PH response contact lens and preparation mold thereof

Abstract

The present invention discloses a pH response contact lens and a preparation mold thereof, and relates to the technical field of contact lens preparation, the pH response contact lens comprises a drug storage layer lens and a covering layer lens, the covering layer lens covers the drug storage layer lens and is located on the inner side of the drug storage layer lens, the covering layer lens is automatically dissolved or degraded when the pH value of tear is higher than a specific threshold value, and at the moment, liquid medicine stored in the medicine storage layer lens flows out. Through mutual cooperation of the medicine storage layer lenses and the covering layer lenses, the covering layer lenses are automatically dissolved when the eyes of a human body are inflamed and the pH value is higher than a normal range, liquid medicine stored in the medicine storage layer lenses automatically flows out, and the precise treatment function of keratitis is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of contact lens preparation, in particular to a pH-responsive contact lens and a preparation mold thereof. Background Art

[0002] The normal pH range of human tears is pH 6.4-7.7. The pH value of tears of patients with dry keratitis, corneal damage and vernal conjunctivitis is higher than this range. Contact lenses are a type of refractive lens used to correct vision. They are evolving from simple vision correction tools to multifunctional devices covering health monitoring, AR interaction, medical treatment and other fields. Therefore, how to use the pH value of human tears to design a pH-responsive contact lens that automatically releases drugs when the human eye is inflamed and the pH value is higher than the normal range to achieve precise treatment of keratitis has become a difficult problem that needs to be solved urgently by those skilled in the art. Summary of the Invention

[0003] The purpose of the present invention is to provide a pH-responsive contact lens and a preparation mold thereof, so as to solve the problem that existing contact lenses do not have the function of accurately treating keratitis.

[0004] A pH-responsive contact lens comprises a drug reservoir lens and a cover layer lens. The cover layer lens covers the drug reservoir lens and is located on the inner side of the drug reservoir lens. The cover layer lens automatically dissolves or degrades when the pH value of tear fluid exceeds a specific threshold, at which time the drug solution stored in the drug reservoir lens flows out.

[0005] Optionally, a drug storage ring and a drug storage groove are provided on the drug storage layer lens, the drug storage ring is located in the non-optical area of ​​the contact lens, one end of the drug storage groove is connected to the drug storage ring, and the other end extends outward along the radial direction of the contact lens, and there are multiple drug storage grooves and they are evenly distributed along the circumference of the drug storage ring.

[0006] Optionally, the cover layer lens covers the drug storage ring and the drug storage groove and forms a drug storage chamber together with the drug storage layer lens.

[0007] Optionally, the drug storage layer lens is made of silicone hydrogel material.

[0008] Optionally, the cover layer lens is made of any one or more of polymethacrylic acid, polyacrylic acid, chitosan, dynamic covalent bond hydrogel, and ion cross-linked gel.

[0009] A mold for preparing the pH-responsive contact lens comprises a lower mold, a first upper mold and a second upper mold, wherein the lower mold is provided with an inner arc surface having an optical function, the outer arc surface of the first upper mold is provided with a raised circular ring and a strip block, the strip block is connected to the circular ring, a plurality of the strip blocks are provided and are evenly distributed along the circumference of the circular ring, and the outer arc surface of the second upper mold matches the inner arc surface of the lower mold.

[0010] Optionally, a limiting groove is provided on the side wall of the lower mold, a first limiting ring is provided on the side wall of the first upper mold, the first limiting ring is clamped in the limiting groove, and the lower mold and the first upper mold are used together to prepare the drug storage layer lens; a second limiting ring is provided on the side wall of the second upper mold, the second limiting ring is clamped in the limiting groove, and the lower mold and the second upper mold are used together to prepare the covering layer lens.

[0011] Compared with the prior art, the present invention has the following beneficial technical effects:

[0012] The present invention achieves precise treatment of keratitis by cooperating between the drug storage layer lens and the cover layer lens. When the human eye is inflamed and the pH value is higher than the normal range, the cover layer lens automatically dissolves and the drug solution stored in the drug storage layer lens automatically flows out. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The present invention will be further described below with reference to the accompanying drawings.

[0014] Figure 1 This is an exploded view of the pH-responsive contact lens of the present invention;

[0015] Figure 2 This is a cross-sectional view of the lower mold of the present invention;

[0016] Figure 3 This is a cross-sectional view of the first upper mold of the present invention;

[0017] Figure 4 This is a cross-sectional view of the second upper mold of the present invention.

[0018] Explanation of the accompanying symbols: 1. Drug storage layer lens; 2. Covering layer lens; 11. Drug storage ring; 12. Drug storage tank; 3. Lower mold; 4. First upper mold; 5. Second upper mold; 31. Limiting groove; 41. Circular ring; 42. Bar block; 43. First limiting ring; 51. Second limiting ring. DETAILED DESCRIPTION

[0019] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0020] like Figure 1 As shown, this embodiment provides a pH-responsive contact lens, comprising a drug reservoir lens 1 and a cover layer lens 2, wherein the cover layer lens 2 covers the drug reservoir lens 1 and is located on the inner side of the drug reservoir lens 1. The cover layer lens 2 automatically dissolves or degrades when the pH value of the tear fluid is higher than a specific threshold value, at which time the drug solution stored in the drug reservoir lens 1 flows out.

[0021] The medicinal solution includes any one or more of natamycin eye drops, pranoprofen eye drops, levofloxacin eye drops, bromfenac sodium eye drops, tobramycin eye drops, olopatadine hydrochloride eye drops, and ofloxacin eye drops.

[0022] Wherein, the specific threshold is preferably pH 7.7.

[0023] Specifically, a drug storage ring 11 and a drug storage groove 12 are provided on the drug storage layer lens 1. The drug storage ring 11 is located in the non-optical area of ​​the contact lens. One end of the drug storage groove 12 is connected to the drug storage ring 11, and the other end extends outward along the radial direction of the contact lens. There are multiple drug storage grooves 12 and they are evenly distributed along the circumference of the drug storage ring 11.

[0024] When tears appear, they first appear at the periphery of the eye rather than the center. At this time, the cover layer lens 2 outside the drug storage tank 12 is dissolved first, and the drug liquid first flows out of the drug storage tank 12, which facilitates the slow outflow of the drug liquid and improves the treatment effect.

[0025] Specifically, the cover layer lens 2 covers the drug storage ring 11 and the drug storage groove 12 and forms a drug storage chamber together with the drug storage layer lens 1 .

[0026] Specifically, the drug storage layer lens 1 is made of silicone hydrogel material.

[0027] Specifically, the cover layer lens 2 is made of any one or more of polymethacrylic acid, polyacrylic acid, chitosan, dynamic covalent bond hydrogel, and ion cross-linked gel.

[0028] like Figure 2-4As shown, this embodiment provides a mold for preparing the pH-responsive contact lens, comprising a lower mold 3, a first upper mold 4 and a second upper mold 5. The lower mold 3 is provided with an inner arc surface with optical function, and the outer arc surface of the first upper mold 4 is provided with a raised ring 41 and a strip block 42. The strip block 42 is connected to the ring 41. There are multiple strip blocks 42 and they are evenly distributed along the circumference of the ring 41. The outer arc surface of the second upper mold 5 matches the inner arc surface of the lower mold 3.

[0029] Specifically, a limiting groove 31 is provided on the side wall of the lower mold 3, and a first limiting ring 43 is provided on the side wall of the first upper mold 4, and the first limiting ring 43 is clamped in the limiting groove 31. The lower mold 3 and the first upper mold 4 are used together to prepare the drug storage layer lens 1; a second limiting ring 51 is provided on the side wall of the second upper mold 5, and the second limiting ring 51 is clamped in the limiting groove 31. The lower mold 3 and the second upper mold 5 are used together to prepare the covering layer lens 2.

[0030] The working process of the present invention is as follows:

[0031] In the first step, the contact lens manufacturing material is injected into the lower mold 3, the first upper mold 4 is clamped on the lower mold 3 and is light-cured by light-curing equipment to obtain the drug storage layer lens 1.

[0032] In the second step, the first upper mold 4 is removed, and the drug storage ring 11 and the drug storage groove 12 of the drug storage layer lens 1 are injected with liquid medicine. Then, the contact lens making material is injected into the lower mold 3, and the second upper mold 5 is clamped on the lower mold 3. The contact lens is cured by light curing equipment to obtain a contact lens with the cover layer lens 2 and the drug storage layer lens 1 combined together.

[0033] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0034] The embodiments described above are merely descriptions of preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Without departing from the spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by persons skilled in the art should fall within the scope of protection defined by the claims of the present invention.

Claims

1. A pH-responsive contact lens, characterized in that: The invention comprises a drug storage layer lens (1) and a cover layer lens (2), wherein the cover layer lens (2) covers the drug storage layer lens (1) and is located inside the drug storage layer lens (1), and the cover layer lens (2) automatically dissolves or degrades when the pH value of tear fluid is higher than a specific threshold value, at which time the drug solution stored in the drug storage layer lens (1) flows out.

2. The pH-responsive contact lens according to claim 1, wherein: The drug storage layer lens (1) is provided with a drug storage ring (11) and a drug storage groove (12); the drug storage ring (11) is located in the non-optical area of ​​the contact lens; one end of the drug storage groove (12) is connected to the drug storage ring (11), and the other end extends outward along the radial direction of the contact lens; a plurality of drug storage grooves (12) are provided and are evenly distributed along the circumference of the drug storage ring (11).

3. The pH-responsive contact lens according to claim 2, wherein: The covering layer lens (2) covers the drug storage ring (11) and the drug storage groove (12) and forms a drug storage chamber together with the drug storage layer lens (1).

4. The pH-responsive contact lens according to claim 1, wherein: The drug storage layer lens (1) is made of silicone hydrogel material.

5. The pH-responsive contact lens according to claim 1, wherein: The cover layer lens (2) is made of any one or more of polymethacrylic acid, polyacrylic acid, chitosan, dynamic covalent bond hydrogel, and ion cross-linked gel.

6. A mold for preparing the pH-responsive contact lens according to any one of claims 1 to 5, characterized in that: The invention comprises a lower mold (3), a first upper mold (4) and a second upper mold (5); the lower mold (3) is provided with an inner arc surface having an optical function; the outer arc surface of the first upper mold (4) is provided with a raised circular ring (41) and a strip block (42); the strip block (42) is connected to the circular ring (41); a plurality of the strip blocks (42) are provided and are evenly distributed along the circumference of the circular ring (41); the outer arc surface of the second upper mold (5) matches the inner arc surface of the lower mold (3).

7. The mold for preparing the pH-responsive contact lens according to claim 6, wherein: A limiting groove (31) is provided on the side circumferential wall of the lower mold (3); a first limiting ring (43) is provided on the side circumferential wall of the first upper mold (4); the first limiting ring (43) is engaged in the limiting groove (31); the lower mold (3) and the first upper mold (4) are used together to prepare the drug storage layer lens (1); a second limiting ring (51) is provided on the side circumferential wall of the second upper mold (5); the second limiting ring (51) is engaged in the limiting groove (31); the lower mold (3) and the second upper mold (5) are used together to prepare the cover layer lens (2).

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