The invention discloses a medical air purifying sterilizer and an operation mode thereof and belongs to the technical field of air exchange devices. The medical air purifying sterilizer comprises a shell, an outdoor new air inlet, a new air inwards-leading fan, a full-heat exchanger core, an indoor direction-changeable vent, an indoor dirt air inlet, a dirt air outwards-leading fan and an outdoor dirt air outlet and further comprises a humidifier, an air purifying and sterilizing system, a centrifugal fan and an indoor sterilizing and purifying outlet. The shell is a cabinet type shell, and the whole cabinet type shell is of an air-pipe-free vertical cabinet floor stand structure. The air purifying and sterilizing system comprises a low-efficiency filter, a medium-efficiency filter, a high-voltage electrostatic dust collector, an activated carbon absorber and a photocatalyst catalyzing and sterilizing sterilizer. A new air inwards-introduced and energy recovery channel, a dirt air discharging and energy recovery channel, an air purifying and sterilizing channel and a new air inwards-leading, energy recovery and air purifying and sterilizing channel can be formed. The medical air purifying sterilizer has the advantages that bacteria, viruses, formaldehyde, benzene and ozone concentration do not exceed standards, pollution of PM2.5 particles do not exist, the sterilizing cost is low, and energy can be recovered.