Polyhexamethylene biguanide based formulations for the treatment of acanthamoeba keratitis and fungal infections

By using polyhexamethylene biguanide (PHMB) formulations with specific concentrations and molecular weights, combined with buffers and isotonic agents, the long-term and drug-resistance issues in the treatment of Acanthamoeba keratitis have been resolved, achieving rapid and safe treatment results.

CN115151265BActive Publication Date: 2026-03-17S I F I SPA
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Patent Information

Application Number
CN202180017024.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2020-11-12
Filing Date
2021-11-11
Publication Date
2026-03-17
Estimated Expiration
2041-11-11

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Abstract

The present invention relates to a stable formulation based on polyhexamethylene biguanide (PHMB) suitable for ocular level administration, a process for its preparation and a relative dosage regimen effective in the treatment of Acanthamoeba keratitis and in particular in the eradication of cysts.
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Citation Information

Patent Citations

  • Compositions with enhanced antimicrobial efficacy against acanthamoebae

    EP1852133A2

  • Ph stable biguanide composition and method of treatment and prevention of infections

    US20070140897A1