19 results about "Hyperoxia" patented technology

FIELD: neurology; psychiatry.SUBSTANCE: used as a non-pharmacological therapy for autism spectrum disorders in children. The method includes a set of procedures: interval hypoxic-hyperoxic training (HHT), hyperbaric oxygenation and ozone therapy. HHT consists of alternating inhalations of a hypoxic mixture with an oxygen content of 9 to 16 vol.% and a hyperoxic mixture with an oxygen content of 32 to 40 vol.% for a total duration of 45-50 minutes under the control of cardiovascular system parameters. Hyperbaric oxygenation is performed in a pressure chamber under a pressure of 1.3 atmospheres of 100% oxygen mixture, flow of 10 liters per minute, for 45 minutes using a mask. Ozone therapy is performed by rectal insufflation with an ozone-oxygen mixture with an ozone concentration of 85 μg / ml in a volume of 20–30 ml or by intravenous administration of a physiological solution enriched with ozone with an ozone concentration of 85 μg / ml at a rate of 200 ml per 100 ml of physiological solution. The procedures are carried out daily for 12 days.EFFECT: method is effective and has a positive impact on the patient’s condition.1 cl, 1 dwg, 3 ex

A large-scale harmful algae bloom mitigation system that is environmentally safe, cost-effective, and scalable utilizing a hyperoxic nanobubble treatment and remote brevetoxin screening, without relying on heavy laboratory equipment. The hyperoxic nanobubble treatment and remote brevetoxin screening system is configured for installation within a narrow cross-section of an area of a body of water. The system is a stationary, high oxygen concentration, gas flow system that injects a large amount of oxygen enriched nanobubbles underwater at a small cross-section of a body of water, thereby controlling a large amount of water rapidly and in an environmentally-safe manner.

The present invention relates to a method for producing hyperoxygenated fatty acids (hereinafter HOFA), the method using an O2 concentrator with an atmospheric air flow rate entered of between 1 to 5 litres / minute, at room temperature and pressure, which is the main subject matter of the invention. The first subject matter of the invention, which is dependent on the main subject matter, are medicinal topical formulations using said HOFA as a carrier, and the second secondary subject matter is the method for producing topical agents for healing and / or preventing epidermis damage.

The invention discloses a low-oxygen affinity deoxidized hemoglobin spray and application thereof. The invention creatively discovers that the oxygen concentration on the surface of a wound is obviously higher than that of pure deoxidized hemoglobin and high-oxygen-affinity deoxidized hemoglobin with higher oxygen carrying capacity after the low-oxygen-affinity deoxidized hemoglobin with higher oxygen release capacity is used; it is proved that the low-oxygen affinity deoxidized hemoglobin is more beneficial to improvement of the oxygen concentration of the wound surface. According to the specific embodiment of the invention, the RSR-13 is combined with the deoxidized hemoglobin, the conformation of the deoxidized hemoglobin is changed, the oxygen affinity of the deoxidized hemoglobin is reduced, the oxygen release of the deoxidized hemoglobin in the hypoxia tissue is effectively enhanced, the drug has no obvious toxicity to skin cells, the effectiveness and safety of the drug in skin wound treatment are improved, and the application prospect is wide. The method is suitable for treating multiple types of wound surfaces, and has wide application value and market prospect.

The invention relates to the field of mobile oxygen generation, oxygen storage and oxygen filling technologies, in particular to a vehicle-mounted oxygen generation, oxygen storage and oxygen filling integrated device which comprises an equipment bin, and an air compressor is arranged in the equipment bin; the filter assembly is connected with the air compressor and is used for filtering impurities in air; the ordinary oxygen tower internally contains a molecular sieve, is connected with the filtering assembly, receives the output gas of the filtering assembly, adsorbs nitrogen molecules of the gas in the tower and outputs high-oxygen-content gas; an argon adsorbent is contained in the pure oxygen tower, and the pure oxygen tower is connected with the ordinary oxygen tower, receives the high-oxygen-content gas output by the ordinary oxygen tower, absorbs argon in the high-oxygen-content gas and outputs the high-oxygen-content gas; the circulating compressor is connected with the pure oxygen tower and is used for extracting output gas of the pure oxygen tower and boosting; and the pure oxygen storage tank is connected with the circulating compressor and stores the high-pressure gas output by the circulating compressor. The device has the effect of efficiently and quickly providing high-quality oxygen in an infinite manner.

Provided herein are methods of using mesenchymal stromal / stem cell (MCS) exosomes in the treatment of diseases associated with thymic dysfunction. In some embodiments, the MSC exosomes restore thymic architecture and development in a subject having thymic dysfunction (e.g., caused by exposure to hyperoxia). In some embodiments, the subject is a human subject (e.g., a human neonate).

The utility model belongs to the technical field of poultry house oxygen supply, and particularly relates to a poultry house ventilation and oxygen supply device for poultry breeding, which comprises a ventilation pipe, an air inlet pipe fixedly mounted on the bottom surface of the ventilation pipe, and exhaust pipes detachably mounted on the two side surfaces of the ventilation pipe, an oxygen supply flow guide pipe and an outer oxygen flow guide pipe are symmetrically and fixedly installed on the surfaces of the two sides of the mixing tank, and a butt joint sleeve shell is detachably installed on the surface of the bottom of the air inlet pipe. The oxygen supply flow guide pipe and the external oxygen flow guide pipe are matched to pour outside air and high oxygen in the oxygen bottle into the mixing tank together, and meanwhile the inclination angle of the oxygen supply flow guide pipe and the inclination angle of the external oxygen flow guide pipe are utilized; according to the oxygen tank, gas injected into the mixing tank by the oxygen supply flow guide pipe and the external oxygen flow guide pipe can circularly flow in the mixing tank along the radian on the inner side wall surface of the mixing tank, and external oxygen and high oxygen in the oxygen tank can be mixed under the circular flow of the gas.

The present invention provides a pre-training method for high-low oxygen training, comprising: obtaining a target low oxygen concentration value; delivering a gas with an oxygen concentration lower than that in the air to the user, so that the gas concentration reaches the target low oxygen concentration value for the first time at a first preset time; delivering a gas with an oxygen concentration higher than the target low oxygen concentration value and lower than that in the air to the user, so that the gas concentration rebounds to the first high value at a second preset time; alternately delivering gases of different oxygen concentrations to the user, so that the gas concentration reaches the target low oxygen concentration value multiple times at the first preset time and rebounds to the corresponding high value at the second preset time, and the high values ​​of the gas concentration rebound gradually decrease until the high value reaches the preset range, so as to complete the pre-training process of high-low oxygen training, thereby achieving a staged change in the oxygen concentration of the delivered gas. The present invention facilitates the user's body to better adapt to the low oxygen environment by delivering a staged change in the concentration of the delivered gas, thereby facilitating the user's high-low oxygen training.

Disclosed is a portable oxygen supply system (100) comprising an oxygen production device (1, 1 ', 1' '). The oxygen generation device (1, 1 ', 1' ') comprises at least one compressor (12, 12') for compressing ambient air (L), and at least one adsorption device (10, 10 ', 10' ') arranged to generate a high oxygen content oxygen gas (S) from the ambient air (L) compressed by the at least one compressor (12, 12') by a pressure swing adsorption method. Furthermore, the oxygen generation device (1, 1 ', 1' ') comprises at least one supercharger (13, 13') for pressurizing the generated gas (S); at least one gas tank (14, 14 ') for storing gas compressed by the at least one supercharger; and one or more gas outlets (15, 15 ') for outputting the generated gas from at least one gas tank (14, 14'). Also disclosed is a method for providing an oxygen gas (S), the method comprising operating an oxygen supply system (100).

A device for intermittent hypoxia-hyperoxia training includes a main chassis; a pressure swing adsorption (PSA) system housed within the chassis, the PSA system configured to generate a hyperoxic gas output and a hypoxic gas output; a buffering reservoir housed within the main chassis, configured to receive the hypoxic gas output from the PSA system; a single user output port; a valve mechanism having a first inlet connected to an output of the buffering reservoir, a second inlet connected to the hyperoxic gas output of the PSA system, and an outlet connected to the single user output port; and a computation unit configured to control the valve mechanism, thereby selecting whether hypoxic gas from the buffering reservoir or hyperoxic gas from the PSA system is delivered to the single user output port.

1. The name of this design product: Intermittent Hyperoxia and Hypoxia Trainer (Professional Edition). 2. The purpose of this product design: It can intermittently provide low-oxygen gas and high-oxygen gas, and through the reciprocating alternation of low-oxygen exercise and high-oxygen recovery stages, it can enhance human functions and improve metabolism. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

This application provides a purity field guidance method for a dual-tower pressure swing adsorption (PSA) oxygen generation system, relating to the field of oxygen separation technology, comprising the following steps: during the initial adsorption process of one adsorption tower, its gas production outlet is closed or restricted to create a gas distribution with increasing purity gradient within the tower; after high-purity gas is formed at the top of the adsorption tower but before adsorption ends, the high-purity gas at the top is guided to the bottom inlet of the other adsorption tower, allowing the high-purity gas to pass through the molecular sieve bed from bottom to top within the first adsorption tower, thereby establishing a high-oxygen environment within the first adsorption tower; during the steady-state operation phase: after the adsorption process of any subsequent adsorption tower is completed, the oxygen-enriched flow from that adsorption tower is guided to the bottom inlet of the other adsorption tower in the desorption phase for pressure equalization, allowing the oxygen-enriched flow to pass through the molecular sieve bed from bottom to top within the other adsorption tower.

The invention relates to the technical field of psychological health dredging, and discloses a college student psychological health education auxiliary dredging device which comprises a base, a physical therapy mechanism is arranged on the upper portion of the base and used for forming a basic environment for dredging operation, and a purification mechanism is arranged in the physical therapy mechanism and used for purifying inhaled outside air. The purification mechanism is communicated with an oxygen supply mechanism which is used for forming a high-oxygen environment, and an audio-visual mechanism is arranged in the physical therapy mechanism and is used for forming an audio-visual environment for dredging operation. Through the purification mechanism and the oxygen supply mechanism, precise regulation and control of the environment can be achieved, sucked outside air is effectively purified, dust, bacteria and other impurities are removed, the oxygen supply mechanism can precisely adjust the oxygen content in the cabin according to the monitoring result of the oxygen content sensor, a high-oxygen environment is formed, and the safety of the cabin is improved. The precise environment regulation and control are beneficial for college students to accept psychological guidance in a healthier and more comfortable environment.

An intermittent hypoxic-hyperoxic training device for both dynamic and static use is provided. The training device has multiple training modes. The training device includes a gas generating device, a control device, an interactive display device, a heart rate wearing device, and a blood oxygen saturation detection device. The control device preliminarily sets an oxygen content parameter of a mixed gas upon receiving a corresponding training instruction sent by the interactive display device in response to the training mode selected by the user instruction; a heart rate parameter of a trained object is acquired from the heart rate wearing device, to adjust the oxygen content parameter under an exercise state according to the heart rate parameter; and / or a blood oxygen parameter of the trained object is acquired from the blood oxygen saturation detection device, to adjust the oxygen content parameter under a non-exercise state according to the blood oxygen parameter.

The invention relates to a hyperxic lung injury treatment medicine based on ferroptosis inhibition, a screening method and application, and relates to the technical field of biological medicines. The application has the advantages that ferroptosis is one of key mechanisms of high-oxygen lung injury, a new target spot is provided for clinical prevention and treatment, and in-vivo and in-vitro experiments prove that high oxygen can induce mouse lung microvascular endothelial cells to generate ferroptosis, high oxygen can induce mice to generate acute lung injury, and ferroptosis participates in the process; the ferroptosis related signal path is activated in the hyperxia lung injury; the ferroptosis inhibitor (such as dexmedetomidine, Liproxstatin-1 and deferoxamine) can be used for remarkably relieving the cell injury induced by high oxygen and the pathological change of lung tissues. The target spot and the biomarker provided by the invention can be used for developing a diagnostic kit for evaluating the severity or prognosis of HALI, and the established screening model and method can be used for high-throughput screening of novel anti-HALI compounds to accelerate the research and development process of new drugs.

The invention discloses a method for detecting megakaryocytes in a bronchopulmonary dysplasia model, and relates to the field of biomedicine. Comprising the following steps: constructing a BPD mouse model, carrying out HE staining, flow cytometry and immunofluorescence detection on lung tissues, and analyzing the number, proportion, ploidy and distribution of megakaryocytes, the construction of the BPD mouse model comprises the following steps: randomly dividing C57BL / 6j strain newborn mice into an experimental group and a control group one day after the newborn mice are born, feeding the experimental group in a 85-90% high oxygen concentration environment for 14 days, and feeding the control group in a C57BL / 6j strain newborn mice in a C57BL / 6j strain newborn mice in a C57BL / 6j strain newborn mice. The control group is fed in the air, and the female rats are interchanged among the groups every 24 hours. By integrating model construction, HE staining, flow cytometry and immunofluorescence, multi-dimensional detection of megakaryocytes in the BPD model is achieved, the method is standardized and good in repeatability, reduction and ploidy change of megakaryocytes in lung tissue can be accurately reflected, and a reliable tool is provided for research of a BPD mechanism.

This invention provides a complex based on neutrophil nanovesicles that combines anti-inflammatory and anti-angiogenic bidirectional trapping with autoluminescent dynamics, along with its preparation method and applications, belonging to the field of biopharmaceutical manufacturing technology. The complex uses neutrophil nanovesicles as a carrier and also encapsulates bis(2,4,5-trichlorosalicylate n-amyl)oxalate (CPPO) and the photosensitizer Ce6. Simultaneously, the surface is modified with ranibizumab via ROS-responsive ketothiols. The complex possesses the characteristics of trapping anti-inflammatory factors and spontaneously targeting corneal neovascularization lesions. Based on ROS-responsive release of ranibizumab to bind vascular endothelial growth factor, it exerts an anti-angiogenic function. Simultaneously, the chemical energy generated by CPPO under hyperoxia conditions excites Ce6 to produce singlet oxygen, thereby inhibiting the tubular formation ability of vascular endothelial cells. This invention provides a new approach for the treatment of eye-related diseases.

A device for intermittent hypoxia-hyperoxia training includes a main chassis; a pressure swing adsorption (PSA) system housed within the chassis, the PSA system configured to generate a hyperoxic gas output and a hypoxic gas output; a buffering reservoir housed within the main chassis, configured to receive the hypoxic gas output from the PSA system; a single user output port; a valve mechanism having a first inlet connected to an output of the buffering reservoir, a second inlet connected to the hyperoxic gas output of the PSA system, and an outlet connected to the single user output port; and a computation unit configured to control the valve mechanism, thereby selecting whether hypoxic gas from the buffering reservoir or hyperoxic gas from the PSA system is delivered to the single user output port.

A system (100, Figure 1) for controlling blood oxygenation in a patient using an oxygenator 200, the system having a controller (150, Figure 1) configured to control a gas supply apparatus (300, Figur