Steam eye mask and preparation method thereof

Abstract

The invention discloses a steam eye patch and a preparation method thereof, the steam eye patch comprises an eye patch and a traditional Chinese medicine matrix liquid, the traditional Chinese medicine matrix liquid comprises the following components in parts by mass: 20-50 parts of wild chrysanthemum, 20-50 parts of golden cypress, 10-50 parts of coptis chinensis, 1-5 parts of salvia miltiorrhiza, 1-5 parts of ginseng, 1-5 parts of dendrobe, 0.00001-1 part of natural borneol, 0.00001-1 part of menthol and 0.5-2 parts of xanthan gum. The eye pad prepared by the invention combines the dual effects of physical hot compress and traditional Chinese medicine components, and various experiments prove that the eye pad can relieve meibomian gland atrophy and blockage, relieve conjunctivitis, keratitis and other inflammatory reactions, improve tear secretion and reduce xerophthalmia, and is very suitable for eye care.

Description

Technical Field

[0001] This invention relates to the field of eye patch technology, and in particular to a steam eye patch and its preparation method. Background Technology

[0002] In today's digital age, people's eyes are under unprecedented pressure. The blue light from electronic screens, dry air-conditioned environments, and the high-intensity pace of eye use have made dry, itchy, and tired eyes common symptoms for modern people. After long-term development and scientific verification, the proper use of eye patches can greatly alleviate and prevent various eye diseases, gradually evolving from an auxiliary tool into an important part of scientific eye care solutions.

[0003] In 2019, the company applied for patent number 201910625850.3, entitled "A Composition for Promoting Transdermal Absorption and Its Preparation Method." This composition is prepared by uniformly dispersing and mixing multiple components, including Dendrobium, Chrysanthemum indicum, Chrysanthemum, Lycium barbarum, Mulberry leaf, Codonopsis pilosula, Perilla frutescens seed, Tribulus terrestris, Acorus tatarinowii, Angelica sinensis, Earthworm, Prunella vulgaris, Lonicera japonica, Carthamus tinctorius, Rosa rugosa, Prunella vulgaris, Salvia miltiorrhiza, Phellodendron chinense, Coptis chinensis, Paeonia lactiflora extract, Houttuynia cordata, Green tea extract, Grape seed extract, Alfalfa extract, Iris tectorum extract, Glauber's salt, Pearl powder, Synthetic borneol, Menthol, Camellia japonica seed oil, Flaxseed oil, and Flaxseed extract. After application to rabbits, it was found to significantly increase tear secretion, relieve dry eyes, and reduce the incidence of dry eye syndrome. However, this composition contains many medicinal components, has a complex mechanism of action, and requires a complex production process. Further optimization of the components and application method is needed to achieve the best eye care effect. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a steam eye patch and its preparation method, so as to solve the problems that the existing eye patches contain a lot of traditional Chinese medicine ingredients and the nursing effect needs to be further improved.

[0005] The objective of this invention is achieved through the following technical solution: a steam eye patch, comprising an eye mask and a traditional Chinese medicine base liquid, wherein, by mass parts, the traditional Chinese medicine base liquid comprises 20-50 parts of wild chrysanthemum, 20-50 parts of phellodendron bark, 10-50 parts of coptis root, 1-5 parts of salvia root, 1-5 parts of ginseng, 1-5 parts of dendrobium, 0.00001-1 part of natural borneol, 0.00001-1 part of menthol, and 0.5-2 parts of xanthan gum.

[0006] Preferably, the herbal matrix liquid comprises, by weight, 35 parts of wild chrysanthemum, 30 parts of phellodendron bark, 25 parts of coptis root, 2 parts of salvia root, 4 parts of ginseng, 3 parts of dendrobium, 0.08 parts of natural borneol, 0.12 parts of menthol, and 0.8 parts of xanthan gum.

[0007] Preferably, the eye mask is a steam-heated eye mask.

[0008] Preferably, the goggles are made of fiber cloth with a built-in heating pack, the heating pack comprising iron powder, activated carbon, vermiculite, and resin.

[0009] A method for preparing a steam eye patch, comprising the following steps: S1. Prepare a heat compress mask by spraying glue and punching a heat pack with various fiber cloths to make an eye mask; S2. Prepare the Chinese herbal extract by weighing wild chrysanthemum, phellodendron bark, coptis rhizome, salvia miltiorrhiza, ginseng, and dendrobium according to the mass fraction ratio. Extract the Chinese herbal extract by decoction, filter, concentrate under vacuum, separate in a tubular tube, and refrigerate to obtain the Chinese herbal extract. S3. Mix the Chinese herbal extract with natural borneol, menthol, and xanthan gum evenly to prepare a Chinese herbal matrix solution; S4. After filling the traditional Chinese medicine matrix liquid, package and seal it together with the goggles.

[0010] Preferably, in step S2, the Chinese medicinal materials are decocted and extracted at 100℃ with 10-15 times their volume of water for 3-5 hours, then filtered. A double-effect vacuum concentration process is used, with the heating temperature controlled at 70℃~80℃ and the vacuum degree controlled at -0.04MPa~-0.06MPa. The decocting yields a mixed extract of 1.0~2.0, which is then separated in a tubular system at 5±0.5kg / min to obtain the Chinese medicinal material extract. The present invention has the following advantages: 1. The steam eye patch prepared by this invention combines the dual effects of physical heat application and traditional Chinese medicine ingredients. It can inhibit eye bacteria, promote blood circulation, relieve fatigue, slow down the atrophy and blockage of meibomian glands, relieve inflammatory reactions such as conjunctivitis and keratitis, increase tear secretion, and reduce dry eye syndrome. It is very suitable for eye care. 2. The steam eye patch prepared by this invention is an optimized selection of multiple existing Chinese medicine components, reducing the number of Chinese medicine components while achieving the same eye care effect as multi-component patches. At the same time, in order to further improve the effect, the penetration-enhancing components and their proportions, as well as the physical application method, are adapted and adjusted. After various experimental verifications, the combination of hot compress and eye patch is significantly better than the combination of cold compress and eye patch or the use of eye patch alone, achieving the best therapeutic and preventive effect of Chinese medicine eye patch. Attached Figure Description

[0011] Figure 1 This is a comparison image of PAS staining of the entire eyeball according to the present invention; Figure 2 This is a comparison image of whole-eye HE staining according to the present invention; Figure 3 This is a comparison image of HE staining of the entire meibomian glands according to the present invention; Figure 4 This is a comparative image of meibomian gland oil red staining according to the present invention; Figure 5 This is a comparison diagram of meibomian gland PCR of the present invention; Figure 6 This is a comparison diagram of PCR for corneal and conjunctival keratology according to the present invention; Figure 7 This is a comparison image of meibomian gland WB in this invention. Detailed Implementation

[0012] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0013] A method for preparing a steam eye patch, comprising the following steps: S1. Prepare the eye mask by spraying glue and punching the heating pack with printed fabric, skin-friendly fabric, elastic fabric and other fiber fabrics to make the eye mask. The heating pack can be made of materials such as iron powder, activated carbon, vermiculite, salts, resin, etc. S2. Preparation of Chinese herbal extract: Weigh wild chrysanthemum, phellodendron bark, coptis rhizome, salvia miltiorrhiza, ginseng, and dendrobium according to the mass ratio. Add 10-15 times the amount of water to the Chinese herbal extract and extract at 100℃ for 3-5 hours. Filter the mixture and use a double-effect vacuum concentration process. Control the heating temperature at 70℃~80℃ and the vacuum degree at -0.04MPa~-0.06MPa. The mixture yields a mixed extract of 1.0-2.0. Then, separate the extract using a tube at 5±0.5kg / min to obtain the Chinese herbal extract. S3. Mix the Chinese herbal extract with natural borneol, menthol, and xanthan gum evenly to prepare a Chinese herbal matrix solution; S4. The traditional Chinese medicine matrix solution is filled into bags, each containing 15.0g ± 0.5g, sealed, irradiated with 8KGy, and finally packaged and sealed together with the goggles.

[0014] Example 1 The steam eye patch prepared according to the above method contains 50 parts of wild chrysanthemum, 20 parts of phellodendron bark, 10 parts of coptis root, 5 parts of salvia root, 5 parts of ginseng, 5 parts of dendrobium, 0.00001 parts of natural borneol, 1 part of menthol, and 0.5 parts of xanthan gum.

[0015] Example 2 The difference from Example 1 is that it contains 40 parts wild chrysanthemum, 30 parts phellodendron bark, 20 parts coptis rhizome, 3 parts salvia miltiorrhiza, 4 parts ginseng, 3 parts dendrobium, 0.5 parts natural borneol, 0.5 parts menthol, and 1 part xanthan gum.

[0016] Example 3 The difference from Example 1 is that the ingredients are: 30 parts wild chrysanthemum, 30 parts phellodendron bark, 25 parts coptis rhizome, 2 parts salvia miltiorrhiza, 4 parts ginseng, 3 parts dendrobium, 1 part natural borneol, 0.00001 parts menthol, and 1.5 parts xanthan gum.

[0017] Example 4 The difference from Example 1 is that the ingredients are 20 parts wild chrysanthemum, 40 parts phellodendron bark, 40 parts coptis root, 1 part salvia root, 3 parts ginseng, 2 parts dendrobium, 0.05 parts natural borneol, 0.05 parts menthol, and 2 parts xanthan gum.

[0018] Example 5 The difference from Example 1 is that the ingredients are 20 parts wild chrysanthemum, 50 parts phellodendron bark, 50 parts coptis root, 1 part salvia miltiorrhiza, 2 parts ginseng, 1 part dendrobium, 0.05 parts natural borneol, 0.05 parts menthol, and 2 parts xanthan gum.

[0019] Example 6 The difference from Example 1 is that the ingredients are: 35 parts wild chrysanthemum, 30 parts phellodendron bark, 25 parts coptis rhizome, 2 parts salvia miltiorrhiza, 4 parts ginseng, 3 parts dendrobium, 0.08 parts natural borneol, 0.12 parts menthol, and 0.8 parts xanthan gum.

[0020] Example 7 The difference from Example 1 is that the ingredients are: 35 parts wild chrysanthemum, 30 parts phellodendron bark, 25 parts coptis rhizome, 2 parts salvia miltiorrhiza, 3 parts ginseng, 3 parts dendrobium, 0.08 parts natural borneol, 0.12 parts menthol, and 0.8 parts xanthan gum.

[0021] Comparative Example 1 The preparation of traditional Chinese medicine matrix liquid was carried out using the company's authorized patent number CN110251614B, entitled "Composition for Promoting Transdermal Absorption and its Preparation Method".

[0022] Comparative Example 2 The difference from Example 1 is that it contains 50 parts wild chrysanthemum, 50 parts phellodendron bark, 40 parts coptis root, 35 parts salvia root, 15 parts dendrobium, 10 parts menthol, and 5 parts xanthan gum.

[0023] A dry eye model was established using mice. The modeling method was as follows: Except for the control group, 5 μL of 0.2% benzalkonium chloride solution was instilled into both eyes of each mouse twice daily for two weeks. The Schirmer test was performed on day 14 of the intervention. Mice were immobilized without anesthesia, and a phenol red-soaked cotton thread was placed in the lower fornix of the eye at approximately one-third of the distance from the outer canthus using fine forceps for 30 seconds. Tear volume was measured under a microscope and expressed as the length of the tear-absorbing color-changing line, in mm. The results are as follows. Group Number of examples Tear secretion (mm) Blank group 10 6.5±0.37 Model group 10 3.2±0.43 Example 1 10 7.6±0.35 Example 2 10 7.7±0.34 Example 3 10 7.6±0.41 Example 4 10 7.6±0.38 Example 5 10 7.5±0.35 Example 6 10 7.8±0.38 Example 7 10 7.7±0.41 Comparative Example 1 10 7.4±0.34 Comparative Example 2 10 7.4±0.42 Based on the above results, it can be seen that by optimizing the components and increasing their content, the same effect as multi-component traditional Chinese medicine matrix liquid can be achieved. By further optimizing the components and adjusting the ratio on the basis of reducing the number of components, a more effective therapeutic effect than multi-component traditional Chinese medicine matrix liquid can be achieved. Among them, the components and ratio of Example 6 are the best.

[0024] In Example 6, the optimal application methods of hot compress, cold compress, and eye patches combined with the herbal matrix solution were explored under the herbal component ratio. Except for the normal group, mice were exposed to blue light with a wavelength of 460 nm and an intensity of 2000 lux for 6 hours a day for 15 consecutive days to establish a mouse model of meibomian gland function changes. After the 15-day blue light exposure ended, the corresponding eye patches were applied for 25 minutes each morning and afternoon for 15 consecutive days. On the 15th day, the meibomian gland openings were photographed to observe the ocular surface and meibomian gland function of the mice, and the degree of corneal epithelial loss was detected by sodium fluorescein staining. After 15 days of treatment as required by the experiment, mice in each group were euthanized by cervical dislocation. The degree of meibomian gland loss was observed by photographing the meibomian glands. Oil red staining was used to observe lipid deposition in the meibomian glands. Periodic acid-Schiff (PAS) staining was used to detect the number of goblet cells in mice. Hematoxylin and eosin (H&E) staining was used to observe histological changes in the meibomian glands. Western blotting (WB) and real-time quantitative PCR were used to detect the degree of inflammation in the meibomian glands. The specific experimental groups and drug administration methods are as follows.

[0025] Group Blu-ray modeling time Method of medication normal group Avoid blue light exposure none Blue light irradiation group From the start of modeling, the model was exposed to blue light (460nm) for 6 hours a day at an intensity of 2000lx. none PBS eye patch set PBS eye patches twice daily Eye patch set Eye patches twice a day Cold compress set Apply cold compresses twice daily Hot compress set Apply heat twice a day Cooling eye patch set Use eye patches and cold compresses twice daily. Steam eye patch set Use eye patches twice daily in conjunction with warm compresses The results of the test are as follows Figures 1-7 As shown.

[0026] like Figure 1 As shown in the comparison of PAS staining of the whole eyeball, in the prevention experiment, both cold compresses and hot compresses combined with eye patches had a significant effect on improving the number of goblet cells, and were significantly better than cold compresses and hot compresses alone at the same time. Furthermore, it was found that hot compresses + eye patches were more effective than cold compresses + eye patches in the prevention experiment.

[0027] like Figure 2 The comparison images of whole-eye HE staining show that in the normal group, the meibomian glands were intact, with clear structure, tightly arranged cells, and no inflammatory cell infiltration between glands. In the blue light group and PBS group, the meibomian glands were disordered, with abnormal morphology, unclear boundaries, excessive mesenchymal cells, and inflammatory cell infiltration between glands. In the prevention experiment, the meibomian glands were basically intact and regularly shaped when treated with warm compresses and eye patches. Tissue hyperplasia and inflammatory cell infiltration were reduced compared to those treated with cold compresses and eye patches, cold compresses and warm compresses alone, and eye patches alone at the same time point.

[0028] like Figure 3 The HE staining comparison images of the entire meibomian glands shown indicate that in the normal group, the meibomian glands were intact, with clear structure, tightly arranged cells, and no inflammatory cell infiltration between glands. In the blue light and PBS groups, the meibomian glands were disordered, with abnormal morphology, unclear boundaries, excessive mesenchymal cells, and inflammatory cell infiltration between glands. In the prevention experiment, the meibomian glands were basically intact and regularly shaped when treated with warm compresses and eye patches. Tissue hyperplasia and inflammatory cell infiltration were reduced compared to those treated with cold compresses and eye patches, cold compresses and warm compresses alone, and eye patches alone at the same time point.

[0029] like Figure 4 The comparison images of meibomian gland oil red staining show that the meibomian glands in the normal group were intact. In the blue light group and the PBS group, after blue light irradiation, the meibomian glands of mice showed significant atrophy, and the lipid accumulation within the meibomian glands decreased. In the prevention experiment, the meibomian gland structure remained largely intact after hot compresses and eye patch administration. Preventive treatment effectively delayed meibomian gland atrophy, resulting in a more uniform lipid distribution within the meibomian glands, demonstrating better preventive effects compared to other treatments at the same time point.

[0030] like Figure 5 The image shows a comparison of meibomian gland PCR results and... Figure 6 The PCR comparison images of cornea and conjunctiva shown indicate that blue light irradiation significantly increases inflammation in the meibomian glands, cornea, and conjunctiva of mice. In the experiment, the combination of eye patch treatment with cold and hot compresses significantly reduced inflammatory factors in the ocular tissues, and these effects were superior to those of eye patches, cold compresses, or hot compresses alone, indicating that combined cold and hot compress treatment can reduce inflammation. Among these, the hot compress + eye patch group showed a more significant effect compared to other treatments at the same time point.

[0031] like Figure 7 The WB comparison images of meibomian glands shown indicate that the expression of inflammatory factors IKKα, IL-6, and IL-13 proteins was increased in the meibomian gland tissue irradiated with blue light, while their expression was reduced in the treatment group, indicating that the inflammation of the meibomian gland tissue was reduced after treatment. The expression of MUC1 in the meibomian gland tissue irradiated with blue light was significantly reduced, indicating that blue light irradiation caused a decrease in ocular surface mucin secretion. The increased expression of MUC1 in the tissue after treatment in the treatment group indicates that the secretion of ocular surface mucin can be restored after treatment.

[0032] In summary, the experimental results show that among the six treatment methods (PBS, eye patch, cold compress, cold compress + eye patch, hot compress, and hot compress + eye patch), the combined hot compress + eye patch treatment showed the most significant therapeutic effect. The results indicate that this eye patch is effective in preventing and treating blue light damage to the meibomian glands, and in improving MGD symptoms. It can slow down meibomian gland atrophy and blockage, and the experimental indicators also show that it reduces the risk of inflammation.

[0033] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A steam eye patch, characterized in that: The product includes an eye mask and a traditional Chinese medicine base liquid. By weight, the traditional Chinese medicine base liquid is composed of the following ingredients: 20-50 parts of wild chrysanthemum, 20-50 parts of phellodendron bark, 10-50 parts of coptis root, 1-5 parts of salvia root, 1-5 parts of ginseng, 1-5 parts of dendrobium, 0.00001-1 part of natural borneol, 0.00001-1 part of menthol, and 0.5-2 parts of xanthan gum.

2. The steam eye patch according to claim 1, characterized in that: The herbal matrix liquid, by weight, is composed of the following components: 35 parts wild chrysanthemum, 30 parts phellodendron bark, 25 parts coptis root, 2 parts salvia root, 4 parts ginseng, 3 parts dendrobium, 0.08 parts natural borneol, 0.12 parts menthol, and 0.8 parts xanthan gum.

3. The steam eye patch according to claim 1, characterized in that: The eye mask is a steam-heated eye mask.

4. A steam eye patch according to claim 3, characterized in that: The goggles are made of fiber cloth with a built-in heating pack, which includes iron powder, activated carbon, vermiculite, and resin.

5. A method for preparing a steam eye patch according to any one of claims 1-4, characterized in that: Prepare according to the following steps. S1. Prepare a heat compress mask by spraying glue and punching a heat pack with various fiber cloths to make an eye mask; S2. Prepare the Chinese herbal extract by weighing wild chrysanthemum, phellodendron bark, coptis rhizome, salvia miltiorrhiza, ginseng, and dendrobium according to the mass fraction ratio. Extract the Chinese herbal extract by decoction, filter, concentrate under vacuum, separate in a tubular tube, and refrigerate to obtain the Chinese herbal extract. S3. Mix the Chinese herbal extract with natural borneol, menthol, and xanthan gum evenly to prepare a Chinese herbal matrix solution; S4. After filling the traditional Chinese medicine matrix liquid, package and seal it together with the goggles.

6. The method for preparing a steam eye patch according to claim 5, characterized in that: In step S2, the Chinese medicinal materials are decocted and extracted with 10-15 times the amount of water at a controlled temperature of 100°C for 3-5 hours, then filtered. A double-effect vacuum concentration process is used, with the heating temperature controlled at 70°C to 80°C and the vacuum degree controlled at -0.04MPa to -0.06MPa. The decocted mixture yields a mixed extract of 1.0 to 2.0, which is then separated in a tubular process at 5±0.5kg / min to obtain the Chinese medicinal material extract.

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