68 results about "Keratoderma" patented technology

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

A non-invasive tool for skin disease diagnosis would be a useful clinical adjunct. The purpose of this study was to determine whether visible / near-infrared spectroscopy can be used to non-invasively characterize skin diseases. In-vivo visible- and near-infrared spectra (400-2500 nm) of skin neoplasms (actinic keratoses, basal cell carcinomata, banal common acquired melanocytic nevi, dysplastic melanocytic nevi, actinic lentigines and seborrheic keratoses) were collected by placing a fiber optic probe on the skin. Paired t-tests, repeated measures analysis of variance and linear discriminant analysis were used to determine whether significant spectral differences existed and whether spectra could be classified according to lesion type. Paired t-tests showed significant differences (p<0.05) between normal skin and skin lesions in several areas of the visible / near-infrared spectrum. In addition, significant differences were found between the lesion groups by analysis of variance. Linear discriminant analysis classified spectra from benign lesions compared to pre-malignant or malignant lesions with high accuracy. Visible / near-infrared spectroscopy is a promising non-invasive technique for the screening of skin diseases.

PCT No. PCT / US97 / 11564 Sec. 371 Date Apr. 14, 1999 Sec. 102(e) Date Apr. 14, 1999 PCT Filed Jul. 8, 1997 PCT Pub. No. WO98 / 01132 PCT Pub. Date Jan. 15, 1998The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especially androgen-independent prostate cancer, skin cancer, pancreatic carcinomas, colon cancer, melanoma, ovarian cancer, liver cancer, small cell lung carcinoma, non-small cell lung carcinoma, cervical carcinoma, brain cancer, bladder cancer, breast cancer, neuroblastoma / glioblastoma, and leukemia. Also, the invention relates to novel adamantyl or adamantyl group derivative compounds which are useful as active agents for the treatment or prevention of keratinization disorders and other dermatological conditions, and other diseases.

The invention provides a flexible skin surface dry electrode and a preparation method thereof. The flexible skin surface dry electrode comprises a flexible conducting substrate and multiple microneedle bodies forming a microneedle array, wherein each microneedle body is of a taper shape and comprises a root part and a front end, the root parts of the multiple microneedle bodies are fixed on one surface of the flexible conducting substrate, and the front ends of the microneedle bodies are higher than the surface of the flexible conducting substrate. According to the invention, the substrate material of an original dry electrode is changed from a rigid material into a flexible material; since the flexible substrate can be tightly attached to the skin, the microneedles on the dry electrode overcome the influence of keratoderma, the electrical contact characteristic of the electrode and the skin is improved and the contact impedance is reduced; when an external force acts on the dry electrode, the flexible substrate can generate elastic deformation, thus the breaking of the microneedles is effectively avoided and the use safety is improved; and the substrate material of the dry electrode with the flexible substrate is elastic, thus the wearing uncomfortableness is alleviated.

The invention discloses a berberis julianae schneid extracting solution and a preparation method and application thereof. The berberis julianae schneid extracting solution prepared by means of water extraction has the remarkable effects of resisting bacteria, diminishing inflammation, regulating internal secretion, promoting skin cell metabolism and improving local blood circulation. With the characteristic, the berberis julianae schneid extracting solution has the effects of repairing injured cells, restraining sebum secretion, dredging facial hair follicle and sebaceous gland holes and protecting keratoderma. By applying the berberis julianae schneid extracting solution to cosmetics, the effects of remarkably repairing and protecting sensitive and acne skin are achieved.

Oil-in-water emulsion formulations contain both free fluorouracil and fluorouracil impregnated in porous microparticles. The formulations are suitable for topical administration, and are useful for the treatment of solar keratoses, actinic keratoses, and superficial basal cell carcinomas.

The invention relates to the field of daily chemicals, in particular to a licorice-extract-containing emulsion and a preparation method thereof. The licorice-extract-containing emulsion comprises the following components in parts by weight: 0.01-10 parts of a licorice extract, 1-20 parts of phospholipid, 5-25 parts of oil, 0.5-20 parts of a nonionic surfactant and 60-90 parts of a dispersion medium, wherein the nonionic surfactant is selected from one or more of span-60, span-80, polyglycerol-10 oleate, polyglycerol monooleate, tween-80, polyoxyethylated castor oil and caprylocaproyl macrogolglycerides. Due to the presence of keratoderma, the active ingredient molecules difficultly pass through the skin obstacle to be absorbed by the organism; according to the licorice extract-containing emulsion, the licorice extract is wrapped in lipid nanoemulsion, so that the water solubility of the licorice extract can be effectively increased, the transdermal absorption capacity of the licorice extract is improved and the application of the licorice extract in the field of skin external use is strengthened.

The invention discloses a twinleaf zzornia extracting solution as well as a preparation method and application thereof. The twinleaf zzornia extracting solution prepared through water extraction has the effects of obviously promoting metabolism of skin cells and eliminating skin toxins, so that the twinleaf zzornia extracting solution has the effects of restoring damaged cells, improving immunity of skin and retaining moisture of keratoderma; the twinleaf zzornia extracting solution has obvious skin restoring effect and obvious effect of protecting sensitive skin when being applied to cosmetics.

The invention relates to an amino-modified tetraphenylporphyrin compound as well as a preparation method and application thereof. The compound has a structure (I) shown in the description, wherein R2 and R3 are positioned at an ortho-position (o-) or meta-position (m-) or para-position (p-) of a benzene ring. The invention relates to the fields of photosensitive medicaments (also known as photosensitizers or photodynamic medicaments) and photodynamic therapy, in particular to a porphyrin photosensitizer, a preparation method thereof and application of the porphyrin photosensitizer in the field of medicine. The photosensitive medicament disclosed by the invention has the advantages of stable chemical property, single component and very strong photodynamic activity, and can be applied to photodynamic therapy of diseases such as tumors, retinal macular degeneration, actinic keratosis, port wine stains and condyloma acuminata.

The invention relates to a cosmetic composition, and more particularly, provides a cosmetic composition containing Gluconolactone and Lactobiaonic Acid at a specific weight ratio and used for removing keratoderma and whitening skin or having the excellent skin color improving effect.

The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and hyperproliferative cell growth diseases, including hyperproliferative keratinocyte diseases such as hyperkeratosis, ichthyosis, keratoderma or lichen planus. These compounds are described according to the chemical structure:where R1 is H, OH, F, Cl, Br, I, a C1-C6 optionally substituted alkyl or alkenyl group, an optionally substituted aryl group or a group;Ra is a H, OH, C1-C10, optionally substituted alkyl or alkenyl group, an optionally substituted O—(C1-C7 alkyl group) or O-aryl group, an amine group which is optionally substituted with at least one C1-C10 alkyl group which may be optionally substituted, or a single optionally substituted aryl group, biphenyl group, (C1-C6) alkylenearyl group, (C1-C6) alkylenebiphenyl group, heteroaryl group, heterocyclic group, (C1-C6) alkylene heteroaryl group or (C1-C6) alkylene heterocyclic group;R2 is a group;Rb is a H, OH, C1-C10, optionally substituted alkyl or alkenyl group, an optionally substituted O—(C1-C7 alkyl group) or O-aryl group, an amine group which is optionally substituted with at least one C1-C10 alkyl group which may be optionally substituted, or a single optionally substituted aryl group, biphenyl group, (C1-C6) alkylenearyl group, (C1-C6) alkylenebiphenyl group, heteroaryl group, heterocyclic group, (C1-C6) alkylene heteroaryl group or (C1-C6) alkylene heterocyclic group;R3 and R6 are each independently selected from H, OH, F, Cl, Br, I, a C1-C6 optionally substituted alkyl or alkenyl group, an optionally substituted aryl group, a carbamate, alkylene carbamate, urethane or alkylene urethane;R4 is a group, wherein Rb is as described above; andR5 is a group, wherein Rb is as described above,with the proviso that at least one of R1 and R2 or R4 and R5 contains an Ra or Rb group which is an amine group which is optionally substituted with at least one C1-C10 alkyl group which may be optionally substituted, or a single optionally substituted aryl group, biphenyl group, (C1-C6) alkylenearyl group, (C1-C6) alkylenebiphenyl group, heteroaryl group, heterocyclic group, (C1-C6) alkylene heteroaryl group or (C1-C6) alkylene heterocyclic group;or a stereoisomer, pharmaceutically acceptable salt, solvate, and polymorph thereof.

Dermatological / cosmetic compositions suited for preventing or treating cell differentiation and / or proliferation and / or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° C. and 40° C.

The animal skin penetrant is compounded with dimethyl sulfoxide and its derivative, methyl salicylate, lipid solvent, water or water buffering solution and common medicine. The transdermal medicine is absorbed through capillary vessels and conveyed to inside of the body through body circulation, and this has the advantages of no first pass effect, stable blood medicine concentration, no-pain administration, etc. The present invention can reach the same disease preventing and treating effect as oral taking and injecting, change the barrier action of the keratoderma reversibly, avoid damage to active cells, expand the permeability of medicine in skin and increase the transdermal absorption of medicine.

The invention discloses a rutin nanocrystal, rutin nanocrystal transdermal drug delivery gel and a preparation method thereof. The rutin nanocrystal contains a drug rutin and a stabilizer in the massratio being (1:0.06)-(1:3). The rutin nanocrystal transdermal drug delivery gel is prepared from 0.01%-5% of the rutin nanocrystal, 0.1%-5% of substrate gel, 1%-30% of a moisturizer and the balance ofwater. The rutin nanocrystal has the advantages of uniform particle size distribution, good stability, high saturation solubility, high dissolution rate and the like, the transdermal drug delivery gel is applied to transdermal drug delivery, can effectively overcome keratoderma barrier and notably improve the in-vitro transdermal permeation performance and the bioavailability of rutin, a preparation has a good treatment effect, besides, and damage to the keratoderma structure to a certain extent due to a physical means such as a common microneedle and the like for overcoming the keratoderma barrier is avoided.

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and / or for improving the texture or appearance of the skin, and / or for enhancing epidermal exfoliation and / or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes which exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. The acidic buffer comprises at least one acidic buffering component that can reversibly disassociate hydrogen ions and has buffering capacity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes. Such types of abnormal biological conditions, diseases or disorders include skin atrophy, i.e., the thinning and / or general degradation of the dermis often characterized by a decrease in collagen and / or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

The invention provides a maleic acid timolol preparation for treating infant superficial hemangioma and application of the maleic acid timolol preparation. The maleic acid timolol preparation adopts water as a dispersing medium and comprises the following components by mass percent with the total percent of 100%: 0.1-1% of maleic acid timolol and 0.5-2% of hyaluronic acid or hyaluronate. The maleic acid timolol preparation provided by the invention is relatively good in viscosity and convenient for medical operators to rub on patients, a film can be formed on the skin surface, the adhesion time is greatly prolonged, and active components can play roles continuously; the maleic acid timolol preparation has a moisturizing function and is not dried within a short time, so that the skin surface can be kept in a wet state for a long time; as the keratoderma of an infant is thin and the water content is higher than that of an adult, the moisturizing function is particularly important for infant skin, however, hyaluronic acid or hyaluronate is not used in infant preparation dressing yet at present; in addition, application of hyaluronic acid or hyaluronate to the dressing shows by accident that the function of promoting wound healing of infant skin can be achieved.

The invention provides a medicine for curing the ringworm of the hand, and belongs to a Chinese medicine composition. The invention comprises an external leachant and an external liniment, the external leachant is made of mylabris, huechys, centipede, petrified bouquet and root of sessile stemona according to the compounding ratio, and the external liniment is made of sulfur, arsenic disulfide, minium and alum according to the compounding ratio. The medicine can soften the keratoderma, can strengthen the sterilization and bacteriostatic capabilities to the ringworm in the keratoderma among each medicine, can improve the blood circulation of the nidus, can eliminate the toxic substance of the nidus, and can promote the absorption and the healing of the nidus to the medicine, the sterilization capability to the ringworm is strong, the sink strength is high, the functions of sterilization and itching-relieving, and removing the putrefaction and promoting the tissue regeneration are greatly improved, the purpose of clinically thorough nidus curing is attained, and the deficiency that the ringworm of the hand can not be thoroughly cured while the Western medicine is taken for a long time is overcome. After the patients use the medicine, the symptoms are immediately alleviated, 90 percent of patients rehabilitate, and the recurernce rate is low, and the medicine has the good therapeutic effect on the ringworm of the feet, the ringworm of the body, the tinea cruris and the fungal nail.

The invention provides a pair of socks for treating beriberi. The socks are characterized in that the bottom of each sock is provided with the drug which is made from the following components by mass ratio: 40-60% of hairy euphorbia, 10-20% of golden cypress, 10-20% of radix sophorae flavescentis, 3-8% of borneol, 2-5% of camphor, 1-3% of menthol and the balance of Vaseline. Therefore, the drug has the effects of constricting to stop sweat, removing dampness to relieve itching, eliminating foot peculiar smell, softening foot keratoderma, improving foot blood circulation and the like; and the drug is arranged at the bottom of each sock, and the socks can be obtained after being naturally dried. The pathomycete of the foot skins can be thoroughly killed after the socks are continuously worn by patients for 2-4 days, and the beriberi can be effectively treated; the patients can be treated by the means that the new drug socks are changed when the patients are infected to have the beriberi again; and the socks after treatment can be taken as the common cotton socks to be used after being cleaned, so that the socks not only are convenient, but also can reduce the use cost. The socks are the ideal socks for treating the beriberi.

The invention relates to application of dendrobium candidum polysaccharide in preparing a drug for promoting hair growth, wherein the dendrobium candidum polysaccharide in the drug is 0.1%-5% by weight. The dendrobium candidum polysaccharide in the drug disclosed by the invention can be used for regulating up expression of a vascular endothelial growth factor (VEGF) gene in a keratoderma forming cell (HaCaT cell) blood vessel, so that the effect of prompting the hair growth is achieved.

The invention provides medicine for treating chronic eczema, dermatitis and keratoderma. The medicine mainly comprises the following drug substances in part by weight: 28 to 38 parts of chaulmoogra, 13 to 20 parts of Chinense golden larch bark, 22 to 32 parts of sulfur, 13 to 20 parts of radix sophorae flavescentis, 10 to 16 parts of dried alum and 0.6 to 1 part of yellow lead; and the medicine further comprises 50 to 500 parts of sesame oil. The invention further provides an ointment of the medicine and a preparation method of the ointment. The medicine provided by the invention has the advantages that the curative effect of treating chronic eczema, dermatitis and keratoderma is exact, the number of ingredients is less at the same time, the preparation technology is simple, the cost is low, the medicine can be manufactured into ointments, plaster, gelata, patches and other external-use medicament forms, and the medicine is more convenient to use and is easy to be accepted by patients.

The invention relates to a micro-gel ball whitening essence and a preparation method thereof, which aims at providing a micro-gel ball whitening essence with the advantage that the whitening componentcan be slowly released at the surface of skin and can deeply permeate into the skin keratoderma. The micro-gel ball whitening essence is prepared from the following components of a phase A: a properamount of deionized water; a phase B1: 3 to 7% of skin moisturizer, and 0.005 to 0.05% of acrylate / C10-30 alkyl acrylate crosslinking polymer; a phase B2: 2.3 to 11% of skin moisturizer; a phase B3: 0.01 to 0.5% of whitening and freckle removal agent; a phase C1: 0.02 to 0.6% of anti-inflammatory agent, 7.9 to 22.8% of moisturizer, and 0.1 to 2% of whitening and freckle removal agent; a phase C2:a proper amount of deionized water, and 0.1 to 0.5% of suspension agent; a phase C: a proper amount of deionized water, and 0.01 to 0.014% of pH (potential of hydrogen) regulator; a phase C4: a properamount of deionized water, and 0.1 to 3.0% of whitening and freckle removal agent; a phase D: 0.01 to 2% of whitening and freckle removal agent. The invention belongs to the technical field of skin-care cosmetics.

The invention relates to the technical field of cosmetics, in particular to an antioxidative composition and a preparation method and application thereof. In the composition, fructus schizandrae and soybeans are compounded, an experiment shows that the composition has a remarkable clearing effect to DPPH free radicals, cell oxidation damage caused by t-Bhp stimulation can be reduced remarkably, growth of cells formed by keratoderma is protected effectively, and an obvious synergistic antioxidative effect is achieved.

The invention provides an application of a 3-[[2-[3-oxo-(1, 2-benzisoxazole-6-yl) methoxyl]-5-[(2-hydroxyl-4-cyclopentoxyl benzoyl)] phenyl] propionic acid (compound I) in preparation for treatment of connexin CX31 mediated skin disease. The connexin CX31 mediated skin disease comprises erythrokeratodermia variabilis or psoriasis. The pharmacological experiment proves that a low-dose group and a high-dose group of the compound I can remarkably reduce skin damage degree of a psoriasis animal sample; the content of TNF-alpha in murine serum can be restrained by the low-dose group of the compound I, then inflammatory cell infiltration is restrained, the inflammatory response is relieved, and the compound I has good psoriasis treatment effect and can be used for treating the connexin CX31 mediated skin disease.

The utility model aims to provide a novel evaluation method which uses a biochemical index that does not cause load to a user and can easily and truly evaluate whether the skin is the rough skin. A keratoderma is collected invasively through an adhesive tape stripping method. Degree of the rough skin is evaluated through measuring expression amount of galectin-7 contained therein.

The invention relates to the field of IPC A61K8 / 68, in particular to a water-soluble ceramide NP composition as well as a preparation process and application thereof. The water-soluble ceramide NP composition is prepared from the following raw materials: ceramide NP, phospholipid, a surfactant, a hydroxyl-terminated compound and a solvent; and the weight ratio of the ceramide NP to the phospholipid is 1: (2-15). The average particle size of the water-soluble ceramide can be as low as 70 nm, the application problems that ceramide is high in melting point, poor in water solubility and difficult to emulsify are successfully solved, and the application convenience of a ceramide formula is greatly improved. When being applied to cosmetics, the composition can repair barriers, delay senescence and immediately repair the skin barrier function; the water content of the keratoderma can be increased, aged fibroblasts are activated, wrinkles are reduced, and the skin softness is improved; meanwhile, free radicals can be effectively removed, the skin is synergistically whitened, and the skin glossiness is improved.

The invention relates to a preparation method of native ice-flower soothing restoring gel. The native ice-flower soothing restoring gel comprises the following ingredients (by weight): A, 7-70 parts of an aqueous phase composition; B, 30-90 parts of a functional phase composition; C, 1-3 parts of an anti-corrosion composition; and D, 0.01-0.1 part of an aroma-increasing composition. The aqueous phase composition comprises water, dipropylene glycol, glycerin and an ammonium acryloyldimethyltaurate / VP copolymer. The functional phase composition comprises an ice-flower extracting solution, an aloe extracting solution, beta(1,3)- glucan or beta(1,6)- glucan, sodium hyaluronate and glycerophosphoinositol choline. The invention has the following advantages: compounding of the functional phase composition has synergetic effects; with cooperation of sodium hyaluronate, the product has good effects of protecting damage of ultraviolet light to skin and repairing damaged keratoderma; and as the ingredients are all natural plant ingredients and only ingredients with a bacteriostasis function is used except conventional preservative ingredients, the product is very safe to skin and will not produce any irritating reaction.

The invention relates to an anti-skin-aging composition, and belongs to the field of drugs and cosmetics. The invention aims at achieving the technical purpose of providing a composition capable of preventing skin aging. The composition is a product with active ingredients including acetyl hexapeptide-8 and mu-conotoxin. Crowd trial results show that the composition is prepared into cosmetics of the forms such as essence and lotion, the cosmetics are smeared to skin, the effects of reducing wrinkles and repairing the keratoderma barrier function can be achieved, the purpose of preventing skinaging is achieved, and use is convenient and safe; the composition achieves the effect rapidly, and the effect is remarkable. Compared with an existing method for preventing skin aging through creotoxin, hyaluronic acid, collagen injection and other intrusive means, the composition has the advantages of being convenient to use, good in safety, lasting in effect and the like, and the application prospect is wide.

The invention relates to an external traditional Chinese medicine composition with relieving and repairing functions. The external traditional Chinese medicine composition with the relieving and repairing functions comprises the following raw material medicines in parts by weight: 30-80 parts of mung beans, 20-60 parts of radix sophorae flavescentis, 5-20 parts of licorice roots, 1-5 parts of coptis chinensis, 1-5 parts of scutellaria baicalensis and 1-5 parts of golden cypress. The invention further relates to a preparation method of the external traditional Chinese medicine composition withthe relieving and repairing functions. The external traditional Chinese medicine composition with the relieving and repairing functions is prepared from the six traditional Chinese medicines, namely the mung beans, the radix sophorae flavescentis, the licorice roots, the coptis chinensis, the scutellaria baicalensis and the golden cypress which cooperate with one another and have synergistic interactions, so that skin can be promoted to meet a balance state, the skin allergy phenomenon can be avoided, good effects in increasing moisture of damaged keratoderma, repairing damaged skin, treatingcouperose skin and the like can be achieved, and in addition, due to adoption of herbal plant extracts, the external traditional Chinese medicine composition is natural and gentle in component.

The invention provides a hydroxy acid-contained composition as well as a preparation method and application thereof. The hydroxy acid-contained composition is prepared from the following components including alpha-hydroxy acid, beta-hydroxy acid and proteases. For the hydroxy acid-contained composition provided by the invention, the alpha-hydroxy acid and the beta-hydroxy acid are specifically selected and are compounded with the protease, and the three components can cooperate with each other to achieve synergistic interaction, so that the finally obtained composition has the effect of removing keratoderma and can further have the comprehensive repairing effects of lowering skin pigmentation, brightening skin and improving skin color and the skin roughness. In addition, as all the components are derived from natural fruits, the hydroxy acid-contained composition can obviously lower potential stimulation to the skin without influencing the capacity of stimulating regeneration of cellsand is wide in application prospect.