Biocompatibility pre-gelatinized modified starch and preparation thereof

Abstract

The invention relates to a biocompatible pre-gelatinized modified starch. The water absorbency is not less than one time, and the biocompatible pre-gelatinized modified starch is taken as biocompatible hemostatic material, biocompatible anti-blocking material, biocompatible tissue-healing promoting material, biocompatible surgical sealant or biocompatible wound closure tissue glue. The invention has the advantages that the biocompatible pre-gelatinized modified starch is directly acted on the wounded area with blood for immediately stopping bleeding, has obviously increased water absorbency and speed of water absorption and greater viscosity and stickiness and further plays the role in preventing the tissue and the blood vessel from being damaged during the process of stopping bleeding; the modified starch is easy to swell or dissolve in water, and is washed by normal saline after the bleeding stopping so as to reduce the residual in the body, to be favorable for wound healing and to avoid the pain due to tearing the gauze and the bandage out; the pre-gelatinized modified starch has the actions of bacterial resistance and anti-inflammatory; and the pre-gelatinized modified starch is stable, not easy to decompose, long in guarantee period, convenient for storage, resistant at high pressure and low pressure, resistant at high temperature and low temperature and not easy to change the physicochemical characteristics.

Description

technical field

[0001] The present invention relates to a biocompatible modified starch material, especially a kind of directly acting on the wounds of humans, mammals, etc., including wounds with blood or exudate, as a hemostatic material, or further used in the human body Body surface, tissues and organs, and tissues or organs in body cavities, as anti-adhesion materials, materials for promoting tissue healing, surgical sealants, wound-free tissue glue, and biocompatible pregelatinized denaturation that can be absorbed by humans and animals Starch and its preparation method. Background technique

[0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will be lost, and it is necessary to use hemostatic means in time. The use of biocompatible absorbable hemostatic materials to stop bleeding on bleeding wounds is a common means of hemostasis, and there is an urgent need for hemostasis in surgical hemostasis, trauma, first aid, an...

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