31 results about "Deoxy hemoglobin" patented technology

Methods and apparatus for measuring cerebral O2 saturation and detecting cerebral hypoxia-ischemia using multi-wavelength near infrared spectroscopy (NIRS). Near-infrared light produced by an emitter is directed through brain tissue. The intensity of the light that passes through the brain tissue is measured using photodiode detectors positioned at distinct distances from the emitter. This process is conducted for at least three wavelengths of near-infrared light. One of the wavelengths used is substantially at an isobestic point for oxy-hemoglobin and deoxy-hemoglobin, but the other two may be any wavelengths within the near-infrared spectrum (700 nm to 900 nm), so long as one of the additional wavelengths is greater than the isobestic point and the other is less than the isobestic point. Tissue oxygenation is calculated using an algorithm derived from the Beer-Lambert law. Cerebral hypoxia-ischemia may be diagnosed using the calculated tissue oxygenation value.

The apparatus for evaluating biological function of the present invention has living body probes 1, a behavioral information measuring part 2 and an apparatus body 3, and it utilizes near-infrared spectroscopy to evaluate biological function; apparatus body 3 has a controller 8 for calculating (based on light information from living body probes 1) a variety of parameters derived from two-dimensional diagrams showing relationships between changes in oxyhemoglobin and changes in deoxyhemoglobin and two-dimensional diagrams showing relationships between absolute amounts of oxyhemoglobin and absolute amounts of deoxyhemoglobin, a behavioral information input part for entering behavioral information measured by means of behavioral information measuring part 12, and a display part 10 for performing various types of image displays based on various parameters calculated by means of controller 8 and / or behavioral information entered in the behavioral information input part.

The invention provides a method and system for measuring skin physiology parameters and optical property parameters based on reflective spectral measurement. The measuring system is composed of measuring equipment for a skin reflection spectrum and a computation and display device. By utilizing an analysis method of combining experimental data with the Monte Carlo simulation, the measuring system provides more accurate corresponding data of reflection light intensity and skin optical property; during the practical measurement of sample skin, on the basis of a practically measured reflection spectrum, the data and more physiology parameters are calculated and fit to obtain the skin physiology parameters and the optical property parameters based on reflective spectral measurement; finally, the optical property parameters of the skin adsorption coefficient mu a, a reduction scattering coefficient mu s' and the like as well as physiological information, such as melanin content, deoxygenated haemoglobin content, oxygenated haemoglobin content, moisture content and the like are also measured are measured in real time in a non-invasive and lossless mode.

A method of measuring the stress or relaxation level of a mammal and a method of measuring the activity of the sympathetic nervous system of a mammal by measuring quantititative levels of deoxyhemoglobin and oxyhemoglobin are disclosed. Preferably, the levels of deoxyhemoglobin and hemoglobin are measured by a noninvasive technique, such as spectroscopy. A method of changing the activity of the sympathetic nervous system of a mammal is also disclosed, wherein the method includes a step of administering an effective amount of sensory regimen to the mammal. The method is useful for humans who are operating vehicles or machinery, who are suffering from cardiovascular disease or related complications, who are pregnant, or who are preparing for sleep. In addition, a method of improving the complexion of the skin of a mammal is disclosed.

The invention discloses an electrocerebral and near-infrared combined drug addiction assessment method. A PC host is responsible for operation of all module software programs, and an experimental paradigm module is composed of an Eprime experimental paradigm program, designed for patients abstained from drugs, induces activation of neurons in different brain regions of a brain through a specific stimulated picture presentation pattern to generate relevant brain activity information, and transmits the relevant brain activity information to an electrocerebral collection module and a near-infrared collection module; the electrocerebral collection module collects electrocerebral signals in the brain activity information under the effect of the Eprime experimental paradigm program through TCP / IP; the near-infrared collection module collects oxyhemoglobin signals and deoxyhemoglobin signals in the brain activity information under the effect of the Eprime experimental paradigm program; and anassessment algorithm module identifies and assesses the severity degree of drug addiction of the patients abstained from the drugs by adopting a support vector machine classifier through informationobtained by the electrocerebral collection module and the near-infrared collection module.

The invention discloses a non-invasive monitoring method and a monitoring device for cerebral blood oxygen, and develops a non-invasive monitoring method for blood oxygen saturation of local tissues of a human brain by utilizing different absorbances of oxyhemoglobin and deoxidized hemoglobin to near-infrared light, so that the method does not cause harm to a human body; continuous real-time monitoring of the cerebral blood oxygen value can be achieved through a continuous cerebral blood oxygen value prediction model, the influence of melanin is considered, correction factors are added, surface interference signals and deep useful signals are detected respectively, the content of the collected signals is richer, and the cerebral blood oxygen signals with the high signal-to-noise ratio canbe obtained through processing conveniently; further, the cerebral forehead lobe area local oxyhemoglobin saturation monitoring value without the human head tissue interference signal is solved, so that the cerebral oxyhemoglobin continuous monitoring stability is better, and the monitoring precision is higher. A new solution is provided for non-invasive monitoring of cerebral blood oxygen, and clinical application of non-invasive monitoring of cerebral blood oxygen can be better promoted.

A method for functional magnetic resonance imaging (fMRI) uses steady-state free precession (SSFP) to image changes in blood oxygenation between two time periods. A center frequency of the SSFP sequence is placed between the different resonant frequencies for oxyhemoglobin and deoxyhemoglobin whereby the signals have a phase difference of 180° and tend to cancel. By repeating the SSFP imaging sequence at different times, the difference in the measured signals provides a measure of change in oxyhemoglobin. RF flip angle of the SSFP sequence is chosen to maximize signal level in the frequency range from that of water in the presence of oxyhemoglobin and that of water in the presence of deoxyhemoglobin.

A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (μa and μs′) at each wavelength are calculated. The obtained pa and μs′ values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.

The invention discloses a near-infrared brain imaging spectrum analysis method, which comprises the following steps of: extracting single-channel full-time-sequence spectrum data of relative concentrations of deoxyhemoglobin and oxyhemoglobin of a plurality of channels in a forehead calibration brain region of a patient under the stimulation of a cognitive task, constructing a detection curve of deoxyhemoglobin and oxyhemoglobin according to the spectrum data; sampling the detection curve, conducting zoning sampling with the total detection time T as the horizontal axis, and conducting normalization processing on the longitudinal axis, so as to obtain a final data set; and constructing a neural network algorithm model according to the standard map curve, respectively inputting the final data sets of the plurality of channels into the neural network algorithm model, judging the proportion of the standard map in the detection curve corresponding to the plurality of channels, and obtaining a judgment result according to a preset corresponding relationship between the preset proportion and the plurality of standard maps. The near-infrared brain imaging spectrum analysis method provided by the invention can provide reference for clinical diagnosis.

The invention discloses a method and device for measuring oxygen-containing hemoglobin and deoxygenated hemoglobin and equipment. The device comprises a near-infrared emission module, a near-infraredreceiving module and a controller, wherein the near-infrared emission module is used for emitting near-infrared light of target compound waveforms to the tested cerebral cortex, the near-infrared receiving module is used for receiving a luminous intensity signal, reflected by the tested cerebral cortex, of the near-infrared light, and the controller is used for receiving target measuring requirement parameters, adjusting the near-infrared light waveforms emitted by the near-infrared emission module according to the target measuring requirement parameters to obtain the target compound waveforms, controlling the near-infrared emission module to emit the near-infrared light according to the target compound waveforms, receiving luminous intensity information output by the near-infrared receiving module, and measuring oxygen-containing hemoglobin parameters and deoxygenated hemoglobin parameters of the tested cerebral cortex according to the luminous intensity information. In this way, thefunction of dynamically adjusting output waveforms to adapt to different testing items and different testees is achieved, and the using adaptability of products is improved.

A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third NIR wavelengths across the brain of the subject. The first NIR wavelength is the isosbestic wavelength for oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb), the second NIR wavelength is shorter than the first NIR wavelength, and the third NIR wavelength is longer than the first NIR wavelength. The detecting means (220) includes a first, second and third detectors (221, 222, 223) for respectively detecting the NIR intensities of the first, second and third NIR wavelengths traveled across the brain. The processor (230) is configured to determine blood oxygen level based on the measured NIR intensities of the first, second and third NIR wavelengths by use of build-in algorithm derived from Beer-Lambert Law. And method of detecting brain hematoma of a subject by use of the present device.

The invention discloses a dynamic brain function dual-mode imaging system based on fluorescence and photoacoustic tomography, which organically combines the two measurement methods of FMT / PAT, so thatthe source and probe of FMT and PAT are distributed on the same horizontal plane in order to avoid the difference in registration position of joint imaging, to achieve high sensitivity, high spatio-temporal resolution and full-brain range imaging dual-mode multi-parameter dynamic imaging of brain function and to take into account the high sensitivity of FMT in dynamics research and advantages ofPAT in high spatial resolution. PAT provides images of deep cerebral oxygen state related to nerve activity, including oxyhemoglobin concentration, deoxyhemoglobin concentration, blood oxygen saturation, etc. FMT provides fluorescence distribution images and kinetic parameter images, including fluorescence metabolism curves, permeability images, etc. The system has both high resolution of PAT andhigh sensitivity of FMT to realize imaging of cranial nerve activity.

The invention discloses an fNIRS emotion recognition method and system based on a graph network and adaptive denoising, and the method comprises the steps: enabling fNIRS collection equipment to continuously collect the variable quantity of light intensity before and after transmitting-receiving, converting the variable quantity of the light intensity into the change of absorbance, and further obtaining the relative variable quantity of the concentration of oxyhemoglobin and the concentration of deoxidized hemoglobin; de-noising is carried out through a self-adaptive de-noising network model to obtain a pure signal, an input signal of the self-adaptive de-noising network model is the relative variation of the concentration of the oxyhemoglobin and the concentration of the deoxidized hemoglobin obtained in the previous step, and an output signal of the self-adaptive de-noising network model is the relative variation data of the concentration of the pure oxyhemoglobin and the concentration of the deoxidized hemoglobin; mapping of graph nodes is carried out in combination with probe and channel characteristics, brain topology restoration is carried out by using a graph network, and emotion tags are output in a classified manner through a dynamic graph attention emotion recognition network model. The problems that a brain-computer interface is complex to wear, difficult to operate and the like in practical application at present are solved.

The invention discloses a method for determining human serum folic acid. The method comprises the steps of preparation of experimental water, preparation of a folic acid standard solution, preparation of a lactobacillus rhamnosus growth medium, preparation of lactobacillus rhamnosus, preparation of a detection medium and detection of the serum folic acid. By adopting activated carbon to adsorb organic impurities in water, the purpose of eliminating interferences can be achieved; the folic acid is unstable in chemical property and easily oxidized; ascorbic acid is added in the growth and detection mediums as an antioxidant, so that the oxygen in dissolved blood is reduced as much as possible, so that the content of deoxyhemoglobin is increased, and the effect of protecting the folic acid is achieved; and during detection, a cell culture plate is sealed by a sealing film, so that growth of the lactobacillus rhamnosus is facilitated, and moisture evaporation and oxidation of the folic acid can also be prevented. The method for determining the human serum folic acid provided by the invention is simple and easy to implement, low in price, high in sensitivity, and is more suitable for the folic acid screening needs of large-scale population.

An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the p resent invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic / electrical / chemical stimulations, drug delivery, micro-dialysis, accompanied by electrical signal recording, wireless image transmission and charging.

The invention provides a brain-computer interface system based on a direct flight time measurement technology, brain-computer interface wearable equipment and a control method thereof, and the system comprises a processor which is used for controlling the whole brain-computer interface system; a light source module, a photoelectric sensor, a trans-impedance amplifier, an analog-to-digital converter, a first height comparator and a second high-speed comparator. According to the system, a direct time-of-flight (DDoF) measurement technology is applied to the field of functional near-infrared brain-computer interfaces. By directly measuring the time difference between the incident ultrashort pulse near-infrared light and the emergent ultrashort pulse near-infrared light, the passing distance of the near-infrared light in the brain is calculated, and according to the scheme, the absolute value of the concentration of deoxyhemoglobin and oxyhemoglobin in the brain can be measured; and the position of the blood oxygen change of the brain can be directly measured.

Described are various embodiments of a self-monitoring oxygenation system and method. In one embodiment, a system is provided for monitoring for abnormal blood oxygenation levels. The system comprises: an optical spectroscopy probe for acquiring blood oxygenation data representative of deoxyhemoglobin levels over time; and a digital data processor operatively connected to said probe and programmedto: monitor relative variations in said deoxyhemoglobin levels to output a signal representative of a higher health risk rating of hyperoxia.

The present invention relates to the technical field of blood oxygen measurement in biomedical engineering, and proposes a method for measuring blood oxygen saturation using a single-distance light source-detector pair, including the following steps: S1, configuring two phantoms with known absorption coefficients Model; S2, measuring the light intensity of the two phantom models at wavelength λ1 and wavelength λ2 by single-distance light source-detector; S3, measuring the light intensity of the sample at wavelength λ1 and wavelength λ2 by single-distance light source-detector; S4. Calculate the absorption coefficients of the samples at the two wavelengths according to the measured light intensity values; S5. Calculate the concentrations of oxyhemoglobin and deoxyhemoglobin in the samples according to the absorption coefficients at the two wavelengths. The present invention can quantify blood oxygen saturation by measuring optical signals with a single-distance light source-detector pair, simplifies the measuring instrument, has high accuracy, and can be widely used in the technical field of blood oxygen measurement.

The invention provides metabolic rate detection method and detection apparatus. The metabolic rate detection method comprises the following steps: detecting characteristic light of oxyhemoglobin at asampling site by adopting the metabolic rate detection apparatus; obtaining a time-absorbance curve and a time-absorbance change rate according to absorbance curve of the oxyhemoglobin or the deoxyhemoglobin; and then, obtaining metabolic rate of the sampling site by combining the time-absorbance curve and the time-absorbance change rate with other parameters. The metabolic rate detection apparatus comprises a pressure regulation device, a detection device and a central processor; the pressure regulation device and the detection device are respectively connected with the central processor; thedetection device is used for detecting the characteristic light of the sampling site, as well as sending the characteristic light to the central processor; and the central processor controls pressurization and pressure relief of the pressure regulation device. The metabolic rate detection apparatus is capable of indirectly measuring metabolic rate of the human body; and moreover, the metabolic rate detection apparatus has less interference factors, and is high in accuracy.

The invention discloses a near-infrared spectrum device capable of being worn on the head, and relates to the technical field of near-infrared spectrum, in particular to the near-infrared spectrum device capable of being worn on the head, which comprises a head ring body, a binding belt arranged on the head ring body and a near-infrared control system arranged in the head ring body, the two ends of the binding belt are fixed to the two ends of the head ring body respectively, and the head ring body can be worn on the frontal lobe area of the head. Near-infrared light is emitted to the frontal lobe area of the head through the near-infrared lamp set, the near-infrared light is matched with the infrared sensor to be used for estimating the blood volume and oxygenation in a light propagation mode through the near-infrared spectrum technology, and the change of the concentration of oxygen and deoxidized hemoglobin in the area near the cortex surface can be measured. The collected data is fed back to the microcontroller, and the data processed by the microcontroller is transmitted to mobile equipment with analysis and feedback software through the communication control module and used for obtaining the blood flow on the brain epidermis.

A non-invasive, continuous, real-time detection system for determining an amount of tissue hypoperfusion in a patient includes an illumination system adapted to illuminate a section of tissue of a patient with light comprising at least five wavelength components, a detection system arranged to detect light from the illumination system after the light has passed through the section of tissue, and a signal processing system adapted to communicate with the detection system. The signal processing system is configured to calculate a relative amount of each of five forms of hemoglobin compared to substantially total hemoglobin, the five forms of hemoglobin being oxy-hemoglobin, deoxy-hemoglobin, met-hemoglobin, carboxy-hemoglobin, and sulf-hemoglobin. The signal processing system outputs information concerning detected sulf-hemoglobin for determining the amount of tissue hypoperfusion, and the illumination system and the detection system are adapted to be at least one of stuck on, clamped on, or attached to an external region of the patient's body.

The invention provides a method and system for measuring skin physiology parameters and optical property parameters based on reflective spectral measurement. The measuring system is composed of measuring equipment for a skin reflection spectrum and a computation and display device. By utilizing an analysis method of combining experimental data with the Monte Carlo simulation, the measuring systemprovides more accurate corresponding data of reflection light intensity and skin optical property; during the practical measurement of sample skin, on the basis of a practically measured reflection spectrum, the data and more physiology parameters are calculated and fit to obtain the skin physiology parameters and the optical property parameters based on reflective spectral measurement; finally, the optical property parameters of the skin adsorption coefficient mu a, a reduction scattering coefficient mu s' and the like as well as physiological information, such as melanin content, deoxygenated haemoglobin content, oxygenated haemoglobin content, moisture content and the like are also measured are measured in real time in a non-invasive and lossless mode.

The invention is suitable for the technical field of muscle oxygen detection, and provides a muscle oxygen detection method and a muscle oxygen recovery method and system.The muscle oxygen detection method is applied to muscle oxygen detection equipment and comprises the steps that when a light source emits light of a first wavelength and a second wavelength to a to-be-detected tissue, the light of the first wavelength and the light of the second wavelength are emitted; respectively acquiring first emergent light intensity, second emergent light intensity, third emergent light intensity and fourth emergent light intensity; according to the light intensity of the light with the first wavelength incident from the to-be-detected tissue, the light intensity of the light with the second wavelength incident from the to-be-detected tissue, the first emergent light intensity, the second emergent light intensity, the third emergent light intensity, the fourth emergent light intensity, the distance between the first detector and the light source and the distance between the second detector and the light source, the light intensity of the light with the first wavelength incident from the to-be-detected tissue is calculated; determining the concentration of oxygen-containing hemoglobin and the concentration of deoxidized hemoglobin of the tissue to be detected; according to the concentration of the oxygen-containing hemoglobin and the concentration of the deoxidized hemoglobin, determining the muscle oxygen of the to-be-detected tissue. Through the method, the accuracy of the obtained muscle oxygen can be improved.

The invention discloses a method and a monitoring device for non-invasive monitoring of cerebral blood oxygen. The invention utilizes the difference in absorption of near-infrared light between oxygenated hemoglobin and deoxygenated hemoglobin to develop a method for monitoring blood oxygen saturation in local tissues of the human brain. Non-invasive monitoring method, this method will not cause harm to the human body, and the continuous real-time monitoring of cerebral blood oxygen value can be realized through the continuous cerebral blood oxygen value prediction model, considering the influence of melanin and adding a correction factor, respectively detecting surface interference signals With the deep useful signal, the collected signal content is more abundant, and it is convenient to process the cerebral blood oxygen signal with high signal-to-noise ratio, and then obtain the local blood oxygen saturation monitoring value in the prefrontal region of the brain that removes the interference signal of the human head tissue, so that Cerebral blood oxygen continuous monitoring has better stability and higher monitoring accuracy. The invention provides a new solution for non-invasive monitoring of cerebral blood oxygen, and is more conducive to promoting the clinical application of non-invasive monitoring of cerebral blood oxygen.

The invention discloses a detection system and method for noninvasive measurement of tissue deoxyhemoglobin, oxyhemoglobin and carbonyl hemoglobin. The detection system comprises a probe and a host; the probe is composed of an upper cover layer, a shell, a signal receiving module and a lower cover layer; and the signal receiving module is composed of an optical filter and a detector, and the shell, the optical filter and the detector are located between the upper cover layer and the lower cover layer to form a sandwich structure. The host is composed of a power supply module, a light source driving module, a light source, a central processing module, a display module, a storage module, a signal processing module and a user information input module. The host and the probe are connected through a cable capable of transmitting optical signals and a cable capable of transmitting electric signals, the probe is completely attached to human tissue, the light source driving module in the host controls a light source to emit light, the signal processing module processes photoelectric signals of the signal receiving module and transmits the photoelectric signals to the storage module, the central processing module calls data in the storage module, the central processing module calculates the data and then the data is displayed through the display module. According to the invention, tissue deoxyhemoglobin, oxyhemoglobin and carbonyl hemoglobin can be noninvasively measured at the same time.

The invention relates to a graded compression stretch sock with a pressure adjusting function, which comprises a stretch sock, the stretch sock comprises a plurality of elastic layers, and the elasticity between two adjacent elastic layers is gradually reduced from bottom to top; each elastic layer is provided with an oxyhemoglobin saturation monitoring device 4, a plurality of groups of oxyhemoglobin saturation monitoring devices 4 can be arranged on each elastic layer, the oxyhemoglobin saturation monitoring devices 4 are uniformly arranged around the sections of the elastic layers, fixing rings are arranged between the elastic layers, and the fixing rings can be clamped to prevent the elastic layers from shifting after the positions of the elastic layers are adjusted; the blood oxygen saturation monitoring device 4 is used for monitoring oxygen-containing hemoglobin parameters and deoxidized hemoglobin parameters of the skin of the detected part; the device has the advantages of being capable of achieving grading of pressure gradients, assisting blood in flowing back upwards into the heart, effectively resisting the gravity effect, increasing the return blood volume, relieving and improving pressure borne by lower limb veins and vein valves, monitoring the skin blood oxygen saturation degree, effectively preventing skin injuries and improving the compliance of a patient to pressure treatment.

A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third NIR wavelengths across the brain of the subject. The first NIR wavelength is the isosbestic wavelength for oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb), the second NIR wavelength is shorter than the first NIR wavelength, and the third NIR wavelength is longer than the first NIR wavelength. The detecting means (220) includes a first, second and third detectors (221, 222, 223) for respectively detecting the NIR intensities of the first, second and third NIR wavelengths traveled across the brain. The processor (230) is configured to determine blood oxygen level based on the measured NIR intensities of the first, second and third NIR wavelengths by use of build-in algorithm derived from Beer-Lambert Law. And method of detecting brain hematoma of a subject by use of the present device.

Problem To provide an apparatus for evaluating biological function, and a method and a program for evaluating biological function, for the purpose of measuring and quantifying biological function, to make possible the quantification of measured values concerning brain characteristics at time of rest.Means for resolution The apparatus for evaluating biological function (1) is [an apparatus] that utilizes the near-infrared spectroscopy method to evaluate biological function; measuring part 5 computes time course change amounts of oxyhemoglobin and time course change amounts of deoxyhemoglobin, based on light information from detecting parts 4; and it has a computing part 8, which obtains a group of zeroset vectors at prescribed sampling times based on 2-dimensional diagrams showing the relationship between change amounts of oxyhemoglobin and change amounts of deoxyhemoglobin, and computes parameters based on the directions and / or scalars of that vector group.