Method and system for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement

A technology of optical characteristic parameters and physiological parameters, which is applied in the field of spectral technology application and biomedical engineering, and can solve the problems of large measurement range, inability to meet tissue uniformity, and application to difficult skin tissue.

Active Publication Date: 2011-05-18
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

(See F. Bevilacqua, D. Piguet, etc., "In vivolocal determination of tissue optical properties: applications to human brain". Applied Optics, 1999) In order to obtain better absorption and scattering resolution, a larger measurement range is required, but The complexity of skin tissue structure makes large-scale measurements unable to meet the conditions of tissue homogeneity
Therefore, it is difficult to apply on skin tissue
The time-domain method for measuring tissue optical properties requires the use of a pulsed laser and a detector with a time-resolution capability on the order of picoseconds, (see B.J.Tromberg, N.Shah, etc., "Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy" , Neoplasia, 2000) The equipment is expensive and the implementability is poor

Method used

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  • Method and system for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement
  • Method and system for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement
  • Method and system for measuring kin physiology parameters and optical property parameters based on reflective spectral measurement

Examples

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Effect test

Embodiment 1

[0127] Example 1: Composition of reflectance spectrum measurement system

[0128] See figure 1 , To introduce the structural composition of the system for measuring skin physiological parameters and optical characteristic parameters based on reflectance spectroscopy:

[0129] The skin reflectance spectrum measurement system includes a skin reflectance spectrum measurement device and a calculation and display device. The skin reflectance spectrum measurement device includes 1. Broad spectrum light source; 2. Spectral detector; 3. Incident optical fiber; 4. Reflection probe; 5. , Receiving fiber; 6, reflection probe holder; 7, data transmission line; calculation and display device is composed of analog-to-digital conversion module, calculation module, memory, display processing module, display, and data bus. Since the light intensity fluctuation of the halogen tungsten lamp under stable voltage is small and the continuity under the wavelength change in the visible and near infrared ...

Embodiment 2

[0131] Example 2: Measurement process of skin physiological parameters and optical characteristic parameters

[0132] In practical applications, the reflected light intensity optimization data T containing a large amount of experimental and Monte Carlo simulation data has been recorded and stored in the storage unit of the computing and display device. The process of using this device to measure tissue physiological parameters and optical characteristic parameters is as follows:

[0133] 1) Connect the components of the device, place the reflection probe vertically on the clean and flat surface of the skin to be tested, and record the skin reflection light intensity M(λ);

[0134] 2) Place the reflection probe vertically at a fixed distance d above the reflection standard, and record the reflected light intensity of the standard film M std (λ);

[0135] 3) The normalized measured skin reflectance spectrum is

[0136] 4) Set four physiological parameters and two scattering parameters:...

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Abstract

The invention provides a method and system for measuring skin physiology parameters and optical property parameters based on reflective spectral measurement. The measuring system is composed of measuring equipment for a skin reflection spectrum and a computation and display device. By utilizing an analysis method of combining experimental data with the Monte Carlo simulation, the measuring system provides more accurate corresponding data of reflection light intensity and skin optical property; during the practical measurement of sample skin, on the basis of a practically measured reflection spectrum, the data and more physiology parameters are calculated and fit to obtain the skin physiology parameters and the optical property parameters based on reflective spectral measurement; finally, the optical property parameters of the skin adsorption coefficient mu a, a reduction scattering coefficient mu s' and the like as well as physiological information, such as melanin content, deoxygenated haemoglobin content, oxygenated haemoglobin content, moisture content and the like are also measured are measured in real time in a non-invasive and lossless mode.

Description

Technical field [0001] The present invention is the field of spectral technology application and biomedical engineering, which involves a measurement method of skin physiological parameters and optical characteristic parameters measured based on reflected spectral measurements. Background technique [0002] In recent years, medical diagnosis and treatment with optical means are gradually receiving widespread attention from biomedical researchers.Compared with other medical testing technologies such as X -ray, CT, and MRI, optical technology can implement the non -destructive structure and functional detection of the tissue in a non -invasive manner, and has the advantages of widely available scope, high portability, and low cost.Organic optical characteristics parameters describe biological tissue response to different wavelength incident light by evaluating the optical characteristics such as absorption and scattering in tissue.The optical characteristic parameters in the quanti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
Inventor 朱骆清铭闻翔
Owner HUAZHONG UNIV OF SCI & TECH
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