carried out in the form of multivitamin capsules, pills or oral liquids, which are undoubtedly beneficial for supplementing vitamins to the human body and preventing vitamin deficiency. In animal husbandry production, most of the vitamin premixes are added to the feed to meet the needs of livestock and poultry for vitamins at various growth stages. [0004] Although the above-mentioned vitam...

Claims

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Application Information

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IPC IPC(8): A23P1/00A23L1/302A23K1/16A23L33/15A23P10/00A23P30/00
Inventor 曹金党刘宗柱
Owner 曹金党
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