The invention discloses a real-time route planning method based on a decision tree. The method comprises the following steps: firstly, a low-altitude airspace probability model is established, a three-dimensional continuous space is expressed by using a discrete two-dimensional space, namely, a planning space is expressed as a discrete grid chart with a certain longitude difference and latitude difference, a dangerous area is divided into a no-fly area and a high-risk area, and then the cost value of each node in the model is calculated; secondly, initial route planning is carried out, a direct flight path and a fly-around path are planned for a high-risk area, only the fly-around path is planned for a no-fly area, a route decision tree is generated, and an initial route set is determined; according to the actual situation in flight, the planned route set is selected, and the planning result is updated in real time. Threatening factors such as terrain obstacles and severe weather are comprehensively considered, and the method is safer; the route decision-making tree comprising a plurality of routes is planned in consideration of uncertainty of prior information of a dangerous area, and the method is more practical; and according to the actual situation in flight, the planning result is updated in real time, which is more flexible.