210 results about "Keratitis" patented technology

The invention provides apparatuses and methods for detecting ocular surface defects. The methods and/or an apparatus of the invention can be used to detect ocular surface diseases, such as dry eye, uveitis, conjunctivitis, keratitis, keratoconjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), autoimmune disorders of the ocular surface, meibomianitis, conjunctival hyperemia, eyelid hyperemia, ocular rosacea, ocular inflammation, or eye lid swelling.

A dripping pill of Chloromycetin eye drops for treating trachnoma, keratitis, conjunctivitis, eyelid inflammation, etc is proportionally prepared from polyethanediol as matrix and Chloromycetin. It is applied in conjunction with the buffer liquid prepared from borax, boric acid, hydroxyphenyl ethylether and the water for injection. Its preparing process is also disclosed.

The present invention discloses calf blood deproteinizing extract, its eye ointment preparation and the preparation process. The preparation process of calf blood deproteinizing extract includes the following steps: collecting calf blood, separating erythrocyte, adding water to swell to destroy erythrocyte membrane and to release inside matter, pasteurization, ultrafiltering and concentration to obtain the intermediate; nano filtering to desalt, reverse penetration to concentrate and decolorizing to obtain calf blood deproteinizing extract. Adding proper amount of excipient and stabilizer into the calf blood deproteinizing extract obtains calf blood deproteinizing extract eye ointment preparation. The said preparation process has less loss of effective components and can maintain the bioactivity at most. The eye ointment preparation is used in treating keratitis, cornea ulcer and other eye diseases via promoting the restoring and regeneration of tissue.

The invention relates to a pharmaceutical composition with dammarane-type tetracyclic triterpene compound as an active component and an application thereof to the pharmaceutical field. Panax notoginseng is separated to obtain three dammarane-type tetracyclic triterpene compounds as shown in the following structural formula, in vitro pharmacological experiments show that the pharmaceutical composition has good in vitro inhibitory activity for herpes simplex virus type I and can be applied to the preparation of medicines for resisting herpes simplex virus type I and is used for treating herpetic keratitis, encephalitis, pneumonia, ulcerative stomatitis, blister and the like caused by herpes simplex virus type I.

The present invention relates to a method of treating an outer eye disorder selected from a cataract, neovascularization, keratitis, epithelium deficiency, or chronic opacity, by administering to the eye a composition comprising acidic electrolytic water. The present invention also relates to a stable acidic electrolyzed oxidizing water characterized by low conductivity, the presence of dissolved chlorine gas (Cl₂), hypochlorous acid (HOCl) and chloride ions (Cl⁻), and by the presence of negligible quantities of hypochlorite ion (OCl⁻).

The invention discloses a medicament for treating herpes simplex keratitis, which is characterized in that the medicament is mainly prepared by the following raw material herbs by weight: 10-15 parts of radix sophorae flavescentis, 10-15 parts of radix stemonae, 15-20 parts of equisetum, 10-15 parts of isatis roots, 7-10 parts of angelica, 10-15 parts of divaricate saposhnikovia roots, 7-10 parts of common carpesium fruits, 10-15 parts of butterflybush flowers, 5-7 parts of lithospermum, and 15-20 parts of wild chrysanthemum flowers. The medicament for treating herpes simplex keratitis prepared by the invention has less side effect, a low recurrence rate, strong antiviral effect, and significant treatment effect. The invention also provides a preparation method of the medicament.

The invention discloses eye drops containing vitamin E derivatives and a preparation method thereof. The eye drops comprise main components of water soluble vitamin E derivatives, a thickening agent, a pH regulator, an isotonic agent and water for injection. The eye drops are mainly used for treating dry eye syndrome, and active pharmacological components can be added according to the need and are used for adjuvant treatment of cataract, retinopathy, macular degeneration, keratitis, conjunctivitis and other various ocular diseases. The eye drops have good effects of moisturizing and lubricating, have antioxidation function, can inhibit lipid peroxide reactions in eyes, have effects of expanding peripheral blood vessels, improving blood circulation, protecting, and accelerating injuries to heal, and have good curative effects on various ocular diseases.

The invention discloses lomefloxacin hydrochloride eye drops and a preparation method and application thereof. The lomefloxacin accounts for 0.3% of the active components. The preparation also comprises a tackifier, a buffer salt system, a wetting agent, an isoosmotic adjusting agent, a pH adjusting agent and a bacteriostatic agent, and is suitable for treating the external eye infections such asacute and chronic bacterial conjunctivitis, blepharitis, hordeolum, meibomiantis, dacryocystitis, keratitis, keratohelcosis and the like caused by sensitive pathogenic bacteria. The product is characterized in that: by adding the sodium hyaluronate with a tackifying effect and a moisturizing effect, the viscosity of the lomefloxacin hydrochloride eye drops is improved, the fluidics property thereof is changed, the residence time of the eye drops in the eyes is prolonged, the sufficient absorption of the medicine is ensured, the bioavailability is increased, the administration times are reduced, the compliance of a patient is improved, and an effective treatment effect is realized.

The invention relates to an eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin, which comprises the following components in parts by weight: 0.05-10 parts of baicalin, 0.1-3 parts of pH sensitive material, 0.1-10 parts of thickening agent, 0.1-10 parts of isoosmotic adjusting agent, 0.001-3 parts of preservative and 80-100 parts of buffer solution of which the pH is 5-6.2. The invention also relates to a preparation method for the eye-purposed in-vivo gel preparation prepared from the pH sensitive type baicalin, and the application of the eye-purposed in-vivo gel preparation prepared from the pH sensitive type baicalin in preparing drugs capable of preventing and/ or curing conjunctivitis, keratitis or cataract.

A traditional Chinese medicine for curing superficial point-like keratitis which belongs to the traditional Chinese medicines for curing keratitis comprises bupleurum root 9 grams, schizonepeta tenuifolia 9 grams, ledebouriella root 9 grams, flos lonicerae 9 grams, capsule of weeping forsythia 9 grams, scutellaria root 9 grams, paeonia obovata maxim 9 grams, gentian 9 grams, cape jasmine 9 grams, and chastetree fruit 9 grams, isatic root 12 grams and grass cassia 12 grams, coptis 6 grams and liquorice 3 grams. The auxiliary prescription of the invention is that rheum officinale 10 grams are charged for curing the patients with constipation, and the prescription stops when the constipation is over at night. The dosage material in the prescription uses the natural Chinese herbal medicine entirely, and the invention is made by the traditional processing method, the material is easy to obtain, and the dispense prescriptions and the process for preparation are very simple, further the costs of the process for preparing the medicament are low. The compatibility of the Chinese herbal medicine is simple, and all the medicaments used in the medicament prescription are natural herbal medicines, the adopting and the using of the invention are convenient, further the process for preparation is simple. The therapeutic effect of using the medicament is good, and the price of the medicament is low, thereby the invention is applicable for the use of the people who live in remote villages far from towns, and the therapeutic expense of the people with superficial point-like keratitis is low. The problems of the low household income, the poor living standard, and the lack of the local medical treatment condition for curing the illness are solved.

The disclosure describes use of flagellin polypeptides to induce tolerance to gram negative bacteria, such as Pseudomonas aeruginosa, in order to alleviate the effects of the inflammatory response to bacterial infection in a patient. Also described are methods and compositions for treating and preventing keratitis, cystic fibrosis, asthma, and other diseases and conditions in which inflammation contributes to the pathology and symptoms.

The invention discloses a traditional Chinese medicine fuming and washing liquid for treating xerophthalmia. The xerophthalmia belongs to the field of the 'chronic conjunctivitis-keratitis' and 'dryness syndrome' in the traditional Chinese medicine. The eyes can not be moistened and nourished by liver blood and body fluid caused by the malfunction of hepatic and renal functions or the deficiency of liver blood, so that the eye dryness can be caused, and the xerophthalmia can be caused. In order to achieve the aims, the traditional Chinese medicine fuming and washing liquid is prepared by traditional Chinese medicine groundsel, eragrostis poaeoides, indigo naturalis, silverweed cinquefoil root, clinopodium megalanthum, root of common peony, blueberry, cowherb seed, radix polygonati officinalis, glossy privet fruit, semen cuscutae and semen coicis. The clinical test of the hospital shows that the total effective rate of a treatment group reaches 93.0%, and is obviously better than that of a control group, so that the traditional Chinese medicine fuming and washing liquid is worth of being popularized and applied in the clinic.

An NGF-containing pharmaceutical composition used for treating corneal epithelium injuries is disclosed. The composition includes an NGF (preferably a human-derived NGF). The composition (in a form of eye drops preferably) can promote proliferation and clonality capabilities of corneal limbal stem cells, and can effectively promote corneal epithelium injury healing including healing of continuous corneal epithelium injuries, diabetic keratopathy treatment, nervous keratitis treatment and treatment of corneal limbal stem cell deficiency.

Methods for generating a feline model for ocular complications arising from amoeba infection are described. The invention further relates to screening methods for therapeutics for the treatment of ocular complications using the feline model referenced to above.

The invention relates to a traditional Chinese medicine for curing ceratitis which causes red heat pain in an eye, belonging to the traditional Chinese medicine for curing ceratitis, which is composed of 9g ash bark, 9g yellow-corktree bark, 9g cassia seed, 9g coptis root, 9g baikal skullcap root, 9g peach kernel, 7 cape jasmines, and 5 jujubes. The ingredient medicine substances in the medical prescription all use natural Chinese herbal medicine, and the invention is made by the traditional processing method, and has the advantage of easy material-taken, simple ingredient and medicament method, and low medicine-medicament cost. The compatibility of the Chinese herbal medicine is simple, and the medicine in the medicine ingredient all uses natural herb, the fetching and using are convenient, the producing method is simple, the intake effect is excellent, and the price of the medicine is low, and the invention is particularly applicable to the people who live in villages far away from downtown and to the people suffering from ceratitis which causes red heat pain in an eye, and the treating cost is low, which solves the problems that the household income is low, the living standard is poor, and local medical condition is lacked, and imperfect reaction during the treating process of people taking the medicine is not produced.

The invention relates to a gel for lysozyme eye and a preparation method thereof. The gel for the lysozyme eye is applicable of treating various normal eye infection diseases, such as a pinkeye, an ophthalmia, a ceratitis, a keratohelcosis, a conjunctivitis and the like, which is caused by bacteria, Chlamydia, virus and drug-resistance bacteria. The gel for the lysozyme eye disclosed by the invention uses a solution containing 0.1-10.0% of lysozyme, 0.01-20% of water soluble macromolecule matrix, 0.1-10% of a pH modifier, 0.01-10% of a bacteriostat and 0.1-10% of a viscosity modifier and takes a solution with a pH value of 5.0-6.5 as a buffer solution. With the adoption of the receipt of the gel for the lysozyme eye provided by the invention, the time that drug lysozyme remains on an eye can be prolonged, and the bacteriostat efficiency of the lysozyme on the eye can be improved.

The invention aims at providing an application of interleukin-6 to repairing of corneal epithelial injuries, namely, the application of the interleukin-6 to cultivating of ocular-surface corneal epithelial stem cells, treating of persistent corneal epithelial defects, treating of diabetic keratopathy, treating of neuropathic keratitis and treating of limbal-stem-cell deficiency diseases. By means of the application of the IL-6 to repairing of corneal epithelial injuries, the multiplication capacity and the clone formation capacity of corneal limbal stem cells can be promoted, repairing of injuries to corneal epithelium of normal mice can be further promoted, and the corneal limbal stem cells have the higher multiplication capacity and the higher clone formation capacity. The IL-6 can be used for cultivating ocular-surface corneal epithelial stem cells, treating persistent corneal epithelial defects, treating diabetic keratopathy, treating neuropathic keratitis and treating limbal-stem-cell deficiency diseases.

The invention discloses a building method for a mouse herpes simplex keratitis model and application. The method comprises the steps that the corneal epithelium in a circle is scrapped off by using acorneal trephine and an iris repositor, the herpes simplex virus SV-1 is inoculated on one eye of an infected mouse, and the mouse herpes simplex keratitis model is built. The depth and area of the corneal defect prepared by using the trephine method are fixed, the built model is more stable and unified, and large differences brought by the model can be avoided. The operation is precise, the influences caused by man-made operation differences can be avoided, and repetition is easy; the building method is suitable for various research directions and various model animals and easy to popularize;the virus is inoculated on the single eye, so that the association with clinic is closer; the corneal defect is large and the viral load is low, so that the death rate is easily controlled within anappropriate range; the animal model is high in repeatability and stability; the building and assessment method is simple in operation, low in requirements for technologies and devices and high in success rate.

The invention relates to eye drops and particularly relates to eye drops of raw material marine organism. A preparation method of the eye drops of raw material marine organism comprises the following steps: (1) adding distilled water into a clean glass container, weighing a chitosan derivative, chondroitin sulfate, N-acetylglucosamine and sodium chloride and adding into the distilled water, and stirring for dissolution for later use; (2) adding a pH regulator into the obtained solution to adjust the pH to 7.0-7.4; and (3) filtering the solution prepared in the step (2) with a 3mu m filter membrane, and sterilizing the filtrate by moist heat sterilization or flash pasteurization. In the invention, due to the chitosan derivative, the eye drops have the functions of promoting epithelium healing, reducing cicatrization, inhibiting bacteria, relieving pain, stopping bleeding and the like; and moreover, the eye drops have good biocompatibility and can be degraded and absorbed while the degradation product does not cause any toxic or side effects. The eye drops provided by the invention have the advantages of good stability, high safety and high comfort and realize a perfect curative effect on dry eye syndrome, keratitis, cornea trauma and the like.

The invention relates to palmatine ophthalmic gel and a preparation method thereof. The method comprises the following steps: adding water for injection into a matrix and an antioxidant in a formula dosage, mixing, swelling or dissolving; adding a pH regulator for uniformly stirring, thereby obtaining a matrix liquid; weighing palmatine according to the formula dosage, adding the water for injection for dissolving, adding a preservative and an isoosmotic adjusting agent, uniformly mixing, adding the mixture into the matrix liquid, adding the water for injection to 1L, uniformly shaking, filtering by virtue of a micro-aperture filter membrane, sterilizing, and split charging, thereby obtaining the product. The gel comprises the following components: 0.5-30g of palmatine, 0.1-30g of a matrix, 0.1-20g of a pH regulator, 1-100g of an isoosmotic adjusting agent, 0.01-8g of a preservative and 0.02-5g of an antioxidant. Compared with palmatine liquid type eye drops, the product disclosed by the invention has certain advantages in the dosage form, the administration frequency can be reduced, loss of the medicine in the eyes is avoided, and the effect of the medicine for treating conjunctivitis and keratitis can be obviously improved.

The invention discloses loop-mediated isothermal amplification primers and kit for detecting acanthamoeba. The sequences of the primers are represented by SEQ ID No.1, SEQ ID No.2, SEQ ID No.3 and SEQ ID No.4 respectively. The loop-mediated isothermal amplification primers designed according to the sequence of the conserved region of the gene of the acanthamoeba can flexibly, quickly and safely detect acanthamoeba; meanwhile, in the kit disclosed by the invention, false positive caused by nucleic acid pollution in a multiple detection process can be radically eliminated by using uracil-DNA glycosylase (UNG), so the problem of susceptibility to pollution and interference, which limits the wide application of a loop-mediated isothermal amplification technique, is solved. When the kit disclosed by the invention is used, the acanthamoeba causing amebic keratitis can be detected within 3 hours, and instead of expensive instrument and equipment, only a water bath pot or metal bath and a centrifuge are needed in a detection process; the detection result is very easy to determine; and compared with the conventional detection technique, the kit is low in cost, the kit is very safe for operators and the environment for the whole process is free from toxic reagents, and the detection sensitivity of the kit is very high.