A method for managing aircraft operations includes determining, via a trajectory predictor, an expected fuel usage for a flight along a desired route, and determining, via at least one processor, an available cargo capacity for the flight along the desired route based at least in part on the expected fuel usage. In addition, the method includes determining, via the at least one processor and the trajectory predictor, a passenger ticket price, a cargo price, and a fuel quantity based at least in part on an available seating capacity, an expected passenger demand, the available cargo capacity, and an expected cargo demand to enhance profitability of a flight network. The method also includes outputting the passenger ticket price, the cargo price, and the fuel quantity to a user interface, to a storage device, and/or to a network.