31 results about "Deoxy hemoglobin" patented technology

A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (μa and μs′) at each wavelength are calculated. The obtained μa and μs′ values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.

The invention discloses a method and device for measuring oxygen-containing hemoglobin and deoxygenated hemoglobin and equipment. The device comprises a near-infrared emission module, a near-infraredreceiving module and a controller, wherein the near-infrared emission module is used for emitting near-infrared light of target compound waveforms to the tested cerebral cortex, the near-infrared receiving module is used for receiving a luminous intensity signal, reflected by the tested cerebral cortex, of the near-infrared light, and the controller is used for receiving target measuring requirement parameters, adjusting the near-infrared light waveforms emitted by the near-infrared emission module according to the target measuring requirement parameters to obtain the target compound waveforms, controlling the near-infrared emission module to emit the near-infrared light according to the target compound waveforms, receiving luminous intensity information output by the near-infrared receiving module, and measuring oxygen-containing hemoglobin parameters and deoxygenated hemoglobin parameters of the tested cerebral cortex according to the luminous intensity information. In this way, thefunction of dynamically adjusting output waveforms to adapt to different testing items and different testees is achieved, and the using adaptability of products is improved.

The invention discloses an fNIRS emotion recognition method and system based on a graph network and adaptive denoising, and the method comprises the steps: enabling fNIRS collection equipment to continuously collect the variable quantity of light intensity before and after transmitting-receiving, converting the variable quantity of the light intensity into the change of absorbance, and further obtaining the relative variable quantity of the concentration of oxyhemoglobin and the concentration of deoxidized hemoglobin; de-noising is carried out through a self-adaptive de-noising network model to obtain a pure signal, an input signal of the self-adaptive de-noising network model is the relative variation of the concentration of the oxyhemoglobin and the concentration of the deoxidized hemoglobin obtained in the previous step, and an output signal of the self-adaptive de-noising network model is the relative variation data of the concentration of the pure oxyhemoglobin and the concentration of the deoxidized hemoglobin; mapping of graph nodes is carried out in combination with probe and channel characteristics, brain topology restoration is carried out by using a graph network, and emotion tags are output in a classified manner through a dynamic graph attention emotion recognition network model. The problems that a brain-computer interface is complex to wear, difficult to operate and the like in practical application at present are solved.

An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the p resent invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic / electrical / chemical stimulations, drug delivery, micro-dialysis, accompanied by electrical signal recording, wireless image transmission and charging.

The invention provides a brain-computer interface system based on a direct flight time measurement technology, brain-computer interface wearable equipment and a control method thereof, and the system comprises a processor which is used for controlling the whole brain-computer interface system; a light source module, a photoelectric sensor, a trans-impedance amplifier, an analog-to-digital converter, a first height comparator and a second high-speed comparator. According to the system, a direct time-of-flight (DDoF) measurement technology is applied to the field of functional near-infrared brain-computer interfaces. By directly measuring the time difference between the incident ultrashort pulse near-infrared light and the emergent ultrashort pulse near-infrared light, the passing distance of the near-infrared light in the brain is calculated, and according to the scheme, the absolute value of the concentration of deoxyhemoglobin and oxyhemoglobin in the brain can be measured; and the position of the blood oxygen change of the brain can be directly measured.

Described are various embodiments of a self-monitoring oxygenation system and method. In one embodiment, a system is provided for monitoring for abnormal blood oxygenation levels. The system comprises: an optical spectroscopy probe for acquiring blood oxygenation data representative of deoxyhemoglobin levels over time; and a digital data processor operatively connected to said probe and programmedto: monitor relative variations in said deoxyhemoglobin levels to output a signal representative of a higher health risk rating of hyperoxia.

The present invention relates to the technical field of blood oxygen measurement in biomedical engineering, and proposes a method for measuring blood oxygen saturation using a single-distance light source-detector pair, including the following steps: S1, configuring two phantoms with known absorption coefficients Model; S2, measuring the light intensity of the two phantom models at wavelength λ1 and wavelength λ2 by single-distance light source-detector; S3, measuring the light intensity of the sample at wavelength λ1 and wavelength λ2 by single-distance light source-detector; S4. Calculate the absorption coefficients of the samples at the two wavelengths according to the measured light intensity values; S5. Calculate the concentrations of oxyhemoglobin and deoxyhemoglobin in the samples according to the absorption coefficients at the two wavelengths. The present invention can quantify blood oxygen saturation by measuring optical signals with a single-distance light source-detector pair, simplifies the measuring instrument, has high accuracy, and can be widely used in the technical field of blood oxygen measurement.

The invention provides a method and system for measuring skin physiology parameters and optical property parameters based on reflective spectral measurement. The measuring system is composed of measuring equipment for a skin reflection spectrum and a computation and display device. By utilizing an analysis method of combining experimental data with the Monte Carlo simulation, the measuring systemprovides more accurate corresponding data of reflection light intensity and skin optical property; during the practical measurement of sample skin, on the basis of a practically measured reflection spectrum, the data and more physiology parameters are calculated and fit to obtain the skin physiology parameters and the optical property parameters based on reflective spectral measurement; finally, the optical property parameters of the skin adsorption coefficient mu a, a reduction scattering coefficient mu s' and the like as well as physiological information, such as melanin content, deoxygenated haemoglobin content, oxygenated haemoglobin content, moisture content and the like are also measured are measured in real time in a non-invasive and lossless mode.

A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers / light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.

The invention discloses a method and a monitoring device for non-invasive monitoring of cerebral blood oxygen. The invention utilizes the difference in absorption of near-infrared light between oxygenated hemoglobin and deoxygenated hemoglobin to develop a method for monitoring blood oxygen saturation in local tissues of the human brain. Non-invasive monitoring method, this method will not cause harm to the human body, and the continuous real-time monitoring of cerebral blood oxygen value can be realized through the continuous cerebral blood oxygen value prediction model, considering the influence of melanin and adding a correction factor, respectively detecting surface interference signals With the deep useful signal, the collected signal content is more abundant, and it is convenient to process the cerebral blood oxygen signal with high signal-to-noise ratio, and then obtain the local blood oxygen saturation monitoring value in the prefrontal region of the brain that removes the interference signal of the human head tissue, so that Cerebral blood oxygen continuous monitoring has better stability and higher monitoring accuracy. The invention provides a new solution for non-invasive monitoring of cerebral blood oxygen, and is more conducive to promoting the clinical application of non-invasive monitoring of cerebral blood oxygen.

The invention discloses a detection system and method for noninvasive measurement of tissue deoxyhemoglobin, oxyhemoglobin and carbonyl hemoglobin. The detection system comprises a probe and a host; the probe is composed of an upper cover layer, a shell, a signal receiving module and a lower cover layer; and the signal receiving module is composed of an optical filter and a detector, and the shell, the optical filter and the detector are located between the upper cover layer and the lower cover layer to form a sandwich structure. The host is composed of a power supply module, a light source driving module, a light source, a central processing module, a display module, a storage module, a signal processing module and a user information input module. The host and the probe are connected through a cable capable of transmitting optical signals and a cable capable of transmitting electric signals, the probe is completely attached to human tissue, the light source driving module in the host controls a light source to emit light, the signal processing module processes photoelectric signals of the signal receiving module and transmits the photoelectric signals to the storage module, the central processing module calls data in the storage module, the central processing module calculates the data and then the data is displayed through the display module. According to the invention, tissue deoxyhemoglobin, oxyhemoglobin and carbonyl hemoglobin can be noninvasively measured at the same time.

A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third NIR wavelengths across the brain of the subject. The first NIR wavelength is the isosbestic wavelength for oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb), the second NIR wavelength is shorter than the first NIR wavelength, and the third NIR wavelength is longer than the first NIR wavelength. The detecting means (220) includes a first, second and third detectors (221, 222, 223) for respectively detecting the NIR intensities of the first, second and third NIR wavelengths traveled across the brain. The processor (230) is configured to determine blood oxygen level based on the measured NIR intensities of the first, second and third NIR wavelengths by use of build-in algorithm derived from Beer-Lambert Law. And method of detecting brain hematoma of a subject by use of the present device.

Problem To provide an apparatus for evaluating biological function, and a method and a program for evaluating biological function, for the purpose of measuring and quantifying biological function, to make possible the quantification of measured values concerning brain characteristics at time of rest.Means for resolution The apparatus for evaluating biological function (1) is [an apparatus] that utilizes the near-infrared spectroscopy method to evaluate biological function; measuring part 5 computes time course change amounts of oxyhemoglobin and time course change amounts of deoxyhemoglobin, based on light information from detecting parts 4; and it has a computing part 8, which obtains a group of zeroset vectors at prescribed sampling times based on 2-dimensional diagrams showing the relationship between change amounts of oxyhemoglobin and change amounts of deoxyhemoglobin, and computes parameters based on the directions and / or scalars of that vector group.