9 results about "Hyperoxia" patented technology

FIELD: neurology; psychiatry.SUBSTANCE: used as a non-pharmacological therapy for autism spectrum disorders in children. The method includes a set of procedures: interval hypoxic-hyperoxic training (HHT), hyperbaric oxygenation and ozone therapy. HHT consists of alternating inhalations of a hypoxic mixture with an oxygen content of 9 to 16 vol.% and a hyperoxic mixture with an oxygen content of 32 to 40 vol.% for a total duration of 45-50 minutes under the control of cardiovascular system parameters. Hyperbaric oxygenation is performed in a pressure chamber under a pressure of 1.3 atmospheres of 100% oxygen mixture, flow of 10 liters per minute, for 45 minutes using a mask. Ozone therapy is performed by rectal insufflation with an ozone-oxygen mixture with an ozone concentration of 85 μg / ml in a volume of 20–30 ml or by intravenous administration of a physiological solution enriched with ozone with an ozone concentration of 85 μg / ml at a rate of 200 ml per 100 ml of physiological solution. The procedures are carried out daily for 12 days.EFFECT: method is effective and has a positive impact on the patient’s condition.1 cl, 1 dwg, 3 ex

The invention discloses a low-oxygen affinity deoxidized hemoglobin spray and application thereof. The invention creatively discovers that the oxygen concentration on the surface of a wound is obviously higher than that of pure deoxidized hemoglobin and high-oxygen-affinity deoxidized hemoglobin with higher oxygen carrying capacity after the low-oxygen-affinity deoxidized hemoglobin with higher oxygen release capacity is used; it is proved that the low-oxygen affinity deoxidized hemoglobin is more beneficial to improvement of the oxygen concentration of the wound surface. According to the specific embodiment of the invention, the RSR-13 is combined with the deoxidized hemoglobin, the conformation of the deoxidized hemoglobin is changed, the oxygen affinity of the deoxidized hemoglobin is reduced, the oxygen release of the deoxidized hemoglobin in the hypoxia tissue is effectively enhanced, the drug has no obvious toxicity to skin cells, the effectiveness and safety of the drug in skin wound treatment are improved, and the application prospect is wide. The method is suitable for treating multiple types of wound surfaces, and has wide application value and market prospect.

Provided herein are methods of using mesenchymal stromal / stem cell (MCS) exosomes in the treatment of diseases associated with thymic dysfunction. In some embodiments, the MSC exosomes restore thymic architecture and development in a subject having thymic dysfunction (e.g., caused by exposure to hyperoxia). In some embodiments, the subject is a human subject (e.g., a human neonate).

A device for intermittent hypoxia-hyperoxia training includes a main chassis; a pressure swing adsorption (PSA) system housed within the chassis, the PSA system configured to generate a hyperoxic gas output and a hypoxic gas output; a buffering reservoir housed within the main chassis, configured to receive the hypoxic gas output from the PSA system; a single user output port; a valve mechanism having a first inlet connected to an output of the buffering reservoir, a second inlet connected to the hyperoxic gas output of the PSA system, and an outlet connected to the single user output port; and a computation unit configured to control the valve mechanism, thereby selecting whether hypoxic gas from the buffering reservoir or hyperoxic gas from the PSA system is delivered to the single user output port.

This application provides a purity field guidance method for a dual-tower pressure swing adsorption (PSA) oxygen generation system, relating to the field of oxygen separation technology, comprising the following steps: during the initial adsorption process of one adsorption tower, its gas production outlet is closed or restricted to create a gas distribution with increasing purity gradient within the tower; after high-purity gas is formed at the top of the adsorption tower but before adsorption ends, the high-purity gas at the top is guided to the bottom inlet of the other adsorption tower, allowing the high-purity gas to pass through the molecular sieve bed from bottom to top within the first adsorption tower, thereby establishing a high-oxygen environment within the first adsorption tower; during the steady-state operation phase: after the adsorption process of any subsequent adsorption tower is completed, the oxygen-enriched flow from that adsorption tower is guided to the bottom inlet of the other adsorption tower in the desorption phase for pressure equalization, allowing the oxygen-enriched flow to pass through the molecular sieve bed from bottom to top within the other adsorption tower.

An intermittent hypoxic-hyperoxic training device for both dynamic and static use is provided. The training device has multiple training modes. The training device includes a gas generating device, a control device, an interactive display device, a heart rate wearing device, and a blood oxygen saturation detection device. The control device preliminarily sets an oxygen content parameter of a mixed gas upon receiving a corresponding training instruction sent by the interactive display device in response to the training mode selected by the user instruction; a heart rate parameter of a trained object is acquired from the heart rate wearing device, to adjust the oxygen content parameter under an exercise state according to the heart rate parameter; and / or a blood oxygen parameter of the trained object is acquired from the blood oxygen saturation detection device, to adjust the oxygen content parameter under a non-exercise state according to the blood oxygen parameter.

The invention relates to a hyperxic lung injury treatment medicine based on ferroptosis inhibition, a screening method and application, and relates to the technical field of biological medicines. The application has the advantages that ferroptosis is one of key mechanisms of high-oxygen lung injury, a new target spot is provided for clinical prevention and treatment, and in-vivo and in-vitro experiments prove that high oxygen can induce mouse lung microvascular endothelial cells to generate ferroptosis, high oxygen can induce mice to generate acute lung injury, and ferroptosis participates in the process; the ferroptosis related signal path is activated in the hyperxia lung injury; the ferroptosis inhibitor (such as dexmedetomidine, Liproxstatin-1 and deferoxamine) can be used for remarkably relieving the cell injury induced by high oxygen and the pathological change of lung tissues. The target spot and the biomarker provided by the invention can be used for developing a diagnostic kit for evaluating the severity or prognosis of HALI, and the established screening model and method can be used for high-throughput screening of novel anti-HALI compounds to accelerate the research and development process of new drugs.

The invention discloses a method for detecting megakaryocytes in a bronchopulmonary dysplasia model, and relates to the field of biomedicine. Comprising the following steps: constructing a BPD mouse model, carrying out HE staining, flow cytometry and immunofluorescence detection on lung tissues, and analyzing the number, proportion, ploidy and distribution of megakaryocytes, the construction of the BPD mouse model comprises the following steps: randomly dividing C57BL / 6j strain newborn mice into an experimental group and a control group one day after the newborn mice are born, feeding the experimental group in a 85-90% high oxygen concentration environment for 14 days, and feeding the control group in a C57BL / 6j strain newborn mice in a C57BL / 6j strain newborn mice in a C57BL / 6j strain newborn mice. The control group is fed in the air, and the female rats are interchanged among the groups every 24 hours. By integrating model construction, HE staining, flow cytometry and immunofluorescence, multi-dimensional detection of megakaryocytes in the BPD model is achieved, the method is standardized and good in repeatability, reduction and ploidy change of megakaryocytes in lung tissue can be accurately reflected, and a reliable tool is provided for research of a BPD mechanism.

A device for intermittent hypoxia-hyperoxia training includes a main chassis; a pressure swing adsorption (PSA) system housed within the chassis, the PSA system configured to generate a hyperoxic gas output and a hypoxic gas output; a buffering reservoir housed within the main chassis, configured to receive the hypoxic gas output from the PSA system; a single user output port; a valve mechanism having a first inlet connected to an output of the buffering reservoir, a second inlet connected to the hyperoxic gas output of the PSA system, and an outlet connected to the single user output port; and a computation unit configured to control the valve mechanism, thereby selecting whether hypoxic gas from the buffering reservoir or hyperoxic gas from the PSA system is delivered to the single user output port.