42 results about "Nitric oxide gas" patented technology

The invention relates to a gas supply method and device based on nitric oxide controllable pulse ionization generation and a nitric oxide therapeutic apparatus, and the method comprises the steps: carrying out the feature extraction of different dimensions of a to-be-ionized gas, and obtaining the basic features of an ionization environment and the component features of an ionization medium; generating a pulse ionization control sequence according to the basic characteristics of the ionization environment, the component characteristics of the ionization medium and the historical pulse ionization control sequence sample; the pulse ionization control sequence is sent to the ionization generation device to execute pulse ionization operation, a nitric oxide gas product is generated, and gas supply operation is executed according to the generated nitric oxide gas product; monitoring a real-time ionization process state of the pulse ionization operation, and generating a real-time ionization process state set according to an ionization discharge intensity characteristic, a medium temperature distribution characteristic and a gas generation rate characteristic in the real-time ionization process state; and performing matching analysis on the real-time ionization process state set and historical real-time ionization process state characteristics to generate a new pulse ionization control sequence.

The utility model discloses a reaction device for normal-pressure leaching of nitric acid, which is characterized in that in the reaction process, nitric oxide in a reaction kettle enters an absorption tower through a nitric oxide exhaust outlet, a first pipeline and a nitric oxide gas inlet, and an oxygen supply device supplies oxygen to the absorption tower; an absorption liquid circulating pump I conveys an absorbent in the absorption tower circulating device to an absorbent circulating inlet I and enters the absorption tower, the absorbent absorbs nitric oxide gas to form nitric acid, nitric oxide released in the process reacts with oxygen to generate nitrogen dioxide, and the nitrogen dioxide reacts with the absorbent to generate nitric acid; according to the device, nitrogen oxide gas generated in the reaction process can be absorbed, the obtained absorption acid (nitric acid) can be cyclically applied to the leaching reaction, and tail gas can be discharged after reaching the standard. And the method is environment-friendly.

The invention relates to a preparation method and application of nitric oxide gas release hydrogel for chronic wound repair of diabetes mellitus, and belongs to the technical field of biomedical materials. According to the invention, hyaluronic acid is modified by tris (hydroxymethyl) aminomethane with mechanical properties and structural stability, so that the stability of the hydrogel is improved, and the problem that traditional hydrogel is fragile and easy to collapse is solved; the epsilon-polylysine is introduced, so that the hydrogel has a sterilization effect, and infectious bacteria at chronic wounds can be efficiently sterilized; nitric oxide donor small molecules are introduced into hydrogel, and on-demand release in a pathological environment is realized by combining a high active oxygen response mechanism; through dynamic inclusion of the hollow meso-porous silicon-selenium hybrid nanostructure and cyclodextrin, the drug loading efficiency and release stability of the nanoparticles are further improved, and the nanoparticles are endowed with good responsiveness, controllability and synergistic function. The prepared nitric oxide gas release hydrogel can significantly accelerate healing of chronic wound surfaces of diabetes, the preparation process is mild, simple and convenient, and large-scale production is easy.

The present application relates to a kind of purification method of nitric oxide gas, comprising the following steps: crude nitric oxide gas is imported into extraction column, and the extraction phase obtained after extraction is imported into resolution column for temperature resolution;Nitric oxide gas resolved is imported into ethanol absorption tower after alkali washing tower and condenser;Again imported into the adsorption tower filled with 13X molecular sieve;After adsorption, the gas is collected into product collection bottle, and the purity of more than 99.99% nitric oxide product is obtained.The present application uses ferrous sulfate solution as extractant, extracts refined nitric oxide, realizes the efficient extraction of nitric oxide by the coordination reaction of ferrous ion and nitric oxide in the purification process, then uses ethanol as absorbent, utilizes the significant difference in solubility of nitric oxide and nitrous oxide in ethanol, can selectively absorb the nitrous oxide impurity difficult to remove, finally uses 13X molecular sieve to further remove nitrous oxide, which is beneficial to reduce disproportionation reaction and improve product purity.

The invention provides a heat pipe enhanced heat exchange reducing absorption tower for nitric acid preparation, which comprises a tower body and a heat pipe exchanger, nitric oxide gas enters from the tower bottom, absorption liquid enters from the tower top, and the nitric oxide gas and the absorption liquid contact and react in the tower body to generate nitric acid, and is characterized in that the tower body is divided into a plurality of sections from top to bottom, the diameters of the sections are different, and the diameters of the sections are different in the direction from top to bottom; the diameter of the tower body is gradually increased; a plurality of heat pipe heat exchangers are arranged, an inclined angle is formed between the heat pipe heat exchangers and the tower body, an evaporation section of each heat pipe is arranged in the tower body, and a condensation end of each heat pipe extends out of the tower body. The design of the reducing absorption tower is matched with the concentration of nitrogen oxide, so that the absorption efficiency can be remarkably improved.

The invention discloses traditional Chinese medicine polysaccharide composite hydrogel as well as a preparation method and application thereof. The traditional Chinese medicine polysaccharide composite hydrogel is formed by a traditional Chinese medicine polysaccharide loaded photothermal agent and a nitric oxide donor, wherein the traditional Chinese medicine polysaccharide is selected from one or more of scutellaria baicalensis polysaccharide, astragalus polysaccharide, rhizoma bletillae polysaccharide, honeysuckle polysaccharide, wild chrysanthemum flower polysaccharide and pinellia ternate polysaccharide; the mass ratio of the photo-thermal agent to the traditional Chinese medicine polysaccharide is 1: (8-15); the mass ratio of the nitric oxide donor to the traditional Chinese medicine polysaccharide is 1: (8-15). The traditional Chinese medicine polysaccharide composite hydrogel can be used for treating MRSA infected wounds and has the effect of cooperating with traditional Chinese medicine polysaccharide, photo-thermal treatment and nitric oxide gas treatment.

The application discloses a method for generating nitric oxide gas, and belongs to the field of gas preparation and medical treatment, and is characterized in that the method for generating nitric oxide gas is to mix liquid medicament with solid medicament, to make the liquid medicament and the solid medicament react chemically, so as to generate nitric oxide gas with a certain concentration, the effective component of the solid medicament is nitrosyl iron sulfate, and the liquid medicament is one or a mixture of several kinds of alkali solution or slurry and salt solution or slurry. The application further discloses a corresponding device for generating nitric oxide gas.

Systems and methods are provided for generating a nitric oxide (NO) gas. A plasma generating device is configured to produce a plasma to ionize a flow of a reactant gas into a product gas that comprises NO, NO2, oxygen, and nitrogen gases. A controller is configured to regulate an amount of NO in the product gas using parameters as input to the controller. A gas separation device comprising a housing including product gas inlets and sweep fluid inlets to receive a flow of the product gas and a flow of the sweep fluid such that the flows of product gas and sweep fluid are opposed flows. A membrane is positioned inside the housing and permits flow of a subset of gases of the product gas therethrough so the product gas exiting the housing includes NO.

The application discloses a purification method for high-purity nitric oxide gas production, which comprises the following steps: adding sulfuric acid drops into a sodium nitrite solution to generate a nitric oxide crude product, removing nitrogen dioxide and carbon dioxide by alkali washing, removing water by pre-cooling, removing nitrogen by deep cooling, and finally obtaining high-purity nitric oxide gas. The residual concentration of nitrous oxide in the purified nitric oxide gas can be reduced to below 3 ppm, and the purity of the nitric oxide reaches above 99.99%. The method can efficiently remove the nitrous oxide impurities, has the advantages of high product yield and simple operation, and has a wide practical application prospect.

The invention provides a gas sampling system and a medical gas transmission system, and relates to the field of sampling monitoring equipment. The gas sampling system comprises a sampling pipe, one end of the sampling pipe is communicated with an inspiration branch of a mechanical ventilation loop, the other end of the sampling pipe is communicated with a gas detection system, and nitric oxide gas is injected into the inspiration branch; the sampling pipe is used for leading gas containing nitric oxide in the gas suction branch to the gas detection system; at least one part of the sampling pipe is a water vapor permeable section, and the pipe wall of the water vapor permeable section is made of a water vapor permeable material; water content is reduced after gas passes through the sampling pipe. The gas sampling system provided by the invention solves the technical problems of inconvenience in use caused by frequent water pouring of a water collection cup or infection risk caused by bacterium breeding caused by long-time water collection of a large-capacity appliance in the prior art.

Provided are methods for delivering NO to patients, systems for delivering NO to patients, devices for generation and storage of NO, and methods for generating NO. Described are systems providing single-step and dual-step dilution of high concentration NO for delivery to a patient without generating toxic levels of NO2. Also described are NO storage cartridges for use in the systems.

The invention discloses a production process and device for preparing liquid nitrogen tetroxide by recycling nitric oxide. Nitrogen oxides in the tail gas are respectively absorbed by water and alkali liquor to prepare a nitric acid solution and a sodium nitrate-nitrous acid solution; a dilute nitric acid solution and a sodium nitrate and nitrite solution are respectively stored and then mixed to enter a nitric oxide generation tower for reaction to generate nitric oxide gas and a sodium nitrate aqueous solution. The nitric oxide gas is lightly oxidized by using oxygen in the nitric oxide generation tower, then enters the oxidation absorption tower and is heavily oxidized by using concentrated nitric acid, so that the nitric oxide gas is completely converted into nitrogen dioxide gas, and the concentrated nitric acid is used for absorption at the upper section of the oxidation absorption tower to form fuming nitric acid. Fuming nitric acid is heated by steam, and liquid nitrogen tetroxide is produced after condensation. The non-condensable gas contains a small amount of nitrogen oxides, and then passes through a denitration device. By adopting the device and the process, the nitrogen oxide in the recovered waste gas can be effectively ensured to be prepared into liquid nitrogen tetroxide, and the content of the nitrogen oxide in the waste gas outlet is reduced.

The invention relates to the technical field of nitric acid production devices, and discloses a nitric acid production high-pressure reaction cooling device suitable for a high-temperature environment, the nitric acid production high-pressure reaction cooling device comprises a reaction tank, a cooling water tank is placed on the left side of the reaction tank, and a nitrogen dioxide high-pressure tank is placed on the right side of the reaction tank; a nitric oxide gas inlet pipe is communicated between the reaction tank and the nitrogen dioxide high-pressure tank, the top end of the reaction tank is rotatably connected with a water supply pipe, the bottom end of the nitrogen dioxide high-pressure tank is communicated with a nitrogen dioxide gas outlet pipe, and the inner wall of the reaction tank is rotatably connected with a first water cooling pipe. According to the device, a servo motor drives a water supply pipe to rotate to drive spraying nozzles on a spraying support to rotate, the contact reaction range of spraying water mist and nitrogen dioxide gas is widened, and the nitrogen dioxide gas is diffused from the periphery of the outer wall of a flow dividing pipe through a waterproof ball at the top end of the flow dividing pipe; the nitrogen dioxide gas and water mist formed by spraying can be fully contacted and reacted, so that the conversion rate of nitric acid can be improved.

This invention relates to a method for preparing a nitric oxide absorbent for flue gas from a coal-fired power plant and its application, comprising the following steps: preparing tridentate aldehyde through a multi-step organic synthesis reaction; preparing triangular prism cage-like molecules; preparing a nitric oxide absorbent stock solution; and formulating the nitric oxide absorbent. The beneficial effects of this invention are: employing the principle of physical adsorption, the triangular prism cage-like compound captures NO through physical adsorption, and through desorption, high-purity nitric oxide gas can be obtained and reused for NO molecule absorption. This method is safer than traditional chemical methods, effectively avoiding the environmental hazards caused by ammonia escape and the impact of byproducts such as ammonium bisulfate on the normal operation of the unit, and also features high recycling rate and long service life.

The present invention describes systems and methods for compensating for long-term drift sensitivity in catalytic-type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient. This is achieved by compensating for drift that may be specific to sensors used atypically in these systems. In at least some cases, the long-term drift sensitivity of catalytic-type electrochemical sensors can be addressed by calibration programs. These programs can account for absolute changes in the set dose of NO delivered to the patient, which may lead to one or more baseline calibrations. The calibration programs used can reduce the number of times the sensor shuts down.The systems and methods described may take into account actions occurring in the supply system and / or aspects of the surrounding environment before performing a baseline calibration, and may postpone calibration and / or reject the use of the sensor output for calibration.

A method for removing sulfur oxides and nitrogen oxides from a gas stream, relating to the technical field of atmospheric pollution control, wherein a treated gas stream is introduced into a desulfurization reactor, and a nitric acid solution absorbent is introduced into the reactor at the same time; sulfur dioxide in the gas stream undergoes a redox reaction with nitric acid in the absorbent, so that the sulfur dioxide is oxidized into sulfur trioxide and then absorbed by the absorbent; nitric oxide gas generated during the reaction between the sulfur dioxide and the nitric acid is introduced into a denitration reactor along with the gas stream, and a ferric chloride absorbent slurry is introduced into the denitration reactor at the same time; the nitric oxide gas in the gas stream undergoes a chemical reaction with ferric chloride and is absorbed; the nitric oxide gas released during regeneration of the saturated absorbent is oxidized, and the resulting nitric acid is recycled as a desulfurization absorbent; and a ferric salt absorbent slurry is regenerated and recycled.

The utility model discloses a nitric oxide generator for treatment and a nitric oxide therapeutic apparatus thereof, the nitric oxide generator comprises a shell, the shell is internally provided with a cavity, the shell is provided with an air inlet and an air outlet which are communicated with the cavity, and the air inlet and the air outlet are communicated with the cavity. The nitric oxide generator comprises two spark plugs which penetrate through the shell, central electrodes of the two spark plugs are arranged in the cavity, the central electrodes of the two spark plugs are opposite and arranged in a spaced mode, and the central electrode of one spark plug is connected with external high-voltage positive electricity to form a positive electrode and the central electrode of the other spark plug is connected with external high-voltage positive electricity to form a negative electrode. And the central electrode of the other spark plug is connected with external high-voltage negative electricity to form a negative electrode. According to the utility model, the disturbance to flowing airflow can be greatly reduced, the flow stability of nitric oxide (NO) gas is improved, and finally, the concentration of the nitric oxide (NO) gas inhaled by a patient can be improved, so that the treatment effect is improved.

The invention discloses an integrated patch for wound pH detection and nitric oxide gas treatment and a preparation method of the integrated patch, relates to a biomedical engineering device, and is used for pH monitoring and nitric oxide (NO) treatment at a wound. According to the system, the pH value of a wound is monitored in real time by adopting a colorimetric method, and a micro light-emitting diode (LED) is used as a switch to control the release of nitric oxide, so that slow-release treatment of low-concentration nitric oxide can be realized, and sterilization treatment can be performed under a high-concentration condition. The patch specifically comprises a flexible circuit and a PVA film, and wireless gas therapy is realized through light by fixing an NO donor in the PVA film. According to the invention, ultrasonic energy can be collected in a living body and is converted into an electric signal based on a piezoelectric effect, so that wireless energy supply is realized. According to the invention, slow release and rapid release of NO can be realized, and different requirements in medical scenes can be realized.

A method for simultaneously removing nitric oxide and sulfur dioxide, belonging to the field of air pollution control technology, is characterized by introducing the gas stream to be treated into a reactor, simultaneously introducing an absorbent into the reactor. Sulfur dioxide in the gas stream undergoes a redox reaction with ferric chloride in the absorbent, causing the sulfur dioxide to be oxidized to sulfate ions, which are then absorbed by the absorbent. Nitric oxide gas in the gas stream reacts chemically with solid ferric chloride crystals in the ferric chloride slurry of the absorbent and is absorbed. The absorbent, after saturation, is regenerated and recycled. This method can also remove harmful gases such as carbon disulfide, carbon oxysulfide, and hydrogen sulfide from the gas stream separately.

The present invention relates to stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy, for the treatment of bacterial, viral or fungal conditions, including the formulas for the gels with new stabilizing ingredients / agents, together with delivery instructions that can permit self-administration of the gas, new dosage protocols for the use of the nitric oxide gas, and new drug concentrations for enhanced effectiveness. Other implementations are described.

The disclosure relates to methods of producing nitric oxide (NO) gas that is administrable without specialized equipment and does not provide nitrogen dioxide (NO2) gas. The methods comprise combining a nitrate and / or nitrite anion and an elemental metal in an acidic solution in a vessel capable of housing liquid and gas constituents, wherein NO gas is produced by the reaction of the nitrate and / or nitrite anion and the elemental metal in the acidic solution. The method further comprises administering the NO gas produced to the subject via inhalation. Also described are compositions and kits for improved delivery of NO gas.

The invention provides a gas inhalation treatment system and device, and relates to the technical field of nitric oxide generation. The gas inhalation treatment system comprises a generation module, a negative pressure extraction unit and a conveying module, the generation module comprises a reaction unit, a separation unit and a first control unit, the reaction unit is in fluid communication with the separation unit, and the first control unit is used for driving reaction liquid to flow from the reaction unit to the separation unit; the negative pressure extraction unit comprises a gas inlet passage and a pump body, one end of the gas inlet passage is provided with a gas inlet, the other end of the gas inlet passage is in fluid communication with a gas-phase inlet of the separation unit, and the pump body is in fluid communication with a gas-phase outlet of the separation unit; the delivery module comprises an output end, and the pump body is in fluid communication with the output end. According to the gas inhalation treatment system and device provided by the invention, the technical problems of small application range and low efficiency of a nitric oxide gas generation system / equipment in the prior art are solved.

Title of the Invention: Pulsed-Mode Nitric Oxide Gas Delivery Apparatus. The invention relates to a NO delivery apparatus (1) comprising a main gas circuit (40; 40.1, 40.2) with flow control means (42, 43) including at least one main solenoid valve (42), and a bypass circuit (41) connecting (140, 141) to the main gas circuit (40; 40.1, 40.2) by bypassing the flow control means (42, 43). Secondary flow control means (45, 46) including at least one on / off secondary solenoid valve (45) are arranged on the bypass circuit (41). A fixed-flow device (46) is arranged on the bypass circuit (41). Control means (50) control the secondary solenoid valve (45) in pulsed mode to alternately switch it between open and closed positions so as to produce a NO / N2 mixture in the form of successive gaseous pulses having a pulse time (di) of non-zero duration.Installation for supplying NO (10) to a patient including the device (1). Figure of the abstract: Figure 2.

The utility model provides a ventilation system with a gas output function, and relates to the field of medical instruments. The ventilation system with the gas output function comprises a ventilation unit and a nitric oxide gas preparation unit. The ventilation unit comprises a ventilation main body and a ventilation loop, one end of the ventilation loop is mounted on the ventilation main body, and the other end is connected with a patient end; the nitric oxide gas production unit comprises a gas production main body and a gas transmission pipeline, the gas production main body is detachably connected with the ventilation unit, one end of the gas transmission pipeline is communicated with the gas production main body, and the other end of the gas transmission pipeline is communicated with the ventilation loop. According to the ventilation system with the gas output function, the technical problems that in the prior art, a nitric oxide therapeutic apparatus and mechanical ventilation equipment are prone to being wrongly connected, and operation is inconvenient are solved.

The present invention relates to stabilized and NO2-inhibited nitric oxide generating gels for nitric oxide therapy, for the treatment of bacterial, viral or fungal conditions, including the formulas for the gels with new stabilizing ingredients / agents, together with delivery instructions that can permit self-administration of the gas, new dosage protocols for the use of the nitric oxide gas, and new drug concentrations for enhanced effectiveness. Liquid compositions for treatment of various conditions and saturation of articles are also described, along with other implementations.

A desorption method of a nitrogen oxide adsorbent belongs to the technical field of air pollution control and environmental protection, and is characterized by comprising two processes of desorption of the adsorbent and treatment of mixed gas after desorption, wherein in the desorption process, at least one of water vapor, ammonia gas or carbon dioxide gas is adopted as desorption regeneration gas to desorb and regenerate the adsorbent after adsorption saturation, and the desorbed mixed gas flow passes through a desorbed mixed gas treatment system to remove moisture, ammonia gas or carbon dioxide and gas contained in the gas flow; the high-concentration nitric oxide gas is obtained, and the regeneration of the adsorbent and the recovery of the nitric oxide gas are realized.

The invention discloses a nanoparticle capable of generating active oxygen and releasing nitric oxide gas molecules and a preparation method and application thereof.UCNPs nanoparticles of an oil-phase core-shell structure are modified through PVP and then co-assembled with BiVO4 and MoN through the electrostatic adsorption effect, and UPBM NPs is formed. According to the nanoparticles prepared by the invention, the photodynamic effect of BiVO4 is activated by utilizing the NIR-UV / vis up-conversion characteristic of UCNPs, so that efficient ROS killing of deep tumors is realized. Meanwhile, a MoN component with Fenton-like catalytic activity is introduced, H2O2 is continuously decomposed in a tumor microenvironment to generate OH, NO gas molecules are released, and the oxygen consumption is reduced and the oxygen dependence problem of photodynamic therapy is relieved by inhibiting cell respiration. The nano composite material is used for realizing synergistic treatment of chemodynamic treatment, NO gas treatment and photodynamic treatment on tumors.

A desorption method for a nitrogen oxide adsorbent, relating to the technical field of atmospheric pollution control and environmental protection. The method comprises two processes, i.e., desorption of an adsorbent and treatment of a mixed gas obtained by desorption, wherein the desorption process comprises using at least one of steam, ammonia or carbon dioxide as a desorption and regeneration gas to desorb and regenerate the adsorbent that has reached saturation, and a mixed gas stream obtained by desorption flowing through a treatment system of said mixed gas to remove moisture, ammonia, or carbon dioxide and gas contained in the gas stream, so as to obtain high-concentration nitric oxide. The present invention realizes regeneration of the absorbent and recovery of a nitrogen oxide gas.