46 results about "Psoriasis universalis" patented technology

The invention provides an oral medicine formula for treating psoriasis, and relates to the field of traditional Chinese medicine formulas. The oral medicine for treating psoriasis is prepared from the following raw materials by weight: 10 g of astragalus membranaceus, 50 g of rhizoma smilacis glabrae, 10 g of salvia miltiorrhiza, 10 g of cassia twig, 10 g of cicada slough, 10 g of ligusticum wallichii, 30 g of angelica sinensis and 10 g of honey-fried licorice root. Salvia miltiorrhiza, ligusticum wallichii, angelica sinensis and other medicines have the effects of promoting blood circulation to remove blood stasis, can improve the blood circulation state of skin and promote repair of skin lesions, and have a certain curative effect on blood stasis type psoriasis patients; cassia twig and cicada slough have the effects of dispelling wind and arresting itching, can relieve the symptom of skin itch, and improve the life quality of patients; astragalus membranaceus, angelica sinensis and honey-fried licorice root have the effects of reinforcing qi and nourishing blood, can improve the overall physique of a patient, enhance the immunity of the body and contribute to disease recovery, the clinical effective rate reaches 70% or above, one treatment course lasts for three months, and the cure rate can reach 40% or above.

The present invention relates to a polymer self-assembly nanocarrier and a method of preparing same, the nanocarrier binding a peptide that targets a specific cell and, simultaneously, carrying an active ingredient that has been verified. The present invention can exhibit various effects such as a moisturizing effect, an increase in filaggrin production, whitening, skin barrier reinforcement and the like by selectively and efficiently delivering a drug through a targeting peptide, can be applied to skin diseases such as atopy or psoriasis, and is expected to enable the maximum effect of an active substance in the pharmaceutical and cosmetic fields to be obtained.

The invention discloses a cream for treating erythroderma type psoriasis and a preparation method thereof, and belongs to the technical field of psoriasis drugs, the cream is prepared from the following raw materials by weight: 20-50 parts of cassia alata, 5-15 parts of prepared myrrh, 2-8 parts of raw rehmannia root, 40-160 parts of water, 40-50 parts of an emulsifier, and 0.05-0.1 part of a preservative. The preparation method comprises the following steps: decocting the cassia alata, the prepared myrrh and the radix rehmanniae recen in water, and then fishing out the medicinal materials to obtain medicine slurry; and mixing the medicine slurry, the emulsifier and the preservative, adding into an emulsifying machine, and emulsifying to obtain the product. The formula can be used for treating erythroderma type psoriasis, and the external emulsifiable paste for psoriasis has the effects of inhibiting various fungi and viruses, removing heat to cool blood, astringing and promoting tissue regeneration, inhibiting epidermal cell proliferation, slowing down epidermal metabolism cycle speed, promoting keratinogenesis, inhibiting sebum secretion and inhibiting the growth environment of bacteria and fungi. The inflammation cells are eliminated; the itching is relieved, and the like.

A topical cutaneous composition remarkably reduced eczema, psoriasis, and other skin problems in human patients. The topical cutaneous composition is formulated using natural and toxicologically harmless components as a skin cream with an acidic or a caustic property. When the topical cutaneous composition is applied to the afflisted area, the topical cutaneous composition attacks, sooths, and cures damaged skin.

The present disclosure includes methods of treating a disease or condition that produces skin inflammation and / or itch. More specifically the present disclosure relates to treating skin inflammation and itch caused by diseases or disorders of the skin such as psoriasis by administering a peptide fragment of the MARCKS protein. Peptide fragments and variants thereof as disclosed in the present disclosure are useful in such methods.

Cosmetic care composition for topical application to sensitive and inflamed skin, in particular for the relief of psoriasis symptoms or atopic dermatitis symptoms, comprising in weight percent: Manuka honey with a defined UMF ≥15+ or MGO ≥540 mg / kg in a concentration of at least 4% in combination with Aloe Vera juice concentrate in a concentration of at least 0.1%, Panthenol in a concentration of at least 3.0%, squalane in a concentration of at least 6.0%, Shea butter in a concentration of at least 4.0%, and hyaluronic acid in a concentration of at least 0.02%, at least one natural emulsifier and humectant, and a preservation system, and where the rest is water ad 100%.

The invention relates to the technical field of tissue engineering repair and regeneration, in particular to application of a human dental pulp stem cell-derived exosome in preparation of drugs, and particularly application of the human dental pulp stem cell-derived exosome in preparation of drugs, in particular to application of the human dental pulp stem cell-derived exosome in preparation of drugs for treating scytitis and psoriasis, and application of the human dental pulp stem cell-derived exosome in preparation of drugs for treating scytitis and psoriasis. A safe and effective biological intervention measure is constructed to replace a traditional treatment mode, the excessive inflammatory response of the skin is effectively inhibited, meanwhile, skin injuries are repaired, recovery of a lesion area is promoted, and a new treatment measure is provided for a patient with skin inflammation.

The invention relates to the use of treg-cell derived exosomes in the treatment of psoriasis.

To provide methods for safe and effective treatment of psoriasis, specifically moderate to severe chronic plaque psoriasis, in pediatric patients.SOLUTION: A method of treating psoriasis in a pediatric patient in need thereof includes administering to the pediatric patient a pharmaceutical composition comprising a safe and effective amount of an anti-IL-12 / IL-23p40 antibody, such as Ustekinumab.SELECTED DRAWING: Figure 1

The present invention provides a method for the in vitro diagnosis of psoriasis and / or psoriasis-associated disease in an individual, which method comprises the steps wherein : (a) a level of a gasdermin in a biological sample from an individual is determined; and (b ) the level of the gasdermin in the test sample from the individual obtained in step (a) is compared with the level of the gasdermin in a reference sample, wherein the reference sample is a sample from a healthy control individual; wherein the level of the gasdermin higher than in the reference sample indicates that the individual suf fers from psoriasis and / or psoriasis- associated disease. The present invention provides also a gasdermin for use as a diagnostic biomarker for psoriasis, as well as preferably a diagnostic biomarker for psoriasis- associated disease. The present invention provides also a test kit for determining a level of a gasdermin in a biological sample from an individual and / or for diagnosing psoriasis, wherein the kit comprises means for determining the level of the gasdermin and optionally detection reagents and possibly instructions for carrying out the determination of the level of the gasdermin.

The invention discloses a traditional Chinese medicine preparation for treating intractable skin diseases and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10-50 parts of paper mulberry leaves, 10-50 parts of rhizoma smilacis glabrae, 10-30 parts of euphorbia cordifolia, 10-30 parts of trichosanthes kirilowii roots, 10-30 parts of spina gleditsiae and 3-5 parts of liquorice. The traditional Chinese medicine preparation is specially used for treating (conditioning) intractable skin diseases such as eczema, psoriasis (psoriasis), allergic dermatitis, lupus erythematosus and the like, is high in cure rate and small in side effect, and solves the problem that no medicine can treat the intractable skin diseases in the world.

A phototherapy system for treating a user can include an applicator, a controller, and a communication cable configured to couple the applicator and the controller. The applicator can include a light source, a thermal sensor, and a fan. The controller can be in communication with the applicator. The controller can be configured to receive a predetermined treatment regimen to be applied to the user via the applicator. A method for treating skin presenting psoriasis includes providing a phototherapy system. The user can select a skin type on the controller. The use can place the applicator adjacent to the skin presenting psoriasis, eczema, or vitiligo. The user can receive a light therapy treatment from the applicator, whereby the psoriasis, eczema, or vitiligo has been treated.

The invention discloses an external compound preparation for treating skin diseases as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation is prepared from the following raw materials in specific parts by weight: borneol, dipterex tablets, cantharides, huechys sanguinea, ephedra, calculus bovis, dragon's blood, centipedes and garter snakes. The preparation method comprises raw material pretreatment, mixing and blending, and sub-packaging and storage, and is simple in process and easy to operate; the ointment is externally applied to skin lesions every morning and evening, and is suitable for diseases such as eczema, psoriasis, neurodermatitis and the like. Through the synergistic effect of multiple components, the comprehensive curative effects of clearing heat, detoxifying, dredging collaterals, relieving itching and promoting tissue regeneration are achieved, the traditional Chinese medicine composition has the advantages of being rapid in effect taking, convenient to externally use and small in side effect, the problems that an existing skin disease treatment medicine is large in side effect and slow in effect taking are solved, and a new effective scheme is provided for clinical treatment of skin diseases.

The utility model relates to the technical field of psoriasis treatment, and discloses a head Chinese medicine fumigation device with a self-heating function, comprising a fumigation cap; a fixing component is provided at the bottom of the fumigation cap; a fumigation treatment component is provided inside the fumigation cap, and the fumigation treatment component comprises: a heat insulation layer, which is arranged on the inner side wall of the fumigation cap; a heating layer, which is arranged on the inner side of the heat insulation layer; a vacuum layer, which is arranged between the heat insulation layer and the heating layer; a water-proof layer, which is fixedly connected to the inner side wall of the heating layer; the fumigation treatment component can heat and keep the internal absorbent cotton warm, and ensure the temperature of hot compress fumigation during treatment, thereby improving the hot compress fumigation treatment effect; the fixing component fixes the head by means of elastic straps and buckles, and can be quickly and firmly fixed on the head, and the internal absorbent cotton can be stably fixed in the cap, further improving the stability of the fixation, so that the patient will not shake or fall off when moving the head.

This invention discloses a traditional Chinese medicine composition for treating skin diseases and its preparation method, belonging to the field of traditional Chinese medicine technology. It is made from the following raw materials in parts by weight: 8-12 parts of Phellodendron bark, 8-12 parts of Cnidium monnieri fruit, 8-12 parts of Dictamnus dasycarpus root bark, 8-12 parts of Stemona japonica root bark, 8-12 parts of alum, 8-12 parts of Carthamus tinctorius flower, 8-12 parts of dragon's blood, 8-12 parts of Panax notoginseng root bark, 8-12 parts of myrrh, 8-12 parts of frankincense, and 1-3 parts of propolis. This invention also provides an external preparation containing this composition and its preparation method. The preparation method includes pulverizing the raw materials, adding 60%-80% ethanol, soaking at 50-80℃ for 2-7 days, pressing, filtering, and allowing to stand, then collecting the supernatant. Pharmacological experiments show that the composition of this invention has significant antibacterial, anti-inflammatory, and antipruritic effects; clinical observations show a total effective rate of 80%-95% for psoriasis, eczema, rashes, pruritus, herpes, urticaria, and insect bite itching. The formulation of this invention is scientific, the process is stable, and the efficacy is definite, making it suitable for clinical application.

Disclosed is a pharmaceutical composition for preventing or treating skin diseases, comprising a Janus kinase inhibitor. A pharmaceutical composition for preventing or treating psoriasis and atopic dermatitis, according to one embodiment, comprises: a Janus kinase inhibitor including at least one of a Janus kinase inhibitory component or a pharmaceutically acceptable salt thereof; and an active ingredient including at least one of octenidine or an octenidine salt, wherein the Janus kinase inhibitory component may include at least one of delgocitinib, ruxolitinib, or tofacitinib.

Uses are described for hemolymph, contents of hemolymph, fragments or components of the contents found within hemolymph, including hemocyanin, any of which may be derived from crustaceans, as functional agents to treat diseases, provide symptomatic relief, provide a beautifying or relieving effect to the intended organ or site-of-intended-use, or be used as an ingredient in formulations designed to aid in the relief of pathologies or states commonly associated with inflammation and dry skin, including, but not limited to eczema, dermatitis, psoriasis, cystitis, asthma, sinusitis, joint pain, as well as other instances of acute and chronic inflammation, and for relief of general symptoms that may be associated with inflammation and dry skin but not linked directly in the intended use, including, but not limited to, redness, itchiness, irritation, muscle or joint fatigue, swelling, hydrating the skin, and reducing transepidermal water loss (TEWL).

The invention relates to a peptide for use in prophylaxis, prevention, inhibition and / or treatment of psoriasis of a mammal, wherein the peptide comprises amino acids joined by peptide bonds, and wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro). The invention also relates to a pharmaceutical composition for use in prophylaxis, prevention, inhibition and / or treatment of psoriasis of a mammal, wherein the pharmaceutical composition comprises a peptide, wherein the peptide comprises amino acids joined by peptide bonds, and wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro). The invention further relates to a composition for skin improvement, a cosmetic composition, a topical skin cream composition and a nutritional compositions, wherein said compositions comprise a peptide comprising amino acids joined by peptide bonds, wherein the peptide comprises an amino acid sequence of from 3 to 5 amino acids comprising 2 acidic amino acids and proline (P) (Pro).

The present invention relates to a composition and use thereof directed towards treating various health ailments, such as skin and respiratory problems and various infections. More particularly, the present invention relates to a lime sulfur solution and use thereof, of varying percentages, directed towards improving vision and treating various skin problems and infections, such as toenail fungus, athlete's foot, jock itch, skin psoriasis, eczema, vaginal yeast infections, head or beard dandruff, respiratory infections, itching of the skin (particularly of the hands), acne (facial and / or body acne), poison ivy, insect bites, head and body lice, crabs, cuts, treating wounds infected by staff and / or MRSA (methicillin-resistant Staphylococcus aureus) bacteria, tongue thrush, ringworm, penis foreskin infections, skin tags, and is also directed towards treating various respiratory infections (such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, and Covid-19 infections). The present invention also relates to use of the aforementioned composition and solution as a disinfectant in gyms, spas, saunas, for professional athletes, or as a body and / or hair wash.

The present disclosure relates to topical treatment of skin diseases, such as psoriasis, atopic dermatitis, alopecia, vitiligo, Reiter's syndrome, pityriasis rubra pilaris, epidermolysis bullosa simplex, palmoplantar keratoderma, pachyonychia congenita, steatocystoma multiplex, cutaneous lichen planus, cutaneous T-cell lymphoma, hidradenitis suppurativa, contact dermatitis, ichthyosis, and a disorder of keratinization, using (a) a JAK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) vitamin D3, a vitamin D3 analog, or a pharmaceutically acceptable salt thereof.

Microneedle Patch for Biphasic Drug Delivery to Enhance the Management of Psoriasis

The invention relates to the technical field of pharmaceutical preparations, in particular to an antibacterial and anti-inflammatory ointment for treating psoriasis and a preparation method thereof.The antibacterial and anti-inflammatory ointment is prepared from, by mass, 0.3%-0.7% of heparin sodium, 12.3%-13.5% of a humectant, 0.05%-0.1% of a penetration enhancer, 0.3%-0.4% of a pH regulator, 0.3%-0.7% of a thickening agent, 0.1%-0.2% of a preservative, 0.1%-0.2% of essence and the balance solvent. The antibacterial and anti-inflammatory ointment for treating psoriasis prepared by the invention has relatively high transdermal absorbability and a good treatment effect.

Disclosed is a pharmaceutical composition for preventing or treating skin diseases, comprising a calcineurin inhibitor. A pharmaceutical composition for preventing or treating psoriasis and atopic dermatitis, according to one embodiment, comprises: a calcineurin inhibitor including at least one of a calcineurin inhibitory component and a pharmaceutically acceptable salt thereof; and an active ingredient including at least one of octenidine and an octenidine salt, wherein the calcineurin inhibitory component may include at least one of tacrolimus and pimecrolimus.

A method to treat the skin condition psoriasis is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol at a concentration of 3%-20% by weight of the composition. The topical application is applied at least twice daily for six weeks.

There is provided topical pharmaceutical formulations comprising montelukast, or a pharmaceutically acceptable salt of solvate thereof, as well as combination products comprising (a) at least one mussel adhesive protein or a derivative thereof; and (b) montelukast, or a pharmaceutically-acceptable salt or solvate thereof. The formulations and combination products find particular utility in direct topical administration for the treatment of inflammation, of inflammatory disorders and / or of condition characterized by inflammation, including wounds, burns, psoriasis, acne and atopic dermatitis.

To provide a composition suitable for topical delivery of cannabidiol to improve availability of cannabidiol at a local administration site of a mammal in a therapeutically effective amount necessary to reduce or alleviate local symptoms of psoriasis or arthritis, such as rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis and / or psoriatic arthritis.SOLUTION: A hydroalcoholic gel composition is disclosed for alleviating symptoms of psoriasis or arthritis, such as pain resulting from arthritic diseases and / or psoriatic arthritis, and / or neurological pain, such as pain resulting from sclerosis, e.g., multiple sclerosis, in a subject. Such a composition may comprise, inter alia, 0.1-20% cannabidiol, a skin penetration enhancer, ethanol, and one or more thickeners and / or gelling agents.SELECTED DRAWING: None

Herein, compounds of Formulae (I-a) and (II) that act as selective agonists of the leukotriene B4 receptor 2 (BLT2) receptor are presented. The invention pertains to these compounds, their synthesis, as well as their medical use, amongst others in the treatment of pain and inflammatory skin diseases such as psoriasis.

The disclosure provides a method of predicting a response to a treatment regimen for psoriasis in a subject. Biomarkers and clinical variables that can be used to predict the response and to select a treatment regimen are described herein. Also described is a kit for predicting a response to a treatment regimen for psoriasis in a subject.

The present disclosure is in the field of the prevention, improvement or treatment of skin conditions, for example skin conditions associated with skin aging and / or skin pigmentation and / or wound healing and / or psoriasis and / or acne. The disclosure provides extracts derived from sugar cane comprising polyphenols for the prevention, improvement or treatment of skin conditions, including skin conditions associated with skin aging and / or skin pigmentation and / or wound healing and / or psoriasis and / or acne.

Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of diseases and / or conditions of the skin, including hidradenitis suppurativa, atopic dermatitis, psoriasis, vitiligo, and alopecia areata, as well as other diseases and / or conditions provided herein.