A method of recombinantly generating a subproduct based on constituent composition

Abstract

The application discloses a method for recombining sub-products based on ingredient composition, which comprises the following steps: separating a homogeneous mixture into a plurality of homogeneous intermediate products with different ingredients by a physical separation method; and selecting at least two homogeneous intermediate products to be uniformly mixed according to a set ratio by using a digital blending technology, so as to obtain a required sub-product. By using the method, a single product can be converted into a plurality of sub-products with different characteristics from the initial product without interfering with the existing production process of the product. The process is simple, the process is controllable, and the method is suitable for large-scale production and has a wide application prospect.

Description

[0001] This invention claims priority to Chinese Patent Application No. 202210388906.X, filed on April 13, 2022, entitled "A Product Homogenization Method Based on Component Analysis". Technical Field

[0002] This invention relates to a method for recombination of components in a homogeneous mixture, and more specifically to a method for generating sub-products based on component recombination. Background Technology

[0003] For homogeneous products such as alcoholic beverages, flavorings, perfumes, and traditional Chinese medicine extracts, the production process is simple, with each raw material producing only one primary product at a time. These primary products are then used as raw materials to be sold directly as the final product (e.g., traditional Chinese medicine extracts), or mixed with other primary products to obtain the final product (e.g., blending multiple base liquors). Generally, a primary product, because its composition is fixed, cannot yield multiple sub-products based solely on itself. These primary products need to be recombine with similar products that have the same types of components but different concentrations to obtain various final products (e.g., blending finished wines using various base liquors from Maotai Town).

[0004] In chemical production, distillation is used to obtain various byproducts (aviation kerosene, gasoline, diesel, etc.) from crude oil. The components of these byproducts differ from the original product; they are only a portion of the original, not all of its components. However, if distillation were used to obtain various products from alcoholic beverages, these products would no longer be baijiu (Chinese white liquor). Based on current technology, it is not possible to obtain different flavors of liquor from a single type. Currently, in the baijiu industry, the blending method based on various base spirits is the culmination of centuries and generations of experience, but it still carries significant uncertainty, and even blenders require decades of experience to accumulate. Currently, blenders are completely incapable of physically separating primary products (such as Maotai-style liquor) and then blending their intermediate products; just as a blender specializing in sauce-aroma baijiu cannot blend strong-aroma baijiu. Similarly, for products such as flavorings, perfumes, and traditional Chinese medicine extracts, it is difficult to physically transform a single product into other byproducts with different characteristics. Summary of the Invention

[0005] The main objective of this invention is to provide a method for generating sub-products based on component composition recombination, so as to overcome the shortcomings of the prior art.

[0006] To achieve the aforementioned objectives, the present invention employs the following technical solution:

[0007] Some embodiments of the present invention provide a method for generating sub-products based on component composition recombination, including:

[0008] A homogeneous mixture is separated into multiple homogeneous intermediate products with different components by physical separation methods;

[0009] Using digital blending technology, at least two homogeneous intermediate products are selected and mixed uniformly in a set ratio to obtain the desired sub-product.

[0010] The digital blending technology described in this invention refers to: establishing a component database of multiple homogeneous intermediate products by performing full component analysis on multiple homogeneous intermediate products, and using an optimization algorithm to select two or more suitable homogeneous intermediate products and calculate their usage ratio based on the component database and the component information of the target product, and then blending these selected homogeneous intermediate products in proportion to obtain the desired sub-product.

[0011] In one embodiment, the homogeneous mixture of all homogeneous intermediate products is the homogeneous mixture; and, at least one of the homogeneous intermediate products contains fewer types of components than the homogeneous mixture contains, and / or, the concentration of a selected component in at least one of the homogeneous intermediate products is different from the concentration of a selected component in the homogeneous mixture.

[0012] In other words, the components of each homogeneous intermediate product are a part of the components of the initial homogeneous mixture, but their composition and / or concentration are different from those of the initial homogeneous mixture, without producing new components.

[0013] Furthermore, one target sub-product may have the same or similar composition as the initial homogeneous mixture, but the concentrations of one or more components may vary from the initial homogeneous mixture. Alternatively, another target sub-product may differ from the initial homogeneous mixture in both composition and the concentration of at least one component.

[0014] In one embodiment, the method specifically includes: separating the homogeneous mixture by a physical separation method and then collecting it by a physical collection method to obtain a variety of homogeneous intermediate products.

[0015] In one embodiment, the physical method includes any one or more combinations of evaporation, extraction, membrane separation, distillation and rectification, capillary electrophoresis, and preparative chromatography, and is not limited thereto.

[0016] In one embodiment, the physical collection method includes any one or more combinations of reflux, elution, condensation, and concentration, and is not limited thereto.

[0017] Furthermore, in this invention, when the homogeneous mixture is physically separated using the physical separation method, precise qualitative / quantitative analysis is not required. It is sufficient that the collected homogeneous intermediate product differs from the initial homogeneous mixture in composition and concentration. For example, the physical collection method of the homogeneous intermediate product can be set according to parameters such as rough temperature changes and collection volume.

[0018] In one embodiment, the method specifically includes:

[0019] Full component analysis was performed on each of the aforementioned homogeneous intermediate products to establish a component database for the various homogeneous intermediate products.

[0020] Determine the component information of the target product;

[0021] Based on the component information of the target product and the component database, at least two homogeneous intermediate products are selected, and the mixing ratio of the selected at least two homogeneous intermediate products is calculated, i.e., the set ratio.

[0022] The selected at least two homogeneous intermediate products are uniformly mixed according to the set ratio to obtain the desired sub-product.

[0023] The aforementioned process involves establishing the component database, selecting two or more homogeneous intermediate products based on the component information of the target product and the component database, determining their mixing ratio, and then mixing the selected two or more homogeneous intermediate products according to the mixing ratio to obtain the desired sub-product, i.e., the sub-product corresponding to the target product. This process of implementing the aforementioned digital blending technology can also be referred to in the inventor's prior Chinese patent applications (patent application number CN202210388906.X, patent application date April 13, 2022; patent application number CN202210412906.9, patent application date April 19, 2022).

[0024] In one embodiment, the method specifically includes: determining the component information of the target product by at least performing a full component analysis on the target product, modifying one or more components of the specified product, or creating a virtual product.

[0025] In one embodiment, the full component analysis is performed using chromatographic separation technology in conjunction with a matching detection instrument, which includes any one or more combinations of mass spectrometry, infrared spectroscopy, ultraviolet spectroscopy, fluorescence spectroscopy, spectrophotometry, and nuclear magnetic resonance detector, and is not limited thereto.

[0026] Furthermore, in this invention, a full component analysis is performed on each homogeneous intermediate product. Various chromatographic separation techniques and detection instruments can be used to analyze the product and obtain a chromatogram. Then, based on the chromatogram data, hundreds of chemical components are identified and recorded using common methods and full component analysis techniques (e.g., methods in ZL201710676249.8 and ZL2018106162309.9). The detection instruments used include, but are not limited to, one or a combination of mass spectrometry, infrared spectroscopy, ultraviolet spectroscopy, PDA, fluorescence spectroscopy, spectrophotometry, and nuclear magnetic resonance detectors. Alternatively, separation can be achieved through chromatographic separation techniques, including but not limited to one or a combination of gas chromatography (strongly polar columns, weakly polar columns, moderately polar columns, non-polar columns, etc.), liquid chromatography (normal phase columns, reversed phase columns, ion exchange columns, etc.), and electrochromatography.

[0027] Furthermore, for full component analysis, in practical use, each component peak in each homogeneous intermediate product with a signal-to-noise ratio of 1.8 or higher in the spectral information needs to be analyzed to obtain the component and concentration information corresponding to that component peak. The co-eluting components also need to be separated by an algorithm and then qualitatively and / or quantitatively analyzed.

[0028] All the above-mentioned components are collected in a component database. The component database information includes not only the component and concentration information of each homogeneous intermediate product, but also its processing information. Specifically: 1) Component information is the chemical structure information of the component, or the spectral information of the component, or artificially specified information, or a mixture of all three; 2) Component concentration can be the absolute or relative concentration information of a component, or a mixture of both. Quantitative methods include, but are not limited to, the following: interpolation method, external standard method, internal standard method, area normalization method, area percentage method, a characteristic wavelength in the spectrum, or a characteristic m / z peak in mass spectrometry, etc. Furthermore, the full component analysis method used in this invention can be selected from, but is not limited to, one or a combination of several of the following: semi-quantitative analysis and full component analysis techniques (e.g., the methods in ZL201710676249.8 and ZL2018106162309.9).

[0029] In this invention, the component database may contain component information and concentration information of multiple homogeneous intermediate products. The component information includes, but is not limited to, any one or more combinations of chemical structure information, spectral information, and manually specified information of the components. The concentration information includes, but is not limited to, any one or more combinations of absolute concentration information, relative concentration information, and custom concentration information of any specified component.

[0030] Furthermore, regarding component and concentration information, this invention does not require the exact chemical structure information of each component, but only information that represents that component, such as the elution time of a component or the information of a major mass spectrometry peak of that component. However, for the same chemical component in the entire analyzed system, the information method used must be consistent. For example, under the same analytical conditions, components in various formulation products that meet the following information are classified as one substance: In the analysis of Damask rose essential oil, the elution time of a certain component is 21.729 minutes, and its mass spectrometry peak with m / z = 149.1 is the highest peak, and the second highest peak is m / z = 167.1. During detection, it can be extracted from the full scan mass spectrometry spectrum, or the combination of the highest and second highest peaks can be analyzed using the SIM mode of mass spectrometry, or a single m / z peak can be analyzed. Similarly, for the concentration information of a component, it is only necessary to confirm that it is the same chemical component using the elution time, mass spectrometry m / z peak information, or chemical structure information, and then use the actual concentration (absolute concentration), relative concentration, or custom concentration, etc. However, a consistent concentration definition method needs to be used for the same chemical component. In the example above, the sum of the abundance of the highest peak at m / z = 149.1 and the second highest peak at m / z = 167.1 can be defined as the custom concentration. Similarly, the sum of the abundance of the strongest peak at 336 nm and the second strongest peak at 240 nm in the UV absorption spectrum of a component can also be used as the custom concentration.

[0031] In one embodiment, the method specifically includes: based on the component database and the optimization algorithm, taking the component composition of the target product as the objective, calculating the mixing ratio of at least two selected homogeneous intermediate products; the optimization algorithm is a locally and / or globally optimal algorithm, such as any one or more combinations of algorithms such as least squares method, simplex method, golden section method, Monte Carlo algorithm, simulated annealing method, etc., and is not limited thereto.

[0032] Compared to existing technologies, the method of this invention uses various simple physical separation methods to transform a single homogeneous mixture into multiple homogeneous intermediate products with different components from the initial homogeneous mixture. These homogeneous intermediate products are then digitally blended to generate various target sub-products. This method can transform a single product into multiple sub-products with different characteristics from the initial product without interfering with the existing production process. It features simple process, controllable process, and is suitable for large-scale production, with broad application prospects. Attached Figure Description

[0033] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0034] Figure 1 This is a schematic diagram of a method for generating sub-products based on component composition recombination in one embodiment of the present invention;

[0035] Figure 2 This is a comparison chart of the components of the target product (Diaoyutai liquor) and the reconstituted liquor in Example 1;

[0036] Figure 3 This is a comparison chart of the components of the target product (herbal fragrance) and recombinant fragrance A in Example 4;

[0037] Figure 4 This is a comparison chart of the components of the target product (mossy fragrance) and recombinant fragrance B in Example 4. Detailed Implementation

[0038] In the food, cosmetics, and pharmaceutical industries, existing blending methods struggle to transform a single initial homogeneous mixture into multiple sub-products, hindering product diversification. Furthermore, methods that rely on controlling raw materials and processes for product diversification have numerous drawbacks. Addressing this long-standing industry challenge, this invention proposes a method for physically separating components of a single homogeneous product to generate various intermediate products, which are then recombine to yield multiple sub-products with different compositions and unique characteristics. This method involves mixture separation and digital blending technologies and is applicable to the recombination of components from various homogeneous mixtures.

[0039] Please see Figure 1 As shown, the method for generating sub-products based on component composition recombination provided by the present invention includes the following steps:

[0040] The first step includes: using simple physical separation and collection methods to transform a single homogeneous product (i.e., the aforementioned homogeneous mixture) into multiple intermediate products (i.e., the aforementioned homogeneous intermediate products), such as intermediate product 1, intermediate product 2, ..., intermediate product n, where n≥2:

[0041] The second step includes: using the aforementioned digital blending technology, mixing multiple intermediate products in proportion to obtain one or more new products (i.e., the aforementioned target sub-products), such as sub-product 1, sub-product 2, ..., sub-product X, where X≥2.

[0042] In the method of this invention, a physical, rather than chemical, method is first used to separate the components of a single homogeneous product (hereinafter also referred to as the initial product) into multiple intermediate products based on their physical properties (e.g., boiling point, molecular polarity, molecular size, etc.). The components of these intermediate products can only originate from the initial product, without the addition of any external components; however, due to the separation process, no single intermediate product can contain all the components of the initial product, only a portion thereof. Then, using the aforementioned digital blending technology, these intermediate products are re-mixed proportionally according to the composition and concentration of the target product (the actual or virtual product), thereby ensuring that the composition and concentration of a sub-product matches the target product. By benchmarking against different target products, sub-products with different functions or flavors are produced. Because the method of this invention reorganizes the concentration of each component of the primary product, it is impossible to convert 100% of the primary product into a single sub-product in practical applications, resulting in some loss. However, by producing multiple different sub-products, the primary product can be utilized as much as possible. Another method is to digitally blend the intermediate products of one primary product and another primary product together to produce multiple sub-products, thereby minimizing loss. Alternatively, multiple unused intermediate products can be simply mixed together and digitally blended with other intermediate products to maximize the utilization rate of primary products.

[0043] While it's theoretically possible to obtain a derivative product through manual blending and repeated experiments using the aforementioned intermediate products, this requires years of experience and is time-consuming and inefficient, and cannot quickly adapt to different primary raw materials. In contrast, this invention, based on the aforementioned digital blending technology, can seamlessly adapt to the blending of these intermediate products. This is because digital blending technology doesn't rely on taste or sensory indicators (appearance, color, aroma, flavor, style), but only on the quantity and concentration of components. For example, various wines and plant extracts may have completely different compositions, but the component analysis methods and algorithms used in digital blending technology are identical, making it very easy to apply without considering changes in the composition of primary and intermediate products.

[0044] Due to the advantages of digital blending technology, the method of this invention does not require precise separation according to certain parameters, unlike other existing technologies (such as ZL201711276800.6, ZL201910863949.7). It only requires differences in composition and concentration between the intermediate and primary products, without the need for a refined separation process. Even with the same primary product, the stability of each sub-product can be guaranteed even if the process and conditions for collecting intermediate products vary each time. For example, during distillation, the distilled components only need to be collected approximately every 10°C change; or an operator only needs to collect the distilled intermediate products sequentially according to the size of the receiving container, without considering temperature parameters. After collection, the intermediate products collected according to temperature or container volume can be digitally blended separately, or they can be combined for digital blending.

[0045] Similarly, in the chromatographic separation of fragrance preparation, since precise separation is not required, there are no special requirements for the uniformity of the pore size of the packing material or whether the packing is uniform. After a single primary product passes through the chromatographic column, multiple intermediate products can be collected according to the time progress or the volume of the collection container. Then, digital blending technology is used to blend these intermediate products individually or together to produce various fragrance sub-products.

[0046] In summary, this invention combines a simple physical separation method with digital blending technology, creatively producing multiple sub-products from a single primary product. Its implementation does not require a rigorous physical separation process; only simple or even rudimentary physical separation is needed. This significantly lowers the application threshold and cost of the method, greatly expanding its application scope.

[0047] The technical solution of the present invention will be described in more detail below with reference to several embodiments. However, it should be understood that the following embodiments are only for explaining and illustrating this method, and do not limit the scope of the present invention.

[0048] Example 1: A method for reconstituted baijiu based on temperature distillation, comprising: taking 10L of a Maotai-style sauce-flavored baijiu (53% vol) produced in a certain Maotai town, and performing single-stage distillation. Without judging by smell or color, four different liquid mixtures were collected at distillation outlet temperatures at intervals of 15℃ (50-65℃, 65-80℃, 80-95℃, 95-101℃), denoted as intermediate liquor A1 to intermediate liquor A4, with collected amounts of 0.6L, 3.1L, 4.2L, and 2.1L, respectively. The collected intermediate liquors are used directly without any smell judgment. Then, using 2020 Diaoyutai baijiu (53% vol) as the target product, two or more of the intermediate liquors A1 to A4 are mixed in proportion using the aforementioned digital blending technology (refer to CN202210388906.X, CN202210412906.9) to prepare reconstituted liquor.

[0049] Specifically, in this embodiment, the component characteristics of each of the aforementioned intermediate liquor segments were obtained through GCMS instrument analysis and data analysis (referencing ZL201710676249.8, ZL2018106162309.9, etc.), and a component database for each segment of intermediate liquor was established accordingly. Analysis revealed that the components of each segment of intermediate liquor are those of the original Maotai-flavor liquor, but their concentrations differ, and each segment of intermediate liquor plays a differentiated enrichment role in the components.

[0050] For the target product, its component characteristic data were obtained through instrumental analysis and data analysis (refer to ZL 201710676249.8, ZL2018106162309.9, etc.). Then, based on the aforementioned component database, optimization algorithms such as least squares method, simplex method, golden section method, Monte Carlo algorithm, and simulated annealing were attempted to find the optimal algorithm that could give the best results, with the component composition of the target product as the objective. At the same time, the mixing ratio of intermediate wine A1 to intermediate wine A4 was calculated and converted into the recombination volume of intermediate wine A1 to intermediate wine A4, as detailed below:

[0051]

[0052] Finally, intermediate spirits A1 through A4 were uniformly mixed according to their respective recombined volumes to obtain a recombined spirit with a volume of 8.0 L and a measured alcohol content of 53.5% vol. Further analysis of the target product and the recombined spirit yielded information on their composition and concentration, such as... Figure 2 As shown, the composition of the two wines is basically the same, with an error of 1.5%.

[0053] Example 2: A method for recombination of baijiu based on different volumes, comprising: similar to Example 1, taking 100L of a certain sauce-flavored baijiu, using a distillation method, without judging by smell or color, simply collecting the distilled liquor sequentially according to the volume, collecting a total of 7 mixtures of different volumes, denoted as intermediate liquor B1-intermediate liquor B7, with collected amounts of 3L, 10L, 10L, 10L, 10L, 15L, and 15L respectively. The undistilled bottom liquid is defined as B8, and subjected to a second distillation, collected by volume, yielding 5 more different liquid mixtures, denoted as intermediate liquor B... 8-1 -B 8-5 The collected intermediate wine B 8-1 -B 8-5 The quantities are 2L, 4L, 6L, 5L, and 10L.

[0054] Similarly, component analysis was performed on the intermediate wines from each of the above sequences to obtain data on their composition and concentration. The volume, component characteristics, and other parameters of the intermediate wines were converted into specific numbers. Using 2020 Xijiu (53% vol) as the target product, and following a digital blending method, the recombined volumes of these wines were obtained as follows:

[0055]

[0056] Finally, a reconstituted liquor similar to Xijiu was obtained, with a volume of 62L and an actual alcohol content of 54% vol.

[0057] In this embodiment, some intermediate products are not involved in the blending; they will be used in the digital blending of other target wines.

[0058] Example 3: A method for reconstituted baijiu based on temperature and volume, comprising: similar to Examples 1 and 2, distilling 100L of a certain strong-aroma baijiu, collecting the first 27L according to the distillation temperature range, and then collecting according to the distillation volume, ultimately obtaining 10 different intermediate products. Then, using 2020 Wuliangye as the target product, digital blending technology was used to achieve a yield of 54% (i.e., the reconstituted baijiu of the target product as a percentage of the initial strong-aroma baijiu by volume). The remaining intermediate product, accounting for 46% of the initial strong-aroma baijiu by volume (defined as the remaining intermediate product), was digitally blended together with intermediate products from another distillation of a certain strong-aroma baijiu, using the component information of Gujinggong baijiu as the target product. 37% of the remaining intermediate product was then used for blending. The remaining intermediate products were simply mixed and treated as a new intermediate product for blending other baijiu.

[0059] Example 4: A method for reconstituted essential oils based on preparative chromatography, comprising:

[0060] A specific rose fragrance was separated using preparative chromatography. Specifically, the rose fragrance sample was passed into a 6-inch C18 packed glass gas chromatography column, and eluted in multiple stages. Seven eluents were collected at RT values ​​of 1-6 min, 6-10 min, 10-16 min, 16-20 min, 20-25 min, 25-32 min, and 32-45 min. Factors that could reduce separation efficiency, such as uneven column packing, were not considered during the elution process.

[0061] Each eluent was analyzed to obtain its composition and concentration information. Two different fragrance mixtures, with grassy and mossy aromas respectively, were selected as the target product. Using a digital blending method, reconstituted fragrances A and B were obtained by recombinating seven eluents. Composition analysis was then performed on the two reconstituted fragrances to obtain their composition and concentration information, revealing an error of approximately 3%–4% compared to the target product. The chromatograms are shown below. Artificial aroma testing also confirmed that the reconstituted fragrances and the target product smelled very similar.

[0062] Example 5: A method for recombining tea beverages based on filtration, comprising:

[0063] A Yixing black tea beverage was processed through a multi-stage filtration device, collecting six filtrates under ceramic membrane material conditions with pore sizes R = 2-10nm, 10nm-50nm, 50nm-200nm, 200nm-1μm, 1μm-50μm, and greater than 50μm. The composition and concentration information of each filtrate were obtained using LCMS. Two black tea beverages (Rizhao black tea and Yingde black tea) were selected as target compounds, and the aforementioned six filtrates were reconstituted using digital blending technology. The filtrate ratios corresponding to the two black tea target compounds were provided. After obtaining the reconstituted products, their composition and concentration information showed similarities of 95.0% and 97.5% with the two target compounds, respectively.

[0064] Example 6: A method for reconstructing a counterfeit perfume into a genuine product, comprising:

[0065] Similar to Example 4, a Dior-inspired perfume was selected. Using an OV-1701 universal quartz capillary column, following a simple heating program, disregarding odor, samples were collected every 4 minutes. A total of 10 intermediate products were collected, denoted as T1-T. 10 Each intermediate product undergoes component analysis to obtain its composition and concentration information. Using a digital blending method, the target ingredients of authentic DIOR J'adore Eau de Toilette (EDT) are mixed from T1 to T... 10The mixture was remixed according to the specified proportions to obtain a reconstituted perfume. This reconstituted perfume was given to 80 volunteers for use and evaluation. 75 volunteers believed that the scent was similar to the original product, and 77 volunteers believed that the lasting power was similar to the original product.

[0066] Example 7: A method for reconstituted soaking solutions of traditional Chinese medicine at different times, comprising:

[0067] Similar to Example 1, a type of Sichuan fritillary bulb from Yunnan was selected, cut into pieces, and placed in a ceramic jar for soaking and heating at approximately 98°C. The soaking liquid was then collected every 10 minutes, with an equal volume of water added to the ceramic jar, for a total of 6 times. The composition and concentration of the soaking liquid at each time point were obtained using liquid chromatography-mass spectrometry.

[0068] Next, a decoction of Fritillaria cirrhosa purchased from a pharmacy was used as the target compound, and its composition and concentration information were obtained using the same liquid chromatography-mass spectrometry (LC-MS) method. Then, digital blending technology was used to obtain the ratio of the recombinant soaking solution. The six soaking solutions were then recombined into a recombinant Fritillaria cirrhosa product according to the specified ratio. LC-MS analysis of this recombinant product revealed that its composition was basically consistent with the target compound, with a concentration similarity of 93%. The original six soaking solutions differed significantly in composition and concentration from the target compound, with similarities ranging from 30% to 50%.

[0069] Although the invention has been described with reference to illustrative embodiments, those skilled in the art will understand that various other changes, omissions, and / or additions may be made without departing from the spirit and scope of the invention, and that substantially equivalent substances may be substituted for the substances described in the embodiments. Furthermore, many modifications may be made without departing from the scope of the invention to adapt particular situations or materials to the teachings of the invention.

Claims

1. A method of reconstituting a sub-product based on the composition of ingredients, characterized in that The method comprises the following steps: separating a homogeneous mixture into a plurality of homogeneous intermediate products with different components by a physical separation method, wherein the homogeneous mixture is a mixture of all the homogeneous intermediate products, and the number of components in at least one of the homogeneous intermediate products is less than that in the homogeneous mixture, and the concentration of a selected component in at least one of the homogeneous intermediate products is different from that in the homogeneous mixture; performing full-component analysis on each of the homogeneous intermediate products to establish a component database of the homogeneous intermediate products, wherein each component peak with a signal-to-noise ratio of 1.8 or more is analyzed to obtain the component information and concentration information corresponding to the component peak; determining the component information of a target product; selecting at least two homogeneous intermediate products required according to the component information of the target product and the component database, and calculating the mixing ratio of the selected at least two homogeneous intermediate products according to the component database and an optimization algorithm, wherein the optimization algorithm is a local and / or global optimization algorithm; mixing the selected at least two homogeneous intermediate products according to the mixing ratio to obtain a sub-product.

2. The method of reconstituting a sub-product based on the composition of ingredients according to claim 1, characterized in that Specifically, the method comprises the following steps: separating the homogeneous mixture by a physical separation method, and then collecting the homogeneous intermediate products by a physical collection method.

3. The method of recombining sub-products based on their composition according to claim 2, characterized in that: The physical separation method comprises any one or a combination of the following methods: evaporation, extraction, membrane separation, distillation and rectification, capillary electrophoresis, and preparative chromatography.

4. The method of recombining sub-products based on their composition according to claim 2, characterized in that: The physical collection method comprises any one or a combination of the following methods: reflux, elution, condensation, and concentration.

5. The method of reconstituting sub-products based on the composition of ingredients according to claim 1, characterized in that Specifically, the method comprises the following steps: The component information of the target product is determined by at least one of the following methods: full-component analysis on the target product, modification of one or more components of a specified product, or establishment of a virtual product.

6. The method of reconstituting a subproduct based on the composition of ingredients according to claim 5, characterized in that, The full-component analysis is performed by using a chromatographic separation technique in cooperation with a detection instrument, wherein the detection instrument comprises any one or a combination of the following detectors: mass spectrometer, infrared detector, ultraviolet detector, fluorescence detector, spectrophotometer, and nuclear magnetic resonance detector.

7. The method of reconstituting a subproduct based on the composition of ingredients according to claim 6, characterized in that Specifically, the method comprises the following steps: During the full-component analysis, the components flowing out of the chromatographic column are separated by an algorithm, and then subjected to qualitative analysis and / or quantitative analysis.

8. The method of reconstituting sub-products based on their composition according to claim 1, characterized in that: The component database comprises at least the component information and concentration information of the plurality of homogeneous intermediate products. The component information comprises any one or a combination of the following information: chemical structure information, spectrum information, and human-specified information. The concentration information comprises any one or a combination of the following information: absolute concentration information, relative concentration information, and self-defined concentration information.

9. The method of reconstituting sub-products based on the composition of ingredients according to claim 1, characterized in that: The optimization algorithm comprises any one or a combination of the following algorithms: least square method, simplex method, golden section method, Monte Carlo algorithm, and simulated annealing method.

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